期刊文献+
共找到10篇文章
< 1 >
每页显示 20 50 100
糖尿病足个性化介入治疗52例 被引量:2
1
作者 狄镇海 任重阳 +5 位作者 毛学群 张建 邹容 张爱琴 王美荣 李权 《陕西医学杂志》 CAS 2012年第3期305-307,共3页
目的:探讨糖尿病足(DF)介入治疗方法的选择和临床疗效。方法DF住院患者52例(65肢),均经数字减影血管造影(DSA)检查证实后,采用经皮腔内血管球囊成形术(PTA组)、球囊成形+内支架植入术(Stent组)及经股动脉局部药物灌注术(灌注组)治疗。... 目的:探讨糖尿病足(DF)介入治疗方法的选择和临床疗效。方法DF住院患者52例(65肢),均经数字减影血管造影(DSA)检查证实后,采用经皮腔内血管球囊成形术(PTA组)、球囊成形+内支架植入术(Stent组)及经股动脉局部药物灌注术(灌注组)治疗。结果经造影证实65侧下肢动脉均存在动脉狭窄/闭塞性病变,病变范围1.3~25.6cm,平均(12.2±5.4)cm。髂动脉、股动脉、膝以下动脉病变分别19、31、15肢。采用PTA术、球囊成形+支架植入术、局部药物灌注(分别为20、29、16肢)治疗7天后,踝肱指数(ABI)由术前的(0.40±0.16)上升至(0.69±0.15),疼痛、肢冷、间歇性跛行均明显改善,皮温升高、足背动脉搏动增强。5例慢性溃疡患者1个月内愈合3例,行低位截肢/趾2例。结论采用微创介入治疗DF具有安全、可靠等特点。根据DF不同类型和血管病变部位采用相应的介入治疗手段是保证疗效的关键。 展开更多
关键词 糖尿病足/治疗 血管成形术 气囊/方法 放射学 介入性 支架/利用 @药物灌注
下载PDF
数字减影血管造影诊断消化道出血及介入治疗的临床研究 被引量:4
2
作者 白安强 郑安婕 +3 位作者 郭卫平 李亚洲 杨帆 黎洪展 《陕西医学杂志》 CAS 2015年第8期970-971,共2页
目的:探讨数字减影血管造影(DSA)诊断消化道出血价值及介入治疗疗效。方法:选择本院于2013年1~6月收治的120例消化道出血患者作为研究对象,均行动脉DSA检查,随机分为两组,即栓塞组、药物灌注组,比较两组疗效。结果:120例患者中,经... 目的:探讨数字减影血管造影(DSA)诊断消化道出血价值及介入治疗疗效。方法:选择本院于2013年1~6月收治的120例消化道出血患者作为研究对象,均行动脉DSA检查,随机分为两组,即栓塞组、药物灌注组,比较两组疗效。结果:120例患者中,经DSA检查诊断阳性率为109例(90.8%),且不同消化道出血病因表现不同;栓塞组止血总有效率53例(96.4%),明显高于药物灌注组45例(83.3%,P〈0.05)。栓塞组不良反应发生率12.7%(7/55);药物灌注组13.0%(7/54),两组比较无明显差异(P〉0.05)。结论:DSA检查诊断消化道阳性率较高,具有重要诊断价值,且于介入下治疗消化道出血效果较佳。 展开更多
关键词 消化性溃疡出血/治疗 血管造影 数字减影 @药物灌注
下载PDF
Side Effects during Treatment of Advanced Gastric Carcinoma by Chemotherapy Combined with CIK-cell Transfusion in Elderly People 被引量:10
3
作者 Jingting Jiang Changping Wu +6 位作者 Liangrong Shi Ning Xu Haifeng Deng Mingyang Lu Mei Ji Hbei Zhu Xueguang Zhang 《Chinese Journal of Clinical Oncology》 CSCD 2008年第2期79-82,共4页
OBJECTIVE To study the side effects and therapeutic results of autologous cytokine-induced killer (CIK) cell treatment in elderly patients with advanced gastric cancer. METHODS CIK cells were induced and cultured us... OBJECTIVE To study the side effects and therapeutic results of autologous cytokine-induced killer (CIK) cell treatment in elderly patients with advanced gastric cancer. METHODS CIK cells were induced and cultured using biotechnics in vitro, and then the cells were infused back into the patients. Sixty elderly gastric cancer patients treated by chemotherapy (FOLFOX4 protocol) were followed-up. Among them, 29 patients were treated with CIK cells during application of chemotherapy. Short-term curative effects and adverse events from the CIK transfusion and chemotherapy were observed. RESULTS Eight cases developed partial remission (PR), 9 cases moderate remission (MR), 7 cases stable disease (SD) and 5 cases progressive disease (PD). Out of a total of 29 patients who received chemotherapy combined with autologous CIK therapy, the total remission rate (PR + MR) was 58.6%. The total remission rate following chemotherapy alone was 45.2%, including 5 PR cases, 9 MR cases, 7 SD cases, and 10 PD cases. There was a relatively lower rate of severe chemotherapic toxicities in the CIK-cell transfusion group. Side effects of autologous CIK transfusion included chills (13 cases), fever (9 cases), nausea and vomiting (1 case) and general malaise (3 cases). Side effects were treated with conventional therapy resulting in their amelioration. No patients developed shock, blood capillary leakage syndrome, or abnormalities in routine blood, urine, liver and renal function tests.CONCLUSION Adoptive immunotherapy with autologous CIK cells may decrease the clinical signs and symptoms of elderly patients who suffer from advanced gastric cancer. Adverse reactions of patients can be alleviated by conventional therapy. Autologous CIK-cell transfusion may improve endurance to chemotherapy. 展开更多
关键词 gastric carcinoma cytokine-induced killer cells IMMUNOTHERAPY ADOPTIVE side effects.
下载PDF
Sacral anterior root stimulated defecation in spinal cord injuries: An experimental study in canine model 被引量:3
4
作者 Shi-MinChang Guang-RongYu +3 位作者 Ying-MinDiao Meng-JieZhang Shi-BoWang Chun-LinHou 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第11期1715-1718,共4页
AIM: To investigate whether there was a dominant sacral root for the motive function of rectum and anal sphincter, and to provide an experimental basis for sacral root electrically stimulated defecation in spinal cord... AIM: To investigate whether there was a dominant sacral root for the motive function of rectum and anal sphincter, and to provide an experimental basis for sacral root electrically stimulated defecation in spinal cord injuries. METHODS: Eleven spinal cord injured mongrel dogs were included in the study. After L4-L7 laminectomy, the bilateral L7-S3 roots were electrostimulated separately and rectal and sphincter pressure were recorded synchronously. Four animals were implanted electrodes on bilateral S2 roots. RESULTS: For rectal motorial innervation, S2 was the most dominant (mean 15.2 kPa, 37.7% of total pressure), S1(11.3 kPa, 27.6%) and S3 (10.9 kPa, 26.7%) contributed to a smaller part. For external anal sphincter, S3 (mean 17.2 kPa, 33.7%) was the most dominant, S2 (16.2 kPa, 31.6%) and S1(14.3 kPa, 27.9%) contributed to a lesser but still a significant part. Above 85% L7 roots provided some functional contribution to rectum and anal sphincter. For both rectum and sphincter, the right sacral roots provided more contribution than the left roots. Postoperatively, the 4 dogs had electrically stimulated defecation and micturition under the control of the neuroprosthetic device. CONCLUSION: S2 root is the most dominant contributor to rectal pressure in dogs. Stimulation of bilateral S2 with implanted electrodes contributes to good micturition and defecation in dogs. 展开更多
关键词 Spinal cord injury DEFECATION Sacral root Electrical Stimulation
下载PDF
Trimetazidine:Is it a promising drug for use in steatotic grafts? 被引量:5
5
作者 IsmailBenMosbah AraníCasillas-Ramírez +3 位作者 CarmeXaus AnnaSerafín JoanRoselló-Catafau CarmenPeralta 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第6期908-914,共7页
AIM: Chronic organ-donor shortage has led to the acceptance of steatotic livers for transplantation, despite the higher risk of graft dysfunction or nonfunction associated with the ischemic preservation period of the... AIM: Chronic organ-donor shortage has led to the acceptance of steatotic livers for transplantation, despite the higher risk of graft dysfunction or nonfunction associated with the ischemic preservation period of these organs. The present study evaluates the effects of trimetazidine (TMZ) on an isolated perfused liver model. METHODS: Steatotic and non-steatotic livers were preserved for 24 h in the University of Wisconsin (UW) solution with or without TMZ. Hepatic injury and function (transaminases, bile production and sulfobromophthalein (BSP) clearance) and factors potentially involved in the susceptibility of steatotic livers to ischemia-reperfusion (I/R) injury, including oxidative stress, mitochondrial damage, microcirculatory diseases, and ATP depletion were evaluated. RESULTS: Steatotic livers preserved in UW solution showed higher transaminase levels, lower bile production and BSP clearance compared with non-steatotic livers. Alterations in perfusion flow rate and vascular resistance, mitochondrial damage, and reduced ATP content were more evident in steatotic livers. TMZ addition to UW solution reduced hepatic injury and ameliorated hepatic functionality in both types of the liver and protected against the mechanisms potentially responsible for the poor tolerance of steatotic livers to I/R. CONCLUSION: TMZ may constitute a useful approach in fatty liver surgery, limiting the inherent risk of steatotic liver failure following transplantation. 展开更多
关键词 Steatotic liver ISCHEMIA-REPERFUSION UW preservation solution
下载PDF
LONG-TERM OBSERVATION FOR OSSEOINTEGRATION OF CALCIUM PHOSPHATE SOL-GEL COATING ON Ti-6Al-4V IMPLANTS
6
作者 Cheng Yang Yuan-ying Li Li-e Meng Jing-xin Chen Yi Huang 《Chinese Medical Sciences Journal》 CAS CSCD 2007年第3期183-186,共4页
Objective To observe the long-term impact of calcium phosphate (CaP) sol-gel coating on bone growth around porous-surfaced implant. Methods The porous-surfaced Ti-6Al-4V implants were prepared with the addition of a... Objective To observe the long-term impact of calcium phosphate (CaP) sol-gel coating on bone growth around porous-surfaced implant. Methods The porous-surfaced Ti-6Al-4V implants were prepared with the addition of a thin film of CaP sol-gel coating, and implanted into the tibiae of 8 rabbits, each with two implants. Implanted sites were allowed to heal for 2, 8, 12, and 24 weeks, after which specimens were obtained for scanning electron microscope analysis using the freezefracture technique. Results The sol-gel coated implants recovered by freeze-fracture technique showed extensive bone growth from the endosteum along the implant surface. The bone was in direct contact with the CaP layer. The cement line-like layer was clearly demonslxated to be an intervening electron dense afibrillar layer between the CaP coat and the overlying newly deposited bone. The stability and osseointegration of the porous-surfaced implants seemed not to be affected by the osteoclastic resorption of CaP layer occurred during 24 weeks of healing. Conclusion Based on the findings in the long-term observation, the addition of a thin layer of CaP promotes an extensive osseointegrated interface between the porous-surfaced Ti-6Al-4V implants and the newly deposited bone. 展开更多
关键词 calcium phosphate sol-gel IMPLANT OSTEOCONDUCTION scanning electron microscopy
下载PDF
Primary choriocarcinoma of uterine cervix treated by uterine artery drug pouring and embolism: one case report
7
作者 Yan Wang Haiyang Jiang Shaoguang Wang Xuan Wang Zhiyun Song 《The Chinese-German Journal of Clinical Oncology》 CAS 2009年第6期366-368,共3页
Primary choriocarcinoma of the uterine cervix (PCC) is an extremely rare disease. The conventional treatment of PCC is a combination of hysterectomy and chemotherapy. We present one rare case proved by cervical biopsy... Primary choriocarcinoma of the uterine cervix (PCC) is an extremely rare disease. The conventional treatment of PCC is a combination of hysterectomy and chemotherapy. We present one rare case proved by cervical biopsy. The patient was an 36-year-old Chinese woman with irregular vaginal bleeding for 60 days. A cervical tumoral mass was seen in the pelvic examination and biopsy revealed active hyperplasia of trophoblastic cell. Because of massive vaginal haemorrhage, the patient accepted uterine artery drug pouring and embolism emergently. This management had gained a satisfactory effect. Thus, Uterine artery drug pouring and embolism is one new and effective weapon for PCC, which can preserve the patient’s productive ability. 展开更多
关键词 primary choriocarcinoma of the uterine cervix (PCC) uterine artery drug pouring EMBOLISM
下载PDF
Hige namine as a Potential Pharmacologic Stress Age nt in the Detection of Coro nary Artery Disease
8
作者 Nana Zhang Zijian Li Haibo Zhu 《Chinese Medical Sciences Journal》 CAS CSCD 2022年第3期275-281,I0014,共8页
Myocardial perfusion imaging(MPI) is valuable for the diagnosis,prognosis,and management of coronary artery disease(CAD).The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic ag... Myocardial perfusion imaging(MPI) is valuable for the diagnosis,prognosis,and management of coronary artery disease(CAD).The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic agents.However,these agents have contraindications and may cause adverse effects in some patients.Thus,other stress agents feasible for more patients are required.Higenamine(HG) is a β-adrenergic receptor agonist currently approved for clinical trials as a stress agent for myocardial infarction.It also has a promising value in MPI for the detection of CAD in preclinical and clinical studies.This review summarizes the application of HG on MPI,including its mechanism of action,stress protocol,efficacy,and safety. 展开更多
关键词 coronary artery disease HIGENAMINE myocardial perfusion imaging stress agent
下载PDF
Changes in cerebral hemodynamics in patients with posttraumatic diffuse brain swelling after external intraventricular drainage 被引量:13
9
作者 Kefei Chen Jirong Dong +4 位作者 Tian Xia Chunlei Zhang Wei Zhao Qinyi Xu Xuejian Cai 《Chinese Journal of Traumatology》 CAS CSCD 2015年第2期90-94,共5页
Purpose: To investigate the changes of cerebral hemodynamics pre- and post-ventricular drainage in patients with posttraumatic acute diffuse brain swelling. Methods: Twenty-four cases of traumatic diffuse brain swel... Purpose: To investigate the changes of cerebral hemodynamics pre- and post-ventricular drainage in patients with posttraumatic acute diffuse brain swelling. Methods: Twenty-four cases of traumatic diffuse brain swelling were analyzed retrospectively. Patients in nonsurgical group were treated by medicine therapy. Patients in surgical group were treated by external ventricular drainage plus medicine therapy. The first CT perfusion scan was completed within 4 -5 h after trauma and scanned again after 7 days. The changes of perfusion parameters in area-of- interest in two groups were analyzed and compared before and after treatment. Results: Compared with the nonsurgical group, the value of cerebral blood volume, cerebral blood flow and mean transit time in bilateral frontal temporoparietal grey matter, basal ganglia, cerebellum, and brain stem at pre- and post-therapy were increased significantly (p 〈 0.05) in surgical group, and consequently the prognosis of patients undergoing surgery was also better than that of nonsurgical group. Conclusion: External ventricular drainage can improve cerebral perfusion and increase survival quality for the patients with posttraumatic acute diffuse brain swelling. 展开更多
关键词 Brain injuries Brain edema Perfusion imaging Hemodynamics
原文传递
Effect of methylprednisolone on reperfusion injury in severe uncontrolled hemorrhagic shock
10
作者 夏芳 曹经山 +3 位作者 詹丽英 夏中元 夏正远 黄海波 《Chinese Journal of Traumatology》 CAS 2003年第6期359-362,共4页
Objective: To study the effect of methylprednisolone (MP) on reperfusion injury in severe uncontrolled hemorrhagic shock and explore the possible mechanism involved. Methods: Twelve dogs were randomly divided into two... Objective: To study the effect of methylprednisolone (MP) on reperfusion injury in severe uncontrolled hemorrhagic shock and explore the possible mechanism involved. Methods: Twelve dogs were randomly divided into two groups, control group (Group I, n=6) and MP group (Group II, n=6). The animals were bled continuously from a femoral artery catheter to produce uncontrolled hemorrhagic shock models. Resuscitation with lactated Ringer’s (LR) solution was initiated when mean arterial pressure (MAP) decreased to 20 mm Hg, and MAP was maintained at 30-40 mm Hg. MP (4 mg/kg) was injected intravenously in Group II when resuscitation began. While in Group I, normal saline (NS) was injected instead. The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were measured before exsanguination (T 1), when MAP decreased to 20 mm Hg (T 2), 60 min (T 3) and 120 min (T 4) after resuscitation. Heart rate, MAP and cardiac output (CO) levels were recorded concomitantly. Results: Infusion volume and hemorrhage volume shed from the superior mesenteric artery in Group I were higher than those in Group II (P< 0.01 and P< 0.05). After reperfusion, blood SOD levels decreased progressively and MDA levels increased rapidly in Group I. In Group II, blood SOD levels at T 3 and T 4 decreased as compared with that at T 1 but a stepwise increase was present. At T 4, blood SOD level was significantly higher in Group II than in Group I (P< 0.01). At T 3 and T 4, MDA levels were markedly lower in Group II than in Group I. During reperfusion, MAP was more steady in Group II than in Group I and survival rate after 120 min (at T 4) was higher in Group II than in Group I (P< 0.05). Conclusions: MP has a protective effect on severe uncontrolled hemorrhagic shock and subsequent reperfusion injury. The mechanism mainly involves the anti-lipid peroxidation activity of MP. 展开更多
关键词 METHYLPREDNISOLONE Reperfusion injury Lipid peroxidation Shock hemorrhagic
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部