Objective:To detect the expression of osteopontin(OPN)in benign and malignant bone tumors and investigate the prognostic influence of OPN expression on the outcome of osteosarcoma patients.Methods:Fifty-seven osteosar...Objective:To detect the expression of osteopontin(OPN)in benign and malignant bone tumors and investigate the prognostic influence of OPN expression on the outcome of osteosarcoma patients.Methods:Fifty-seven osteosarcomas and 11 osteoblastomas as well as 5 bone specimens with remodeling sites were immunohistochemically analyzed for expression of OPN and cyclooxygenase-2(COX-2).Results:OPN was not detected in osteoblasts of remodeling sites.Osteo- blastoma osteoblasts as well as osteoclastlike giant cells and osteosarcoma mononuclear cells showed variable staining.In osteosarcomas OPN and COX-2 expression correlated with each other(r=0.390,P=0.003,Spearman’s test).Although osteosarcoma patients with high COX-2 expression showed a trend towards shorter overall survival(P=0.0841,log-rank test), OPN expression had no influence on patients overall or on disease-free survival.Conclusion:Our data indicated that expres- sion of this protein might be unregulated in bone neoplasia.Although OPN expression correlates with COX-2 expression in osteosarcomas,OPN expression does not provide predictive information about the outcome of osteosarcoma patients.展开更多
文摘Objective:To detect the expression of osteopontin(OPN)in benign and malignant bone tumors and investigate the prognostic influence of OPN expression on the outcome of osteosarcoma patients.Methods:Fifty-seven osteosarcomas and 11 osteoblastomas as well as 5 bone specimens with remodeling sites were immunohistochemically analyzed for expression of OPN and cyclooxygenase-2(COX-2).Results:OPN was not detected in osteoblasts of remodeling sites.Osteo- blastoma osteoblasts as well as osteoclastlike giant cells and osteosarcoma mononuclear cells showed variable staining.In osteosarcomas OPN and COX-2 expression correlated with each other(r=0.390,P=0.003,Spearman’s test).Although osteosarcoma patients with high COX-2 expression showed a trend towards shorter overall survival(P=0.0841,log-rank test), OPN expression had no influence on patients overall or on disease-free survival.Conclusion:Our data indicated that expres- sion of this protein might be unregulated in bone neoplasia.Although OPN expression correlates with COX-2 expression in osteosarcomas,OPN expression does not provide predictive information about the outcome of osteosarcoma patients.
