Objectives: To evaluate the efficacy of Danhong injection in the treatment of vascular dementia. Methods: CNKI, VIP, CBM, MEDLINE, PubMed, and SCI Expanded databases were searched, and the clinical research literature...Objectives: To evaluate the efficacy of Danhong injection in the treatment of vascular dementia. Methods: CNKI, VIP, CBM, MEDLINE, PubMed, and SCI Expanded databases were searched, and the clinical research literature of Danhong injection in the treatment of vascular dementia was collected. Literature screening and literature quality assessment were performed independently by two investigators based on inclusion criteria and the Cochrane System Evaluator’s Handbook version 5.0.0. Meta-analysis was performed using RevMan 5.0 software. Results: A total of 16 studies were included in a total of 1383 patients. Meta-analysis showed that Danhong injection combined with conventional chemotherapy can reduce the incidence of vascular dementia compared with conventional chemotherapy alone (odds ratio 3.13, 95% CI2.02 to 4.85, P < 0.0001), improved Mini-mental State Examination (MMSE)) score (SDD 1.76, 95% CI 0.67 to 2.85, P = 0.002). Conclusion: Danhong transfusion combined with chemical drugs for the treatment of vascular dementia is superior to the simple treatment of chemical drugs, which can improve the efficacy and quality of life of patients, indicating that Danhong injection has an auxiliary effect on the treatment of vascular dementia.展开更多
Background:To systematically evaluate the efficacy and safety of the Chinese patent medicine Shuxuening injection combined with western medicine in vascular dementia treatment.Methods:Randomized controlled trials of t...Background:To systematically evaluate the efficacy and safety of the Chinese patent medicine Shuxuening injection combined with western medicine in vascular dementia treatment.Methods:Randomized controlled trials of the Chinese patent medicine Shuxuening injection in vascular dementia treatment is searched in the databases of CNKI,Wanfang,VIP,CBM,PubMed,The Cochrane Library,Embase and Web of Science from the establishment time to December 2020.After screen the literature,extract the data and evaluate the bias risk of studies included;tRevMan5.3 was used for met-analysis.Results:Nine randomized controlled trials including 932 patients were included.The results of meta-analysis included:(1)the total effective rate(RR=1.27,95%CI(1.18,1.36),P<0.00001);(2)MMSE score(MD=4.78,95%CI(1.75,7.80),P=0.002);(3)ADL score(MD=8.87,95%CI(6.70,11.05),P<0.00001);(4)NIHSS score(MD=−6.60,95%CI(−7.04,−6.16).P<0.00001).The results of meta-analysis of the test group are better than those in the control group.Conclusion:The Chinese patent medicine Shuxuening injection combined with conventional western medicine has showed some advantages in the total effective rate,MMSE score,ADL score,NIHSS score than conventional western medicine without more side effects in vascular dementia treatment.More randomized,double-blind,large sample clinical studies are needed to confirm the above conclusions.展开更多
文摘Objectives: To evaluate the efficacy of Danhong injection in the treatment of vascular dementia. Methods: CNKI, VIP, CBM, MEDLINE, PubMed, and SCI Expanded databases were searched, and the clinical research literature of Danhong injection in the treatment of vascular dementia was collected. Literature screening and literature quality assessment were performed independently by two investigators based on inclusion criteria and the Cochrane System Evaluator’s Handbook version 5.0.0. Meta-analysis was performed using RevMan 5.0 software. Results: A total of 16 studies were included in a total of 1383 patients. Meta-analysis showed that Danhong injection combined with conventional chemotherapy can reduce the incidence of vascular dementia compared with conventional chemotherapy alone (odds ratio 3.13, 95% CI2.02 to 4.85, P < 0.0001), improved Mini-mental State Examination (MMSE)) score (SDD 1.76, 95% CI 0.67 to 2.85, P = 0.002). Conclusion: Danhong transfusion combined with chemical drugs for the treatment of vascular dementia is superior to the simple treatment of chemical drugs, which can improve the efficacy and quality of life of patients, indicating that Danhong injection has an auxiliary effect on the treatment of vascular dementia.
文摘Background:To systematically evaluate the efficacy and safety of the Chinese patent medicine Shuxuening injection combined with western medicine in vascular dementia treatment.Methods:Randomized controlled trials of the Chinese patent medicine Shuxuening injection in vascular dementia treatment is searched in the databases of CNKI,Wanfang,VIP,CBM,PubMed,The Cochrane Library,Embase and Web of Science from the establishment time to December 2020.After screen the literature,extract the data and evaluate the bias risk of studies included;tRevMan5.3 was used for met-analysis.Results:Nine randomized controlled trials including 932 patients were included.The results of meta-analysis included:(1)the total effective rate(RR=1.27,95%CI(1.18,1.36),P<0.00001);(2)MMSE score(MD=4.78,95%CI(1.75,7.80),P=0.002);(3)ADL score(MD=8.87,95%CI(6.70,11.05),P<0.00001);(4)NIHSS score(MD=−6.60,95%CI(−7.04,−6.16).P<0.00001).The results of meta-analysis of the test group are better than those in the control group.Conclusion:The Chinese patent medicine Shuxuening injection combined with conventional western medicine has showed some advantages in the total effective rate,MMSE score,ADL score,NIHSS score than conventional western medicine without more side effects in vascular dementia treatment.More randomized,double-blind,large sample clinical studies are needed to confirm the above conclusions.
