参附注射液辅助冠脉搭桥治疗冠心病疗效及对患者心脏收缩功能影响

目的:研究参附注射液辅助冠脉搭桥治疗冠心病的临床疗效对患者心脏收缩功能影响。方法:选取冠脉搭桥治疗冠心病患者108例,按照奇偶法,将纳入患者分为观察组和对照组(各54例),两组患者采用同样的冠脉搭桥术,观察组辅助以参附注射液、对照组予以等量葡萄糖注射液(或0.9%氯化钠注射液),7d为1个疗程,连续两个疗程。观察和比较两组患者术前、术后7d、术后14d心脏收缩功能、心肌损伤标志物、血脑钠肽(BNP)水平和术后随访60d心血管事件。结果:术后7d、术后14d,观察组患者左心室射血分数(LVEF)、右心室舒张期射血分数(RVEF)、心脏指数(CI)水平均高于对照组,左室舒张末期前后径(LVESD)、左室收缩末期前后径(LVESD)、左心室收缩压(LVSP)水平低于对照组,差异均有统计学意义(P<0.05)。血清肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、BNP水平均低于对照组,差异均有统计学意义(P<0.05)。术后随访60d,观察组心血管事件率3.70%,低于对照组的18.52%,差异有统计学意义(P<0.05)。结论:参附注射液辅助冠脉搭桥术治疗冠心病能显著增强患者术后心脏收缩能力,降低术后并发症和死亡率,值得临床使用。

参附注射液治疗慢性充血性心力衰竭

目的探讨参附注射液联合西医方案对慢性充血性心力衰竭(CHF)的治疗效果及安全性。方法选取慢性充血性心力衰竭患者60例,随机分为治疗组与对照组,各30例,2组入院均给予西药常规治疗,治疗组在常规治疗的基础上加用参附注射液50 m L加氯化钠溶液50 m L静滴,1次/d;对照组仅给予西医常规治疗。对比2组治疗前及治疗4周后心脏射血分数(EF)、每搏输出量(SV)、中医证候积分改善、临床疗效及不良反应发生情况。结果 2组治疗后EF、SV均较治疗前显著上升(P<0.05),中医证候积分较治疗前显著下降(P<0.05),且治疗组优于对照组(P<0.05);治疗组总有效率96.7%,高于对照组的86.7%(P<0.05);2组治疗过程中均未发生明显不良反应。结论参附注射液联合西医方案治疗慢性充血性心力衰竭,可有效提高患者心脏功能,改善患者临床症状。

A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis

Hypoxia-inducible factor 1 （HIF-1） attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxidative stress or hypoxia in cortical neurons. In this study, we construct-ed a recombinant adeno-associated virus （rAAV） vector expressing the human HIF-1αgene （rAAV-HIF-1α）, and tested the assumption that rAAV-HIF-1αrepresses hippocampal neuronal apoptosis induced by amyloid-beta protein. Our results conifrmed that rAAV-HIF-1αsigniifcant-ly reduces apoptosis induced by amyloid-beta protein in primary cultured hippocampal neurons. Direct intracerebral rAAV-HIF-1αadministration also induced robust and prolonged HIF-1αproduction in rat hippocampus. Single rAAV-HIF-1αadministration resulted in decreased apoptosis of hippocampal neurons in an Alzheimer＇s disease rat model established by intrace-rebroventricular injection of aggregated amyloid-beta protein （25-35）. Our in vitro and in vivo ifndings demonstrate that HIF-1 has potential for attenuating hippocampal neuronal apoptosis induced by amyloid-beta protein, and provides experimental support for treatment of neurode-generative diseases using gene therapy.

Comparative effect of intrathecal meperidine,tramadol,magnesium sulfate,and dexmedetomidine on preventing post-spinal anesthesia shivering and adverse events in hip fracture repair patients:A randomized clinical trial

Objective:To compare effect of intrathecal meperidine,tramadol,magnesium sulfate,and dexmedetomidine on the prevention of post-spinal anesthesia shivering and adverse events in hip fracture repair patients.Methods:In a randomized,double-blind trial,132 patients with American Society of Anesthesiology(ASA)ⅠandⅡspinal anesthesia who needed hip fracture surgery were enrolled.Patients were stratified into 4 intervention groups based on a randomized block pattern:meperidine,tramadol,magnesium sulfate,and dexmedetomidine.Hemodynamic parameters including blood pressure,heart rate,and oxygen saturation,as well as the severity of shivering,core body temperature,Ramsay sedation score,adverse events,meperidine consumption were recorded and compared.Results:There was no statistically significant difference in the normal hemodynamic parameters,temperature,duration of surgery,meperidine consumption,and adverse events such as dizziness,hypotension,nausea,and bradycardia among groups(P>0.05).Compared to other groups,severity of shivering was the lower in the dexmedetomidine group 6 and 8 h after surgery.The Ramsay sedation scores were higher in the dexmedetomidine and meperidine groups 4 h after surgery(P=0.020).Conclusion:Dexmedetomidine acts better than the other three adjuvants in reducing complications such as shivering.Overall,these four adjuvants are helpful to prevent postoperative shivering and could be put forward as promising local anesthetics in spinal anesthesia,based on anesthesiologists’discretion and patients’general conditions.Clinical registration:The study was approved by the Research and Ethics Committee at the Valiasr Hospital(Arak,Iran)with the clinical trial code of IRCT20141209020258N153.

Use of gated myocardial perfusion imaging to assess clinical value of Xinmailong injection in chronic congestive heart failure

OBJECTIVE: This study used gated myocardial perfusion imaging(G-MPI) to assess the clinical value of Xinmailong injection in chronic congestive heart failure(CHF).METHODS: A total of 102 CHF patients were randomly divided into the control group(n=51) and the Xinmailong group(n=51). Patients in the control group were routinely treated. Patients in the Xinmailong group were additionally treated with Xinmailong injection in addition to routine treatment. Before and 3 months after treatment, G-MPI was used to determine changes in the left ventricular ejection fraction(LVEF), left ventricular end-diastolic volume(LVEDV) and left ventricular end-systolic volume(LVESV). Fourteen days after treatment, changes in plasma brain natriuretic peptide(BNP) levels were determined.RESULTS: Before treatment, there were no significant differences in LVEF, LVEDV, LVESV, and BNP levels between the two groups(all P>0.05). After treatment, LVEDV, LVESV, and BNP levels were significantly lower, and LVEF was significantly higher in the Xinmailong group than in the control group(all P<0.05).CONCLUSION: Additional use of Xinmailong injection in addition to routine treatment improves cardiac function of CHF patients. Because of the safety and effectiveness of Xinmailong injection, this therapy should be promoted.

Nonlinear dynamics of 1550 nm VCSELs subject to polarization-preserved optical feedback and orthogonal optical injection

Based on spin-flip model （SFM）, the nonlinear dynamics of 1550nm vertical-cavity surface-emitting lasers （VCSELs） subject to polarization-preserved optical feedback （PPOF） and orthogonal optical injection （OOI） are theoretically investigated. The results show that two linear polarization （LP） modes can be simultaneously stimulated and polarization switching （PS） can be observed, which is different from the case that only y LP mode exists in a VCSEL with PPOF. Under the joint action of PPOF and OOI, the two LP modes will exhibit rich dynamical states, such as period one, period two, multi- period and chaos oscillation. Different evolution routes to chaos can be also observed. Moreover, frequency detuning Af（Af=fm fs, wherefn andfs are the center frequencies of free-running master VCSEL and slave VCSEL, respectively） has an obvious influence on the PS. With the increase of the positive frequency detuning PS points shift toward larger injection strengths; meanwhile, a suitable negative frequency demning value makes the injection strength for PS be the lowest.