Objective:To better understand the clinical phenotype of Méenière’s disease(MD),we examined family history,thyroid disorder,migraine,and associated disorders in complaints of people living with MD.Method:We...Objective:To better understand the clinical phenotype of Méenière’s disease(MD),we examined family history,thyroid disorder,migraine,and associated disorders in complaints of people living with MD.Method:We designed the study as a retrospective and examined data gathered from 912 participants with MD.Their data were originally collected by the Finnish M′eni`ere Federation(FMF).The survey data included individual case histories for environmental factors,comorbidities,disease-specific complaints,impact-related questions,cognitive complaints,health-related quality of life(HRQoL),and sense of coherence(SOC).Results:We observed significant differences between those with and without sporadic occurrence,family history,thyroid disorder,and migraine-associated complaints.Family history explained 20%of variability in patient complaints.Patients with a family history of MD whose disease started at younger age experienced balance problems,more severe vertigo spells,more severe vestibular drop attacks(VDA),and less nausea,although they had good SOC.Thyroid disorder explained 14%of variability in patient complaints.MD patients with a thyroid disorder comorbidity suffered more often from constant dizziness,balance problems,greater impact of hearing problems,cognitive complaints,and poor HRQoL.Migraine explained 12%of variability in patients’complaints and was associated with poor SOC and cognitive balance problems.MD patients with both thyroid disorder and migraine used antidepressants more often than other groups.Logistic regression analysis showed comorbidities of ischemic brain disorder(among 7.1%),kidney insufficiency(among 1.2%),and diabetes(among 7.3%)had statistically significant but restricted association with balance and gait problems,VDA,and reduced HRQoL.Conclusions:Family history of MD and thyroid disorder or migraine comorbidities in MD influence the complaint pattern and partially explain complex symptom profiles,including symptoms of cognitive problems.Confounders play a minimal role in complaint profile and impact of MD whereas comorbidities influence the complaint structure and partly explain the complex symptom profile in MD.展开更多
Based on the analysis of coseismic deformation in the macroscopic epicentral region extracted by Differential Interferometric Synthetic Aperture Radar (D-InSAR), and combined with the seismic activity, focal mechanism...Based on the analysis of coseismic deformation in the macroscopic epicentral region extracted by Differential Interferometric Synthetic Aperture Radar (D-InSAR), and combined with the seismic activity, focal mechanism solutions of the earthquake and field investigation, the characteristic of coseismic deformation of MS=8.1 western Kunlunshan Pass earthquake in 2001 was researched. The study shows that its epicenter lies in the northeast side of Hoh Sai Hu; and the seismogenic fault in the macroscopic epicentral region can be divided into two central deformation fields: the west and east segments with the lengths of 42 km and 48 km, respectively. The whole fault extends about 90 km. From the distribution of interferometry fringes, the characteristic of sinistral strike slip of seismogenic fault can be identified clearly. The deformations on both sides of the fault are different with an obviously higher value on the south side. In the vicinity of macroscopic epicenter, the maximum displacement in look direction is about 288.4 cm and the minimum is 224.0 cm; the maximum sinistral horizontal dislocation of seismogenic fault near the macroscopic epicenter is 738.1 cm and the minimum is 551.8 cm.展开更多
文摘Objective:To better understand the clinical phenotype of Méenière’s disease(MD),we examined family history,thyroid disorder,migraine,and associated disorders in complaints of people living with MD.Method:We designed the study as a retrospective and examined data gathered from 912 participants with MD.Their data were originally collected by the Finnish M′eni`ere Federation(FMF).The survey data included individual case histories for environmental factors,comorbidities,disease-specific complaints,impact-related questions,cognitive complaints,health-related quality of life(HRQoL),and sense of coherence(SOC).Results:We observed significant differences between those with and without sporadic occurrence,family history,thyroid disorder,and migraine-associated complaints.Family history explained 20%of variability in patient complaints.Patients with a family history of MD whose disease started at younger age experienced balance problems,more severe vertigo spells,more severe vestibular drop attacks(VDA),and less nausea,although they had good SOC.Thyroid disorder explained 14%of variability in patient complaints.MD patients with a thyroid disorder comorbidity suffered more often from constant dizziness,balance problems,greater impact of hearing problems,cognitive complaints,and poor HRQoL.Migraine explained 12%of variability in patients’complaints and was associated with poor SOC and cognitive balance problems.MD patients with both thyroid disorder and migraine used antidepressants more often than other groups.Logistic regression analysis showed comorbidities of ischemic brain disorder(among 7.1%),kidney insufficiency(among 1.2%),and diabetes(among 7.3%)had statistically significant but restricted association with balance and gait problems,VDA,and reduced HRQoL.Conclusions:Family history of MD and thyroid disorder or migraine comorbidities in MD influence the complaint pattern and partially explain complex symptom profiles,including symptoms of cognitive problems.Confounders play a minimal role in complaint profile and impact of MD whereas comorbidities influence the complaint structure and partly explain the complex symptom profile in MD.
文摘Based on the analysis of coseismic deformation in the macroscopic epicentral region extracted by Differential Interferometric Synthetic Aperture Radar (D-InSAR), and combined with the seismic activity, focal mechanism solutions of the earthquake and field investigation, the characteristic of coseismic deformation of MS=8.1 western Kunlunshan Pass earthquake in 2001 was researched. The study shows that its epicenter lies in the northeast side of Hoh Sai Hu; and the seismogenic fault in the macroscopic epicentral region can be divided into two central deformation fields: the west and east segments with the lengths of 42 km and 48 km, respectively. The whole fault extends about 90 km. From the distribution of interferometry fringes, the characteristic of sinistral strike slip of seismogenic fault can be identified clearly. The deformations on both sides of the fault are different with an obviously higher value on the south side. In the vicinity of macroscopic epicenter, the maximum displacement in look direction is about 288.4 cm and the minimum is 224.0 cm; the maximum sinistral horizontal dislocation of seismogenic fault near the macroscopic epicenter is 738.1 cm and the minimum is 551.8 cm.
基金The Science and Technology Plan Project of General Administration of Quality Supervision,Inspection and Quarantine of the People's Republic of China(2013IK200)
