<正> In this paper the reaction of substituted β-nitrostyrene with O,O-dialkyl phosphite under cocatalysis of trimethylsilyl chloride （TMS-C1） and triethylamine （or other acidbinding agent） has been first s...<正> In this paper the reaction of substituted β-nitrostyrene with O,O-dialkyl phosphite under cocatalysis of trimethylsilyl chloride （TMS-C1） and triethylamine （or other acidbinding agent） has been first studied and the new cyclization reaction leading to the formation of product Ⅱ, as a new class of derivatives of 1-hydroxyindoles, difficultly accessible or inaccessible with usual methods has been observed. In the related reaction it is surprising that when the Arbuzov rearrangement occurs under mild conditions, the addition, reduction and cyclization as a one-pot reaction take place simultaneously with the formation of products Ⅰ, Ⅱ, Ⅲ. By controlling the reaction conditions the products were formed almost in specificity, and thus the most interesting cyclic products Ⅱa-hcontaining phosphorus-carbon bond were obtained. Their structures were confirmed by elemental analysis, IR,1H or31p NMR and MS spectra. The crystal structure of representative compound Ⅱhwas determined by X-ray diffract展开更多
基金Project supported by the National Natural Science Foundation of China. This paper was reported at CHAC, Kobe, Japan, 1987.
文摘<正> In this paper the reaction of substituted β-nitrostyrene with O,O-dialkyl phosphite under cocatalysis of trimethylsilyl chloride （TMS-C1） and triethylamine （or other acidbinding agent） has been first studied and the new cyclization reaction leading to the formation of product Ⅱ, as a new class of derivatives of 1-hydroxyindoles, difficultly accessible or inaccessible with usual methods has been observed. In the related reaction it is surprising that when the Arbuzov rearrangement occurs under mild conditions, the addition, reduction and cyclization as a one-pot reaction take place simultaneously with the formation of products Ⅰ, Ⅱ, Ⅲ. By controlling the reaction conditions the products were formed almost in specificity, and thus the most interesting cyclic products Ⅱa-hcontaining phosphorus-carbon bond were obtained. Their structures were confirmed by elemental analysis, IR,1H or31p NMR and MS spectra. The crystal structure of representative compound Ⅱhwas determined by X-ray diffract
