Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. In the present study, a streptozotocin-induced diabetic animal model was given an intraperitoneal injection of tauroursodeox...Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. In the present study, a streptozotocin-induced diabetic animal model was given an intraperitoneal injection of tauroursodeoxycholic acid. Results from immunofluorescent co-localization experiments showed that both caspase-12 protein and c-Jun N-terminal kinase 1 phosphorylation levels significantly in- creased, which was associated with retinal ganglion cell death in diabetic retinas. The C/ERB ho- mologous protein pathway directly contributed to glial reactivity, and was subsequently responsible for neuronal loss and vascular abnormalities in diabetic retinopathy. Our experimental findings in- dicate that endoplasmic reticulum stress plays an important role in diabetes-induced retinal neu- ronal loss and vascular abnormalities, and that inhibiting the activation of the endoplasmic reticulum stress pathway provides effective protection against diabetic retinopathy.展开更多
The angle-differential cross sections of neutron-induced deuteron production from carbon were measured at six neutron energies from 25 to 52 MeV relative to those of n-p elastic scattering at the China Spallation Neut...The angle-differential cross sections of neutron-induced deuteron production from carbon were measured at six neutron energies from 25 to 52 MeV relative to those of n-p elastic scattering at the China Spallation Neutron Source(CSNS)Back-n white neutron source.By employing theΔE-E telescopes of the Light-charged Particle Detector Array(LPDA)system at 15.1°to 55.0°in the laboratory system,ratios of the angle-differential cross sections of the ^(12)C(n,xd)reactions to those of the n-p scattering were measured,and then,the angle-differential cross sections of the ^(12)C(n,xd)reactions were obtained using the angle-differential cross sections of the n-p elastic scattering from the JENDL-4.0/HE-2015 library as the standard.The obtained results are compared with data from previous measurements,all of which are based on mono-energic neutrons,the evaluated data from the JENDL-4.0/HE-2015 library and the ENDF-B/VIII.0 library,and those from theoretical calculations based on INCA code and Talys-1.9 code.Being the first white-neutron-source-based systematic measurement of the angle-differential cross sections of neutron-induced deuteron production reactions on carbon in several tens of MeV,the present work can provide a reference to the data library considering the lack of experimental data.展开更多
Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to dire...Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given.展开更多
基金supported by the National Natural Science Foundation of China,No.81170877the National Basic Research Program of China,No.2007CB512203
文摘Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. In the present study, a streptozotocin-induced diabetic animal model was given an intraperitoneal injection of tauroursodeoxycholic acid. Results from immunofluorescent co-localization experiments showed that both caspase-12 protein and c-Jun N-terminal kinase 1 phosphorylation levels significantly in- creased, which was associated with retinal ganglion cell death in diabetic retinas. The C/ERB ho- mologous protein pathway directly contributed to glial reactivity, and was subsequently responsible for neuronal loss and vascular abnormalities in diabetic retinopathy. Our experimental findings in- dicate that endoplasmic reticulum stress plays an important role in diabetes-induced retinal neu- ronal loss and vascular abnormalities, and that inhibiting the activation of the endoplasmic reticulum stress pathway provides effective protection against diabetic retinopathy.
基金Supported by the National Natural Science Foundation of China(11775006)the National Key R&D Program of China(2016YFA0401604)。
文摘The angle-differential cross sections of neutron-induced deuteron production from carbon were measured at six neutron energies from 25 to 52 MeV relative to those of n-p elastic scattering at the China Spallation Neutron Source(CSNS)Back-n white neutron source.By employing theΔE-E telescopes of the Light-charged Particle Detector Array(LPDA)system at 15.1°to 55.0°in the laboratory system,ratios of the angle-differential cross sections of the ^(12)C(n,xd)reactions to those of the n-p scattering were measured,and then,the angle-differential cross sections of the ^(12)C(n,xd)reactions were obtained using the angle-differential cross sections of the n-p elastic scattering from the JENDL-4.0/HE-2015 library as the standard.The obtained results are compared with data from previous measurements,all of which are based on mono-energic neutrons,the evaluated data from the JENDL-4.0/HE-2015 library and the ENDF-B/VIII.0 library,and those from theoretical calculations based on INCA code and Talys-1.9 code.Being the first white-neutron-source-based systematic measurement of the angle-differential cross sections of neutron-induced deuteron production reactions on carbon in several tens of MeV,the present work can provide a reference to the data library considering the lack of experimental data.
基金supported by the National Natural Science Foundation of China(Grant Nos.11490560 and 11321064)the National Basic Research Program of China(Grant No.2013CB834406)
文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given.
