Some organic phosphines labeled with ^117mSn(IV) have been proved promising for imaging and pain palliation of bone tumor.In this paper,a preliminary investigation on the adsorption characteristics of EDTMP(ethelenedi...Some organic phosphines labeled with ^117mSn(IV) have been proved promising for imaging and pain palliation of bone tumor.In this paper,a preliminary investigation on the adsorption characteristics of EDTMP(ethelenediaminetetramethylene phosphoric acid)labeled with ^117Sn(IV) on HA( hydroxyapatitie)and collagen,and an investigation on the adsorption mechanism of ^117mSn(IV)-EDTMP on HA was presented.展开更多
Tin-117m(t1/2 14d; γ 159keV, 86%) is an ideal tracer for studyingbiological behavior of tin compounds as well as for developing clinically-useful radio-pharmaceuticals. It had been reported that Sn-117m[4+] DTPA has ...Tin-117m(t1/2 14d; γ 159keV, 86%) is an ideal tracer for studyingbiological behavior of tin compounds as well as for developing clinically-useful radio-pharmaceuticals. It had been reported that Sn-117m[4+] DTPA has unexpectedlyhigh bone uptake and bone-to-blood ratio, and is potentially useful as an agent forskeletal scintigraphy and radiotherapy of bone tumors. In this work, HEDTMP [N-(2-hydroxyethyl) ethlenediamine-1,1,2-tri (methylene phosphonic acid)] was synthesized.Let it form complex with 117mSn. The formation conditions, stability and distributioncoefficient between oil and water of the complex were investigated.展开更多
Tin is an essential ingredient of most technetium-99m radiopharmaceuticals but its in-vivo distribution and long-term fate are not well understood. This work describes distribution in mice of several tin-117m labeled ...Tin is an essential ingredient of most technetium-99m radiopharmaceuticals but its in-vivo distribution and long-term fate are not well understood. This work describes distribution in mice of several tin-117m labeled compounds. The results indicate that stannic-HEDTMP appears to be the best overall bone localizing agent with very low blood, muscle, kidney, or liver uptake, and its binding to bone is higher than that of tin-117m-DTPA, which make it potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors.展开更多
基金Supported by the Chinese Academy of Engineering Physics JM fund and Institute of Nuclear Physics and Chemistry Master fund
文摘Some organic phosphines labeled with ^117mSn(IV) have been proved promising for imaging and pain palliation of bone tumor.In this paper,a preliminary investigation on the adsorption characteristics of EDTMP(ethelenediaminetetramethylene phosphoric acid)labeled with ^117Sn(IV) on HA( hydroxyapatitie)and collagen,and an investigation on the adsorption mechanism of ^117mSn(IV)-EDTMP on HA was presented.
文摘Tin-117m(t1/2 14d; γ 159keV, 86%) is an ideal tracer for studyingbiological behavior of tin compounds as well as for developing clinically-useful radio-pharmaceuticals. It had been reported that Sn-117m[4+] DTPA has unexpectedlyhigh bone uptake and bone-to-blood ratio, and is potentially useful as an agent forskeletal scintigraphy and radiotherapy of bone tumors. In this work, HEDTMP [N-(2-hydroxyethyl) ethlenediamine-1,1,2-tri (methylene phosphonic acid)] was synthesized.Let it form complex with 117mSn. The formation conditions, stability and distributioncoefficient between oil and water of the complex were investigated.
文摘Tin is an essential ingredient of most technetium-99m radiopharmaceuticals but its in-vivo distribution and long-term fate are not well understood. This work describes distribution in mice of several tin-117m labeled compounds. The results indicate that stannic-HEDTMP appears to be the best overall bone localizing agent with very low blood, muscle, kidney, or liver uptake, and its binding to bone is higher than that of tin-117m-DTPA, which make it potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors.
