2020年氯化镭(^(223)Ra)注射液(多菲戈;)获中国国家食品药品监督管理总局(China Food and Drug Administration,CFDA)批准用于治疗伴症状性骨转移,且无已知内脏转移的去势抵抗性前列腺癌(Castration?resistant Prostate Cancer and bone...2020年氯化镭(^(223)Ra)注射液(多菲戈;)获中国国家食品药品监督管理总局(China Food and Drug Administration,CFDA)批准用于治疗伴症状性骨转移,且无已知内脏转移的去势抵抗性前列腺癌(Castration?resistant Prostate Cancer and bone metastases,mCRPC)患者,它是目前世界上第一个应用于mCRPC患者的α粒子靶向放射活性治疗药物。近年来,国外应用核医学技术评估^(223)Ra治疗mCRPC患者的疗效已经十分普遍,国内仅少数医院刚进入临床应用阶段。为使该药在国内得到规范使用,现将国内外^(223)Ra治疗mCRPC患者的临床核医学评估技术进行分析评述。展开更多
Radium-224 activities in the western Arctic Ocean were measured viaship-board ^(220)Rn emanation technique during the Second Chinese National Arctic Expedition. Theresults showed that the ^(224)Ra activities in the st...Radium-224 activities in the western Arctic Ocean were measured viaship-board ^(220)Rn emanation technique during the Second Chinese National Arctic Expedition. Theresults showed that the ^(224)Ra activities in the study areas ranged from being less than 0.08 to3.58 Bq/m^3, with an average of 0.23 Bq/m^3. The low ^(224)Ra concentration in the surface water wasattributed to the influence of sea ice melted water. The horizontal distribution of surface^(224)Ra in the western Arctic Ocean showed a high ^(224)Ra characteristics occurred along the slopearound 160°W, providing evidence for the importance of ice-rafted sediments to controlling thedistribution of radium isotopes in the Arctic Ocean. Mostly, ^(224)Ra concentrations increased withthe depth in the shelf region and reached a maximum at 75 m at the central Canada Basin, whichfurther confirms the importance of the transport of shelf bottom water to maintaining the upperhalocline layer in the Canada Basin.展开更多
文摘2020年氯化镭(^(223)Ra)注射液(多菲戈;)获中国国家食品药品监督管理总局(China Food and Drug Administration,CFDA)批准用于治疗伴症状性骨转移,且无已知内脏转移的去势抵抗性前列腺癌(Castration?resistant Prostate Cancer and bone metastases,mCRPC)患者,它是目前世界上第一个应用于mCRPC患者的α粒子靶向放射活性治疗药物。近年来,国外应用核医学技术评估^(223)Ra治疗mCRPC患者的疗效已经十分普遍,国内仅少数医院刚进入临床应用阶段。为使该药在国内得到规范使用,现将国内外^(223)Ra治疗mCRPC患者的临床核医学评估技术进行分析评述。
基金supported by Program for New Century Excellent Talents in University of China under contract No.NCET-04-0593Chinese Second Arctic Expedition Foundation.
文摘Radium-224 activities in the western Arctic Ocean were measured viaship-board ^(220)Rn emanation technique during the Second Chinese National Arctic Expedition. Theresults showed that the ^(224)Ra activities in the study areas ranged from being less than 0.08 to3.58 Bq/m^3, with an average of 0.23 Bq/m^3. The low ^(224)Ra concentration in the surface water wasattributed to the influence of sea ice melted water. The horizontal distribution of surface^(224)Ra in the western Arctic Ocean showed a high ^(224)Ra characteristics occurred along the slopearound 160°W, providing evidence for the importance of ice-rafted sediments to controlling thedistribution of radium isotopes in the Arctic Ocean. Mostly, ^(224)Ra concentrations increased withthe depth in the shelf region and reached a maximum at 75 m at the central Canada Basin, whichfurther confirms the importance of the transport of shelf bottom water to maintaining the upperhalocline layer in the Canada Basin.
