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释“■(免)”
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作者 程邦雄 杨灿 王斐 《三峡大学学报(人文社会科学版)》 2025年第1期108-115,共8页
甲骨文“■”等形体,孙诒让最早在《契文举例·释文字》里,进行了分析讨论,正误参半。“■”等字,在卜辞里意义多是“分娩”,但是从文字角度看,应隶定为何字,学界讨论甚多,意见不一。结合传世文献与最新的出土文献,从“■”的构形... 甲骨文“■”等形体,孙诒让最早在《契文举例·释文字》里,进行了分析讨论,正误参半。“■”等字,在卜辞里意义多是“分娩”,但是从文字角度看,应隶定为何字,学界讨论甚多,意见不一。结合传世文献与最新的出土文献,从“■”的构形、上下文语境、涉及的句式语法、语义搭配、字词关系等多角度观察、分析,“■”等甲骨文形体应隶释为“免”字,记录的是“分娩”义的{免},而不应该隶为“娩”字,以记录“分娩”义的{娩}。《说文》不收单字“免”,是遗漏,“分娩”义的“免”字非后出,《说文》收有含声符和义符“免”的合体字多例,并单独立有“儿部”,金文、战国(楚)简帛也有从“子”或从“儿(■)”的“免”字。郑珍释“免,子脱胞也。从二儿:上儿,母也;下儿,子也”,其说有据。 展开更多
关键词 {免}
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“少/免不得”“少/免/短不了”的情态演变及表达功用
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作者 周红 李文洁 《河北工业大学学报(社会科学版)》 2024年第3期79-86,共8页
能性述补词语“少/免不得”“少/免/短不了”经历了由道义情态到认识情态的演变过程。受“少”“免”“短”语义制约,以及“X不得”“X不了”结构的影响,五个词语在情态表达类别及使用频率上产生了此消彼长的变化。“少/免不得”出现早... 能性述补词语“少/免不得”“少/免/短不了”经历了由道义情态到认识情态的演变过程。受“少”“免”“短”语义制约,以及“X不得”“X不了”结构的影响,五个词语在情态表达类别及使用频率上产生了此消彼长的变化。“少/免不得”出现早于“少/免不了”,前者数量由多到少,后者数量由少到多。“短不了”数量一直极低。“少不得”“少不了”多表道义情态,“免不得”“免不了”“短不了”多表认识情态。“少不得”“少不了”多后接中性成分,“免不得”“免不了”“短不了”多后接消极性成分。五者均都用于叙事,不同的是“少不得”还用于议论,“免不得”“免不了”多用于议论,“短不了”多用于对话。 展开更多
关键词 少不得 不得 少不了 不了 短不了 情态演变 表达功用
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“少不了”与“免不了”的构式特点与共时发展 被引量:5
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作者 潘晓军 周正红 《合肥工业大学学报(社会科学版)》 2015年第4期105-108,136,共5页
"少不了"与"免不了"这对近义构式在共时层面上逐渐虚化,兼有谓词性与副词性用法。伴随着构造意义的定型化、搭配方式的多样化、修饰范围的扩大化,使得其副词性功能更加明显。它们逐渐固化,目前尚处在从构式到虚词... "少不了"与"免不了"这对近义构式在共时层面上逐渐虚化,兼有谓词性与副词性用法。伴随着构造意义的定型化、搭配方式的多样化、修饰范围的扩大化,使得其副词性功能更加明显。它们逐渐固化,目前尚处在从构式到虚词的过程中。 展开更多
关键词 少不了 不了 位置分布 表义功能 虚化
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“不免”、“难免”、“未免”的语义语用分析 被引量:6
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作者 周红 《汉语学习》 CSSCI 北大核心 2011年第4期36-43,共8页
"不免"、"难免"、"未免"都基于因果关系,"不免"重自然而然性,"难免"重因果推断性,"未免"重主观评价性。"不免"分为"不免_1"与"不免_2",前... "不免"、"难免"、"未免"都基于因果关系,"不免"重自然而然性,"难免"重因果推断性,"未免"重主观评价性。"不免"分为"不免_1"与"不免_2",前者是客观陈述,后者是主观陈述。文章运用"刺激-反应"理论考察因果关系主观性连续统,得出从"不免_1"、"不免_2"、"难免"到"未免"主观性不断增强。并从前加词语的客观性与主观性、结果事件的行动性与状态性、现实性与虚拟性、积极性与消极性、肯定性与否定性等方面进行了句法语义验证。最后讨论了三者不可替换与可替换的条件,并分析了三者表达功能的差异。 展开更多
关键词 因果推断 刺激-反应 主观评价 语义特征 语用功能
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“省得”、“免得”语义语用分析 被引量:6
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作者 周红 《贵州师范学院学报》 2011年第1期1-6,共6页
"省得"、"免得"是二价动词,主体与客体论元都是事件,事件之间是互斥关系,其语义背景是"在某一事件的作用下,避免了某一事件的发生"。事件AP与"省得/免得+事件BQ"之间存在目的关系,具体表现为... "省得"、"免得"是二价动词,主体与客体论元都是事件,事件之间是互斥关系,其语义背景是"在某一事件的作用下,避免了某一事件的发生"。事件AP与"省得/免得+事件BQ"之间存在目的关系,具体表现为有意目的和无意目的、外向目的和返身目的、已现目的和未现目的。"省得"可分为"省得1"与"省得2",分别表示"节省人力、物力、财力以避免浪费"、"避免麻烦的事件发生"。"免得"表示"避免较为严重的事件发生"。"省得2"与"免得"会有交叉,但"免得"比"省得2"主观程度高,感情色彩上严肃、严重。通过考察"省得"与"免得"的词汇化更加印证了两者的语义与语用差异。 展开更多
关键词 省得 语义 语用 词汇化
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“以免”的词汇化 被引量:4
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作者 刘红妮 《楚雄师范学院学报》 2008年第5期18-23,共6页
连词"以免"最初是"连词‘以’+动词‘免’"的非句法结构。"以免"最初连用在先秦,词汇化的过渡阶段在宋代,发展和成熟在明代和清代。"以免"的词汇化是句法、语义、语用和韵律等方面合力的结果。
关键词 “以 词汇化 句法 语义 语用 韵律
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副词“不免”、“难免”、“未免”比较分析 被引量:8
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作者 谷晓恒 《青海民族学院学报(社会科学版)》 2005年第4期107-110,共4页
本文就现代汉语中副词“不免”、“难免”和“未免”进行了分析。认为“不免”、“难免”主要用于修饰或限定动词性复杂短语,“未免”既可以修饰限定动词性复杂短语,也可以修饰限定形容词及形容词短语。文章还进一步指出了它们的不同语... 本文就现代汉语中副词“不免”、“难免”和“未免”进行了分析。认为“不免”、“难免”主要用于修饰或限定动词性复杂短语,“未免”既可以修饰限定动词性复杂短语,也可以修饰限定形容词及形容词短语。文章还进一步指出了它们的不同语义背景和语义特征。 展开更多
关键词 语法特征 语义背景
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“以免”的词汇化 被引量:2
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作者 刘红妮 《玉林师范学院学报》 2008年第4期39-43,共5页
连词"以免"最初是"连词‘以’+动词‘免’"的非句法结构。"以免"最初连用在先秦,词汇化的过渡阶段在宋代,发展和成熟在明代和清代。"以免"的词汇化是句法、语义、语用和韵律等方面合力的结果。
关键词 “以 词汇化 句法 语义 语用 韵律
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人脑心肌炎病毒免疫球蛋白M捕获酶联免疫吸附试验的建立及初步应用 被引量:2
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作者 张海霞 冯若飞 +4 位作者 王丹 徐雷 谢晶莹 李向茸 马忠仁 《检验医学与临床》 CAS 2015年第15期2139-2141,2144,共4页
目的建立脑心肌炎病毒(EMCV)免疫球蛋白M(IgM)捕获酶联免疫吸附试验(ELISA)检测方法,用于感染EMCV血清学早期诊断。方法用抗人IgM(μ链)单抗进行包被,辣根过氧化物酶(HRP)标记的EMCV为酶标抗原,初步建立EMCV IgM捕获ELISA;对建立的方法... 目的建立脑心肌炎病毒(EMCV)免疫球蛋白M(IgM)捕获酶联免疫吸附试验(ELISA)检测方法,用于感染EMCV血清学早期诊断。方法用抗人IgM(μ链)单抗进行包被,辣根过氧化物酶(HRP)标记的EMCV为酶标抗原,初步建立EMCV IgM捕获ELISA;对建立的方法进行条件优化及特异性、精密性、稳定性等验证。结果建立的EMCV IgM捕获ELISA检测方法抗体包被浓度为1μg/mL,EMCV-HRP工作浓度和反应时间分别为1∶400和45min,封闭液为10%马血清时该法检测效果可达最佳,3批试剂批内及批间变异系数均小于5%,且特异性、精密性及稳定性较好。结论建立的EMCV IgM捕获ELISA法特异、精密且稳定,可用于人感染EMCV的早期检查,为EMCV的诊断奠定基础。 展开更多
关键词 脑心肌炎病毒 酶联疫吸附试验 初步应用
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UBE2C as an Immune-Related Biomarker for Breast Cancer:A Study Based on Multiple Databases
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作者 Yue Cui Hong-Zhi Wang +3 位作者 Ye Song Shuang Yang Feng-Ying Sai De-Jun Yu 《Chinese Medical Sciences Journal》 CAS CSCD 2024年第3期173-184,共12页
Objective To screen the target genes that are associated with survival of breast cancer(BRCA) and explore their prognostic values and immune correlations with BRCA using multiple databases..Methods The microarray expr... Objective To screen the target genes that are associated with survival of breast cancer(BRCA) and explore their prognostic values and immune correlations with BRCA using multiple databases..Methods The microarray expression datasets of BRCA were downloaded from the Gene Expresssion Omnibus database(GEO) and analyzed to obtain differentially expressed genes(DEGs). Hub genes were obtained by constructing and visualizing the protein-protein interaction network of DEGs. The key gene was determined using R language, STRING, and Cytoscape, and the differential expression of the key gene was verified using external datasets The Cancer Genome Atlas(TCGA) and quantitative real-time PCR(q RT-PCR) for BRCA tissues of 37 patients. The prognostic value and immunological correlation of UBE2C in BRCA were explored using R language, TIMER, and Gene Set Enrichment Analysis(GSEA).Results Of 10 hub genes seleceed from 302 DEGS, UBE2C was identified as the gene associated with BRCA survival. The expression of UBE2C was differentially upregulated in BRCA, as verified by TCGA and q RT-PCR. Prognostic analysis revealed that UBE2C served as an independent prognostic factor. High expression of UBE2C was associated with decreased immune infiltration levels of B cells, CD4+ T cells, CD8+ T cells, macrophages, and myeloid dendritic cells in BRCA tissue. The expression of UBE2C in BRCA showed a significant correlation with immune checkpoints genes PDCD1, CD274, and CTLA4 expressions. There was a positive correlation between the expression of UBE2C and the tumor mutational burden and microsatellite instability. GSEA demonstrated that UBE2C expression significantly enriched 786 immune-related gene sets.Conclusions UBE2C expression in BRCA tissues is closely related to the BRCA immune microenvironment and showes predictive values on the survivals and prognosis of BRCA patients and the effecacy of immunotherapy. UBE2C may be an potential immune-related prognostic biomarker for BRCA. 展开更多
关键词 UBE2C breast Cancer prognostic biomarker IMMUNE bioinformatics analyses SURVIVAL
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Prognositic value of anoikis and tumor immune microenvironment-related gene in the treatment of osteosarcoma
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作者 WANG Dong DENG Qing +7 位作者 PENG Yi TONG Zhaochen LI Zixin HUANG Liping ZENG Jin LI Jinsong MIAO Jinglei CHEN Shijie 《中南大学学报(医学版)》 CAS CSCD 北大核心 2024年第5期758-774,共17页
Objective:Osteosarcoma is a highly aggressive primary malignant bone tumor commonly seen in children and adolescents,with a poor prognosis.Anchorage-dependent cell death(anoikis)has been proven to be indispensable in ... Objective:Osteosarcoma is a highly aggressive primary malignant bone tumor commonly seen in children and adolescents,with a poor prognosis.Anchorage-dependent cell death(anoikis)has been proven to be indispensable in tumor metastasis,regulating the migration and adhesion of tumor cells at the primary site.However,as a type of programmed cell death,anoikis is rarely studied in osteosarcoma,especially in the tumor immune microenvironment.This study aims to clarify prognostic value of anoikis and tumor immune microenvironment-related gene in the treatment of osteosarcoma.Methods:Anoikis-related genes(ANRGs)were obtained from GeneCards.Clinical information and ANRGs expression profiles of osteosarcoma patients were sourced from the therapeutically applicable research to generate effective therapies and Gene Expression Omnibus(GEO)databases.ANRGs highly associated with tumor immune microenvironment were identified by the estimate package and the weighted gene coexpression network analysis(WGCNA)algorithm.Machine learning algorithms were performed to construct long-term survival predictive strategy,each sample was divided into high-risk and low-risk subgroups,which was further verified in the GEO cohort.Finally,based on single-cell RNA-seq from the GEO database,analysis was done on the function of signature genes in the osteosarcoma tumor microenvironment.Results:A total of 51 hub ANRGs closely associated with the tumor microenvironment were identified,from which 3 genes(MERTK,BNIP3,S100A8)were selected to construct the prognostic model.Significant differences in immune cell activation and immune-related signaling pathways were observed between the high-risk and low-risk groups based on tumor microenvironment analysis(all P<0.05).Additionally,characteristic genes within the osteosarcoma microenvironment were identified in regulation of intercellular crosstalk through the GAS6-MERTK signaling pathway.Conclusion:The prognostic model based on ANRGs and tumor microenvironment demonstrate good predictive power and provide more personalized treatment options for patients with osteosarcoma. 展开更多
关键词 ANOIKIS tumor immune microenvironment BIOINFORMATICS PROGNOSIS OSTEOSARCOMA
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DYNAMIC ANALYSIS OF A TYPE OF FINANCIAL RISK CONTAGION MODEL INVOLVING IMMUNITY PERIOD AND SELF-RESCUE
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作者 ZHANG Shuang-hui WANG Hai-xia XU Hui-ling 《数学杂志》 2024年第5期413-425,共13页
In this paper,we study the dynamics of a Susceptible-Exposed-Infectious-Recovered(SEIR)nancial risk contagion model with time delay.Using stability theory and Hopf bifurcation theory,equilibria stability and Hopf bifu... In this paper,we study the dynamics of a Susceptible-Exposed-Infectious-Recovered(SEIR)nancial risk contagion model with time delay.Using stability theory and Hopf bifurcation theory,equilibria stability and Hopf bifurcation are analyzed in detail.Based on the epidemic model,we improve it by taking prior prevention and self-rescue into consideration,conclude pre-ventive intensity and self-rescue capabilities e ect the number of infections.At the same time,the analytical conditions for Hopf bifurcation are obtained,and the relevant results are veri ed by numerical simulations. 展开更多
关键词 nancial risk contagion SELF-RESCUE time delay Hopf bifurcation
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Platinum Nanoparticle-based Collision Electrochemistry for Rapid Detection of Breast Cancer MCF-7 Cells
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作者 Fu-Xing Qin Ming-Ke Li +4 位作者 Hui-Long Zhou Wei Wen Xiu-Hua Zhang Sheng-Fu Wang Zhen Wu 《电化学(中英文)》 CAS 北大核心 2024年第10期19-27,共9页
Cancer metastasis is the leading cause of death in cancer patients worldwide and one of the major challenges in treating cancer.Circulating tumor cells(CTCs)play a pivotal role in cancer metastasis.However,the content... Cancer metastasis is the leading cause of death in cancer patients worldwide and one of the major challenges in treating cancer.Circulating tumor cells(CTCs)play a pivotal role in cancer metastasis.However,the content of CTCs in peripheral blood is minimal,so the detection of CTCs in real samples is extremely challenging.Therefore,efficient enrichment and early detection of CTCs are essential to achieve timely diagnosis of diseases.In this work,we constructed an innovative and sensitive single-nanoparticle collision electrochemistry(SNCE)biosensor for the detection of MCF-7 cells(human breast cancer cells)by immunomagnetic separation technique and liposome signal amplification strategy.Liposomes embedded with platinum nanoparticles(Pt NPs)were used as signal probes,and homemade gold ultramicroelectrodes(Au UME)were used as the working electrodes.The effective collision between Pt NPs and UME would produce distinguishable step-type current.MCF-7 cells were accurately quantified according to the relationship between cell concentration and collision frequency(the number of step-type currents generated per unit time),realizing highly sensitive and specific detection of MCF-7 cells.The SNCE biosensor has a linear range of 10 cells·mL^(-1)to 10^(5) cells·mL^(-1)with a detection limit as low as 5 cells·mL^(-1).In addition,the successful detection of MCF-7 cells in complex samples showed that the SNCE biosensors have great potential for patient sample detection. 展开更多
关键词 Circulating tumor cells Single-nanoparticle collision electrochemistry Immunomagnetic separation LIPOSOME Platinum nanoparticles
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Two-sample Mendelian randomization analysis of causal relationship between eczema and autoimmune diseases
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作者 CHEN Chunli YAN Siyu +4 位作者 WAN Bangbei YU Yangyiyi ZENG Jinrong TAN Lina LU Jianyun 《中南大学学报(医学版)》 CAS CSCD 北大核心 2024年第6期932-942,共11页
Objective:The causal relationship between eczema and autoimmune diseases has not been previously reported.This study aims to evaluate the causal relationship between eczema and autoimmune diseases.Methods:The two‐sam... Objective:The causal relationship between eczema and autoimmune diseases has not been previously reported.This study aims to evaluate the causal relationship between eczema and autoimmune diseases.Methods:The two‐sample Mendelian randomization(MR)method was used to assess the causal effect of eczema on autoimmune diseases.Summary data from the Genome-Wide Association Study Catalog(GWAS)were obtained from the Integrative Epidemiology Unit(IEU)database.For eczema and autoimmune diseases,genetic instrument variants(GIVs)were identified according to the significant difference(P<5×10−8).Causal effect estimates were generated using the inverse‐variance weighted(IVW)method.MR Egger,maximum likelihood,MR-PRESSO,and MR-RAPS methods were used for alternative analyses.Sensitivity tests,including heterogeneity,horizontal pleiotropy,and leave-one-out analyses,were performed.Finally,reverse causality was assessed.Results:Genetic susceptibility to eczema was associated with an increased risk of Crohn’s disease(OR=1.444,95%CI 1.199 to 1.738,P<0.001)and ulcerative colitis(OR=1.002,95%CI 1.001 to 1.003,P=0.002).However,no causal relationship was found for the other 6 autoimmune diseases,including systemic lupus erythematosus(SLE)(OR=0.932,P=0.401),bullous pemphigoid(BP)(OR=1.191,P=0.642),vitiligo(OR=1.000,P=0.327),multiple sclerosis(MS)(OR=1.000,P=0.965),ankylosing spondylitis(AS)(OR=1.001,P=0.121),rheumatoid arthritis(RA)(OR=1.000,P=0.460).Additionally,no reverse causal relationship was found between autoimmune diseases and eczema.Conclusion:Eczema is associated with an increased risk of Crohn’s disease and ulcerative colitis.No causal relationship is found between eczema and SLE,MS,AS,RA,BP,or vitiligo. 展开更多
关键词 ECZEMA atopic eczema autoimmune diseases Crohn’s disease ulcerative colitis Mendelian randomization
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Correlation Between Granulomatous Mastitis and Autoimmune Function and the Immuneregulating Role of Traditional Chinese Medicine
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作者 Jiangshan Yuan Xufeng Cheng +1 位作者 Beibei Wang Zepeng Wang 《Chinese Medicine and Natural Products》 CAS 2024年第3期88-92,共5页
Granulomatous mastitis(GM)is a benign granulomatous condition,and its pathogenesis may be related to autoimmune disorders.Cellular immunity,humoral immunity,immunoglobulins,and complement could all play a role in the ... Granulomatous mastitis(GM)is a benign granulomatous condition,and its pathogenesis may be related to autoimmune disorders.Cellular immunity,humoral immunity,immunoglobulins,and complement could all play a role in the disease process,showing certain clinical patterns.Corticosteroids can quickly control disease progression,and immunosuppressants can be used for complex and refractory GM cases.In traditional Chinese medicine(TCM),“healthy qi”is similar to immune system function.For GM with deficient healthy qi,TCM treatments such as internal and external herbal applications can help regulate immune function and shorten disease duration by staged and TCM treatment,regulating viscera,reinforcing healthy qi,and eliminating pathogenic factors. 展开更多
关键词 GRANULOMATOUS MASTITIS TCM immune regulation TCM treatment staged treatment
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Characterization of spontaneous breast tumor in tree shrews(Tupaia belangeri chinenesis) 被引量:20
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作者 夏厚军 王春艳 +3 位作者 张海林 何保丽 角建林 陈策实 《Zoological Research》 CAS CSCD 北大核心 2012年第1期55-59,共5页
Breast cancer is a common malignant tumor.It is essential to develop suitable animal models for discovering novel preventive and therapeutic approaches.Tree shrews(Tupaia belangeri chinensis) have a closer evolution... Breast cancer is a common malignant tumor.It is essential to develop suitable animal models for discovering novel preventive and therapeutic approaches.Tree shrews(Tupaia belangeri chinensis) have a closer evolutionary relationship with humans than do rodents,which have been widely used in laboratory research.Spontaneous breast tumors were identified in tree shrews in 1960s;however,no detailed studies about tree shrew breast tumors have been conducted to date.Here,we characterized a spontaneous breast tumor from tree shrews by Haematoxylin Eosin(HE) staining.This tumor was identified as a papillary tumor.Immunohistochemical staining(IHC) for progesterone receptor(PR),Ki-67 and cleaved caspase-3 showed that tumor cells were positive for PR,highly proliferative,and less apoptotic compared to normal breast epithelial cells.Thus,the spontaneous tumor of tree shrew is very close to human papillary tumors in terms of morphology and pathology and we concluded that tree shrew may be a suitable animal model for breast cancer research. 展开更多
关键词 Spontaneous breast cancer Tree shrew IMMUNOHISTOCHEMISTRY
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Effect of Glycyrrhiza Polysacchride on Growth Performance and Immunity Function of Mice 被引量:20
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作者 王丽荣 李杰 +2 位作者 董永军 杭柏林 刘兴昌 《Agricultural Science & Technology》 CAS 2008年第2期129-131,共3页
Aniso-dose glycyrrhiza polysaccharide was injected into abdominal cavity of mice. The effect of glycyrrhiza polysaccharide on growth performance and immune ruction of mice was determined. The results showed that the g... Aniso-dose glycyrrhiza polysaccharide was injected into abdominal cavity of mice. The effect of glycyrrhiza polysaccharide on growth performance and immune ruction of mice was determined. The results showed that the growth performance and immune function of mice were improved and there were significant differences among the treatment groups and control group. 展开更多
关键词 Glycyrrhiza polysaccharide MICE Growth performance E-rosettes experiment
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Studies on Active Polysaccharides from Ganoderma lucidum vith Immune Activity 被引量:5
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作者 何云庆 李荣芷 +3 位作者 陈琪 林志彬 夏冬 马莉 《Journal of Chinese Pharmaceutical Sciences》 CAS 1992年第1期79-81,共3页
从云头状灵芝[Ganoderma Lucidum(Leyss.ex Fr.)Karst.]中分离得到三种灵芝多糖BN3A,BN3B及BN3C,它们均表现明显免疫调节作用。从灵芝多糖BN3B及BN3C中各分离得到四个多糖均一体,对其中主要成分BN3C1,BN3C3,BN3B1及BN3B3进行了物... 从云头状灵芝[Ganoderma Lucidum(Leyss.ex Fr.)Karst.]中分离得到三种灵芝多糖BN3A,BN3B及BN3C,它们均表现明显免疫调节作用。从灵芝多糖BN3B及BN3C中各分离得到四个多糖均一体,对其中主要成分BN3C1,BN3C3,BN3B1及BN3B3进行了物理及化学研究,它们的平均分子量依次为1.6×10^4,2.5×10^4,3.5×10^4及4.0×10^4。经完全酸水解、红外光谱测定、过碘酸氧化、甲酸生成、Smith降解等证明,BN3B1及BN3C1均为β-(1→6)(1→3)甙键相连的葡聚糖。BN3B3为阿拉伯半乳聚糖。BN3C3为由葡萄糖和阿拉伯糖组成的肽多糖。它们均为β-(1→6)(1→3)甙键相连。 展开更多
关键词 Ganoderma lucidum Ganoderma polysaccharides Immune activity
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Immunologic pathogenesis of multiple sclerosis 被引量:6
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作者 郭敏芳 纪宁 马存根 《Neuroscience Bulletin》 SCIE CAS CSCD 2008年第6期381-386,共6页
Multiple sclerosis (MS) is an autoimmune disease. The etiology and pathogenesis of MS remain unclear. At present, there are substantial evidences to support the hypothesis that genetics plays a crucial role. The peo... Multiple sclerosis (MS) is an autoimmune disease. The etiology and pathogenesis of MS remain unclear. At present, there are substantial evidences to support the hypothesis that genetics plays a crucial role. The people who have genetic predisposing genes easily develop immune-mediated disorder, probably in conjunction with environmental factors. The aim of this review is to describe recent observations regarding the immunologic pathogenesis of MS. 展开更多
关键词 multiple sclerosis IMMUNOLOGY PATHOGENESIS
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Effects of Mycotoxin from Maize on Immune Response of Vaccine for Piglets 被引量:9
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作者 马飞 刘文强 +1 位作者 刘桂芹 秦绪岭 《Agricultural Science & Technology》 CAS 2010年第7期117-119,共3页
[Objective] The aim of this study was to investigate the effects of mycotoxin from moldy maize on immune response of piglets.[Method] ELISA method was used to determine the content of Aflatoxin B1 and ochratoxin A in ... [Objective] The aim of this study was to investigate the effects of mycotoxin from moldy maize on immune response of piglets.[Method] ELISA method was used to determine the content of Aflatoxin B1 and ochratoxin A in maize; after the piglets were fed with the moldy maize,the corresponding antibody titers in the serums of piglets were measured.[Result] Antibody levels of tested group were obvious lower than that of the control,while the histological section of immune organs also suggested that mycotoxin could significantly inhibit the immune response of piglets.[Conclusion] Mycotoxin in maize had important effects on the internal organs and immune response of piglets. 展开更多
关键词 MAIZE MYCOTOXIN PIGLETS Immune response
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