基於秦漢簡帛語料庫的記{杯}用字考察

基於秦漢簡帛語料庫,從使用頻率、文獻類型等方面考察秦漢簡帛中記{杯}之字,可以看到,秦至西漢初期常用“杯”“桮”二字,偶見用“咅”字。西漢中晚期用“杯”“桮”“棓”。從使用頻率上看,“杯”“桮”的使用頻率較高,并且“杯”逐漸取代“桮”,占據優勢地位。“棓”出現較晚,使用頻率較低。在文獻分布方面,“杯”“桮”在遣策和醫方中呈現此消彼長的態勢。“棓”見於西北簡中,與表棍棒義的“棓”是同形字關係。此外,“咅”記{杯}是馬王堆漢墓簡帛中特有的用字習慣。

面条机搅拌杯多重倒扣成型注塑模具设计

针对某面条机搅拌杯产品存在多重倒扣难以脱模的问题,设计了单型腔模具结构。采用圆周式薄片侧浇口,并实现了流道废料自动切除。针对产品不同部位的脱模要求设计了不同的脱模机构:型腔侧扣位采用前模抽芯机构进行脱模,型芯侧外侧面多重扣位采用哈夫滑块抽芯机构进行脱模,型芯侧内侧面多重扣位采用斜顶机构进行脱模,产品的完全顶出采用推件板顶出方式顶出脱模。结合一侧哈夫滑块抽芯时,需先行将螺纹镶件抽出的特点,在该哈夫滑块的结构基础上,设计了复合式斜导柱+弯销+螺纹滑块脱模机构,实现了产品上各局部扣位的脱模。设计的模具完成了所有的侧抽芯脱模动作,实现了自动化注塑生产。

也谈网络流行语“杯具”的形成

论文先介绍了非网络流行语的"杯具"的用法及意义,然后叙述了网络流行语"杯具"的形成与发展过程;再着重从谐音双关的角度论述了"杯具"一词形成的机理,最后描述了"杯具"用法进一步的发展情况。网络流行语"杯具"与"悲剧"一词谐音双关;以"杯具"为中心,形成了"洗具(喜剧)"、"餐具(惨剧)"、"茶具(差距)"等一系列新词;"杯具"

Nanogrinding of SiC wafers with high flatness and low subsurface damage

Nanogrinding of SiC wafers with high flatness and low subsurface damage was proposed and nanogrinding experiments were carried out on an ultra precision grinding machine with fine diamond wheels. Experimental results show that nanogrinding can produce flatness less than 1.0μm and a surface roughness Ra of 0.42nm. It is found that nanogrinding is capable of producing much flatter SiC wafers with a lower damage than double side lapping and mechanical polishing in much less time and it can replace double side lapping and mechanical polishing and reduce the removal amount of chemical mechanical polishing.

GRINDING FORCE IN PRECISION MACHINING OF WC-Co COATING BY CUP WHEEL

High machining precision and machining efficiency can be obtained in grinding WC-Co coating by cup wheel. The conventional model of the grinding force is not suitable for the grinding of the cup wheel due to the difference in grinding style between the cup wheel and the conventional external wheel. So the grit grinding process of the cup wheel is studied, and a new concept of the effective grinding width of the cup wheel is presented. Then the grinding force in grinding WC-Co coating materials by cup wheel is analyzed and a theoretical formula is deduced. Finally, experimental results of the grinding force verify the correctness and the precision of the theoretical formula.

Effects of Traditional Chinese Medicine on Numbers of Lymphocytes and Goblet Cells in Villus Epithelia of Layers under Heat Stress

[Objective] This study aimed to investigate the effects of traditional Chinese medicine additives on numbers of lymphocytes and goblet cells in villus epithelia of layers under heat stress.[Method] A total of 180 88-d-old healthy Esa Brown cocks were selected.They were randomly divided into 9 experimental groups：Room temperature control,High temperature control,VC addition group,High formula I,Moderate formula I,Low formula I,High formula II,Moderate formula II and Low formula II.The formula I and formula II were to add different herbal extracts to the diet of cocks with different doses.The cocks in the VC addition group were administered orally with same-concentration VC solution.After certain time,the cocks were slaughtered.Then the numbers of epithelial lymphocytes and goblet cells in various segments of small intestine were counted by using conventional histological section and HE staining.[Result] The numbers of lymphocytes and goblet cells in villus epithelia of layers under heat stress were decreased gradually with the proceeding of experiment.The herbal extracts of formula I and formula II all could promote the generation of lymphocytes and goblet cells.But the promoting effect of formula II was best.[Conclusion] The Chinese herbal medicine additives have a good relieving effect on heat stress in layers.

Distribution Law of Goblet Cells in the Intestinal Tracts of African Ostrich Chicks

[Objective] This study aimed to investigate the distribution law of different goblet cells in the intestinal tracts of African ostrich chicks. [Method] Alcian blue/pe- riodic acid-schiff reaction （AB/PAS） was adopted to observe and analyze the types and distribution of goblet cells in the intestinal tracts of ostrich chicks. Acid mu- copolysaccharide could be stained blue with alcian blue （AB）, and neutral mu- copolysaccharide could be stained red with periodic acid-schiff reagent （PAS）. [Result] According to AB/PAS results, goblet cells in the intestinal tracts were divided in- to four types： TypeⅠ was pure red, with AB negative result and PAS positive result containing neutral mucoitin; type Ⅱ was pure blue, with AB positive result and PAS negative result containing acidic mucoitin; type Ⅲ was purple reddish, with PAS posi- tive result greater than AB; typeⅣ was purple blue, with AB positive result greater than PAS. Large quantities of goblet cells were found in the intestinal tracts of os- trich chicks, mostly type III and IV.The quantities of goblet cells were decreased gradually in the duodenum, jejunum and ileum, while the quantities were increased in the cecum, colon and rectum. The goblet cells in the large intestine are more than that in the small intestine. The most quantities of goblet cells were contained in rectum. [Conclusion] These results indicate that the distribution of goblet cells is closely related with the structure and function of intestinal tracts. The mucus secret- ed by the goblet Cells plays a series of important roles in the digestion and mucosal immunization.

Effects of tribological behavior of DLC film on micro-deep drawing processes

To decrease the size effects of friction in microforming, three kinds of surface coatings, such as diamond-like carbon（DLC）, TiN and MoS2, were deposited on surfaces of dies with plasma based ion implantation and deposition（PBII D） method and magnetron sputtering technique, respectively. The tribological behavior of surface coatings was analyzed considering plastic deformation of specimen at contact interface. The analyses indicate that there is a lower coefficient of friction（COF） and a high wear resistance under the condition of large strain/stress when using the DLC film. The graphitization of DLC film occurs after 100 times of tests. The mechanism of graphitization was analyzed considering energy induced by friction work. The effects of DLC film properties on qualities of micro-deep drawn parts were investigated by analyzing the reduction of wall thickness, etc. The results indicate that DLC film is very helpful for improving the qualities of the micro-parts.

Ultrastructural Studies on the Development of Oil Cells in Litsea pungens

The developmental process of oil cells in the shoot of Litsea pungens Hemsl. has been studied with transmission electron microscopy. According to the development of the three layers of cell wall, the developmental process could be divided into 4 stages. In stage 1, the cell wall consisted only of a primary (the outmost) cellulose layer, which might further be divided into two substages, the oil cell initial, and the vacuolizing oil cell. During this stage, there were some small electron translucent vesicles and dark osmiophilic droplets of variant sizes in the different-shaped plastids. It was observed that some dark and gray osmiophilic materials coalesced to vacuoles in the cytoplasm. In stage 2, a lamellated suberin layer accumulated inside the primary cellulose layer. In stage 3, a thicker and looser inner cellulose wall layer was formed gradually inside the suberin layer. Some dark osmiophilic droplets have been observed in this loose inner cellulose wall layer. The plasmodesmata were blocked up and became a special structure. Then, the big vacuole, which is the oil sac, was full of osmiophilic oil. In stage 4, the oil cell became matured and the cytoplasm disintegrated. The oil sac enveloped from plasmalemma was attached to the cupule, which was formed by the protuberance of the inner cellulose wall layer into the lumen. After the maturity of oil cell, the ground cytoplasm began to disintegrate and became electron opaque or exhibited in a disordered state, and the osmiophilic oil appeared light gray.

Analysis of elliptical cup drawing process of stainless sheet metal

Prandtl-Reuss flow rule and Hill’s yield criterion were adopted and combined with the concept of finite deformation theory, updated Lagrangian formulation, and a three-dimensional finite element analytical model was established by application of quadrilateral four-node degenerated shell elements coupling into a rigid matrix to deal with the sheet metal forming problems. The fractured thickness of a specimen obtained from a simple tension test was used to be the fracture criterion for the numerical analysis to explore the relationship between punch load and stroke, the thickness distribution, the deformation history and the forming limit of work-piece in the elliptical cup drawing process. The numerical analysis and experiment results show that the punch load increases with the increase of punch stroke, and when the load reaches its maximum, the blank continues to deform with the increase of the punch stroke, resulting in a reduced load until the extension is completed. The minimum thickness of the work-piece concentrates in the contact region of the work-piece and long axis of the punch due to the smaller radius of the curvature of the long axis than the short axis. So the blanks bore the maximum tensile stress in the long axis. Through the limit drawing ratio defined by perimeter of the elliptical punch, the limit drawing ratio of this elliptical cup drawing is defined to be 2.136.

STUDIES OF SURFACE GRINDING TEMPERATURE AFFECTED BY DIFFERENT GRINDING WAYS OF SILICON WAFER

The surface grinding temperature of the silicon wafer ground by diamond wheels is studied.Rudimentally,the properties of the surface grinding temperature generated by two grinding methods,ground by straight and cup wheels respectively,are analyzed.In addition,considering the effects of grain size and grinding depth on surface grinding temperature during these two grinding processes,significant results and conclusions are obtained from experimental research.

Process window diagram of conical cups in hydrodynamic deep drawing assisted by radial pressure

Major defects in forming of conical cups are wrinkles and rupture.Hydrodynamic deep drawing assisted by radial pressure（HDDRP） is a sheet hydroforming process for production of shell cups in one step.In this work,process window diagrams（PWDs） for Al1050-O,pure copper and DIN 1623 St14 steel are obtained for HDDRP process.The PWD is determined to provide a quick assessment of part producibility for sheet hydroforming process.Finite element method is used for this purpose considering the process parameters including pressure path,and the blank material and its thickness.Numerical results are validated by experiments.It is shown that the sheets with less initial thickness and higher strength show better formability and uniformity of thickness distribution on final product.The results demonstrate that the obtained PWD can predict appropriate forming area and probability of rupture or wrinkling occurrence under different pressure loading paths.

Hydrodynamic deep drawing of double layered conical cups

Hydrodynamic deep drawing assisted by radial pressure is an advanced sheet forming technology with great advantages such as higher drawing ratio, good surface quality and higher dimensional accuracy. In this process, both the bottom surface and the peripheral edge of sheets are under hydrodynamic pressure, so that the forming procedure is more uniform with low failure probability. Multi-layered sheets with complex geometries could be formed more easily with this technique compared with other traditional methods. Rupture is the main irrecoverable failure form in sheet forming processes. Prediction of rupture occurrence is of great importance for determining and optimizing the proper process parameters. In this research, a theoretical model was proposed to calculate the critical rupture pressure in production of double layered conical parts with hydrodynamic deep drawing process assisted by radial pressure. The effects of other process parameters on critical rupture pressure, such as punch tip radius, drawing ratio, coefficient of friction, sheet thickness and material properties were also discussed. The proposed model was compared with finite element simulation and validated by experiments on Al1050/St13 double layered sheets, where a good agreement was found with analytical results.

From intestinal stem cells to inflammatory bowel diseases

The pathogenesis of both entities of inflammatory bowel disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC), is still complex and under investigation. The importance of the microbial flora in developing IBD is beyond debate. In the last few years, the focus has changed from adaptive towards innate immunity. Crohn's ileitis is associated with a deficiency of the antimicrobial shield, as shown by a reduced expression and secretion of the Paneth cell defensin HD5 and HD6, which is related to a Paneth cell differentiation defect mediated by a diminished expression of the Wnt transcription factor TCF4. In UC, the protective mucus layer, acting as a physical and chemical barrier between the gut epithelium and the luminal microbes, is thin- ner and in part denuded as compared to controls. This could be caused by a missing induction of the goblet cell differentiation factors Hath1 and KLF4 leading to immature goblet cells. This defective Paneth and goblet cell differentiation in Crohn's ileitis and UC may enablethe luminal microbes to invade the mucosa and trigger the inflammation. The exact molecular mechanisms behind ileal CD and also UC must be further clarified, but these observations could give rise to new therapeutic strategies based on a stimulation of the protective innate immune system.

MUC5AC EXPRESSION UP-REGULATION GOBLET CELL HYPERPLASIA IN THE AIRWAY OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Objective To determine the number of goblet cells, the change of MUC5AC expression in chronic obstructive pul- monary disease (COPD) patients and the relationship of smoking with goblet cell, MUC5AC, and lung function. Methods Eighteen patients undergoing lung resections for a solitary peripheral carcinoma were classified by lung function as having COPD. Twenty patients with normal lung function served as the control group. Normal lobe bronchioles far away from the lesion site were taken for paraffin section. Goblet cells were identified by AB/PAS staining and the ex- pression of MUC5AC in the paraffin’s section was tested by immunohistochemistry. Results Goblet cell hyperplasia was observed in the COPD group. The positive rate of goblet cell in COPD group (0.20% ± 0.10%) was significantly higher than that in the normal lung function group (0.13% ± 0.06%, P < 0.05). The posi- tive rate of MUC5AC expression in the COPD group (0.27% ± 0.09%) was higher than that in the normal lung function group (0.20% ± 0.10%, P < 0.05). The positive rate of goblet cell in smokers (27.93% ± 9.00%) of the COPD group and normal lung function group was higher than that in non-smokers (17.70% ± 9.37%, P < 0.05), while MUC5AC expression had no significant difference between smokers and non-smokers (17.88% ± 6.44% and 10.88% ± 7.10%, respectively). Conclusion For COPD patients with declined lung function, there were goblet cell hyperplasia and increased expres- sion of MUC5AC. MUC5AC expression up-regulation may due to goblet cell hyperplasia. Smoking may be an important factor for goblet cell hyperplasia.

Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix

Goblet cell carcinoid is an uncommon primary tumor of the vermiform appendix, characterized by dual endocrine and glandular differentiation. Whether goblet cell carcinoid represents a morphological variant of appendiceal classical carcinoid or a mucin-producing adenocarcinoma is a matter of conjecture. Rare cases of goblet cell carcinoid with other concomitant appendiceal epithelial neoplasms have been documented. In this report, we describe a rare case of combined appendiceal goblet cell carcinoid and mucinous cystadenoma, and discuss the possible histopathogenesis of this combination.

Optimization and experimental research on a new-type short cylindrical cup-shaped harmonic reducer

In order to obtain a new-type short cylindrical cup-shaped flexspline that can be applied to space mechanisms,the APDL language of ANSYS software was employed to develop a parameterized equivalent contact model between a flexspline and a wave generator. The validity of the parameterized equivalent contact model was verified by comparing the results of the analytic value of the contact model and the value calculated by the theoretical formula. The curvilinear trend of stress was obtained by changing the structural parameter of the flexspline. Based on the curvilinear trend of stress,multi-objective optimizations of key structural parameters were achieved. Flexspline,wave generator,and circular spline of a new 32-type short cylindrical cup-shaped harmonic reducer were designed and manufactured. A performance test bench to carry out tests on the harmonic reducer was designed. Contrast experiments were implemented to determine the efficiency of the new 32-type short cylindrical cup-shaped harmonic reducer and the conventional 32-type harmonic reducer under different conditions. The experimental results reveal that there is approximately equality in terms of efficiency between the new 32-type short cylindrical cup-shaped harmonic reducer and the conventional 32-type harmonic reducer. The volume of the flexspline of the new 32-type short cylindrical cup-shaped harmonic reducer is reduced by approximately 30% through multi-objective optimization. When the new 32-type short cylindrical cup-shaped harmonic reducer is used on the wheel of a rover prototype,the mass of the wheel hub is decreased by 0.42 kg. Test analysis of wheel motion verifies that the new 32-type short cylindrical cup-shaped harmonic reducer can meet the requirements regarding bearing capacity and efficiency.

Numerical simulation of wrinkle phenomenon during multi-point forming process of shallow rectangle cup

In this paper, the principle of multi-point forming (MPF) technique is presented. One of the most serious defects, wrinkling, during the multi-point forming process of a shallow rectangle cup is discussed by means of numerical simulation on the shallow rectangle cup forming process. The effects of thickness, material of sheet metal and the pressure of the blank holder are investigated. Based on the simulation results, the reasons and control methods of wrinkling are pointed out. Moreover, the experiment on the multi-point die forming of the shallow rectangle cup by the MPF machine is done to validate the efficiency of the numerical simulation, and the result proves that the application of an elastic cushion in the forming can restrain wrinkling efficiently.

NADPH oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice

AIM To test whether Nox1 plays a role in typhlitis induced by Salmonella enterica serovar Typhimurium(S. Tm) in a mouse model.METHODS Eight-week-old male wild-type(WT) and Nox1 knockout(KO) C57BL6/J(B6) mice were administered metronidazole water for 4 d to make them susceptible to S. Tm infection by the oral route. The mice were given plain water and administered with 4 different doses of S. Tm by oral gavage. The mice were followed for another 4 d. From the time of the metronidazole application, the mice were observed twice daily and weighed daily. The ileum, cecum and colon were removed for sampling at the fourth day post-inoculation. Portions of all three tissues were fixed for histology and placed in RNAlater for m RNA/c DNA preparation and quantitative real-time PCR. The contents of the cecum were recovered for estimation of S. Tm CFU.RESULTS We found Nox1-knockout(Nox1-KO) mice were not more sensitive to S. Tm colonization and infection than WT B6 mice. This conclusion is based on the following observations:(1) S. Tm-infection induced similar weight loss in Nox1-KO mice compared to WT mice;(2) the same S. Tm CFU was recovered from the cecal content of Nox1-KO and WT mice regardless of the inoculation dose, except the lowest inoculation dose(2 × 106 CFU) for which the Nox1-KO had one-log lower CFU than WT mice;(3) there is no difference in cecal pathology between WT and Nox1-KO groups; and(4) there are no S. Tm infection-induced changes in gene expression levels(IL-1b, TNF-α, and Duox2) between WT and Nox1-KO groups. The Alpi gene expression was more suppressed by S. Tm treatment in WT than the Nox1-KO cecum. CONCLUSION Nox1 does not protect mice from S. Tm colonization. Nox1-KO provides a very minor protective effect against S. Tm infection. Using NOX1-specific inhibitors for colitis therapy should not increase risks in bacterial infection.

Effects of basicity and temperature on mineralogy and reduction behaviors of high-chromium vanadium-titanium magnetite sinters

The effects of basicity and temperature on the reduction process of Hongge high-chromium vanadium-titanium magnetite(HCVTM)sinter were investigated in this work.The main characterization methods of X-ray fluorescence(XRF),X-ray diffraction(XRD),scanning electron microscope(SEM),and metallographic microscope were employed in this study.In this work,the reduction of HCVTM sinter with different temperature and basicity were experimented.The Fe,FeO,and TiO in reductive samples increase with increasing basicity and temperatures.The increase of basicity and temperature is favorable to the reduction of HCVTM sinter.The Fe phase has out-migration tendency to the surface of sinter while the perovskite and silicate phases have in-migration tendency to the inside of sinter.The reduction degradation index(RDI)decreases while the reduction index(RI)increases with increasing basicity.The RI increases from 67.14%to 82.09%with increasing temperature from 1073 K to 1373 K.