目的分析原发性低颅压性头痛(SIH)的临床及影像特征,探讨其诊断及治疗。方法回顾分析17例SIH患者临床资料、诊断及治疗。结果 17例患者均有典型体位性头痛和低颅压,脑脊液压力为0~60 mm H2O,平均(38.22±24.85)mm H2O。头颅MRI表现...目的分析原发性低颅压性头痛(SIH)的临床及影像特征,探讨其诊断及治疗。方法回顾分析17例SIH患者临床资料、诊断及治疗。结果 17例患者均有典型体位性头痛和低颅压,脑脊液压力为0~60 mm H2O,平均(38.22±24.85)mm H2O。头颅MRI表现为脑组织下垂(41.18%)、硬膜下积液(11.76%)及硬脑膜强化(33.33%);其中1例(占5.88%)合并有脑静脉窦血栓(CVST)形成。患者经卧床休息、补液、使用地塞米松等治疗全部治愈。结论典型的临床表现、低颅压及头颅MRI特点有助于SIH的早期诊断;SIH可能是导致CVST危险因素之一。展开更多
Penicillinosis Marneffei （PSM） is a rare fungal disease caused by systemic infection of Penicillium Mameffei （PM）. Disseminated PSM is one of the most common opportunistic infections in patients with acquired immu...Penicillinosis Marneffei （PSM） is a rare fungal disease caused by systemic infection of Penicillium Mameffei （PM）. Disseminated PSM is one of the most common opportunistic infections in patients with acquired immunodeficiency syndrome （AIDS） living in Southeastern region during the endstage of disease. Sporadic and individual cases have been reported recently in China and there appeared a tendency of increase of PM infections because of the increase of AIDS cases. To improve our understanding of this disease, we report here 8 cases of AIDS associated PSM.展开更多
As a multi-factorial degenerative disease, Parkinson＇s disease （PD） leads to tremor, gait rigidity, and hypokinesia, thus hampering normal living. As this disease is usually detected in the later stages when neuron...As a multi-factorial degenerative disease, Parkinson＇s disease （PD） leads to tremor, gait rigidity, and hypokinesia, thus hampering normal living. As this disease is usually detected in the later stages when neurons have degenerated completely, cure is on hold, ultimately leading to death due to the lack of early diagnostic techniques. Thus, biomarkers are required to detect the disease in the early stages when prevention is possible. Various biomarkers providing early diagnosis of the disease include those of imaging, cerebrospinal fluid, oxidative stress, neuroprotection, and inflammation. Also, biomarkers, alone or in combination, are used in the diagnosis and evolution of PD. This review encompasses various biomarkers available for PD and discusses recent advances in their development.展开更多
文摘目的分析原发性低颅压性头痛(SIH)的临床及影像特征,探讨其诊断及治疗。方法回顾分析17例SIH患者临床资料、诊断及治疗。结果 17例患者均有典型体位性头痛和低颅压,脑脊液压力为0~60 mm H2O,平均(38.22±24.85)mm H2O。头颅MRI表现为脑组织下垂(41.18%)、硬膜下积液(11.76%)及硬脑膜强化(33.33%);其中1例(占5.88%)合并有脑静脉窦血栓(CVST)形成。患者经卧床休息、补液、使用地塞米松等治疗全部治愈。结论典型的临床表现、低颅压及头颅MRI特点有助于SIH的早期诊断;SIH可能是导致CVST危险因素之一。
文摘Penicillinosis Marneffei （PSM） is a rare fungal disease caused by systemic infection of Penicillium Mameffei （PM）. Disseminated PSM is one of the most common opportunistic infections in patients with acquired immunodeficiency syndrome （AIDS） living in Southeastern region during the endstage of disease. Sporadic and individual cases have been reported recently in China and there appeared a tendency of increase of PM infections because of the increase of AIDS cases. To improve our understanding of this disease, we report here 8 cases of AIDS associated PSM.
文摘As a multi-factorial degenerative disease, Parkinson＇s disease （PD） leads to tremor, gait rigidity, and hypokinesia, thus hampering normal living. As this disease is usually detected in the later stages when neurons have degenerated completely, cure is on hold, ultimately leading to death due to the lack of early diagnostic techniques. Thus, biomarkers are required to detect the disease in the early stages when prevention is possible. Various biomarkers providing early diagnosis of the disease include those of imaging, cerebrospinal fluid, oxidative stress, neuroprotection, and inflammation. Also, biomarkers, alone or in combination, are used in the diagnosis and evolution of PD. This review encompasses various biomarkers available for PD and discusses recent advances in their development.
