First record of abnormal body coloration in a rockfish Sebastes koreanus(Scorpaenoidei:Sebastidae)from coastal water of China based on morphological characteristics and DNA barcoding

The first record of abnormal body coloration in Sebastes koreanus Kim and Lee,1994,from the Yellow Sea of China,was documented based on morphological characteristics and DNA barcoding.The two rockfish specimens were collected from the coastal waters of Qingdao,China,and the whole body and all fins of them were red.Of the two red-colored rockfish,there were tiny deep red spots on each fin,2 red radial stripes behind and below the eyes and 1 large deep red blotch on the opercula,while the similar stripe and spot patterns are also present in the S.koreanus specimens with normal body coloration.The countable characteristics of the two specimens are in the range of the morphometry of S.koreanus.To further clarify the species identity and taxonomic status of the two specimens,DNA barcode analysis was carried out.The genetic distance between the red-colored rockfish and S.koreanus was 0,and the minimum net genetic distances between the red-colored rockfish and other Sebastes species except for S.koreanus were 3.0%,which exceeds the threshold of species delimitation.The phylogenetic analysis showed that the DNA barcoding sequences of the two red-colored rockfish clustered with the S.koreanus sequences.The above results of DNA barcode analysis also support that the two red-colored rockfish could be identified as the species of S.koreanus.The mechanism of color variation in S.koreanus is desirable for further research and the species could be an ideal model to study the color-driven speciation of the rockfishes.

Characteristics of Abnormal Pressure Systems and Their Responses of Fluid in Huatugou Oil Field,Qaidam Basin

Based on the comprehensive study of core samples, well testing data, and reservoir fluid properties, the construction and the distribution of the abnormal pressure systems of the Huatugou oil field in Qaidam Basin are discussed. The correlation between the pressure systems and hydrocarbon accumulation is addressed by analyzing the corresponding fluid characteristics. The results show that the Huatugou oil field as a whole has low formation pressure and low fluid energy; therefore, the hydrocarbons are hard to migrate, which facilitates the forming of primary reservoirs. The study reservoirs, located at the Xiayoushashan Formation （N1/2） and the Shangganchaigou Formation （N1） are relatively shallow and have medium porosity and low permeability. They are abnormal low-pressure reservoirs with an average formation pressure coefficient of 0.61 and 0.72 respectively. According to the pressure coefficient and geothermal anomaly, the N1 and N1/2 Formations belong to two independent temperature-pressure systems, and the former has slightly higher energy. The low-pressure compartments consist of a distal bar as the main body, prodelta mud as the top boundary, and shore and shallow lake mud or algal mound as the bottom boundary. They are vertically overlapped and horizontally paralleled. The formation water is abundant in the Cl^- ion and can be categorized as CaCl2 type with high safinity, which indicates that the abnormal low-pressure compartments are in good sealing condition and beneficial for oil and gas accumulation and preservation.

Study of the Constituent of Abnormal Low Pressure Compartment and Fluid Characteristics in Huatugou Oilfield,Qaidam Basin

Based on the comprehensive research on core samples,well testing data and fluid parameters of the reservoirs,the depositional architecture of the abnormal low pressure compartment and fluid characteristics of Huatugou oilfield of Qaidam basin were reported,and the correlation between the compartment and hydrocarbon accumulation was revealed. The result indicates that the reservoirs are located

CHARACTERISTICS AND CAUSE ANALYSIS OF WESTERN PACIFIC SUBTROPICAL HIGH DURING THE HUAIHE RIVER FLOODS IN 2003

1 INTRODUCTION In summer, different assembly of the intensity, location and vertical structure of the subtropical high and the earlier/later time of its seasonal northwards jump bring about different precipitation patterns over China. Therefore, subtropical high activity and its cause during the occurrence of extreme climatic event over China and the cause of China drought/flood are studied to improve weather forecasting.

THE GEOCHEMISTRY CHARACTERISTICS OF BLUESCHIST IN THE GANGMAR AREA, QIANGTANG BLOCK, TIBET

The Qinghai—Xizang (Tibet) Plateau was assembled by the successive accretion of continental and arc terranes to Asia during the Palaeozoic, Mesozoic and early Tertiary. From north to south, the Plateau was divided into four terranes (from north to south): Songpan\|Garze, Qingtang, Lhasa and India terranes. The Qiangtang terrane was divided into two parts by Chabu\|Shuanghu suture: Northern Qiangtang and Southern Qiangtang blocks. It was believed that there is a suture as Palaeotethyan suture between the two blocks from Lungmu lake to Chabu, to Shuanghu, to Langcangjiang, but some geologists opposited this opinion, such as Wang Chengshan et al.(1987) and Deng Wanming et al.(1996). The blueschists that bear the typical glaucophane were found in the Gangmar Area in summer of 1997. The blueschists consist of glaucophane, crossite, phengite, actinolite, epidote, sphene ,rutile, and so on. Blueschists show nappe structures in enclosing rocks, and thrust over Tertiary from north to south.The age of blueschist is 275～285Ma which stand for the metamorphic age of blueschist. The geochemical contents of blueschists are the following: SiO\-2 is 45 37%～53 82%, Na 2O>K 2O, K 2O+Na 2O are 3 72%～7 61%, Na 2O/K 2O is 1 70～19 67, MnO is 0 16%～0 22%, FeO+Fe 2O 3 are 11 12%～14 27%, TiO 2 is 2 34%～4 28%, P 2O 5 is 0 34%～1 03%. From the contents, SiO 2 is inverse relation with K 2O+Na 2O, K 2O and FeO+Fe 2O 3. In the SiO 2\|K 2O+Na 2O diagram, the blueschists fall in the field of Alkali basalt; in the TiO 2\|MnO(10\|P 2O 5×10 triangular diagram, these plot within the Ocean Island Basalts(OIB) field. The whole REE content is (117 03～390 97)×10 -6 , LREE/HREE is 5 05～9 80, the REE diagram shows the feature that LREE is rich and HREE is depleted, this is similar to the OIB. In the spidergram of trace elements show the same characterristics as the OIB. Meanwhile, the trace elements ratios, such as Ba/Nb, La/Nb, Nb/Th, Nb/Y, Zr/Y, Zr/Nb, Hf/Sm, Ta/Hf, Nb/Ta, Nb/U, suggest the tectonic setting is OIB. On the basis of these materials, the blueschists are akin to within\|plate ocean island basalts. This shows that there is a ocean or oceanic basin in the Chabu\|Shuanghu belts and the formation of blueschists is the quicky subduction of the Ocean Island Basalts in Early Permian between the Gondwana and Eurasia continents. It demonstrated, therefore, that the Chabu\|Suanghu suture exists and may extend to the east to Lnagchangjiang, and may extend into Thailand\|Malaysia Peninsula.

Clinical characteristics and current management of hepatitis B and C in China

AIM: To describe a population of outpatients in China infected by hepatitis B virus (HBV) and/or hepatitis C virus (HCV), and assess their current management status. METHODS: A multicenter, cross-sectional study of HBV- and/or HCV-infected patients was conducted from August to November, 2011 in western China. Patients >= 18 years of age with HBV and/or HCV infections who visited outpatient departments at 10 hospitals were evaluated, whether treated or not. Data were collected on the day of visit from medical records and patient interviews. RESULTS: A total 4010 outpatients were analyzed, including 2562 HBV- infected and 1406 HCV-infected and 42 HBV/HCV co-infected patients. The median duration of documented infection was 7.5 years in HBV- infected and 1.8 years in HCV-infected patients. Cirrhosis was the most frequent hepatic complication (12.2%), appearing in one-third of patients within 3 years prior to or at diagnosis. The HCV genotype was determined in only 10% of HCV-infected patients. Biopsy data were only available for 54 patients (1.3%). Antiviral medications had been received by 58.2% of patients with HBV infection and 66.6% with HCV infection. Nucleos(t) ide analogs were the major antiviral medications prescribed for HBV- infected patients (most commonly adefovir dipivoxil and lamivudine). Ribavirin + pegylated interferon was prescribed for two-thirds of HCV-infected patients. In the previous 12 mo, around one-fifth patients had been hospitalized due to HBV or HCV infection. CONCLUSION: This observational, real-life study has identified some gaps between clinical practice and guideline recommendations in China. To achieve better health outcomes, several improvements, such as disease monitoring and optimizing antiviral regimens, should be made to improve disease management. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

Resistance Characteristics of Hydraulic Oil through Isodiametric T-type Duct with Sharp Corners

Rational determination and reduction of local energy loss of oil flow at pipe junctions are of important significance to improve hydraulic pipeline＇s work efficiency, especially for complex hydraulic pipeline connected by isodiametric T-type ducts with sharp comers to get combined and divided flow. From this point of view, the formulae of resistance loss for combined flow and divided flow through isodiametric T-type duct with sharp comers as well as the correlations of resistance loss coefficients in the branches of the duct are derived using energy method. On this basis, resistance characteristics of hydraulic oil in the duct are obtained by numerical simulation of different flow modes, which are commonly applied in hydraulic pipelines, using computational fluid dynamics （CFD） method, and the reasons for the resistance loss are analyzed based on the pressure change mechanism in the flow field. A part of simulation results was validated with the reference data. The research shows that for combined flows the resistance loss of symmetrical is lower than that of unsymmetrical to obtain low speed in common branch, but to gain high speed is quite the contrary, for divided flows, the symmetrical is always a reasonable choice to reduce resistance loss. These conclusions can be applied to optimize the design of hydraulic pipeline.

A simulating investigation into the characteristics of the mass transfer between molten steel and particles in the 150 t RH-IJ refining

The characteristics of the mass transfer between powder particles and liquid steel in the Ruhrstahl Heraeus process injection （RH-IJ） refining were simulatively investigated by the use of a 1/4 scale water model of a 150 t Ruhrstahl Heraeus（RH） degasser. The influences of the lifting gas flow rate, the up-snorkel and down-snorkel inner diameters and the size of powder particles on the characteristics of the mass transfer were examined. The results show that under the condition that the inner diameters of both the up-snorkel and the down-snorkel are the same, the mass transfer coefficient in the liquid,k increases with the increase of the inner diameter of the up-snorkel,the particle size and the lifting gas flow rate （Q1）. However, the increase of Q~ should not result in a saturated circulation rate. Under the current working condition,k ranges from 3. 392 × 10 -5 m/s to 2. 661 × 10-4 m/s. On the other hand,with a given lifting gas flow rate and up-snorkel inner diameters ,the mass transfer weakens with the increase of the down-snorkel inner diameter. An inherently nonlinear relationship between the circulation rate （Q~） of molten steel in the RH degasser and k,which increases with the increase of Q1,was found. Under the condition of other parameters being the same,k increases with the increase of the powder particle size. In order to enhance the mass transfer,it is better not to use extremely fine powder.

Analysis of the Self-Protection Characteristics of a 1.5T Bitter-Like HTS Magnet Operated at 65K

We present a conceptual configuration of a high-temperature superconducting（HTS）magnet made from REBCO（Re=Rare Earth,B=Barium,C=Copper,O=Oxide）annular plates,called a Bitter-like HTS magnet,which can operate in persistent current mode without joint resistance and can be excited by a flux pump and without current leads and a persistent power supply.An REBCO annular magnet which can generate 1.5 T corresponding to the operating current density 80%of critical current density of the magnet at an operating temperature of65 K is conceptually designed.Then the thermal stability of the magnet is numerically simulated by Comsol software.Whein a piece of RBCO annular plate quenches,the maximum released energy is its stored energy because each REBCO annular plate in the Bitter-like magnet is in parallel.To calculate the stored energy in the REBCO annular plate,the inductance of every annular plate,including self-inductance and mutual inductance,is calculated.Compared with the minimum quench energy（MQE）and stored energy in one REBCO annular plate,the stored energy in one REBCO annular plate is always smaller than the MQE,and the REBCO annular plate will not be damaged even though the stored energy in the REBCO annular plate is fully released,which indicates that this 1.5 T Bitter-like magnet has the property of self-protection.

Non Ideal Schottky Barrier Diode’s Parameters Extraction and Materials Identification from Dark I-V-T Characteristics

Several parameters of a commercial Si-based Schottky barrier diode (SBD) with unknown metal material and semiconductor-type have been investigated in this work from dark forward and reverse I-V characteristics in the temperature (T) range of [274.5 K - 366.5 K]. Those parameters include the reverse saturation current (Is), the ideality factor (n), the series and the shunt resistances (Rs and Rsh), the effective and the zero bias barrier heights (ΦB and ΦB0), the product of the electrical active area (A) and the effective Richardson constant (A**), the built-in potential (Vbi), together with the semiconductor doping concentration (NA or ND). Some of them have been extracted by using two or three different methods. The main features of each approach have been clearly stated. From one parameter to another, results have been discussed in terms of structure performance, comparison on one another when extracted from different methods, accordance or discordance with data from other works, and parameter’s temperature or voltage dependence. A comparison of results on ΦB, ΦB0, n and NA or ND parameters with some available data in literature for the same parameters, has especially led to clear propositions on the identity of the analyzed SBD’s metal and semiconductor-type.

被困空腔对T-bar循环贯入软黏土流动特性影响的试验研究

为观测和分析T-bar循环贯入过程中被困空腔对软黏土流动特性的影响,利用Laponite RD、焦磷酸钠和去离子水配制透明黏土,自制由加载设备、CCD相机、激光器和控制系统组成的T-bar循环贯入试验装置,开展T-bar在透明黏土中的循环贯入试验。结果表明:T-bar初次贯入过程中,被困空腔影响土体绕探头的流动,土体不能进入全流动状态;T-bar初次上拔过程中,被困空腔与探头发生脱离,悬浮于探头上方,对土体流动的影响逐渐减弱,T-bar上拔2倍探头直径深度时土体流动不再受被困空腔影响,进入到全流动状态;第2—第10次循环贯入过程中,被困空腔稳定悬浮于土中,不影响土体流动,T-bar贯入1倍探头直径深度时土体流动表现为全流动状态;被困空腔对于T-bar循环贯入测试结果无显著影响,在T-bar初次贯入被困空腔阶段下通过T-bar循环贯入测试软黏土重塑强度是合理的。

异常表达CD20的结外NK/T细胞淋巴瘤病理特点分析并文献复习

目的探索异常表达CD20的结外NK/T细胞淋巴瘤的病理形态特点、诊断要点及鉴别诊断。方法分析3例异常表达CD20的结外NK/T细胞淋巴瘤,结合病理形态特点、免疫表型及与其他形态学特点和免疫表型类似的淋巴瘤的鉴别诊断,并进行文献复习。结果异常表达CD20的结外NK/T细胞淋巴瘤形态学特点与普通型结外NK/T细胞淋巴瘤类似,免疫表型表现为部分T细胞标记阳性、CD56、细胞毒标记物、EBER ISH阳性、CD20弱-中等阳性,其余B细胞标记物CD79a、PAX-5均为阴性。其中2例肿瘤细胞阳性表达CD8。结论异常表达CD20的结外NK/T细胞淋巴瘤是一种罕见免疫表型的NK细胞源性淋巴瘤,需要综合分析抗体表达情况及和其他淋巴瘤进行鉴别诊断,免疫组织化学染色阳性模式以及多抗体联合应用对于明确诊断有重要作用。

不同HDAC水平的外周T细胞淋巴瘤患者预后复发的影响因素分析

目的:基于潜在类别分析不同组蛋白去乙酰化酶(HDAC)水平的外周T细胞淋巴瘤(PTCL)患者预后复发的影响因素分布特征。方法:选取2012年9月至2019年9月在本院就诊的PTCL患者112例,将患者分为复发组和未复发组,比较两组患者的临床资料。通过多因素Logistic回归分析影响患者预后复发的危险因素。采用潜在类别分析法比较复发高风险组与复发低风险组间预后复发影响因素的分布特征差异。结果:复发组患者87例(77.68%),未复发组患者25例(22.32%)。多因素Logistic回归分析结果显示,ECOG评分≥2分、Ann Arbor分期为III-IV期、IPI评分>2分、骨髓受累、血清β2-微球蛋白(β2-MG)水平升高、近期疗效未达到完全缓解(CR)和部分缓解(PR)、HDAC高表达为患者复发的独立危险因素(P<0.05)。HDAC高水平患者的复发率明显高于HDAC低水平患者(P<0.05)。聚类分析结果显示,预后复发风险呈明显聚集性,可将患者分为预后复发高风险组(HDAC>5分)和低风险组(HDAC≤5分)。潜在类别分析结果显示,与预后复发低风险组相比,预后复发高风险组中“危险因素分布较多型”占比较高(P<0.05)。结论:不同HDAC水平的PTCL患者的预后复发情况以及预后复发高风险与低风险人群中危险因素分布特征均有差异。

胃癌患者血浆hsa_circ_0001588水平与TLR4和T淋巴细胞亚群相关性

目的 探究胃癌患者血浆中hsa_circ_0001588水平,并分析其血浆水平与患者临床特征、Toll样受体4(Toll-like receptors 4,TLR4)、T淋巴细胞亚群的关系。方法 选取2021年3月至2022年5月于我院治疗的胃癌患者124例为研究组,另选取接受胃镜检查确诊为浅表性胃炎的患者130例作为良性组以及健康体检者130例作为对照组。采用实时荧光定量聚合酶链反应、Wmini5146流式细胞仪和双抗体夹心ELISA法检测受试者血浆hsa_circ_0001588水平、TLR4水平和CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平。分析血浆hsa_circ_0001588、TLR4、T淋巴细胞对于胃癌的诊断效能以及血浆hsa_circ_0001588水平与TLR4和T淋巴细胞水平的关系。结果 研究组血浆hsa_circ_0001588、TLR4和CD8^(+)表达水平高于良性组和对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平低于良性组和对照组(P<0.05),且研究组患者术后hsa_circ_0001588水平下降。临床分期越高、浸润深度越深、分化程度越低,发生远端转移的患者血浆hsa_circ_0001588水平越高(P<0.05)。血浆hsa_circ_0001588、TLR4和T淋巴细胞对于胃癌均有较好的诊断效能,其联合诊断的整体效能最高。血浆hsa_circ_0001588高表达患者CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)表达较低,TLR4和CD8^(+)表达较高(P<0.05),其血浆hsa_circ_0001588水平与CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)表达呈负相关性,与TLR4和CD8^(+)呈正相关性。结论 胃癌患者血浆hsa_circ_0001588水平偏高,且与CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平呈负相关性,与TLR4、CD8^(+)呈正相关性。

Electromagnetic Abnormity Observed at Sujiatun Seismic Station and Its Relation toEarthquake

The Sujiatun seismic station is a local professional seismic observation station in the city of Shenyang, Liaoning province. Electromagnetic radiations observation apparatus, of the type EMAOS-L, are used there. In this paper, four years observation data and observed earthquakes with M_S≥4.0 were collected in the Sujiatun observation station. The characteristics of electromagnetic radiation abnormities and earthquakes are analyzed from such aspects as capabilities of the apparatus used, tectonic structure, origins of electromagnetic radiations and so on. By analysis, precursor abnormities observed at this observation station are remarkable. The electric and magnetic abnormities are with good synchronism and the abnormities can respond better to the earthquakes with the epicenter distance being less than 20km and taking place in the upper crust. At the same time, for earthquakes with large magnitudes, the variation of precursor abnormities shows a periodic diurnal variation.

B7-H6在宫颈上皮内瘤变、宫颈癌组织中表达差异及与肿瘤浸润T淋巴细胞、预后的相关性

目的探究宫颈上皮内瘤变、宫颈癌组织中B7同源体6(B7-H6)表达差异与肿瘤浸润T淋巴细胞、预后相关性。方法选取2019年6月—2021年3月60例经病理检查确诊为宫颈癌的手术患者作为研究组,另选同期同年龄段60例宫颈上皮内瘤变作为对照组。比较2组组织B7-H6表达情况(H-score评分)及血清B7-H6水平,并比较研究组不同肿瘤浸润T淋巴细胞浸润程度患者H-score评分、血清B7-H6水平,分析研究组H-score评分、血清B7-H6水平与肿瘤浸润T淋巴细胞浸润程度的相关性。研究组术后随访1年,比较不同预后患者一般资料、H-score评分、血清B7-H6水平,探讨预后影响因素,并分析H-score评分和血清B7-H6水平预测患者预后的价值。结果研究组H-score评分和血清B7-H6水平高于对照组(P<0.01)。研究组肿瘤浸润T淋巴细胞浸润程度0级患者H-score评分、血清B7-H6水平高于1级、2级患者,且1级患者高于2级患者(P<0.05)。研究组H-score评分、血清B7-H6水平与肿瘤浸润T淋巴细胞浸润程度呈负相关(P<0.01)。多因素Logistic回归分析显示,肿瘤直径、国际妇产科协会(FIGO)分期、淋巴结转移、间质浸润深度、H-score评分、血清B7-H6水平均为宫颈癌手术患者预后不良的独立危险因素(P<0.01)。肿瘤直径、FIGO分期、淋巴结转移、间质浸润深度、H-score评分和血清B7-H6水平预测宫颈癌手术患者预后不良的曲线下面积(AUC)分别为0.736、0.726、0.714、0.712、0.842和0.840,H-score评分和血清B7-H6水平预测的AUC分别大于肿瘤直径、FIGO分期、淋巴结转移、间质浸润深度预测的AUC(P<0.05)。H-score评分和血清B7-H6水平在预测宫颈癌手术患者预后不良方面拥有良好的临床效用。结论宫颈癌组织B7-H6表达高于宫颈上皮内瘤变,且宫颈癌组织B7-H6表达、血清B7-H6水平与肿瘤浸润T淋巴细胞浸润程度呈负相关,也是宫颈癌手术患者预后不良的独立危险因素,在预测预后方面具有一定临床价值。

外周血PD-1、CTLA-4、T-reg、pDC与鼻咽癌患者临床特征及疗效的相关性

目的:探讨初治鼻咽癌患者治疗前外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC与患者临床特征及即刻疗效的关系,以及以上指标在鼻咽癌患者及健康人群中的表达差异。方法:收集112例初治鼻咽癌患者治疗前临床资料及淋巴细胞亚群和树突细胞亚群数据,进行外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC与鼻咽癌患者临床特征及即刻疗效的相关性分析,从112例鼻咽癌患者中随机选取30例患者作为病例组,年龄、性别匹配的30例同期体检健康者作为对照组,分析两组外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC表达差异。结果:112例初治鼻咽癌患者中,年龄≥50岁组与年龄<50岁组相比,外周血PD-1/CTL(%)更高。CTLA-4/CTL(%)与T分期、N分期、TNM分期呈负相关,CTLA-4/CT(%)越高,疗效越好。T-reg(%)与N分期呈正相关,T-reg(%)与M分期存在“S”型曲线关系。pDC与N分期、TNM分期呈负相关。病例组与对照组外周血PD-1/CTL(%)、T-reg(%)差异存在统计学意义,病例组与对照组外周血CTLA-4/CTL(%)差异不存在统计学意义。结论:外周血CTLA-4/CT(%)越高,鼻咽癌T分期、N分期、TNM分期越早,外周血CTLA-4/CT(%)越高,疗效越好。外周血T-reg(%)越高,N分期越晚。当外周血T-reg(%)<20%时,鼻咽癌可能未发生远处转移,当外周血T-reg(%)为20%~50%时,外周血T-reg(%)表达越高,发生远处转移的可能越大,当外周血T-reg(%)>50%时,鼻咽癌已经远处转移的可能性大。外周血pDC越高,N分期、TNM分期越早。外周血以上指标可动态观察,有望成为预测鼻咽癌患者疗效及预后的生物标志物。

基于STL-Bayesian时空模型的分布式光伏系统异常检测

分布式光伏发电系统一般不配备多种类的传感器和监测设备,反映设备运行状态且可用于异常检测的数据有限。提出了基于STL-Bayesian时空模型的光伏异常状态检测方法,利用气象在时空上的传递性,挖掘光伏发电出力的关联性进而完成异常检测。首先,用季节性分解(seasonal and trend decomposition using loess,STL)将光伏发电有功功率时序数据分解为3个分量;然后,研究不同长度数据输入对分解结果的影响和区域内分量的时空分布特性;接着,通过构建贝叶斯模型分别对趋势分量和剩余分量做短期和超短期空间插值,得到区域内光伏出力;最后,计算真实值与回归值的推土机距离(earth move's distance,EMD)用于检测异常状态。算例分析表明,所提模型在分布式光伏场景检测可逆异常和不可逆异常状态均有较高准确率。

ST-T段改变患者心电瀑布图形态特征及其对心血管疾病的预测价值

目的探讨究ST-T段改变患者心电瀑布图形态特征及其对心血管疾病的预测价值。方法选择2020年6月1日至2022年6月1日在该院进行心电瀑布图及传统心电图检查的疑似心脏病患者970例作为研究对象,根据24 h动态心电图分为ST-T段改变216例及正常心电图754例。分析心电图ST段下降、ST段抬高、T波低平、T波负向、T波正向、T波双向波长中心电瀑布图形态特征;采用一致性检验法检测心电瀑布图、常规心电图与24 h动态心电图诊断ST-T段改变的一致性;采用四格表法检测心电瀑布图、常规心电图诊断ST-T段改变的灵敏度、特异度。结果正常心电图受检者心电图波及波群TP带、P峰带、PR峰、QPS带、ST带、T峰带、TP带心电瀑布图特征主要表现浅蓝色、亮蓝色、蓝色、红色/黄色/橙色、蓝色、蓝色/亮蓝色、浅蓝色。216例ST-T段改变患者中,156例患者心电图显示为ST段下降,其中68例患者为T波负向,心电瀑布图表现为深蓝色62例(91.18%)、蓝黑色6例(8.82%);73例患者为T波正向,心电瀑布图表现为蓝黑色66例(90.41%)、深蓝色7例(9.59%)。60例患者心电图显示为ST段抬高,其中51例患者为T波正向,心电瀑布图表现为亮蓝色43例(84.31%)、深蓝色6例(11.76%)、淡黄色2例(3.92%)。74例患者存在T波负向,心电瀑布图表现为蓝黑色;124例患者存在T波正向,心电瀑布图随T波幅度呈浅蓝-亮蓝-黄-红改变;12例存在T波低平,心电瀑布图上方随T波幅度呈浅蓝-亮蓝-黄-红改变,下方主要表现为蓝黑色。心电瀑布图诊断ST-T段改变的灵敏度、特异度、准确度分别为96.30%、88.73%、90.41%,常规心电图诊断ST-T段改变的灵敏度、特异度、准确度分别为83.33%、72.68%、75.05%。一致性检验结果显示,心电瀑布图与24 h动态心电图诊断ST-T段改变的一致性极强,常规心电图与24 h动态心电图诊断ST-T段改变的一致性较好。结论ST-T改变患者心电瀑布图具有明显特征性改变,其在诊断心血管疾病方面的价值优于常规心电图,可推广应用。

SPEN基因变异致Radio-Tartaglia综合征一例报告并文献复习

目的分析Radio-Tartaglia综合征(OMIM#619312)的临床表现及遗传学特征。方法回顾分析1例确诊为Radio-Tartaglia综合征患儿(OMIM#619312)的临床和分子遗传学检测资料。并以“Radio-Tartaglia syndrome”或“Radio-Tartaglia综合征”或“SPEN gene”或“SPEN基因”为关键词在PUBMED、万方数据库、维普检索平台进行文献复习。结果患儿,男,4岁,主要表现为全面发育迟缓,语言延迟。头围较小,窄额头,高低眉,睑裂倾斜,高弓腭。全外显子基因测序显示患儿SPEN基因(Chr1:15932638)新发(De novo)可解释患者表型的致病性变异NM_015001.3:exon11:c.6398T>A(p.Leu2133*),结合临床表现和基因检测结果,确诊为Radio-Tartaglia综合征。检索到相关文献16篇,SPEN变异88例,涉及错位变异、缺失变异、重复变异和插入变异。结论本例研究发现了Radio-Tartaglia综合征的新的SPEN基因变异点c.6398T>A(p.Leu2133*)。临床诊疗中,全身发育迟缓伴有智力障碍、言语迟缓和各种行为异常伴颅面部畸形的情况,可考虑此病,应建议家属早日进行基因检测以明确诊断,以便及时进行多学科综合干预,以促进患儿全面发育。