α,α'-Dicinnamoyl ketene cyclic S, S-acetals 4 were reacted with ethylenediamine to afford α,α'-dicinnamoyl ketene cyclic N,N-acetals 5. This process provides a new method for thesynthesis of 5 in high yiel...α,α'-Dicinnamoyl ketene cyclic S, S-acetals 4 were reacted with ethylenediamine to afford α,α'-dicinnamoyl ketene cyclic N,N-acetals 5. This process provides a new method for thesynthesis of 5 in high yield under mild conditions.展开更多
The crystals of α,α’-dioxoketene cyclic dithioacetals were prepared and their crystal structures were determined by X-ray crystallography.The influence of bond lengths,bond angles,dihedral angles and the molecular ...The crystals of α,α’-dioxoketene cyclic dithioacetals were prepared and their crystal structures were determined by X-ray crystallography.The influence of bond lengths,bond angles,dihedral angles and the molecular conformation on different substituted cyclic dithionacetals aldehyde ketone was discussed.Compound A is Monoclinic form,P21/c Space group,Unit cell dimensions,a=0.78337（6）nm,b=O54937（4）nm,c=2.8243（2）nm,α=90°,β=90.7740（10）°,γ=90°,V=1.215（4）nm3,Z=4,Dc=1.445g/cm3,F（000）=552.Compound B is Orthorhombic form,P212121 Space group,Unit cell dimensions,a=0.5665（5）nm,b=0.7980（7）nm,c=2.924（3）nm,α=90°,β=90°,γ=90°,V=1.322（2）nm3,Z=4,Dc=1.399g/cm3,F（000）=584.展开更多
Thermal effects of coordination reaction of Cu(Ⅱ )-α,α’-bipyridyl-macrocyclic diox-otetraaming ternary complex compounds have been determined in aqueous solution at 25.0±0.1℃and I=0.1 mol.dm-3 KNO3 by means ...Thermal effects of coordination reaction of Cu(Ⅱ )-α,α’-bipyridyl-macrocyclic diox-otetraaming ternary complex compounds have been determined in aqueous solution at 25.0±0.1℃and I=0.1 mol.dm-3 KNO3 by means of model RD-1 automatic conduction calorimeter. Linearthermodynamic function relationships have been found to exist in this ternary system. Ther-modynamic properties of Cu(Ⅱ)biPy/phen-HRTADO ternary systems have been compared anddiscussed. The effects of substituents and stacking of aromatic ring to the thermodynamic prop-erties Cu(Ⅱ)-bipy/phen-HRTADO ternary systems also have been discussed.展开更多
Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) ...Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) to afford α,α'-bis(substituted benzylidene) cycloalkanones in good yields.展开更多
The title compound α,α′-bis（3,5-bismethyl-pyrozole-N-yl）-carbene-acetyl-isopropenyl hydrazine （C16H22N6O, Mr = 314.40） has been prepared. It was characterized by elemental analysis as well as IR, MS, ^1H-NMR an...The title compound α,α′-bis（3,5-bismethyl-pyrozole-N-yl）-carbene-acetyl-isopropenyl hydrazine （C16H22N6O, Mr = 314.40） has been prepared. It was characterized by elemental analysis as well as IR, MS, ^1H-NMR and ^13C-NMR spectra. Its crystal structure was determined by single-crystal X-ray diffraction, getting the following data： triclinic, space group P1^- with a = 6.9734（16）, b = 10.773（3）, c = 12.001（3）A, α = 75.311（4）, β = 82.695（4）, ）,γ = 77.143（4）°, Z = 2, V = 847.9（3）A^3, Dc = 1.231 g/cm^3, F（000） = 336 and/μ（MoKα） = 0.082 mm^-1 （λ= 0.71073A）. The results of crystal structure determination show that there exist intermolecular and intramolecular hydrogen bonds, resulting in a two-dimensional supramolecular framework of the title compound. The binding of the title compound to DNA was investigated by absorption, emission, and viscosity measurements. The title compound shows absorption hyperchromicity accompanied by a blue shift at about 254 nm. The binding constant Kb for the title compound has been determined to be 1.89 × 10^4 M^-1 from absorption measurements. The addition of the title compound to DNA pretreated with EB causes appreciable reduction in the emission intensity, indicating that the DNA-bound EB fluorophore is partially replaced by the title compound. The value of K is 3.093 × 10^4 M^-1. The relative viscosity of DNA decreased with the addition of the title compound. Results suggest that the title compound binds to DNA with a non-classical intercalative or groove interaction mode. The observed efficient nuclease activity of the title compound is interesting and may have further influences on the chemistry of DNA minor groove binders.展开更多
文摘α,α'-Dicinnamoyl ketene cyclic S, S-acetals 4 were reacted with ethylenediamine to afford α,α'-dicinnamoyl ketene cyclic N,N-acetals 5. This process provides a new method for thesynthesis of 5 in high yield under mild conditions.
文摘The crystals of α,α’-dioxoketene cyclic dithioacetals were prepared and their crystal structures were determined by X-ray crystallography.The influence of bond lengths,bond angles,dihedral angles and the molecular conformation on different substituted cyclic dithionacetals aldehyde ketone was discussed.Compound A is Monoclinic form,P21/c Space group,Unit cell dimensions,a=0.78337（6）nm,b=O54937（4）nm,c=2.8243（2）nm,α=90°,β=90.7740（10）°,γ=90°,V=1.215（4）nm3,Z=4,Dc=1.445g/cm3,F（000）=552.Compound B is Orthorhombic form,P212121 Space group,Unit cell dimensions,a=0.5665（5）nm,b=0.7980（7）nm,c=2.924（3）nm,α=90°,β=90°,γ=90°,V=1.322（2）nm3,Z=4,Dc=1.399g/cm3,F（000）=584.
文摘Thermal effects of coordination reaction of Cu(Ⅱ )-α,α’-bipyridyl-macrocyclic diox-otetraaming ternary complex compounds have been determined in aqueous solution at 25.0±0.1℃and I=0.1 mol.dm-3 KNO3 by means of model RD-1 automatic conduction calorimeter. Linearthermodynamic function relationships have been found to exist in this ternary system. Ther-modynamic properties of Cu(Ⅱ)biPy/phen-HRTADO ternary systems have been compared anddiscussed. The effects of substituents and stacking of aromatic ring to the thermodynamic prop-erties Cu(Ⅱ)-bipy/phen-HRTADO ternary systems also have been discussed.
文摘Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) to afford α,α'-bis(substituted benzylidene) cycloalkanones in good yields.
基金financially supported by young science found of Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Zhejiang Sci-Tech University), Ministry of Education
文摘The title compound α,α′-bis（3,5-bismethyl-pyrozole-N-yl）-carbene-acetyl-isopropenyl hydrazine （C16H22N6O, Mr = 314.40） has been prepared. It was characterized by elemental analysis as well as IR, MS, ^1H-NMR and ^13C-NMR spectra. Its crystal structure was determined by single-crystal X-ray diffraction, getting the following data： triclinic, space group P1^- with a = 6.9734（16）, b = 10.773（3）, c = 12.001（3）A, α = 75.311（4）, β = 82.695（4）, ）,γ = 77.143（4）°, Z = 2, V = 847.9（3）A^3, Dc = 1.231 g/cm^3, F（000） = 336 and/μ（MoKα） = 0.082 mm^-1 （λ= 0.71073A）. The results of crystal structure determination show that there exist intermolecular and intramolecular hydrogen bonds, resulting in a two-dimensional supramolecular framework of the title compound. The binding of the title compound to DNA was investigated by absorption, emission, and viscosity measurements. The title compound shows absorption hyperchromicity accompanied by a blue shift at about 254 nm. The binding constant Kb for the title compound has been determined to be 1.89 × 10^4 M^-1 from absorption measurements. The addition of the title compound to DNA pretreated with EB causes appreciable reduction in the emission intensity, indicating that the DNA-bound EB fluorophore is partially replaced by the title compound. The value of K is 3.093 × 10^4 M^-1. The relative viscosity of DNA decreased with the addition of the title compound. Results suggest that the title compound binds to DNA with a non-classical intercalative or groove interaction mode. The observed efficient nuclease activity of the title compound is interesting and may have further influences on the chemistry of DNA minor groove binders.
