1-（4-Acetylaminophenyl）-α-bromo-1-propanone was synthesized from 1-（4-acetylaminophenyl） propanone through α-hydrogen brominating using Br2 in ethanol as bromination agent,and the yield was 70.4%.The melting poi...1-（4-Acetylaminophenyl）-α-bromo-1-propanone was synthesized from 1-（4-acetylaminophenyl） propanone through α-hydrogen brominating using Br2 in ethanol as bromination agent,and the yield was 70.4%.The melting point of the target compound was tested and the structure was confirrmed by FT-IR and MS.The route with little pollution and less loss of solvent is practically valuable.展开更多
4-(2-Benzyloxyethoxycarbonyl)-2-oxetanone, an β-substituted-β-lactones with latent pendent hydroxyl groups,was synthesized from L-aspartic acid. Firstly, bromosuccinic acid was synthesized from L-aspartic acid and i...4-(2-Benzyloxyethoxycarbonyl)-2-oxetanone, an β-substituted-β-lactones with latent pendent hydroxyl groups,was synthesized from L-aspartic acid. Firstly, bromosuccinic acid was synthesized from L-aspartic acid and it was dehydrated to bromosuccinic anhydride by TFFA. Then the anhydride was alcoholysized to the monoester mixture by 2-benzyloxy ethanol. Finally, the novel monomer was got through a intromolecular cyclization of the mixture ester, and then it was further purified by silicon gel chromatogram. The product and the intermediates were characterized by {{}+1H NMR}, {}+{13}C NMR and elemental analysis. In addition, 2-benzyloxy ethanol was synthesized with a simplyified procedure and high yield by using Williamson method.展开更多
文摘1-（4-Acetylaminophenyl）-α-bromo-1-propanone was synthesized from 1-（4-acetylaminophenyl） propanone through α-hydrogen brominating using Br2 in ethanol as bromination agent,and the yield was 70.4%.The melting point of the target compound was tested and the structure was confirrmed by FT-IR and MS.The route with little pollution and less loss of solvent is practically valuable.
文摘4-(2-Benzyloxyethoxycarbonyl)-2-oxetanone, an β-substituted-β-lactones with latent pendent hydroxyl groups,was synthesized from L-aspartic acid. Firstly, bromosuccinic acid was synthesized from L-aspartic acid and it was dehydrated to bromosuccinic anhydride by TFFA. Then the anhydride was alcoholysized to the monoester mixture by 2-benzyloxy ethanol. Finally, the novel monomer was got through a intromolecular cyclization of the mixture ester, and then it was further purified by silicon gel chromatogram. The product and the intermediates were characterized by {{}+1H NMR}, {}+{13}C NMR and elemental analysis. In addition, 2-benzyloxy ethanol was synthesized with a simplyified procedure and high yield by using Williamson method.
