α-(吡唑酰氧基)烃基膦酸酯的合成

Many pyrazole derivatives have good bioactivity.In this paper, five new pyrazolylacyloxylalkylphosphonate derivatives have been synthesized by condensation of 4chloro1,3bismethylpyrazole5carboxlic acid with relative αhydroxyalkylphosphonates. All compounds synthesized are confirmed by 1H NMR,IR and MS.The synthesis of key intermediate pyrazole carboxlic acid has been studied.