CeCl_3·7H_2O supported on silica（CeCl_3·7H_2O-SiO_2） is used as a heterogeneous,efficient and recyclable catalyst for a three component one-pot reaction of an amine,aldehydes and diethyl phosphite to synth...CeCl_3·7H_2O supported on silica（CeCl_3·7H_2O-SiO_2） is used as a heterogeneous,efficient and recyclable catalyst for a three component one-pot reaction of an amine,aldehydes and diethyl phosphite to synthesizeα-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction conditions.Tenα-diaminophosphonates（6a-j） of 4,4＇-sulfonyldianiline（Dapsone）（3） were synthesized and structural elucidation was confirmed by spectral data.Antifungal and antioxidant activities were evaluated include minimum inhibitory concentrations and IC_（50） values,respectively of the titled compounds.Compounds 6h,6i exhibited promising antioxidant activity at lower IC_（50） values 53.7μg/mL, 53.2μg/mL,respectively as compared with standard IC_（50） value 51.6μg/mL.展开更多
基金support from University Grants Commission[UGC-BSR,UGC F.No.40-71/2011 (SR)]
文摘CeCl_3·7H_2O supported on silica（CeCl_3·7H_2O-SiO_2） is used as a heterogeneous,efficient and recyclable catalyst for a three component one-pot reaction of an amine,aldehydes and diethyl phosphite to synthesizeα-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction conditions.Tenα-diaminophosphonates（6a-j） of 4,4＇-sulfonyldianiline（Dapsone）（3） were synthesized and structural elucidation was confirmed by spectral data.Antifungal and antioxidant activities were evaluated include minimum inhibitory concentrations and IC_（50） values,respectively of the titled compounds.Compounds 6h,6i exhibited promising antioxidant activity at lower IC_（50） values 53.7μg/mL, 53.2μg/mL,respectively as compared with standard IC_（50） value 51.6μg/mL.
