A straightforward protocol for the synthesis of mono-fluorinated allenes via catalytic defluorinative silylation of the readily availableα,α-difluoroalkylalkynes with commercially available copper catalyst and phosp...A straightforward protocol for the synthesis of mono-fluorinated allenes via catalytic defluorinative silylation of the readily availableα,α-difluoroalkylalkynes with commercially available copper catalyst and phosphine ligand is described.A broad scope ofα,α-difluoroalkylalkynes were well accommodated and a gram-scale synthesis demonstrated the synthetic utility of this methodoglogy.展开更多
基金support of the National Natural Science Foundation of China(No.21871138)Distinguished Youth Foundation of Jiangsu province.
文摘A straightforward protocol for the synthesis of mono-fluorinated allenes via catalytic defluorinative silylation of the readily availableα,α-difluoroalkylalkynes with commercially available copper catalyst and phosphine ligand is described.A broad scope ofα,α-difluoroalkylalkynes were well accommodated and a gram-scale synthesis demonstrated the synthetic utility of this methodoglogy.
