2-(4-Hydroxyphenyl)-3-hydroxymethyl-1,4-benzodioxane-6-aldehyde 8,the key intermediate of sinaiticin 10,was synthesized in 6 step from caffeic acid 4 and 4- hydroxybenzsaldehyde 1.the coupling reaction is the key step.
The title compound,3β-acetoxy-20（29）-lupen-28-aldehyde,is a pentacyclic triterpene which was first isolated from the acetyl acetate fraction of Platanus acerifolia Willd bark and characterized by 1 H-NMR and 13 C-N...The title compound,3β-acetoxy-20（29）-lupen-28-aldehyde,is a pentacyclic triterpene which was first isolated from the acetyl acetate fraction of Platanus acerifolia Willd bark and characterized by 1 H-NMR and 13 C-NMR.Besides,the crystal of the compound was acquired,and the relative configuration of 3β-acetoxy-20（29）-lupen-28-aldehyde was determined by single-crystal X-ray diffraction analysis for the first time.It crystallizes in the monoclinic system,space group C2 with a=14.428（3）,b=6.6620（13）,c=30.399（6）,β=103.73（3）°,Z=4,C32 H50 O3,M r=482.72,Dc =1.130 g/cm 3,V=2838.5（10）3,μ（MoKa）=0.070 mm-1,F（000）= 1064,the final R=0.0657 and wR=0.1855 for 2839 independent reflections （R int=0.0802）and 1963 observed ones （I〉2（I））.Intramolecular van der waals force contributes to the stability of the structure.展开更多
7α-Hydroxy-8β,9β-H- cis- bicyclo[4,3,0]non-4-ene-4-aldehyde, a nonane compound with novel skeleton, named tsaokoin, was isolated from the fruits of Amomum tsao-ko. Its structure was established on the basis of spec...7α-Hydroxy-8β,9β-H- cis- bicyclo[4,3,0]non-4-ene-4-aldehyde, a nonane compound with novel skeleton, named tsaokoin, was isolated from the fruits of Amomum tsao-ko. Its structure was established on the basis of spectral analysis.展开更多
文摘2-(4-Hydroxyphenyl)-3-hydroxymethyl-1,4-benzodioxane-6-aldehyde 8,the key intermediate of sinaiticin 10,was synthesized in 6 step from caffeic acid 4 and 4- hydroxybenzsaldehyde 1.the coupling reaction is the key step.
基金supported by Independent Research Program (cultivation for National Natural Science Foundation of China) of Nanjing University of Science and Technology (No. 2010GJPY009)
文摘The title compound,3β-acetoxy-20（29）-lupen-28-aldehyde,is a pentacyclic triterpene which was first isolated from the acetyl acetate fraction of Platanus acerifolia Willd bark and characterized by 1 H-NMR and 13 C-NMR.Besides,the crystal of the compound was acquired,and the relative configuration of 3β-acetoxy-20（29）-lupen-28-aldehyde was determined by single-crystal X-ray diffraction analysis for the first time.It crystallizes in the monoclinic system,space group C2 with a=14.428（3）,b=6.6620（13）,c=30.399（6）,β=103.73（3）°,Z=4,C32 H50 O3,M r=482.72,Dc =1.130 g/cm 3,V=2838.5（10）3,μ（MoKa）=0.070 mm-1,F（000）= 1064,the final R=0.0657 and wR=0.1855 for 2839 independent reflections （R int=0.0802）and 1963 observed ones （I〉2（I））.Intramolecular van der waals force contributes to the stability of the structure.
文摘7α-Hydroxy-8β,9β-H- cis- bicyclo[4,3,0]non-4-ene-4-aldehyde, a nonane compound with novel skeleton, named tsaokoin, was isolated from the fruits of Amomum tsao-ko. Its structure was established on the basis of spectral analysis.
