The title compounds 3 and 4 condensed with aromatic aldehydes to give a--aroylsicinnamoyl ketene cyclic dithioacetals 5 and 6 with sodium ethoxide as the base. The stereochemistryofs and 6 was assigned as E-configurat...The title compounds 3 and 4 condensed with aromatic aldehydes to give a--aroylsicinnamoyl ketene cyclic dithioacetals 5 and 6 with sodium ethoxide as the base. The stereochemistryofs and 6 was assigned as E-configuration by 1H NMR.展开更多
α-Oxoketene dithioacetals（ compound 1 ） are versatile synthons for organic synthesis due to their specially structural characteristic, that is, the masked ketene is conjugated with the convertible carbonyl in their...α-Oxoketene dithioacetals（ compound 1 ） are versatile synthons for organic synthesis due to their specially structural characteristic, that is, the masked ketene is conjugated with the convertible carbonyl in their molecules. Although there have been numerous reports covering the reactions in which they have been taken as 1,3-electrophiles, the reaction at the α-carbon atom of α-oxoketene dithioacetals has seldom been investigated. Junjappa and co-workers found the α- bromination of compound 2 in the presence of NBS led to α-aroyl-α-bromo ketenedithioacetals. However, the flexibility of the functional groups at the α-carbon atom of compound 2 are still limited.展开更多
Twelve new (3-benzyl-4-aroyl-1,2,4-triazole-5-yl)[5-(3,4,5-trimethoxyphenyl)-1,3,4- oxadiazole-2-yl]sulfides(2) have been synthesized from the nucleophilic displacements of 3-benzyl-4- trimethoxyphenyl)-1,3,4-oxadiazo...Twelve new (3-benzyl-4-aroyl-1,2,4-triazole-5-yl)[5-(3,4,5-trimethoxyphenyl)-1,3,4- oxadiazole-2-yl]sulfides(2) have been synthesized from the nucleophilic displacements of 3-benzyl-4- trimethoxyphenyl)-1,3,4-oxadiazole(1). Compounds(2) were screened for their antibacterial activity against E.Coli at 0.01%. The results show that some compounds(2) have strong inhibiting effects展开更多
Phytochemical investigation of Lagotis yunnanensis led to the isolation and identification of a new iridoid glucoside 1, named as 10-O-(3,4-dimethoxy-(E)-cinnamoyl)aucubin. Its structure was elucidated by spectroscopi...Phytochemical investigation of Lagotis yunnanensis led to the isolation and identification of a new iridoid glucoside 1, named as 10-O-(3,4-dimethoxy-(E)-cinnamoyl)aucubin. Its structure was elucidated by spectroscopie methods.展开更多
Two new iridoid glucosides 1 and 2, 10-O-(3, 4-dimethoxy-(E)-cinnamoyl)catalpol and 10-O-(3, 4-dimethoxy-(Z)-cinnamoyl)catalpol, were isolated from Lagotis yunnanensis. Their structures were elucidated by spectroscop...Two new iridoid glucosides 1 and 2, 10-O-(3, 4-dimethoxy-(E)-cinnamoyl)catalpol and 10-O-(3, 4-dimethoxy-(Z)-cinnamoyl)catalpol, were isolated from Lagotis yunnanensis. Their structures were elucidated by spectroscopic methods.展开更多
The fused heterocyclic compounds 2 : imidazo [1.2-a] pyriding 2a-c and pyrido [ 1 .2-a] pyrimidine 2d were obtained from the reaction of α-cinnamoyl ketene dibenzylthio acetals 1 with diamine. When α-cinnamoyl -a...The fused heterocyclic compounds 2 : imidazo [1.2-a] pyriding 2a-c and pyrido [ 1 .2-a] pyrimidine 2d were obtained from the reaction of α-cinnamoyl ketene dibenzylthio acetals 1 with diamine. When α-cinnamoyl -a'-benzoyl ketene N. N-acetals 3a-b were treated by t-BuONa/t- BuOH Solution. 8- benzoyl-pyrido[1.2-a] pyrimidine 4 was produced.展开更多
A new and novel class of bis(heterocycles) viz., bis pyrroles, pyrrolyl pyrazoles and pyrrolyl isoxazoles are prepared from 1-aroyl-2-styrylsulfonylethenes by 1,3-dipolar cycloaddition of tosylmethyl isocyanide, diazo...A new and novel class of bis(heterocycles) viz., bis pyrroles, pyrrolyl pyrazoles and pyrrolyl isoxazoles are prepared from 1-aroyl-2-styrylsulfonylethenes by 1,3-dipolar cycloaddition of tosylmethyl isocyanide, diazomethane, nitrile imines and nitrile oxides. The lead compounds are screened for antimicrobial activity.展开更多
A three-dimensional quantitative structure-activity relationship(3 D-QSAR) study was conducted to analyze the A1 AR density(Bmax) of 56 3-aroyl-5-substituted thiophene derivatives(ASTDs) in human A1 Chinese hamster ov...A three-dimensional quantitative structure-activity relationship(3 D-QSAR) study was conducted to analyze the A1 AR density(Bmax) of 56 3-aroyl-5-substituted thiophene derivatives(ASTDs) in human A1 Chinese hamster ovary(hA1 CHO) membranes by the comparative molecular field analysis(CoMFA) method. A training set of 45 compounds was used to establish the predictive model, which was verified by the test set of 17 compounds containing template molecule and 5 newly designed molecules. The cross-validation(R2 cv) and non-cross-validation(R2) coefficients of the training set were 0.655 and 0.959, respectively. The model was used to predict the activities of the compounds of the training and test sets, and the results indicated that the models had strong stability and good prediction ability. According to model analysis, the contribution of steric and electrostatic fields was 51.4% and 48.6%, respectively. Based on the 3 D contour maps, five excellent ASTDs agonists were designed, which need to be further verified by biomedical experiments.展开更多
The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using （S,S）-RuCl（p-cymene）TsDPEN （TsDPEN=N-（tosyl）-1,2-diphenylethylenediamine） in formic acid/triethyl...The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using （S,S）-RuCl（p-cymene）TsDPEN （TsDPEN=N-（tosyl）-1,2-diphenylethylenediamine） in formic acid/triethylamine （5 ： 2, molar ratio）, afforded the desired products in good yields （up to 85%） with diastereomeric ratio up to 〉99 ： 1 and high enantiomeric excesses （up to 〉99%）. The absolute configuration of major the product was con- firmed by X-ray crystal structure analysis.展开更多
文摘The title compounds 3 and 4 condensed with aromatic aldehydes to give a--aroylsicinnamoyl ketene cyclic dithioacetals 5 and 6 with sodium ethoxide as the base. The stereochemistryofs and 6 was assigned as E-configuration by 1H NMR.
基金Supported by the National Natural Science Foundation of China(No. 29862004) Scientific and Technological DevelopmentProgram Foundation of Jilin Province(No. 20040565).
文摘α-Oxoketene dithioacetals（ compound 1 ） are versatile synthons for organic synthesis due to their specially structural characteristic, that is, the masked ketene is conjugated with the convertible carbonyl in their molecules. Although there have been numerous reports covering the reactions in which they have been taken as 1,3-electrophiles, the reaction at the α-carbon atom of α-oxoketene dithioacetals has seldom been investigated. Junjappa and co-workers found the α- bromination of compound 2 in the presence of NBS led to α-aroyl-α-bromo ketenedithioacetals. However, the flexibility of the functional groups at the α-carbon atom of compound 2 are still limited.
文摘Twelve new (3-benzyl-4-aroyl-1,2,4-triazole-5-yl)[5-(3,4,5-trimethoxyphenyl)-1,3,4- oxadiazole-2-yl]sulfides(2) have been synthesized from the nucleophilic displacements of 3-benzyl-4- trimethoxyphenyl)-1,3,4-oxadiazole(1). Compounds(2) were screened for their antibacterial activity against E.Coli at 0.01%. The results show that some compounds(2) have strong inhibiting effects
文摘Phytochemical investigation of Lagotis yunnanensis led to the isolation and identification of a new iridoid glucoside 1, named as 10-O-(3,4-dimethoxy-(E)-cinnamoyl)aucubin. Its structure was elucidated by spectroscopie methods.
文摘Two new iridoid glucosides 1 and 2, 10-O-(3, 4-dimethoxy-(E)-cinnamoyl)catalpol and 10-O-(3, 4-dimethoxy-(Z)-cinnamoyl)catalpol, were isolated from Lagotis yunnanensis. Their structures were elucidated by spectroscopic methods.
文摘The fused heterocyclic compounds 2 : imidazo [1.2-a] pyriding 2a-c and pyrido [ 1 .2-a] pyrimidine 2d were obtained from the reaction of α-cinnamoyl ketene dibenzylthio acetals 1 with diamine. When α-cinnamoyl -a'-benzoyl ketene N. N-acetals 3a-b were treated by t-BuONa/t- BuOH Solution. 8- benzoyl-pyrido[1.2-a] pyrimidine 4 was produced.
文摘A new and novel class of bis(heterocycles) viz., bis pyrroles, pyrrolyl pyrazoles and pyrrolyl isoxazoles are prepared from 1-aroyl-2-styrylsulfonylethenes by 1,3-dipolar cycloaddition of tosylmethyl isocyanide, diazomethane, nitrile imines and nitrile oxides. The lead compounds are screened for antimicrobial activity.
基金supported by the National Natural Science Foundation of China (21676292,21075138)special fund of State Key Laboratory of Structure Chemistry (2016028)。
文摘A three-dimensional quantitative structure-activity relationship(3 D-QSAR) study was conducted to analyze the A1 AR density(Bmax) of 56 3-aroyl-5-substituted thiophene derivatives(ASTDs) in human A1 Chinese hamster ovary(hA1 CHO) membranes by the comparative molecular field analysis(CoMFA) method. A training set of 45 compounds was used to establish the predictive model, which was verified by the test set of 17 compounds containing template molecule and 5 newly designed molecules. The cross-validation(R2 cv) and non-cross-validation(R2) coefficients of the training set were 0.655 and 0.959, respectively. The model was used to predict the activities of the compounds of the training and test sets, and the results indicated that the models had strong stability and good prediction ability. According to model analysis, the contribution of steric and electrostatic fields was 51.4% and 48.6%, respectively. Based on the 3 D contour maps, five excellent ASTDs agonists were designed, which need to be further verified by biomedical experiments.
文摘The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using （S,S）-RuCl（p-cymene）TsDPEN （TsDPEN=N-（tosyl）-1,2-diphenylethylenediamine） in formic acid/triethylamine （5 ： 2, molar ratio）, afforded the desired products in good yields （up to 85%） with diastereomeric ratio up to 〉99 ： 1 and high enantiomeric excesses （up to 〉99%）. The absolute configuration of major the product was con- firmed by X-ray crystal structure analysis.
