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Fresh human amniotic membrane effectively promotes the repair of injured common peroneal nerve 被引量:5
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作者 Zhong-Yuan Zhang Jin Yang +5 位作者 Zhen-Hai Fan Da-Li Wang Yu-Ying Wang Tao Zhang Li-Mei Yu Chang-Yin Yu 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第12期2199-2208,共10页
Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of... Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of nerve regeneration and repair. Previous studies have shown that human amniotic membrane can promote the healing of a variety of tissues. In this study, the right common peroneal nerve underwent a 5-mm transection in rats. Epineural nerve repair was performed using 10/0 non-absorbable surgical suture. The repair site was wrapped with a two-layer amniotic membrane with α-cyanoacrylate rapid medical adhesive after suture. Hindlimb motor function was assessed using footprint analysis. Conduction velocity of the common peroneal nerve was calculated by neural electrical stimulation. The retrograde axoplasmic transport of the common peroneal nerve was observed using fast blue BB salt retrograde fluorescent staining. Hematoxylin- eosin staining was used to detect the pathological changes of the common peroneal nerve sputum. The mRNA expression of axon regeneration-related neurotrophic factors and inhibitors was measured using real-time polymerase chain reaction. The results showed that the amniotic membrane significantly improved the function of the injured nerve;the toe spread function rapidly recovered, the nerve conduction velocity was restored, and the number of fast blue BB salt particles were increased in the spinal cord. The amniotic membrane also increased the recovery rate of the tibialis anterior muscle and improved the tissue structure of the muscle. Meanwhile, mRNA expression of nerve growth factor, growth associated protein-43, collapsin response mediator protein-2, and brain-derived neurotrophic factor recovered to near-normal levels, while Lingo-1 mRNA expression decreased significantly in spinal cord tissues. mRNA expression of glial-derived neurotrophic factor did not change significantly. Changes in mRNA levels were more significant in amniotic-membrane-wrapping-treated rats compared with model and nerve sutured rats. These results demonstrate that fresh amniotic membrane wrapping can promote the functional recovery of sutured common peroneal nerve via regulation of expression levels of neurotrophic factors and inhibitors associated with axonal regeneration. The study was approved by the Committee on Animal Research and Ethics at the Affiliate Hospital of Zunyi Medical University, China (approval No. 112) on December 1, 2017. 展开更多
关键词 NERVE REGENERATION human amniotic membrane AXONAL Schwann cells α-cyanoacrylate rapid medical adhesive NEURAL suture TIBIAL anterior muscle neuronal growth factor common PERONEAL NERVE injury NEURAL REGENERATION
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VATS联合肺大疱内OB胶固定治愈宽基底型巨大肺大疱并严重胸膜粘连1例及文献复习 被引量:1
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作者 姜友军 张培蓓 +3 位作者 赵丽 郑梦凝 许川 叶贤伟 《重庆医学》 CAS 2021年第14期2375-2379,共5页
目的为临床个体化治疗肺大疱提供丰富的思路与参考。方法总结双孔电视胸腔镜手术(VATS)联合肺大疱内α-氰基丙烯酸酯快速医用胶(OB胶)固定治愈1例宽基底型巨大肺大疱并严重胸膜粘连患者的临床经验,并复习近年关于肺大疱治疗方法的文献... 目的为临床个体化治疗肺大疱提供丰富的思路与参考。方法总结双孔电视胸腔镜手术(VATS)联合肺大疱内α-氰基丙烯酸酯快速医用胶(OB胶)固定治愈1例宽基底型巨大肺大疱并严重胸膜粘连患者的临床经验,并复习近年关于肺大疱治疗方法的文献。采用静吸全身麻醉下双腔气管插管单肺通气,VATS松解左侧胸膜粘连带,定位并刺破靶肺大疱后向萎陷的肺大疱内注入适量的OB胶固定,胸腔内1次性灌注50%葡萄糖注射液200 mL行胸膜固定,持续胸腔闭式引流。结果治疗后,患者左侧肺组织复张良好,活动耐量较前提高,高二氧化碳血症得到纠正,胸膜破口愈合后康复出院。结论应用VATS联合肺大疱内OB胶固定治疗宽基底型巨大肺大疱,具有手术创伤小、手术时间短、疗效确切等优点。 展开更多
关键词 胸腔镜 肺大疱 α-氰基丙烯酸酯快速医用胶
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