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甲胎蛋白联合甲胎蛋白异质体L3诊断原发性肝癌的Meta分析 被引量:6
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作者 王浩 李家军 +2 位作者 马怀幸 高仁焘 孟水平 《安徽医学》 2016年第10期1211-1213,1214,共4页
目的系统评价甲胎蛋白(AFP)联合甲胎蛋白异质体L3(AFP-L3)在原发性肝癌(HCC)中的诊断价值。方法计算机检索国内外重要数据库,依据纳入和排除标准筛选文献,运用诊断试验准确性质量评价工具(QUADAS)评价纳入文献的质量。数据采用Meta-Di S... 目的系统评价甲胎蛋白(AFP)联合甲胎蛋白异质体L3(AFP-L3)在原发性肝癌(HCC)中的诊断价值。方法计算机检索国内外重要数据库,依据纳入和排除标准筛选文献,运用诊断试验准确性质量评价工具(QUADAS)评价纳入文献的质量。数据采用Meta-Di Sc 1.4和Stata 12.0软件进行统计分析。结果共纳入8篇文献,AFP联合AFP-L3检测原发性肝癌的合并敏感度(SEN)、合并特异度(SPE)、阳性似然比(+LR)、阴性似然比(-LR)、诊断优势比(DOR)分别为:0.697(0.663,0.731),0.813(0.792,0.832),4.891(3.219,7.432),0.276(0.171,0.447),20.953(10.233,42.900)。汇总受试者工作曲线(SROC)曲线下面积为0.8907,Q指数为0.8214。结论 AFP联合AFP-L3检测原发性肝癌有一定诊断价值,可作为重要的筛选指标,但仍需更多高质量、大样本、多中心的研究加以论证。 展开更多
关键词 肝肿瘤 甲胎蛋白 甲胎蛋白异质体l3 META分析
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FINITE DIFFERENCE FRACTIONAL STEP METHODS FOR THE TRANSIENT BEHAVIOR OF A SEMICONDUCTOR DEVICE 被引量:4
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作者 袁益让 《Acta Mathematica Scientia》 SCIE CSCD 2005年第3期427-438,共12页
Characteristic finite difference fractional step schemes are put forward. The electric potential equation is described by a seven-point finite difference scheme, and the electron and hole concentration equations are t... Characteristic finite difference fractional step schemes are put forward. The electric potential equation is described by a seven-point finite difference scheme, and the electron and hole concentration equations are treated by a kind of characteristic finite difference fractional step methods. The temperature equation is described by a fractional step method. Thick and thin grids are made use of to form a complete set. Piecewise threefold quadratic interpolation, symmetrical extension, calculus of variations, commutativity of operator product, decomposition of high order difference operators and prior estimates are also made use of. Optimal order estimates in l2 norm are derived to determine the error of the approximate solution. The well-known problem is thorongley and completely solred. 展开更多
关键词 General region semiconductor device 3-dimensional heat conduction characteristic finite difference parallel fractional steps l^2 error estimate.
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FINITE ELEMENT METHOD AND ANALYSIS FOR CHEMICAL-FLOODING SIMULATION 被引量:1
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作者 YUAN Yirang(Institute of Mathematics, Shandong University, Jinan 250100, China) 《Systems Science and Mathematical Sciences》 SCIE EI CSCD 2000年第3期302-308,共7页
This article discusses the enhanced oil recovery numerical simulation of the chemical-flooding (such as surfactallts, alcohol, polymers) composed of three-dimensional multicomponent, multiphase and incompressible mixe... This article discusses the enhanced oil recovery numerical simulation of the chemical-flooding (such as surfactallts, alcohol, polymers) composed of three-dimensional multicomponent, multiphase and incompressible mixed fluids. The mathematical model can be described as a coupled system of nonlinear partial differential equations with initialboundary value problerns. viom the actual conditions such as the effect of cross interference and the three-dimensional charederistic of large-scale science-engineering computation,this article puts forward a kind of characteristic finite element fractional step schemes and obtain the optimal order error estdriates in L2 norm. Thus we have thoroughly solved the well-known theoretical problem proppsed by a famous scientist, R. E. Ewing. 展开更多
关键词 Chemical-flooding cross interference 3-dimensional fractionAl STEPS characteristic FINITE element method l^2 error ESTIMATES
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Correlated Lvy flight in external force fields
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作者 L Yan BAO JingDong 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2014年第3期418-423,共6页
The correlated Levy flight is studied analytically in terms of the fractional Fokker-Planck equation and simulated numerically by using the Langevin equation, where the usual white Ltvy noise is generalized to an Orns... The correlated Levy flight is studied analytically in terms of the fractional Fokker-Planck equation and simulated numerically by using the Langevin equation, where the usual white Ltvy noise is generalized to an Ornstein-Uhlenbeck Levy process (OALP) with a correlation time τc. We analyze firstly the stable behavior of OULP. The probability density function of Ltvy flight particle driven by the OULP in a harmonic potential is exactly obtained, which is also a Ltvy-type one with Tc-dependence width; when the particle is bounded by a quartic potential, its stationary distribution has a bimodality shape and becomes noticeable with the increase of τc. 展开更多
关键词 l3vy flight OUlP fractional Fokker-Planck equation
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Expert consensus on the role of hematological markers in the earlyclinical screening of hepatocellular carcinoma
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作者 Infectious diseases branch of Chinese Preventive Medicine Association 《Liver Research》 CSCD 2022年第2期66-71,共6页
The disease burden of hepatocellular carcinoma (HCC) in China is heavy, and the prognosis is stillunfavourable. Therefore, early screening of high-risk groups of HCC through simple methods is the key toachieving early... The disease burden of hepatocellular carcinoma (HCC) in China is heavy, and the prognosis is stillunfavourable. Therefore, early screening of high-risk groups of HCC through simple methods is the key toachieving early diagnosis and treatment and improving survival. At present, alpha-fetoprotein and otherhematological tests are still the main methods in the early screening of HCC, but the sensitivity andspecificity are limited, and the risk of missed diagnosis is high. In recent years, with the continuousdevelopment of science and technology, the improvement of traditional detection methods and theemergence of novel markers such as methylated deoxyribonucleic acid and microRNA have brought hopefor further improving the sensitivity and specificity of early HCC screening. This consensus summarizesthe research progress of traditional and new hematological test methods and puts forward expertguidance on the role of hematological markers in the early screening of HCC to provide a basis forimproving the prevention and control level in China. 展开更多
关键词 Hepatocellular carcinoma(HCC) Early screening Hematological marker Alpha-fetoprotein(AFP) lens culinaris agglutinin-reactive fraction of AFP(afp-l3) Des-gamma-carboxyprothrombin(DCP) Expert consensus
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三维多组分可压缩驱动问题的分数步特征差分方法 被引量:4
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作者 袁益让 《应用数学学报》 CSCD 北大核心 2001年第2期242-249,共8页
本文提出三维多组分驱动问题的分数步长特征差分格式,并应用变分形式、能量方法、粗细网格配套、叁二次插值、高阶差分算子的分解和乘积交换性理论和技巧,得到最佳阶 L~2误差估计.该方法已成功应用到油资源评估、强化采油数值模拟... 本文提出三维多组分驱动问题的分数步长特征差分格式,并应用变分形式、能量方法、粗细网格配套、叁二次插值、高阶差分算子的分解和乘积交换性理论和技巧,得到最佳阶 L~2误差估计.该方法已成功应用到油资源评估、强化采油数值模拟和海水入侵预测和防治的数值模拟中. 展开更多
关键词 多组分驱动 三维可压缩 分数步特征差分 l^2估计 数模应用 非线性偏微分方程组 初边值问题
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