Cytochrome P4502D6 （CYP2D6） is an important cytochrome P450 enzyme which catalyzes the metabolism of more than 80 drugs. Many of these drugs have a narrow therapeutic index and the combined use of substrates may res...Cytochrome P4502D6 （CYP2D6） is an important cytochrome P450 enzyme which catalyzes the metabolism of more than 80 drugs. Many of these drugs have a narrow therapeutic index and the combined use of substrates may result in significant pharmacokinetic interactions, leading to substrate accumulation and deleterious drug effects. Since the discovery of the debrisoquine/sparteine oxidation polymorphism in the 1970s, numerous studies have investigated its status in various ethnic groups. Currently more than 70 different alleles have been described. The gene frequency of individual alleles of CYP2D6 shows a marked interethnic difference. For Chinese population, the most common alleles of the CYP2D6 gene are CYP2D6＊1, CYP2D6＊2 and CYP2D6＊10. Thus, it is very important to study the relationship between drug interactions and the genetic polymorphism of CYP2D6.展开更多
基金This work was supported by a grant from the state 863 High Technology Project of China (No. 2004AA2Z3765).
文摘Cytochrome P4502D6 （CYP2D6） is an important cytochrome P450 enzyme which catalyzes the metabolism of more than 80 drugs. Many of these drugs have a narrow therapeutic index and the combined use of substrates may result in significant pharmacokinetic interactions, leading to substrate accumulation and deleterious drug effects. Since the discovery of the debrisoquine/sparteine oxidation polymorphism in the 1970s, numerous studies have investigated its status in various ethnic groups. Currently more than 70 different alleles have been described. The gene frequency of individual alleles of CYP2D6 shows a marked interethnic difference. For Chinese population, the most common alleles of the CYP2D6 gene are CYP2D6＊1, CYP2D6＊2 and CYP2D6＊10. Thus, it is very important to study the relationship between drug interactions and the genetic polymorphism of CYP2D6.
