From the stems ofMarsdenia tenacissima two new polyoxypregnanes were isolated, their structures were elucidated by 1D, 2D-NMR as 11α,12β-di-O-tigloyl-tenacigenin B （1） and tenacigenoside E （2）.
The enteric nervous system （ENS） controls the function of the gastrointestinal tract and has been impli- cated in various diseases, including Parkinson＇s disease （PD）. PD is a neurodegenerative disease with Lewy ...The enteric nervous system （ENS） controls the function of the gastrointestinal tract and has been impli- cated in various diseases, including Parkinson＇s disease （PD）. PD is a neurodegenerative disease with Lewy bodies （LBs） and Lewy neurites （LNs） as the main pathological features. In addition to the typical motor symptoms in PD, attention has been drawn to non-motor symptoms, such as constipation, implying dysfunction of the ENS. In the present study, we characterized the age-dependent mor- phological alterations and aggregation of α-synuclein （α- syn）, the primary protein component in LBs and LNs, in the ENS in an α-syn transgenic mouse model. We found that the expression and accumulation of α-syn increased gradually in neurons of Meissner＇s and Auerbach＇s plexuses of the gastrointestinal tract with age （from 1 week to 2 years）. In addition, α-syn was increasingly phosphorylated at the serine 129 residue, reflecting patho- logical alterations of the protein over time. Furthermore,α- syn was present in different subtypes of neurons expressing vasoactive intestinal polypeptide, neuronal nitric oxide synthase, or calretinin. The results indicated that BAC-α- Syn-GFP transgenic mice provide a unique model in which to study the relationship between ENS and PD pathogenesis.展开更多
文摘From the stems ofMarsdenia tenacissima two new polyoxypregnanes were isolated, their structures were elucidated by 1D, 2D-NMR as 11α,12β-di-O-tigloyl-tenacigenin B （1） and tenacigenoside E （2）.
基金supported by the National Natural Science Foundation of China (81430025)Northeastern University, China, as well as the Swedish Research Council (K201561X-22297-03-4)+5 种基金the EU Joint Programme-Neurodegenerative Disease Research (aSyn Protec and REfre AME),EU H2020-MSCAITN-2016 (Syndegen)Basal Ganglia Disorders Linnaeus Consortium-Excellence in Parkinson and Huntington Researchthe Strong Research Environment Multi Park (Multidisciplinary Research on Parkinson's disease)the Swedish Parkinson Foundation (Parkinsonfonden)the Torsten Sderbergs Foundation, and the Olle Engkvist Byggmstere Foundationsupported by a scholarship from the China Scholarship Council
文摘The enteric nervous system （ENS） controls the function of the gastrointestinal tract and has been impli- cated in various diseases, including Parkinson＇s disease （PD）. PD is a neurodegenerative disease with Lewy bodies （LBs） and Lewy neurites （LNs） as the main pathological features. In addition to the typical motor symptoms in PD, attention has been drawn to non-motor symptoms, such as constipation, implying dysfunction of the ENS. In the present study, we characterized the age-dependent mor- phological alterations and aggregation of α-synuclein （α- syn）, the primary protein component in LBs and LNs, in the ENS in an α-syn transgenic mouse model. We found that the expression and accumulation of α-syn increased gradually in neurons of Meissner＇s and Auerbach＇s plexuses of the gastrointestinal tract with age （from 1 week to 2 years）. In addition, α-syn was increasingly phosphorylated at the serine 129 residue, reflecting patho- logical alterations of the protein over time. Furthermore,α- syn was present in different subtypes of neurons expressing vasoactive intestinal polypeptide, neuronal nitric oxide synthase, or calretinin. The results indicated that BAC-α- Syn-GFP transgenic mice provide a unique model in which to study the relationship between ENS and PD pathogenesis.
