Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 compon...Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 components make accurate separation,identification,and quantification challenging.In this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple esters.The separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD analysis.The polysorbate compound database and library were expanded over 7-time compared to the commercial database.The method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process relationship.UHPLC-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different sources.The method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to change.HPLC-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.展开更多
The objective of this study is to investigate themethods for soil liquefaction discrimination. Typically, predicting soilliquefaction potential involves conducting the standard penetration test (SPT), which requires f...The objective of this study is to investigate themethods for soil liquefaction discrimination. Typically, predicting soilliquefaction potential involves conducting the standard penetration test (SPT), which requires field testing and canbe time-consuming and labor-intensive. In contrast, the cone penetration test (CPT) provides a more convenientmethod and offers detailed and continuous information about soil layers. In this study, the feature matrix based onCPT data is proposed to predict the standard penetration test blow count N. The featurematrix comprises the CPTcharacteristic parameters at specific depths, such as tip resistance qc, sleeve resistance f s, and depth H. To fuse thefeatures on the matrix, the convolutional neural network (CNN) is employed for feature extraction. Additionally,Genetic Algorithm (GA) is utilized to obtain the best combination of convolutional kernels and the number ofneurons. The study evaluated the robustness of the proposed model using multiple engineering field data sets.Results demonstrated that the proposed model outperformed conventional methods in predicting N values forvarious soil categories, including sandy silt, silty sand, and clayey silt. Finally, the proposed model was employedfor liquefaction discrimination. The liquefaction discrimination based on the predicted N values was comparedwith the measured N values, and the results showed that the discrimination results were in 75% agreement. Thestudy has important practical application value for foundation liquefaction engineering. Also, the novel methodadopted in this research provides new ideas and methods for research in related fields, which is of great academicsignificance.展开更多
Fast neutron flux measurements with high count rates and high time resolution have important applications in equipment such as tokamaks.In this study,real-time neutron and gamma discrimination was implemented on a sel...Fast neutron flux measurements with high count rates and high time resolution have important applications in equipment such as tokamaks.In this study,real-time neutron and gamma discrimination was implemented on a self-developed 500-Msps,12-bit digitizer,and the neutron and gamma spectra were calculated directly on an FPGA.A fast neutron flux measurement system with BC-501A and EJ-309 liquid scintillator detectors was developed and a fast neutron measurement experiment was successfully performed on the HL-2 M tokamak at the Southwestern Institute of Physics,China.The experimental results demonstrated that the system obtained the neutron and gamma spectra with a time accuracy of 1 ms.At count rates of up to 1 Mcps,the figure of merit was greater than 1.05 for energies between 50 keV and 2.8 MeV.展开更多
Objectives To investigate discrimination against people living with HIV （PLWH） and its impacts. Methods Forty people who were either HIV positive （7/40） or had high risk behavior （33/40） were interviewed. Focus ...Objectives To investigate discrimination against people living with HIV （PLWH） and its impacts. Methods Forty people who were either HIV positive （7/40） or had high risk behavior （33/40） were interviewed. Focus group discussion was held in the interview with people who were suspected to be infected with HIV, and in-depth interview was conducted in the survey of HIV positive persons whose privacy was strictly protected to ensure the confidentiality of the collected information. Results It was identified that six forms of discrimination against people living with HIV occurred in health care service in Gejiu, including speaking to patients in an insulting manner, refusing to provide health care service, delaying treatment, treating differently, uncovering patients＇ privacy, and over-protecting themselves against patients. Discrimination against people living with HIV greatly affected their health conditions. Conclusions Discrimination against people living with HIV in health service has negative impact on their physical and mental health.展开更多
Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Dopple...Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Doppler frequency for positioning is a promising research direction on communication and navigation integration. To tackle the high Doppler frequency and low signal-to-noise ratio(SNR) in satellite communication, this paper proposes a Red and Blue Frequency Shift Discriminator(RBFSD) based on the pseudo-noise(PN) sequence.The paper derives that the cross-correlation function on the Doppler domain exhibits the characteristic of a Sinc function. Therefore, it applies modulation onto the Delay-Doppler domain using PN sequence and adjusts Doppler frequency estimation by red-shifting or blue-shifting. Simulation results show that the performance of Doppler frequency estimation is close to the Cramér-Rao Lower Bound when the SNR is greater than -15dB. The proposed algorithm is about 1/D times less complex than the existing PN pilot sequence algorithm, where D is the resolution of the fractional Doppler.展开更多
A new polarization measurement algorithm by using the sum and difference beam differential property of mono-pulse radar is given.Based on the generation mechanism differences between the target scattering and multi-fa...A new polarization measurement algorithm by using the sum and difference beam differential property of mono-pulse radar is given.Based on the generation mechanism differences between the target scattering and multi-false-target jamming,the signal models of real targets and digital deceptive false target jamming for sum and delta channel are presented.The polarization discrimination parameters are designed,and the discrimination method and its performance are discussed.This novel method does not need the accurate estimation of the absolute value of full target polarization scattering matrix,but only requires the relative estimation of the orthogonal polarized component of the targets.Without the need to add additional polarization channels,the proposed method is more suitable for engineering realization.The simulation experiment verifies that the correctly identifying probability can be better than 90%.展开更多
An adaptable and compact fast pulse sampling module was developed for the neutron–gamma discrimination. The developed module is well suited for low-cost and low-power consumption applications. It is based on the Domi...An adaptable and compact fast pulse sampling module was developed for the neutron–gamma discrimination. The developed module is well suited for low-cost and low-power consumption applications. It is based on the Domino Ring Sampler 4(DRS4) chip, which offers fast sampling speeds up to 5.12 giga samples per second(GSPS) to digitize pulses from front-end detectors. The high-resolution GSPS data is useful for obtaining precise real-time neutron–gamma discrimination results directly in this module. In this study, we have implemented real-time data analysis in a field programmable gate array. Real-time data analysis involves two aspects: digital waveform integral and digital pulse shape discrimination(PSD). It can significantly reduce the system dead time and data rate processed offline. Plastic scintillators(EJ-299-33), which have proven capable of PSD, were adopted as neutron detectors in the experiments. A photomultiplier tube(PMT)(model #XP2020) was coupled to one end of a detector to collect the output light from it. The pulse output from the anode of the PMT was directly passed onto the fast sampling module. The fast pulse sampling module was operated at 1 GSPS and 2 GSPS in these experiments, and the AmBe-241 source was used to examine the neutron–gamma discrimination quality. The PSD results with different sampling rates and energy thresholds were evaluated. The figure of merit(FOM) was used to describe the neutron–gamma discrimination quality. The best FOM value of 0.91 was obtained at 2 GSPS and 1 GSPS sampling rates with an energy threshold of 1.5 MeV_(ee)(electron equivalent).展开更多
Chinese liquor Moutai is the “National alcoholic drink” in China and plays a very important role of social activities in Chinese people’s life. In pursuit of high profits, some illegal counterfeit Moutai liquors ha...Chinese liquor Moutai is the “National alcoholic drink” in China and plays a very important role of social activities in Chinese people’s life. In pursuit of high profits, some illegal counterfeit Moutai liquors have begun to appear in the market. Therefore, it is an urgent need for new techniques to discriminate the genuine and counterfeit Moutai liquor. In this work, the conventional Ultraviolet-Visible (UV-Vis) spectroscopy and two-dimensional correlation UV-Vis spectroscopy are applied to obtain the UV-Vis characteristic of Moutai liquor and counterfeit one, respectively. The experimental results reveal that the conventional UV-Vis spectra of the genuine and counterfeit Moutai liquor are similar. However, the two-dimensional correlation UV-Vis spectra of them are different and this method would be applied to differentiate the counterfeit Moutai liquor from the genuine Moutai liquor. Compared with conventional methods, this novel method has the advantages of easy operation, simple instrumentation and direct recognition, which make it a potential tool in the fields of food safety.展开更多
Objective In order to explore the features of discrimination against people with HIV/AIDS in rural areas, a community-based intervention was carried out in two pilot communities of X County of Shanxi Province from Se...Objective In order to explore the features of discrimination against people with HIV/AIDS in rural areas, a community-based intervention was carried out in two pilot communities of X County of Shanxi Province from September 2002 to October 2003. Methods Data were collected using qualitative methods (in-depth interview and focus group discussion) and anonymously structured questionnaires. Results (1) Severe discrimination against people infected with HIV/AIDS was revealed in the target communities. However, the response to HIV/AIDS was different in each community. (2) People were reluctant to disclose their HIV status or get tested for HIV, which endangered their sexual partners to contract HIV through unprotected sexual intercourses. (3) Attitudes towards people infected with HIV/AIDS varied. (4) Public education promoted a better understanding of HIV/AIDS which in turn improved community attitudes and behaviors towards people with HIV/AIDS. Conclusion HIV/AIDS-related discrimination undermines both individuals and communities responses to HIV/AIDS and may be a serious obstacle towards effective HIV/AIDS prevention and control.展开更多
Four FPGA-based α/γ pulse shape discrimination algorithms for Ba F2 detector are investigated and compared in this paper. A 2-GSPS fast waveform sampling board based on DRS4 chip is employed to sample the pulses. Th...Four FPGA-based α/γ pulse shape discrimination algorithms for Ba F2 detector are investigated and compared in this paper. A 2-GSPS fast waveform sampling board based on DRS4 chip is employed to sample the pulses. The test results with a22 Na γ-source and the natural radioactivity of Ba F2 show good discrimination performance of the algorithms, with false rates around 1%. Small logical resource occupancy and short dead time are achieved. About 4400 slices are used in FPGA for pulse sampling and real-time discrimination altogether.展开更多
基金financial support from the Science Research Program Project for Drug Regulation,Jiangsu Drug Administration,China(Grant No.:202207)the National Drug Standards Revision Project,China(Grant No.:2023Y41)+1 种基金the National Natural Science Foundation of China(Grant No.:22276080)the Foreign Expert Project,China(Grant No.:G2022014096L).
文摘Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 components make accurate separation,identification,and quantification challenging.In this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple esters.The separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD analysis.The polysorbate compound database and library were expanded over 7-time compared to the commercial database.The method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process relationship.UHPLC-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different sources.The method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to change.HPLC-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.
基金the Center University(Grant No.B220202013)Qinglan Project of Jiangsu Province(2022).
文摘The objective of this study is to investigate themethods for soil liquefaction discrimination. Typically, predicting soilliquefaction potential involves conducting the standard penetration test (SPT), which requires field testing and canbe time-consuming and labor-intensive. In contrast, the cone penetration test (CPT) provides a more convenientmethod and offers detailed and continuous information about soil layers. In this study, the feature matrix based onCPT data is proposed to predict the standard penetration test blow count N. The featurematrix comprises the CPTcharacteristic parameters at specific depths, such as tip resistance qc, sleeve resistance f s, and depth H. To fuse thefeatures on the matrix, the convolutional neural network (CNN) is employed for feature extraction. Additionally,Genetic Algorithm (GA) is utilized to obtain the best combination of convolutional kernels and the number ofneurons. The study evaluated the robustness of the proposed model using multiple engineering field data sets.Results demonstrated that the proposed model outperformed conventional methods in predicting N values forvarious soil categories, including sandy silt, silty sand, and clayey silt. Finally, the proposed model was employedfor liquefaction discrimination. The liquefaction discrimination based on the predicted N values was comparedwith the measured N values, and the results showed that the discrimination results were in 75% agreement. Thestudy has important practical application value for foundation liquefaction engineering. Also, the novel methodadopted in this research provides new ideas and methods for research in related fields, which is of great academicsignificance.
基金supported by the National Magnetic Confinement Fusion Program of China(No.2019YFE03020002)the National Natural Science Foundation of China(Nos.12205085 and12125502)。
文摘Fast neutron flux measurements with high count rates and high time resolution have important applications in equipment such as tokamaks.In this study,real-time neutron and gamma discrimination was implemented on a self-developed 500-Msps,12-bit digitizer,and the neutron and gamma spectra were calculated directly on an FPGA.A fast neutron flux measurement system with BC-501A and EJ-309 liquid scintillator detectors was developed and a fast neutron measurement experiment was successfully performed on the HL-2 M tokamak at the Southwestern Institute of Physics,China.The experimental results demonstrated that the system obtained the neutron and gamma spectra with a time accuracy of 1 ms.At count rates of up to 1 Mcps,the figure of merit was greater than 1.05 for energies between 50 keV and 2.8 MeV.
文摘Objectives To investigate discrimination against people living with HIV （PLWH） and its impacts. Methods Forty people who were either HIV positive （7/40） or had high risk behavior （33/40） were interviewed. Focus group discussion was held in the interview with people who were suspected to be infected with HIV, and in-depth interview was conducted in the survey of HIV positive persons whose privacy was strictly protected to ensure the confidentiality of the collected information. Results It was identified that six forms of discrimination against people living with HIV occurred in health care service in Gejiu, including speaking to patients in an insulting manner, refusing to provide health care service, delaying treatment, treating differently, uncovering patients＇ privacy, and over-protecting themselves against patients. Discrimination against people living with HIV greatly affected their health conditions. Conclusions Discrimination against people living with HIV in health service has negative impact on their physical and mental health.
文摘Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Doppler frequency for positioning is a promising research direction on communication and navigation integration. To tackle the high Doppler frequency and low signal-to-noise ratio(SNR) in satellite communication, this paper proposes a Red and Blue Frequency Shift Discriminator(RBFSD) based on the pseudo-noise(PN) sequence.The paper derives that the cross-correlation function on the Doppler domain exhibits the characteristic of a Sinc function. Therefore, it applies modulation onto the Delay-Doppler domain using PN sequence and adjusts Doppler frequency estimation by red-shifting or blue-shifting. Simulation results show that the performance of Doppler frequency estimation is close to the Cramér-Rao Lower Bound when the SNR is greater than -15dB. The proposed algorithm is about 1/D times less complex than the existing PN pilot sequence algorithm, where D is the resolution of the fractional Doppler.
基金supported by the National Natural Science Foundation of China (6073600660802078)the Hunan Provincial Innovation Foundation for Postgraduate (CX2009B010)
文摘A new polarization measurement algorithm by using the sum and difference beam differential property of mono-pulse radar is given.Based on the generation mechanism differences between the target scattering and multi-false-target jamming,the signal models of real targets and digital deceptive false target jamming for sum and delta channel are presented.The polarization discrimination parameters are designed,and the discrimination method and its performance are discussed.This novel method does not need the accurate estimation of the absolute value of full target polarization scattering matrix,but only requires the relative estimation of the orthogonal polarized component of the targets.Without the need to add additional polarization channels,the proposed method is more suitable for engineering realization.The simulation experiment verifies that the correctly identifying probability can be better than 90%.
基金supported by the Instrument Developing Project of the Chinese Academy of Sciences(No.29201707)
文摘An adaptable and compact fast pulse sampling module was developed for the neutron–gamma discrimination. The developed module is well suited for low-cost and low-power consumption applications. It is based on the Domino Ring Sampler 4(DRS4) chip, which offers fast sampling speeds up to 5.12 giga samples per second(GSPS) to digitize pulses from front-end detectors. The high-resolution GSPS data is useful for obtaining precise real-time neutron–gamma discrimination results directly in this module. In this study, we have implemented real-time data analysis in a field programmable gate array. Real-time data analysis involves two aspects: digital waveform integral and digital pulse shape discrimination(PSD). It can significantly reduce the system dead time and data rate processed offline. Plastic scintillators(EJ-299-33), which have proven capable of PSD, were adopted as neutron detectors in the experiments. A photomultiplier tube(PMT)(model #XP2020) was coupled to one end of a detector to collect the output light from it. The pulse output from the anode of the PMT was directly passed onto the fast sampling module. The fast pulse sampling module was operated at 1 GSPS and 2 GSPS in these experiments, and the AmBe-241 source was used to examine the neutron–gamma discrimination quality. The PSD results with different sampling rates and energy thresholds were evaluated. The figure of merit(FOM) was used to describe the neutron–gamma discrimination quality. The best FOM value of 0.91 was obtained at 2 GSPS and 1 GSPS sampling rates with an energy threshold of 1.5 MeV_(ee)(electron equivalent).
文摘Chinese liquor Moutai is the “National alcoholic drink” in China and plays a very important role of social activities in Chinese people’s life. In pursuit of high profits, some illegal counterfeit Moutai liquors have begun to appear in the market. Therefore, it is an urgent need for new techniques to discriminate the genuine and counterfeit Moutai liquor. In this work, the conventional Ultraviolet-Visible (UV-Vis) spectroscopy and two-dimensional correlation UV-Vis spectroscopy are applied to obtain the UV-Vis characteristic of Moutai liquor and counterfeit one, respectively. The experimental results reveal that the conventional UV-Vis spectra of the genuine and counterfeit Moutai liquor are similar. However, the two-dimensional correlation UV-Vis spectra of them are different and this method would be applied to differentiate the counterfeit Moutai liquor from the genuine Moutai liquor. Compared with conventional methods, this novel method has the advantages of easy operation, simple instrumentation and direct recognition, which make it a potential tool in the fields of food safety.
基金The project was funded by NGO section related to Health Ⅸ Project, the World Bank Loan.
文摘Objective In order to explore the features of discrimination against people with HIV/AIDS in rural areas, a community-based intervention was carried out in two pilot communities of X County of Shanxi Province from September 2002 to October 2003. Methods Data were collected using qualitative methods (in-depth interview and focus group discussion) and anonymously structured questionnaires. Results (1) Severe discrimination against people infected with HIV/AIDS was revealed in the target communities. However, the response to HIV/AIDS was different in each community. (2) People were reluctant to disclose their HIV status or get tested for HIV, which endangered their sexual partners to contract HIV through unprotected sexual intercourses. (3) Attitudes towards people infected with HIV/AIDS varied. (4) Public education promoted a better understanding of HIV/AIDS which in turn improved community attitudes and behaviors towards people with HIV/AIDS. Conclusion HIV/AIDS-related discrimination undermines both individuals and communities responses to HIV/AIDS and may be a serious obstacle towards effective HIV/AIDS prevention and control.
基金supported by the National Natural Science Foundation of China(No.11205154)
文摘Four FPGA-based α/γ pulse shape discrimination algorithms for Ba F2 detector are investigated and compared in this paper. A 2-GSPS fast waveform sampling board based on DRS4 chip is employed to sample the pulses. The test results with a22 Na γ-source and the natural radioactivity of Ba F2 show good discrimination performance of the algorithms, with false rates around 1%. Small logical resource occupancy and short dead time are achieved. About 4400 slices are used in FPGA for pulse sampling and real-time discrimination altogether.
