Synthesis of novel chiral phosphine-triazine ligand derived fromα-phenylethylamine for Pd-catalyzed asymmetric allylic alkylation

A novel chiral phosphine-triazine ligand was synthesized from chiral α-phenylethylamine through a three-step procedure. In a model reaction of Pd-catalyzed allylic alkylation of rac-1,3-diphenylprop-2-en-1-y1 pivalate with dimethyl malonate, good enantioselectivity （90% e.e.） was obtained by using this ligand.

Preparation of (+)-1-Phenylethylamine by Optical Resolution of Racemic 1-Phenylethylamine with a Chiral Biopolymer,Casein

1 Results It has been reported that crystalline form racemates can be resoluted by various methods[1],but for optical resolution of liquid form racemates,the method is limited in chromatograph.So chiral compounds cannot be obtained on large scale by such method.In our previous paper,(+)-3-chloro-1,2-propanediol has been obtained by optical resolution of its racemata (liquid) with a chiral biopolymer,casein[2].

Bischler-Napieralski Reaction of 2-(3,4-Dimethoxy-2-nitrophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[(S)-1-phenylethyl] acetamide Accompanied by Elimination of Chiral Auxiliary

Unexpected dealkylation of Bischler-Napieralski cyclization of 2-(3,4-dimethoxy-2- nitro-phenyl)-N-[2-(3,4-dimethoxyphenyl) ethyl]-N-[(S)-1-phenyl-ethyl] acetamide 3 was reported. The electronic effect of the substituent at 2-position of C ring was also discussed.

Enantiomeric separation of α-phenylethylamine and its analogs by mixed chiral and achiral stationary phase

A mixed stationary phase of modified β-cyclodextrin, 2,6-di-O-butyl-3-O-butyryl-β-cyclodextrin (phase A), and SE-54 (phase B) was used for enantiomeric separation of α-phenylethylami-ne, o,m,p-methyl and o,m,p-methoxy-substituted analogs. The composition of mixed phase was selected by comparison of each calculated amin(= (γm,i+1)/(γm,i))> the relative retention values of the most adjacent peaks, and γm,last, the relative retention values of the last eluting peak at each preselected ratio. Values of γm,i,α calculated by derived equations were in good agreement with the experimental results obtained with two specified mixed phases. All solutes investigated were almost baseline separated at a predicted composition of phase A and phase B in a single run within 18 minutes.

Fabrication of high sensitivity 2-PEA sensor based on Aldehyde-functionalized mesoporous carbon

2-Phenylethylamine(2-PEA)is one of the main ingredients for stimulants.Therefore,it is necessary to limit its use and illegal trade by conveniently detecting 2-PEA vapour.Here,a QCM based 2-PEA gas sensor was constructed by using aldehyde functionalized mesoporous carbon(FDU-15-CHO)as sensing materials designed according to Schiff base adsorption role.The 2D hexagonal mesoporous structures of the sensing material have been confirmed by small-angle X-ray diffraction(SXRD),transmission electron microscopy(TEM),and N2adsorption-desorption isotherms.The covalent grafting of aldehyde group onto the FDU-15 was confirmed by Fourier transform infrared spectroscopy(FT-IR).FDU-15-CHO based Quartz Crystal Microbalance(QCM)sensor shows better sensitivity to 2-PEA than its parent FDU-15.Besides,the detection limit of FDU-15-CHO based sensor can reach down to 1 ppm,and its selectivity and reproducibility are satisfactory.The high concentrations of active sites in the mesopores of FDU-15 are believed to facilitate 2-PEA adsorption,and thus the presence of the-CHO group leading to sensitive and selective response,which is verified by Gaussian simulation.