Objective:To explore the easily applicable indicators of practical value to evaluate the prognosis of acute respiratory distress syndrome（ARDS）.Methods:Blood and biochemical tests and bloodgas analyses were performe...Objective:To explore the easily applicable indicators of practical value to evaluate the prognosis of acute respiratory distress syndrome（ARDS）.Methods:Blood and biochemical tests and bloodgas analyses were performed upon entry into the ICUs,12 h,24 h,48 h and 72 h after that in 72 ARDS patients（who were admitted to the ICUs of our hospital from January 2000 to December 2009）.Then APACHEⅡscores were achieved by combining relevant physiological parameters and laboratory results.Results:There was a statistical difference between the death group and survival group at different time points upon entering the ICUs in terms of APACHEⅡscore, alveolar-arterial oxygen difference and arterial blood lactate clearance rate.PaO<sub>2</sub>/FiO<sub>2</sub> values were recorded to be statistically different between the death group and survival group 24 h,48 h and 72 h,respectively after entry into the ICUs.In addition,registered linear regression existed between APACHEⅡscore,alveolar-arterial oxygen difference or PaO<sub>2</sub>/FiO<sub>2</sub> value and time. APACHEⅡscore 24 h and 72 h after entering ICUs predicted mortality with an area under the ROC curve（AUC） standing respectively at 0.919 and 0.9SS.Arterial blood lactate clearance rate 12 h, 24 h,48 h and 72 h after entering ICUs predicted mortality with an area under the ROC curve （AUC） at 0.918,0.918,0.909 and 0.991,respectively.Conclusions:APACHEⅡscore applied in combination with arterial blood lactate clearance rate is of clinical significance in assessing the prognosis of ARDS patients.展开更多
目的:探讨二甲双胍联合益气补血法对2型糖尿病合并糖尿病肾病患者HGF、肌酐清除率及临床疗效的影响。方法:回顾性研究我院2型糖尿病合并糖尿病肾病患者120例,按照就诊先后顺序分为实验组和对照组,每组各60例,对照组患者采取二甲双胍治疗...目的:探讨二甲双胍联合益气补血法对2型糖尿病合并糖尿病肾病患者HGF、肌酐清除率及临床疗效的影响。方法:回顾性研究我院2型糖尿病合并糖尿病肾病患者120例,按照就诊先后顺序分为实验组和对照组,每组各60例,对照组患者采取二甲双胍治疗,实验组患者采取二甲双胍联合益气补血法进行治疗。比较治疗前后两组患者血清肝细胞生长因子(Hepatocyte growth factor,HGF)、血清胱抑素C(Cystatin C)、转化生长因子-β1(Transforming growth factor-β1,TGF-β1)、血清肌酐(Serum creat imine,SCr)、血尿素氮(Blood urea nitrogen,BUN)、肌酐清除率(Serum creat inine clearance rate,Ccr)及24 h尿蛋白定量(24 h Upro)水平变化,同时比较治疗结束后两组临床疗效。结果:与治疗前相比,两组患者的HGF、Ccr显著升高,TGF-β1、Cys C、Scr、BUN及24 h Upro显著降低(P<0.05);治疗结束后与对照组相比,实验组患者HGF水平较高(P<0.05);Cys C、TGF-β1水平较低(P<0.05);SCr、BUN、24 h Upro水平较低(P<0.05);Ccr水平较高(P<0.05)。结论:二甲双胍联合益气补血法能够提高2型糖尿病合并糖尿病肾病的临床疗效,推测其机制可能与降低Cys C、TGF-β1、SCr、BUN、24 h Upro水平,提高HGF、CCr水平有关。展开更多
基金sponsored by Guangdong Science and Technology Project(No:2009B03081118)
文摘Objective:To explore the easily applicable indicators of practical value to evaluate the prognosis of acute respiratory distress syndrome（ARDS）.Methods:Blood and biochemical tests and bloodgas analyses were performed upon entry into the ICUs,12 h,24 h,48 h and 72 h after that in 72 ARDS patients（who were admitted to the ICUs of our hospital from January 2000 to December 2009）.Then APACHEⅡscores were achieved by combining relevant physiological parameters and laboratory results.Results:There was a statistical difference between the death group and survival group at different time points upon entering the ICUs in terms of APACHEⅡscore, alveolar-arterial oxygen difference and arterial blood lactate clearance rate.PaO<sub>2</sub>/FiO<sub>2</sub> values were recorded to be statistically different between the death group and survival group 24 h,48 h and 72 h,respectively after entry into the ICUs.In addition,registered linear regression existed between APACHEⅡscore,alveolar-arterial oxygen difference or PaO<sub>2</sub>/FiO<sub>2</sub> value and time. APACHEⅡscore 24 h and 72 h after entering ICUs predicted mortality with an area under the ROC curve（AUC） standing respectively at 0.919 and 0.9SS.Arterial blood lactate clearance rate 12 h, 24 h,48 h and 72 h after entering ICUs predicted mortality with an area under the ROC curve （AUC） at 0.918,0.918,0.909 and 0.991,respectively.Conclusions:APACHEⅡscore applied in combination with arterial blood lactate clearance rate is of clinical significance in assessing the prognosis of ARDS patients.
文摘目的:探讨二甲双胍联合益气补血法对2型糖尿病合并糖尿病肾病患者HGF、肌酐清除率及临床疗效的影响。方法:回顾性研究我院2型糖尿病合并糖尿病肾病患者120例,按照就诊先后顺序分为实验组和对照组,每组各60例,对照组患者采取二甲双胍治疗,实验组患者采取二甲双胍联合益气补血法进行治疗。比较治疗前后两组患者血清肝细胞生长因子(Hepatocyte growth factor,HGF)、血清胱抑素C(Cystatin C)、转化生长因子-β1(Transforming growth factor-β1,TGF-β1)、血清肌酐(Serum creat imine,SCr)、血尿素氮(Blood urea nitrogen,BUN)、肌酐清除率(Serum creat inine clearance rate,Ccr)及24 h尿蛋白定量(24 h Upro)水平变化,同时比较治疗结束后两组临床疗效。结果:与治疗前相比,两组患者的HGF、Ccr显著升高,TGF-β1、Cys C、Scr、BUN及24 h Upro显著降低(P<0.05);治疗结束后与对照组相比,实验组患者HGF水平较高(P<0.05);Cys C、TGF-β1水平较低(P<0.05);SCr、BUN、24 h Upro水平较低(P<0.05);Ccr水平较高(P<0.05)。结论:二甲双胍联合益气补血法能够提高2型糖尿病合并糖尿病肾病的临床疗效,推测其机制可能与降低Cys C、TGF-β1、SCr、BUN、24 h Upro水平,提高HGF、CCr水平有关。
