Facies logging identification of intermediate-basic volcanic rocks in Huoshiling Formation of Songliao Basin

Volcanic oil and gas reservoirs are generally buried deep,which leads to a high whole-well coring cost,and the degree of development and size of reservoirs are controlled by volcanic facies.Therefore,accurately identifying volcanic facies by logging curves not only provides the basis of volcanic reservoir prediction but also saves costs during exploration.The Songliao Basin is a‘fault-depression superimposed’composite basin with a typical binary filling structure.Abundant types of volcanic lithologies and facies are present in the Lishu fault depression.Volcanic activity is frequent during the sedimentary period of the Huoshiling Formation.Through systematic petrographic identification of the key exploratory well(SN165C)of the Lishu fault-depression,which is a whole-well core,it is found that the Huoshiling Formation in SN165C contains four facies and six subfacies,including the volcanic conduit facies(crypto explosive breccia subfacies),explosive facies(pyroclastic flow and thermal wave base subfacies),effusive facies(upper and lower subfacies),and volcanogenic sedimentary facies(pyroclastic sedimentary subfacies).Combining core,thin section,and logging data,the authors established identification markers and petrographic chart logging phases,and also interpreted the longitudinal variation in volcanic petro-graphic response characteristics to make the charts more applicable to this area's volcanic petrographic interpretation of the Huoshiling Formation.These charts can provide a basis for the further exploration and development of volcanic oil and gas in this area.

Development of Long-Range,Low-Powered and Smart IoT Device for Detecting Illegal Logging in Forests

Forests promote the conservation of biodiversity and also play a crucial role in safeguarding theenvironment against erosion,landslides,and climate change.However,illegal logging remains a significant threatworldwide,necessitating the development of automatic logging detection systems in forests.This paper proposesthe use of long-range,low-powered,and smart Internet of Things(IoT)nodes to enhance forest monitoringcapabilities.The research framework involves developing IoT devices for forest sound classification andtransmitting each node’s status to a gateway at the forest base station,which further sends the obtained datathrough cellular connectivity to a cloud server.The key issues addressed in this work include sensor and boardselection,Machine Learning(ML)model development for audio classification,TinyML implementation on amicrocontroller,choice of communication protocol,gateway selection,and power consumption optimization.Unlike the existing solutions,the developed node prototype uses an array of two microphone sensors forredundancy,and an ensemble network consisting of Long Short-Term Memory(LSTM)and ConvolutionalNeural Network(CNN)models for improved classification accuracy.The model outperforms LSTM and CNNmodels when used independently and also gave 88%accuracy after quantization.Notably,this solutiondemonstrates cost efficiency and high potential for scalability.

SiRAP2-12,a Positive Regulatory Factor,Effectively Improves the Waterlogging Tolerance of Foxtail Millet(Setaria italica)

Foxtail millet(Setaria italica)growth was inhibited because of waterlogging stress,which has caused yield reduc-tion.ERF family plays an important role to plant adversity tolerance.In our study,we obtained 19,819 differential expressed genes(DEGs)between the two treatments based on the RNA-seq sequencing of foxtail millet of water-logging stress.Furthermore,a total of 28 ERF family members were obtained,which have a complete open read-ing frame.We studied the evolution and function of SiERF family and how they affected the waterlogging tolerance.It was found that SiERF1A/B/C(GenBank ID:OR775217,OR775219,OR775218)and SiRAP2-12(GenBank ID:OR775216)have similar functions to the known waterlogging tolerance genes of other plants.Among them,the SiRAP2-12 expression was obviously significantly up-regulated in foxtail millet after 5d water-logging stress.After SiRAP2-12 was silenced,the activity of defense enzymes in millet decreased significantly.In details,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD),the osmotic regulator proline(Pro),and the activity of the anaerobic respiratory enzyme alcohol dehydrogenase(ADH)content were decreased by 78.61%,29.52%,79.95%,19.41%and 54.77%,respectively.In contrast,the relative electrical conductivity contents(REC),malondialdehyde(MDA),and hydrogen peroxide(H_(2)O_(2))of the foxtail millet subjected to virus-induced gene silencing clearly increased by 1.03-fold,36.09%,and 15.21%,respectively.The content of sodium(Na^(+))in the SiRAP2-12-silenced foxtail millet also increased,but that of potassium(K^(+))decreased.Interestingly,we found that ethylene content was significantly reduced.Further,the SiAOC1 expression,an essential gene for ethylene synthesis,was inhibited in SiRAP2-12-silenced foxtail millet after waterlogging stress.Taken together,we hypothesized that SiRAP2-12 might be a positive regulator of millet tolerance to waterlogging stress.

含零收益率的金融非对称Log-GARCH模型研究

在实际外汇市场中,由于诸如交易缺失、舍入误差等原因使得收益率序列中出现零值,常见GARCH族模型无法对含零收益率数据进行有效拟合,导致波动率估计结果产生较大偏差。为了更准确地估计汇率波动率,本文对含有零收益率的外汇数据进行建模。首先运用不受条件方差为正限制的log-GARCH模型对汇率市场收益率数据进行拟合,同时提出一个处理含有零收益率的数据处理框架,即将零值视为缺失的观测值。然后通过结合QMLE方法和期望最大化(EM)算法对含缺失观测值的log-GARCH模型进行无偏估计。最后通过实证分析比较零收益率两种不同处理方法——非零值代替零值方法和将零值视为缺失值方法下波动率估计结果的差异。研究结果显示零收益率的存在会增加波动率的估计偏差,将非零值作为缺失值方法得到的估计结果更接近市场真实情况。

Permeability Logging:A Breakthrough from 0 to1

On March 3,2024,the prototype permeability logging instrument independently developed in China successfully completed its first downhole test in Ren 91 standard well in PetroChina Huabei Oilfield.In the open hole section at a depth of 3925 metres and at a temperature of 148℃,the device collected high-quality permeability logging data.This marks a key technological breakthrough from 0 to 1 in permeability logging,and lays the foundation for the next step in developing a complete set of permeability logging equipment.

Integrated Geological and Geophysical Mapping for Groundwater Potential Studies at Ekwegbe-Agu and Environs, Enugu State, Nigeria

The study integrates both the geological and geophysical mapping techniques for groundwater potential studies at Ekwegbe-Agu and the environs, Enugu state, Nigeria for optimal citing of borehole. Located in the Anambra Basin between latitudes 6˚43'N and 6˚47'N and longitudes 7˚28'E and 7˚32'E, it is stratigraphycally underlain by, from bottom to top, the Enugu/Nkporo, Mamu and Ajali Formation respectively, a complex geology that make citing of productive borehole in the area problematic leading to borehole failure and dry holes due to inadequate sampling. The study adopted a field and analytic sampling approach, integrating field geological, electrical resistivity and self-potential methods. The software, SedLog v3.1, InterpexIx1Dv.3, and Surfer v10 were employed for the data integration and interpretation. The result of the geological field and borehole data shows 11 sedimentary facies consisting of sandstone, shales and heterolith of sandstone/shale, with the aquifer zone mostly prevalent in the more porous sand-dominated horizons. Mostly the AK and HK were the dominant curve types. An average of 6 geo-electric layers were delineated across all transects with resistivity values ranging from 25.42 - 105.85 Ωm, 186.38 - 3383.3 Ωm, and 2992 - 6286.4 Ωm in the Enugu, Mamu and Ajali Formations respectively. The resistivity of the main aquifer layer ranges from 1 to 500 Ωm. The aquifer thickness within the study area varies between 95 and 140 m. The western and northwestern part of the study area which is underlain mainly by the Ajali Formation showed the highest groundwater potential in the area and suitable for citing productive boreholes.

A log-based method for fine-scale evaluation of lithofacies and its applications to the Gulong shale in the Songliao Basin,Northeast China

The Gulong shale demonstrates high clay content and pronounced thin laminations,with limited vertical variability in log curves,complicating lithofacies classification.To comprehend the distribution and compositional features of lithofacies in the Gulong shale for optimal sweet spot selection and reservoir stimulation,this study introduced a lithofacies classification scheme and a log-based lithofacies evaluation method.Specifically,theΔlgR method was utilized for accurately determining the total organic carbon(TOC)content;a multi-mineral model based on element-to-mineral content conversion coefficients was developed to enhance mineral composition prediction accuracy,and the microresistivity curve variations derived from formation micro-image(FMI)log were used to compute lamination density,offering insights into sedimentary structures.Using this method,integrating TOC content,sedimentary structures,and mineral compositions,the Qingshankou Formation is classified into four lithofacies and 12 sublithofacies,displaying 90.6%accuracy compared to core description outcomes.The classification results reveal that the northern portion of the study area exhibits more prevalent fissile felsic shales,siltstone interlayers,shell limestones,and dolomites.Vertically,the upper section primarily exhibits organic-rich felsic shale and siltstone interlayers,the middle part is characterized by moderate organic quartz-feldspathic shale and siltstone/carbonate interlayers,and the lower section predominantly features organic-rich fissile felsic/clayey felsic shales.Analyzing various sublithofacies in relation to seven petrophysical parameters,oil test production,and fracturing operation conditions indicates that the organic-rich felsic shales in the upper section and the organic-rich/clayey felsic shales in the lower section possess superior physical properties and oil content,contributing to smoother fracturing operation and enhanced production,thus emerging as dominant sublithofacies.Conversely,thin interlayers such as siltstones and limestones,while producing oil,demonstrate higher brittleness and pose great fracturing operation challenges.The methodology and insights in this study will provide a valuable guide for sweet spot identification and horizontal well-based exploitation of the Gulong shale.

Identification of reservoir types in deep carbonates based on mixedkernel machine learning using geophysical logging data

Identification of reservoir types in deep carbonates has always been a great challenge due to complex logging responses caused by the heterogeneous scale and distribution of storage spaces.Traditional cross-plot analysis and empirical formula methods for identifying reservoir types using geophysical logging data have high uncertainty and low efficiency,which cannot accurately reflect the nonlinear relationship between reservoir types and logging data.Recently,the kernel Fisher discriminant analysis(KFD),a kernel-based machine learning technique,attracts attention in many fields because of its strong nonlinear processing ability.However,the overall performance of KFD model may be limited as a single kernel function cannot simultaneously extrapolate and interpolate well,especially for highly complex data cases.To address this issue,in this study,a mixed kernel Fisher discriminant analysis(MKFD)model was established and applied to identify reservoir types of the deep Sinian carbonates in central Sichuan Basin,China.The MKFD model was trained and tested with 453 datasets from 7 coring wells,utilizing GR,CAL,DEN,AC,CNL and RT logs as input variables.The particle swarm optimization(PSO)was adopted for hyper-parameter optimization of MKFD model.To evaluate the model performance,prediction results of MKFD were compared with those of basic-kernel based KFD,RF and SVM models.Subsequently,the built MKFD model was applied in a blind well test,and a variable importance analysis was conducted.The comparison and blind test results demonstrated that MKFD outperformed traditional KFD,RF and SVM in the identification of reservoir types,which provided higher accuracy and stronger generalization.The MKFD can therefore be a reliable method for identifying reservoir types of deep carbonates.

A Real-time Lithological Identification Method based on SMOTE-Tomek and ICSA Optimization

In petroleum engineering,real-time lithology identification is very important for reservoir evaluation,drilling decisions and petroleum geological exploration.A lithology identification method while drilling based on machine learning and mud logging data is studied in this paper.This method can effectively utilize downhole parameters collected in real-time during drilling,to identify lithology in real-time and provide a reference for optimization of drilling parameters.Given the imbalance of lithology samples,the synthetic minority over-sampling technique(SMOTE)and Tomek link were used to balance the sample number of five lithologies.Meanwhile,this paper introduces Tent map,random opposition-based learning and dynamic perceived probability to the original crow search algorithm(CSA),and establishes an improved crow search algorithm(ICSA).In this paper,ICSA is used to optimize the hyperparameter combination of random forest(RF),extremely random trees(ET),extreme gradient boosting(XGB),and light gradient boosting machine(LGBM)models.In addition,this study combines the recognition advantages of the four models.The accuracy of lithology identification by the weighted average probability model reaches 0.877.The study of this paper realizes high-precision real-time lithology identification method,which can provide lithology reference for the drilling process.

Well logging evaluation of fine-grained hydrate-bearing sediment reservoirs: Considering the effect of clay content

Hydrate reservoirs are different from the host reservoirs of all other fossil energy sources because the characteristics of hydrate reservoirs are generally controlled by deep-sea fine-grained sedimentation. In such reservoirs, the reliability of the classical logging evaluation models established for diagenetic reservoirs is questionable. This study used well W8 in the Qiongdongnan Basin to explore the clay content, porosity, saturation, and hydrate-enriched layer identification of a logging-based hydrate reservoir, and it was found that considering the effect of the clay content on the log response is necessary in the logging evaluation of hydrate reservoirs. In the evaluation of clay content, a method based on the optimization inversion method can obtain a more reliable clay content than other methods. Fine-grained sediment reservoirs have a high clay content, and the effect of clay on log responses must be considered when calculating porosity. In addition, combining density logging and neutron porosity logging data can obtain the best porosity calculation results, and the porosity calculation method based on sonic logging predicted that the porosity of the studied reservoir was low. It was very effective to identify hydrate layers based on resistivity, but the clay distribution and pore structure will also affect the relationship between resistivity, porosity and saturation, and it was suggested that the factors effecting the resistivity of different layers should be considered in the saturation evaluation and that a suitable model should be selected. This study also considered the lack of clarity of the relationships among the lithology, physical properties, hydrate-bearing occurrence properties, and log response properties of hydrate reservoirs and the lack of specialized petrophysical models. This research can directly help to improve hydrate logging evaluation.

Application of Secondary Logging Interpretation—Taking Yan 9 Reservoir in X Area as an Example

Logging data and its interpretation results are one of the most important basic data for understanding reservoirs and oilfield development. Standardized and unified logging interpretation results play a decisive role in fine reservoir description and reservoir development. Aiming at the problem of the conflict between the development effect and the initial interpretation result of Yan 9 reservoir in Hujianshan area of Ordos Basin, by combining the current well production performance, logging, oil test, production test and other data, on the basis of making full use of core, coring, logging, thin section analysis and high pressure mercury injection data, the four characteristics of reservoir are analyzed, a more scientific and reasonable calculation model of reservoir logging parameters is established, and the reserves are recalculated after the second interpretation standard of logging is determined. The research improves the accuracy of logging interpretation and provides an effective basis for subsequent production development and potential horizons.

Logging curves characteristics and response mechanisms of basaltic facies and sub-facies: A case study from eastern sag of Liaohe depression, Northeast China

Based on five types of conventional logging curves including GR,RLLD,CNL,DEN and AC,and 39 core samples from 30 representative boreholes,the logging characteristics and lithofacies and sub-facies of the basaltic rocks were studied.Three basaltic facies and four sub-facies are recognized from the well logs,includ-ing volcanic conduit facies(post intrusive sub-facies),explosive facies,and effusive lava flow facies(tabular flow,compound flow and hyaloclastite sub-facies).The post intrusive,tabular flow and compound flow sub-facies logging curves are mainly controlled by the distribution of vesiculate zones and vesiculate content,which are characterized by four curves with good correlation.Post intrusive sub-facies are characterized by high RLLD,high DEN,with a micro-dentate logging curve pattern,abrupt contact relationships at the top and base.Tabular flow sub-facies are characterized by high RLLD,high DEN,with a bell-shaped log curve pattern,abrupt contact at the base and gradational contact at the top.Compound flow sub-facies are characterized by medium-low RLLD,with a micro-dentate or finger-like logging curve pattern,abrupt contact at the base and gradational contact at the top.Explosive facies and hyaloclastite sub-facies logging curves are mainly controlled by the distribution of the size and sorting of rock particles,which can be recognized by four kinds of logging curves with poor cor-relation.Explosive facies are characterized by low RLLD,medium-low CNL and low DEN,with a micro-dentate logging curve pattern.Hyaloclastite sub-facies are characterized by low RLLD,high CNL,low DEN and high AC,with a micro-dentate logging curve pattern.The present research is beneficial for the prediction of basaltic reser-voirs not only in the Liaohe depression but also in the other volcanic-sedimentary basins.

多模态遥感图像模板匹配Log-Gabor滤波方法

针对多模态遥感图像匹配难的问题,本文提出了一种基于Log-Gabor滤波的高精度匹配方法。该方法采用由粗到细的多层级密集匹配框架,无须进行特征点检测,避开了多模态图像特征点检测重复率低的问题,能够提取大量高精度匹配点对。本文方法主要分为两步:首先,利用多尺度多角度Log-Gabor滤波器构建对图像间非线性辐射差异稳健的特征金字塔;然后,利用粗尺度的底层特征图进行密集模板匹配,提取大量粗粒度的特征匹配点对,在此基础上再利用特征金字塔,实现粗匹配点自下而上的逐层优化,完成高精度特征匹配点对的提取。同时,针对模板匹配滑窗运算效率不高的问题,提出了一种密集模板匹配的快速实现方式,有效减少了密集模板匹配的运算时间。本文使用多组不同模态的遥感图像进行试验,结果表明,本文方法能够克服图像间非线性辐射差异的影响,在正确匹配数目、匹配准确率与匹配精度上均优于现有多模态图像特征匹配方法。

基于非凸log模型的脑电时-频-空特征选择方法

针对运动想象脑电时-频-空特征选择问题,提出了基于非凸log模型的稀疏特征选择方法(LOG方法)。首先,对原始脑电信号进行时-频分解,得到多个时-频段;其次,针对每个时-频段使用共空域模式(CSP)提取特征,得到时-频-空特征集合;最后,通过提出的基于log函数的非凸稀疏优化模型进行特征选择和分类,该模型可有效缓解L1范数正则化的有偏估计。为验证本方法的有效性,用3个公开的运动想象脑电数据集进行实验,相比现有的凸稀疏优化模型,非凸log模型取得了82.5%的平均分类准确率。实验结果表明,LOG方法不仅分类准确率高,且模型具有较好的稳定性和鲁棒性。

反应-扩散logistic模型前向欧拉法的数值Hopf分支

利用前向欧拉法研究具有二阶混合时滞和瞬时密度制约的logistic反应扩散种群模型,并对其数值离散系统的动力学问题进行分析。随着时滞的增加,证明了在正平衡点处出现了一系列Hopf分支,分析了不动点的稳定性。最后,通过数值模拟验证理论结果的正确性。

Research on hsa-miR-155-3p and hsa-miR-155-5p as biomarkers for systemic sclerosis and their role in regulating biological behavior

Objective: This study was to investigate the role of hsa-miR-155-3p and hsa-miR-155-5p as biomarkers and regulators of biological behavior in Systemic Sclerosis. Methods: A total of 10 SSc patients and 10 healthy controls were selected for the study. The expression levels of hsa-miR-155-3p and hsa-miR-155-5p in peripheral blood mononuclear cells of SSc patients and healthy controls were measured using RT-qPCR. The diagnostic value of these miRNAs was explored using Receiver Operating Characteristic curve analysis. Pearson or Spearman correlation analysis was performed to assess the correlation between miRNAs and clinical indicators in SSc patients. Potential target genes of hsa-miR-155-3p and hsa-miR-155-5p were predicted using miRDB, Targetscan, and miRDIP databases. GO functional annotation, KEGG pathway enrichment analysis, protein-protein interaction network construction, and selection of central genes were conducted. Results: The expression levels of hsa-miR-155-3p and hsa- miR-155-5p were significantly higher in PBMCs of SSc patients compared to healthy controls (P<0.001). The ROC curve analysis showed that hsa-miR-155-3p and hsa-miR-155-5p had a high diagnostic value for SSc (AUC=1, P<0.001). Correlation analysis revealed that hsa- miR-155-3p, hsa-miR-155-5p, and clinical indicators such as high-resolution CT, neutrophil percentage, lymphocyte percentage, and albumin to globulin ratio were correlated (P<0.05). The signaling pathways enriched with target genes of hsa-miR-155-3p and hsa-miR-155- 5p were closely associated with the occurrence and development of SSc fibrosis, immunity, and inflammation. Conclusions: hsa-miR-155-3p and hsa-miR-155-5p may be involved in regulating the occurrence and development of SSc fibrosis, immunity, and inflammation. They have the potential to serve as biomarkers for clinical diagnosis and treatment of SSc.

Response analyses on the drill-string channel for logging while drilling telemetry

Downhole acoustic telemetry(DAT),using a long drill string with periodical structures as the channel,is a prospective technology for improving the transmission rate of logging while drilling(LWD)data.Previous studies only focused on the acoustic property of a free drill string and neglected the coupling between pipes and fluid-filled boreholes.In addition to the drill-string waves,a series of fluid waves are recorded in the DAT channel,which has not been investigated yet.Unpredictable channel characteristics result in lower transmission rates and stability than expected.Therefore,a more realistic channel model is needed considering the fluid-filled borehole.In this paper,we propose a hybrid modeling method to investigate the response characteristics of the DAT channel.By combining the axial wavenumbers and excitation functions of mode waves in radially layered LWD structures,the channel model is approximated to the 1-D propagation,which considers transmission,reflection,and interconversion of the drillstring and fluid waves.The proposed 1-D approximation has been well validated by comparing the 2-D finite-difference modeling.It is revealed that the transmitted and converted fluid waves interfere with the drill-string wave,which characterizes the DAT channel as a particular coherent multi-path channel.When a fluid-filled borehole surrounds the drill string,the channel responses exhibit considerable delay as well as strong frequency selectivity in amplitude and phase.These new findings suggest that the complexity of the channel response has been underestimated in the past,and therefore channel measurements on the ground are unreliable.To address these channel characteristics,we apply a noncoherent demodulation strategy.The transmission rate for synthetic data reaches 15 bps in a 94.5 m long channel,indicating that the acoustic telemetry is promising to break the low-speed limitation of mud-pulse telemetry.

ControlLogix PLC与S7-1200 PLC无网关异构数据交互实现

针对罗克韦尔自动化PLC与西门子PLC的开发编程环境不同,两种PLC之间不能通过硬件组态配置方式进行数据交互,导致数据交互困难,需要借助第三方协议网关才能实现数据共享的问题,提出一种采用以太网套接字进行异构数据交互的方法。通过应用MSG、TSEND_C、TRCV_C等指令分别在ControlLogix PLC和S7-1200 PLC控制器中进行编程,实现了两种PLC间无网关数据交互。

Characterization of reservoir properties and pore structure based on micro-resistivity imaging logging: Porosity spectrum, permeability spectrum, and equivalent capillary pressure curve

According to the capillary theory,an equivalent capillary model of micro-resistivity imaging logging was built.On this basis,the theoretical models of porosity spectrum(Ф_(i)),permeability spectrum(K_(i))and equivalent capillary pressure curve(pe)were established to reflect the reservoir heterogeneity.To promote the application of the theoretical models,the Archie's equation was introduced to establish a general model for quantitatively characterizing bi,K,and pei.Compared with the existing models,it is shown that:(1)the existing porosity spectrum model is the same as the general equation of gi;(2)the Ki model can display the permeability spectrum as compared with Purcell's permeability model;(3)the per model is constructed on a theoretical basis and avoids the limitations of existing models that are built only based on the component of porosity spectrum,as compared with the empirical model of capillary pressure curve.The application in the Permian Maokou Formation of Well TsX in the Central Sichuan paleo-uplift shows that the Ф_(i),K_(i),and p_(ci) models can be effectively applied to the identification of reservoir types,calculation of reservoir properties and pore structure parameters,and evaluation of reservoir heterogeneity.

Bone marrow-derived mesenchymal stem cell-derived exosomeloaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage

BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain.