Human CTRP4 is a member of the C1q/TNF-related protein(CTRP)superfamily.This family,originally identified by Lodish and coworkers,is a highly conserved family consisting of secreted proteins that were cloned on the ba...Human CTRP4 is a member of the C1q/TNF-related protein(CTRP)superfamily.This family,originally identified by Lodish and coworkers,is a highly conserved family consisting of secreted proteins that were cloned on the basis of an adiponectin homology sequence.1 Up to now,15 members have been identified in CTRP superfamily(CTRP1–CTRP15)(Figure 1).Those,together with adiponectin,leptin and resistin,are collectively known as the adipocytokine superfamily.2 CTRPs usually assume a homotrimeric structure and each subunit is composed of an N-terminal signal peptide,a short variable region,a collagen domain and a C-terminal C1q globular domain.3 Accumulating evidence has demonstrated that CTRPs play important regulatory roles in inflammation,metabolism and tumor angiogensis.展开更多
文摘Human CTRP4 is a member of the C1q/TNF-related protein(CTRP)superfamily.This family,originally identified by Lodish and coworkers,is a highly conserved family consisting of secreted proteins that were cloned on the basis of an adiponectin homology sequence.1 Up to now,15 members have been identified in CTRP superfamily(CTRP1–CTRP15)(Figure 1).Those,together with adiponectin,leptin and resistin,are collectively known as the adipocytokine superfamily.2 CTRPs usually assume a homotrimeric structure and each subunit is composed of an N-terminal signal peptide,a short variable region,a collagen domain and a C-terminal C1q globular domain.3 Accumulating evidence has demonstrated that CTRPs play important regulatory roles in inflammation,metabolism and tumor angiogensis.
