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Bone marrow-derived mesenchymal stem cell-derived exosomeloaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage 被引量:1
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作者 Yue-Ying Wang Ke Li +5 位作者 Jia-Jun Wang Wei Hua Qi Liu Yu-Lan Sun Ji-Ping Qi Yue-Jia Song 《World Journal of Diabetes》 SCIE 2024年第9期1979-2001,共23页
BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patie... BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain. 展开更多
关键词 Bone marrow mesenchymal stem cells Exosome Diabetic cerebral hemorrhage Neuroinflammation MicroRNA-129-5p High mobility group box 1
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MiR-142-3p Regulates ILC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss 被引量:1
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作者 Xiang-li PANG Jie LI +2 位作者 Jing WANG Si-si YAN Jing YANG 《Current Medical Science》 SCIE CAS 2024年第1期195-211,共17页
Objective Innate lymphoid cells(ILCs)are a class of newly discovered immunocytes.Group 1 ILCs(ILC1s)are identified in the decidua of humans and mice.High mobility group box 1(HMGB1)is predicted to be one of the target... Objective Innate lymphoid cells(ILCs)are a class of newly discovered immunocytes.Group 1 ILCs(ILC1s)are identified in the decidua of humans and mice.High mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related diseases.Furthermore,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling pathway.This study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling pathway.Methods Mouse models of normal pregnancy and abortion were constructed,and the alterations of ILC1s,miR-142-3p,ILC1 transcription factor(T-bet),and pro-inflammatory cytokines of ILC1s(TNF-α,IFN-γand IL-2)were detected in mice from different groups.The targeting regulation of HMGB1 by miR-142-3p in ILC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were investigated.In addition,the regulatory effects of miR-142-3p and HMGB1 on ILC1s were detected in vitro by CCK-8,Annexin-V/PI,ELISA,and RT-PCR,respectively.Furthermore,changes of the NF-κB signaling pathway in ILC1s were examined in the different groups.For the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of ILC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling pathway.Results The number of ILC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all P<0.05).In addition,miR-142-3p was found to drastically inhibit the activation of the NF-κB signaling pathway(P<0.05).The number of ILC1s and the levels of pro-inflammatory cytokines were significantly downregulated and the activation of the NF-κB signaling pathway was inhibited in the miR-142-3p Agomir group(all P<0.05).Conclusion miR-142-3p can regulate ILC1s by targeting HMGB1 via the NF-κB signaling pathway,and attenuate the inflammation at the maternal-fetal interface in abortive mice. 展开更多
关键词 maternal-fetal interface group 1 innate lymphoid cells(ILCis) high mobility group box 1(HMGB1) miR-142-3p ABORTION
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A New Characterization of Simple K_3-groups 被引量:1
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作者 王临红 《Northeastern Mathematical Journal》 CSCD 2001年第2期205-209,共5页
In this paper, We show that the simple K\-3-groups can be characterized by the orders of their maximal abelian subgroups. That is, we have Theorem Let G be a finite group and M a simple K \-3-group. Then ... In this paper, We show that the simple K\-3-groups can be characterized by the orders of their maximal abelian subgroups. That is, we have Theorem Let G be a finite group and M a simple K \-3-group. Then G is isomorphic to M if and only if the set of the orders of the maximal abelian subgoups of G is the same as that of M . 展开更多
关键词 finite group simple K\-3-group maximal abelian subgroup prime graph
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Cloning and Sequence Analysis of Ma-14-3-3d Encoding a Homologue 14-3-3 Protein from Banana 被引量:4
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作者 李美英 徐碧玉 +3 位作者 杨小亮 刘菊华 张建斌 金志强 《Agricultural Science & Technology》 CAS 2008年第3期75-79,共5页
[Objective] The aim of the study is to clone and analyze the gene encoding 14-3-3 protein from banana. [Method] Combined with PCR amplification, RACE (rapid amplification of cDNA ends) technique was employed to clone ... [Objective] The aim of the study is to clone and analyze the gene encoding 14-3-3 protein from banana. [Method] Combined with PCR amplification, RACE (rapid amplification of cDNA ends) technique was employed to clone 14-3-3 gene from banana; then the amplified sequence was sequenced and homologically analyzed. [Result] A new cDNA homologous with 14-3-3 protein genes were obtained by RT-PCR and RACE ( rapid amplification of cDNA ends ) approaches. The full length of this cDNA was 866 bp encoding 197 amino acids. Alignment of deduced amino acid sequence with those from other plants revealed that the cDNA shared high homology with 14-3-3 protein genes from other plants, and was designated as Musa acuminata 14-3-3 gene (Ma-14-3-3d). Phylogenetic analysis reveals that Ma-14-3-3d has closer genetic relationship with those from monocotyledon species than those from other species. [Conclusion] Ma-14-3-3d belongs to the same lineage of 14-3-3 from monocotyledon. 展开更多
关键词 MUSA acuminate L. AA group cv. BRAZILIAN Ma-14-3-3d 14-3-3 PROTEIN
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胃癌组织高迁移率族蛋白A2与基质金属蛋白酶-9表达与肿瘤侵袭转移的关系及预后意义 被引量:7
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作者 吕柏楠 石晓明 +2 位作者 吴胜春 唐雷 杨永宾 《河北医药》 CAS 2014年第6期819-822,共4页
目的探讨胃癌组织中高迁移率族蛋白A2(HMGA2)及基质金属蛋白酶-9(MMP-9)表达与肿瘤侵袭和转移能力的关系及预后意义。方法采用免疫组化法(SP法)检测93例胃癌组织、30例正常胃黏膜组织中HMGA2、MMP-9的表达;收集患者临床病历资料,并进行... 目的探讨胃癌组织中高迁移率族蛋白A2(HMGA2)及基质金属蛋白酶-9(MMP-9)表达与肿瘤侵袭和转移能力的关系及预后意义。方法采用免疫组化法(SP法)检测93例胃癌组织、30例正常胃黏膜组织中HMGA2、MMP-9的表达;收集患者临床病历资料,并进行随访。结果 HGMA2蛋白在胃癌组织中阳性表达率分别为明显高于正常胃黏膜(P<0.01);MMP-9蛋白在胃癌组织中阳性表达率明显高于正常胃黏膜(P<0.01)。HMGA2与MMP-9在胃癌组织中的蛋白阳性表达均与胃癌组织的肿瘤浸润深度、肿瘤分化程度、淋巴结转移、TNM分期有关(P<0.05);与患者的性别、年龄、肿瘤直径无关(P>0.05)。相关性分析发现,HMGA2与MMP-9在胃癌组织中的表达情况呈正相关(r=0.317,P<0.01)。经Kaplan-Meier生存分析显示,HMGA2、MMP-9蛋白表达阳性患者的生存率均低于表达阴性患者(P<0.01)。结论 HMGA2、MMP-9与胃癌浸润和转移有关,两者表达具有相互协同作用,对胃癌的侵袭和转移起重要的促进作用。HMGA2、MMP-9是影响预后的危险因素,可能成为胃癌治疗的新靶点。 展开更多
关键词 胃癌 高迁移率族蛋白A2 基质金属蛋白酶-9 侵袭 转移 预后 high mobility group protein A2 matrix metalloproteinase-9
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逆半群在给定群上的E-囿盖 被引量:3
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作者 徐芒 喻秉钧 《四川师范大学学报(自然科学版)》 CAS CSCD 2001年第2期124-127,共4页
通过反例证明了并非对任意群G ,逆半群S在它上都有E 囿盖 ,给出了逆半群S在群G上有E
关键词 逆半群 E-囿逆半群 E-囿盖 可因子分解逆半群 最小群同余 幂等元分离同态
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丙泊酚对急性肺损伤大鼠HMGB-1表达的影响 被引量:3
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作者 王曾庚 杨春丽 聂祥碧 《南昌大学学报(医学版)》 CAS 2014年第3期10-12,17,共4页
目的探讨丙泊酚的肺保护作用及其可能作用机制。方法采用尾静脉注射内毒素建立急性肺损伤模型,丙泊酚和锌原卟啉同样经过尾静脉给药。将Wistar大鼠按随机数字表法分为实验对照组(C组)、脂多糖组(L组)、脂多糖+丙泊酚组(LP组)。C组尾静... 目的探讨丙泊酚的肺保护作用及其可能作用机制。方法采用尾静脉注射内毒素建立急性肺损伤模型,丙泊酚和锌原卟啉同样经过尾静脉给药。将Wistar大鼠按随机数字表法分为实验对照组(C组)、脂多糖组(L组)、脂多糖+丙泊酚组(LP组)。C组尾静脉注射生理盐水;L组尾静脉注射LPS 7.5mg·kg-1;LP组尾静脉注射LPS 7.5mg·kg-1,同时静脉注射丙泊酚30mg·kg-1。给药前及开始后第3、6和12h测定动脉血氧分压(PaO2),实验结束后观察肺湿/干重(W/D)比值、肺组织病理学检查并进行肺损伤轻重程度评分,同时观察各组大鼠肺组织高迁移率族蛋白1(HMGB-1)含量。结果实验前各组PaO2无明显差异,注射LPS后L组PaO2持续下降,和C组相比其PaO2显著降低(P<0.05)。实验结束后L组和C组相比其W/D比值、肺组织病理学检查评分、HO-1及HMGB-1含量显著增加(P<0.05)。而LP组和L组相比其PaO2显著改善,而W/D比值、肺组织病理学检查评分及HMGB-1含量显著降低(P<0.05)。结论丙泊酚具有肺保护作用,且该作用可能与其抑制HMGB-1过度表达作用相关。 展开更多
关键词 丙泊酚 急性肺损伤 高迁移率族蛋白-1 动物 实验 大鼠 HIGH MOBILITY group box-1
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超-π-Brauer特征标理论
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作者 钟艳林 郑秉文 《哈尔滨师范大学自然科学学报》 CAS 2014年第5期31-33,共3页
通过使用π-理论和p-Brauer特征标理论来建立超-π-Brauer特征标理论,得到一些结果并给出两个具有非平凡超-π-Brauer特征标理论的π-可分群的例子.
关键词 有限群 Π-可分群 超π-Brauer特征标
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SSH环境下的销售“3-1分栏报表”生成技术与算法研究
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作者 邓子云 杨晓峰 翦象慧 《西南科技大学学报》 CAS 2012年第3期97-101,共5页
针对某集团ERP系统SSH(Strust,Spring,Hibernate)环境下需要研发销售"3-1分栏报表"时遇到的数据操作过于频繁和算法复杂度太高的问题,给出了解决问题的思路,以业务员、区域、客户、产品系列4个分栏使用"Groupby"HQ... 针对某集团ERP系统SSH(Strust,Spring,Hibernate)环境下需要研发销售"3-1分栏报表"时遇到的数据操作过于频繁和算法复杂度太高的问题,给出了解决问题的思路,以业务员、区域、客户、产品系列4个分栏使用"Groupby"HQL语句生成List集合,再转换为二维字符串数组,进而给出了算法假设、设计和实现,最终生成数据矩阵,使复杂度降低为O(n3),经测试该方法比"通常方法"约快19倍。 展开更多
关键词 销售“3-1分栏报表” group by”HQL查询 开源框架技术SSH(Strust Spring Hibernate)
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Blood group type antigens in pancreatic intraductal papillary mucinous neoplasms 被引量:1
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作者 Adriana Handra-Luca 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2014年第1期74-80,共7页
BACKGROUND: There are few data on blood group(BG) types and types of pancreatic cancers. The aims of this study were to study BG types and BG-antigens in pancreatic intraductal papillary mucinous neoplasms(IPMNs). MET... BACKGROUND: There are few data on blood group(BG) types and types of pancreatic cancers. The aims of this study were to study BG types and BG-antigens in pancreatic intraductal papillary mucinous neoplasms(IPMNs). METHODS: BG type and tumor BG-antigen(glycoprotein) expression(studied by immunohistochemistry on tissue microarrays) were analyzed with regard to characteristics of 101 surgically resected pancreatic IPMNs. RESULTS: Non-O BG type predicted invasive carcinoma independently from high serum CA19-9 and male gender. BG type A was observed more frequently in women than in men. Chronic pancreatitis was more frequently seen in patients with BG type B or AB. Aberrant tumor expression(with regard to BG type) of loss of A antigen expression type occurred in 15.0% of IPMNs and of loss of B antigen expression type in 62.5% of IPMNs. Intraneoplasm BG-antigen expression was not related to dysplasia grade or invasion. CONCLUSION: The results of the study suggest that in pancreatic IPMN, non-O BG type predicted invasive carcinoma, whereas for intratumor BG-antigen expression no specific patterns were detected with regard to the progression of glandular epithelial dysplasia or invasion. 展开更多
关键词 blood group type blood group antigen IMMUNOHISTOCHEMISTRY CA19-9 PROGNOSIS invasive carcinoma PANCREAS intraductal papillary mucinous neoplasm
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SYNTHESIS AND CHARACTERIZATION OF POLY{4-[2-(tert-BUTYLDIMETHYLSILOXY)ETHYL]STYRENE}AND ITS HYDROLYSIS DERIVATIVE 被引量:1
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作者 郭文莉 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2009年第3期399-405,共7页
The living cationic polymerization of 4-[2-(tert-butyldimethylsiloxy)ethyl]styrene (TBDMES) was studied in methylcyclohexane (MeChx)/methylchloride (MeCl) (50/50 V/V) solvent mixture at -80 degrees C. The initiator 1,... The living cationic polymerization of 4-[2-(tert-butyldimethylsiloxy)ethyl]styrene (TBDMES) was studied in methylcyclohexane (MeChx)/methylchloride (MeCl) (50/50 V/V) solvent mixture at -80 degrees C. The initiator 1,1-diphenylethylene (DPE) capped 2-chloro-2,4,4-trimethylpentane (TMPCl) was formed in situ in conjunction with titanium tetrachloride (TiCl(4)). The Lewis acidity of TiCl(4) was decreased by the addition of titanium(IV) isopropoxide (Ti(OiPr)(4)) to accomplish living polymerization of TBDMES. Hydrolysis of poly(TBDMES) in the presence of tetra-butylammonium fluoride yielded poly[4-(2-hydroxyethyl)styrene] (poly(HOES)). FT-IR, NMR and DSC demonstrated the hydrolysis was complete. 展开更多
关键词 Living carbocationic polymerization Poly[4-(2-hydroxyethyl)styrene] HYDROLYSIS Pendant hydroxyl groups
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New Investigation on the Space Group of Chevkinite
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作者 Yang Guangming Pan Zhaolu Wu Xiuling Liu XiangwenChina University of Geosciences , Wuhan 430074 《Journal of Earth Science》 SCIE CAS CSCD 1991年第1期78-81,共4页
Chevkinite specimen from a rare-earth mineral deposit in Sichuan, southwest of China have been studied in detail by means of transmission electron microscope (TEM).The selected area electron diffraction (SAED)and conv... Chevkinite specimen from a rare-earth mineral deposit in Sichuan, southwest of China have been studied in detail by means of transmission electron microscope (TEM).The selected area electron diffraction (SAED)and convergent beam electron diffraction (CBED) patterns , obtained from different crystal zone axis direction , proved coincidently that the space group of chevkinite is C2/m . Fringe lattice image observation showed the mineral crystal is structurally uniform in microscale , and it is an ideal specimen for electron diffraction analysis . The mineral studied here is similar to the one from Bayan Obo , Inner Mongolia , China , in chemical composition and REE distribution . The chemical formula of the crystal is (Ce , La ,… , Ca) 4 Fe2+ (Fe, Ti, Nb) 2 O8 (Si2O7)2 From our study , we come to the conclusion that the space group of the natural chevkinite is C2/m , instead of P21/a as synthetic one . Up to now , chevkinite compositionally similar to the synthetic one , in which the complete replacements of Ce , La by Nd and Fe by Mg or Co occur , has not been discovered in nature . So we suggest that the name for synthesized chevkinite should be further discussed . 展开更多
关键词 chevkinite space group - C2/m SAED CBED fringe lattice image
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STUDY ON PERSISTENT INFECTION OF COXSACKIEVIRUSGROUP B IN MURINE MODEL OF CHRONICVIRAL MYOCARDITIS
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作者 陈忠明 刘晶星 +3 位作者 陆德源 朱莉 王灵枢 姚季生 《Medical Bulletin of Shanghai Jiaotong University》 CAS 1999年第1期11-15,共5页
Objective To investigate the dynamic change of coxsackievirus B3 (CVB3) in murine model ofchronic myocarditis and revel the molecular mechanism of the persistent infection of the tirus.Methods Strand - specific RT- PC... Objective To investigate the dynamic change of coxsackievirus B3 (CVB3) in murine model ofchronic myocarditis and revel the molecular mechanism of the persistent infection of the tirus.Methods Strand - specific RT- PCR(ssRT- PCR), quantitative RT- PCR (qRT - PCR) and multiplexRT- PCR(mRT- PCR). Results The positive strand of CVB3 RNA existed in heart tissue up to 3 monthsalthough its amount decreased by 103~4 folds from acute to chronic phase. The negative strand RNA for virusreplication kept its amount on la moleculars per gram heart tissue. Some conserved areas of virus RNA 5’NTRand 3’NTR were lost in chronic phase. Conclusion The virus kept replication during the whole phase ofmyocarditis and speeded down on chronic period in the status of persistent infection. That may be due to theterminal lose of CVB RNA. 展开更多
关键词 coxsackievirus B group CHRONIC VIRAL MYOCARDITIS PERSISTENT infectionstrand - specific RT- PCR quantitative RT - PCR multiplex RT - PCR
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The Tate Kernel of the Number Field Q (-3)
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作者 Sun Ailing 《Journal of Southeast University(English Edition)》 EI CAS 1998年第1期134-136,共3页
A complete characterization of Tate kernel of the number field Q (-3) is given.Our method can also be used in other fields.
关键词 number field Q (-3) Tate kernel K 2 group
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A NEW POLYMER-BOUND 1,2-DIOL AS A PROTECTING AGENT FOR SYMMETRICAL DIALDEHYDE
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作者 任启生 黄文强 +1 位作者 赵芬芝 何炳林 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1989年第4期346-353,共8页
A novel polymer-bound 1,2-diol, 3-polystyrylsulfonyl-1,2-propanediol (6) had been prepared by the reaction of sodium polystyrylsulfinate with allyl bromide, followed by oxidation and. hydrolysis or directly with 3-chl... A novel polymer-bound 1,2-diol, 3-polystyrylsulfonyl-1,2-propanediol (6) had been prepared by the reaction of sodium polystyrylsulfinate with allyl bromide, followed by oxidation and. hydrolysis or directly with 3-chloro-1,2-propanediol in the presence of a phase transfer catalyst, n-tetrabutylammonium iodide. The capacity of resin 6 for terephthaidehyde reached 1.43 mmol/g. The aldehydic groups attached to polymer 6 reacted with hydroxylamine hydrochloride or reduced by sodium borohydride giving p-formylbenzaldoxime (yield: 89%)and p-formyl-benzalcohol (yield: 734%), respectively. The high yields of these polymer-supported reactions showed that the polymer 6 possessed the effective isolation of its reactive sites. 展开更多
关键词 3-polystyrylsulfonyl-1 2 - propanediol polymer-supported protecting group solid - phase organic synthesis cleavage of aldol linkages
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STUDIES ON ORGANIC PEROXIDE/N, NDI(2-α-METHYL-ACRYLOYLOXY PROPYL)-PARA-TOLUIDINE BINARY SYSTEMS
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作者 丘坤元 傅杰 +1 位作者 郭新秋 冯新德 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1990年第2期188-195,共8页
The polymerization of methyl methacrylate (MMA) initiated by organic peroxide and polymerizable aromatic tertiary amine such as N, N-di (2-α-methylacryloyloxy propyl)-p-toluidine (MP)_2PT binary system has been studi... The polymerization of methyl methacrylate (MMA) initiated by organic peroxide and polymerizable aromatic tertiary amine such as N, N-di (2-α-methylacryloyloxy propyl)-p-toluidine (MP)_2PT binary system has been studied. It was found that the (MP)_2PT promotes MMA polymerization, and the kinetics of MMA polymerization fits the radical polymerization rate equation. Based on the ESR studies and the end-group analysis the initiation mechanism is proposed. 展开更多
关键词 Organic peroxide N N-Di(2-α-methylacryloyloxy-propyl)-p-toluidine Redox initiation system MMA polymerization ESR End group analysis.
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Influence of functional groups on the self-assembly of liquid crystals 被引量:1
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作者 Shanchao Tan Jiayu Tao +5 位作者 Wendi Luo Hao Jiang Yuhong Liu Haijun Xu Qjngdao Zeng Hongyu Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第3期1149-1152,共4页
Functional groups in the molecule play an important role in the molecular o rganization process.To reveal the influence of functional groups on the self-assembly at interface,herein,the self-assembly structures of thr... Functional groups in the molecule play an important role in the molecular o rganization process.To reveal the influence of functional groups on the self-assembly at interface,herein,the self-assembly structures of three liquid crystal molecules,which only differ in the functional groups,are explicitly characterized by using scanning tunneling microscopy(STM).The high-resolution STM images demonstrate the difference between the supramolecular assembly structures of three liquid crystal molecules,which attribute to the hydrogen bonding interaction andπ-πstacking interaction between different functional groups.The density functional theory(DFT)results also confirm the influence of these functional groups on the self-assemblies.The effort on the self-assembly of liquid crystal molecules at interface could enhance the understanding of the supramolecular assembly mechanism and benefit the further application of liquid crystals. 展开更多
关键词 SELF-ASSEMBLY Liquid crystal Functional group Hydrogen bond π-πStacking interaction
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Studies on the combinatorial modifications with two amino groups on the catalytic core of 10-23 DNAzyme
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作者 李朋羽 李志文 +1 位作者 王琦 何军林 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2017年第12期851-857,共7页
As a small catalytic DNA molecule, 10-23 DNAzyme has cleavage ability against complementary RNA. Previous studies of chemical modification have shown that its catalytic core can be further optimized in order to obtain... As a small catalytic DNA molecule, 10-23 DNAzyme has cleavage ability against complementary RNA. Previous studies of chemical modification have shown that its catalytic core can be further optimized in order to obtain more powerful catalytic ability. The analogues of 2'-deoxyadenosine (5) and 2'-deoxyguanosine (6) could improve the cleavage ability of the DNAzyme when positioned at positions A9, (32 and G14 in the catalytic core, respectively. Moreover, their combinatorial incorporations were studied, the results implicated that the effect was position-dependent, and positive additive results could be achieved at some positions. The highly conserved G1, G2 and G14 could be optimized by single or combinatorial modification with 2'-deoxyguanosine analogues. Chemical modifications on the functional groups of the core residues would be a feasible approach for the optimization of 10-23 DNAzyme. 展开更多
关键词 10-23 DNAzyme Chemical modification Amino group Nucleoside analogues Observed rate constant
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Minimal inner-Σ-Ω-groups and their applications
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作者 LI XianHua XU Yong 《Science China Mathematics》 SCIE 2011年第9期1927-1936,共10页
We introduce and study the minimal inner-Σ-Ω-groups and the minimal outer-Σ-■-groups.Then we give some applications and obtain some interesting results,including characterizations of nilpotent,supersolvable,solvab... We introduce and study the minimal inner-Σ-Ω-groups and the minimal outer-Σ-■-groups.Then we give some applications and obtain some interesting results,including characterizations of nilpotent,supersolvable,solvable,and p-closed groups in terms of the join of two conjugate cyclic subgroups having the same property. 展开更多
关键词 nilpotent subgroup supersolvable subgroup a pair of conjugate subgroups minimal inner--Ω- group
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The effect of OH^(-) groups on the spectroscopic properties of erbium-doped tellurite glasses
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作者 YU Chunlei DAI Shixun +3 位作者 ZHOU Gang ZHANG Junjie HU Lili JIANG Zhonghong 《Science China(Technological Sciences)》 SCIE EI CAS 2005年第6期638-647,共10页
A series of five different concentration erbium-doped tellurite glasses with various hydroxl groups were prepared. Infrared spectra of glasses were measured. In order to estimate the exact content of OH? groups in sam... A series of five different concentration erbium-doped tellurite glasses with various hydroxl groups were prepared. Infrared spectra of glasses were measured. In order to estimate the exact content of OH? groups in samples, various absorption coefficients of the OH? vibration band were analyzed under the different oxygen bubbling times. The absorption spectra of the glasses were measured, and the Judd-Ofelt intensity parameters Ω i of samples with the different erbium ions concentration and OH? contents were calculated on the basis of the Judd-Ofelt theory. The peak stimulated emission cross-section of 4|13/2→4|15/2 transition of the samples was finally calculated by using the McCumber theory. The fluorescence spectra of Er3+:4|13/2→4|15/2 transition and the lifetime of Er3+:4|13/2 level of the samples were measured. The effects of OH? groups on the spectroscopic properties of Er3+ doped samples with the different concentrations were discussed. The results showed that the OH? groups had great influences on the Er3+ lifetime and the fluorescence peak intensity. The OH? group is a main influence factor of fluorescence quenching when the doping concentration of Er2O3 is smaller than 1.0 mol%, but higher after this concentration, the energy transfer of Er3+ ions turns into the main function of the fluorescence quenching. And basically, there is no influence on the other spectroscopic properties (FWHM, absorption spectra, peak stimulated emission cross section, etc.). 展开更多
关键词 OH^(-)groups tellurite glasses erbium ions spectroscopic properties
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