The human UDP-glucuronosyltransferase 1A1(UGT1A1),one of the most essential conjugative enzymes,is responsible for the metabolism and detoxification of bilirubin and other endogenous substances,as well as many differe...The human UDP-glucuronosyltransferase 1A1(UGT1A1),one of the most essential conjugative enzymes,is responsible for the metabolism and detoxification of bilirubin and other endogenous substances,as well as many different xenobiotic compounds.Deciphering UGT1A1 relevance to human diseases and characterizing the effects of small molecules on the activities of UGT1A1 requires reliable tools for probing the function of this key enzyme in complex biological matrices.Herein,an easy-to-use assay for highly-selective and sensitive monitoring of UGT1A1 activities in various biological matrices,using liquid chromatography with fluorescence detection(LC-FD),has been developed and validated.The newly developed LC-FD based assay has been confirmed in terms of sensitivity,specificity,precision,quantitative linear range and stability.One of its main advantages is lowering the limits of detection and quantification by about 100-fold in comparison to the previous assay that used the same probe substrate,enabling reliable quantification of lower amounts of active enzyme than any other method.The precision test demonstrated that both intra-and inter-day variations for this assay were less than 5.5%.Furthermore,the newly developed assay has also been successfully used to screen and characterize the regulatory effects of small molecules on the expression level of UGT1A1 in living cells.Ove rall,an easy-to-use LC-FD based assay has been developed for ultra-sensitive UGT1A1 activities measurements in various biological systems,providing an inexpensive and practical approach for exploring the role of UGT1A1 in human diseases,interactions with xenobiotics,and characterization modulatory effects of small molecules on this conjugative enzyme.展开更多
In this paper, the design and verification process of an automobile-engine-fan control system on chip （SoC） are introduced. The SoC system, SHU-MV08, reuses four new intellectual property （IP） cores and the design...In this paper, the design and verification process of an automobile-engine-fan control system on chip （SoC） are introduced. The SoC system, SHU-MV08, reuses four new intellectual property （IP） cores and the design flow is accomplished with 0.35 btm chartered CMOS technology. Some special functions of IP cores, the detailed integration scheme of four IP cores, and the verification method of the entire SoC are presented. To settle the verification problems brought by analog IP cores, NanoSim based chip-level mixed-signal verification method is introduced. The verification time is greatly reduced and the first tape-out achieves success which proves the validity of our design.展开更多
We investigate the structure of rings over which every finitely generated g- supplemented module is supplemented. Some characterizations of this type of rings are given. We establishe some properties of ⊙-δ-suppleme...We investigate the structure of rings over which every finitely generated g- supplemented module is supplemented. Some characterizations of this type of rings are given. We establishe some properties of ⊙-δ-supplemented modules. It is showed that for a ring R, finitely generated δ-supplemented R-modules are supplemented if and only if finitely generated ⊙-δ-supplemented R-modules are ⊙-supplemented.展开更多
In this paper we introduce the notion of relative syzygy modules. We then study the extension closure of the category of modules consisting of relative syzygy modules (resp. relative к-torsionfree modules).
一、2014年正式实施的2项国家标准
1.GB/T 29848-2013光伏组件封装用乙烯-醋酸乙烯酯共聚物（EVA）胶膜,2014年4月15日实施。英文名称：Ethylene-vinyl acetate copolymer（EVA）film for encapsulant solar module。
Silicon photonics has become very popular because of their compatibility with mature CMOS technologies. However, pure silicon is still very difficult to be utilized to obtain various photonic functional devices for la...Silicon photonics has become very popular because of their compatibility with mature CMOS technologies. However, pure silicon is still very difficult to be utilized to obtain various photonic functional devices for large-scale photonic integration due to intrinsic properties. Silicon-plus photonics, which pluses other materials to break the limitation of silicon, is playing a very important role currently and in the future. In this paper, we give a review and discussion on the progresses of siliconplus photonics, including the structures, devices and applications.展开更多
This paper describes a low-power low-cost 24-bit ∑-△ digital-to-analog converter （DAC） for portable digital-audio applications. The interpolation filter uses a no-multiplier scheme to implement the arithmetic unit...This paper describes a low-power low-cost 24-bit ∑-△ digital-to-analog converter （DAC） for portable digital-audio applications. The interpolation filter uses a no-multiplier scheme to implement the arithmetic units and reading-writing common storage scheme for the delay-line to significantly reduce the die area. A 15-level quantizer, third-order, single-stage ∑-△ modulator is employed to reduce the passband quantization noise, relax the out-of-band filtering requirements, and enhance immunity to clock jitter. A data weighted averaging algorithm is used to mitigate the nonlinearity caused by capacitor mismatch. A direct charge transfer switched-capacitor low-pass filter （DCT-SC LPF） is used to reconstruct the analog signal to reduce the kTIC noise and capacitor mismatch effect with a small increase of the power dissipation. The chip was fabricated in the SMIC 0.13 μm 1P5M CMOS process. The cell area of the digital part is 0.056 mm^2 and the total area of the analog part is 0.34 mm^2. The supply voltage is 1.2 V for the digital circuit and 3.3 V for the analog circuit. The power consumption of the analog part is 3.5 mW. The audio DAC achieves a 100 dB dynamic range and an 84 dB peak signal-to-noise-plus-distortion ratio over a 20 kHz passband. The results show that these performances are good enough for high quality portable audio applications.展开更多
This paper describes a 4 GHz fractional-N frequency synthesizer for a 3.1 to 5 GHz IR-UWB transceiver. Designed in a 0.18μm mixed-signal ＆ RF 1P6M CMOS process, the operating range of the synthesizer is 3.74 to 4.44...This paper describes a 4 GHz fractional-N frequency synthesizer for a 3.1 to 5 GHz IR-UWB transceiver. Designed in a 0.18μm mixed-signal ＆ RF 1P6M CMOS process, the operating range of the synthesizer is 3.74 to 4.44 GHz. By using an 18-bit third-order ∑-△ modulator, the synthesizer achieves a frequency resolution of 15 Hz when the reference frequency is 20 MHz. The measured amplitude mismatch and phase error between I and Q signals are less than 0.1 dB and 0.8° respectively. The measured phase noise is -116 dBc/Hz at 3 MHz offset for a 4 GHz output. Measured spurious tones are lower than -60 dBc. The settling time is within 80°s. The core circuit conupSigmaes only 38.2 mW from a 1.8 V power supply.展开更多
A multi-bit quantized high performance sigma-delta（Σ-Δ） audio DAC is presented.Compared to its singlebit counterpart,the multi-bit quantization offers many advantages,such as simplerΣ-Δmodulator circuit,lower cl...A multi-bit quantized high performance sigma-delta（Σ-Δ） audio DAC is presented.Compared to its singlebit counterpart,the multi-bit quantization offers many advantages,such as simplerΣ-Δmodulator circuit,lower clock frequency and smaller spurious tones.With the data weighted average（DWA） mismatch shaping algorithm,element mismatch errors induced by multi-bit quantization can be pushed out of the signal band,hence the noise floor inside the signal band is greatly lowered.To cope with the crosstalk between digital and analog circuits,every analog component is surrounded by a guard ring,which is an innovative attempt.The 18-bit DAC with the above techniques,which is implemented in a 0.18μm mixed-signal CMOS process,occupies a core area of 1.86 mm^2.The measured dynamic range（DR） and peak SNDR are 96 dB and 88 dB,respectively.展开更多
基金finically supported by the NSF of China(81773687,81922070,81973286,81703604)the National Key Research and Development Program of China(2017YFC1700200,2017YFC1702000)+5 种基金the Open Project Program of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica(No.JKLPSE-201803)the Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)Program of Shanghai Academic/Technology Research Leader(18XD1403600)Drug Innovation Major Project(2018ZX09731016)Shuguang Program(18SG40)supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commissionthe Graduate Innovation Project of Shanghai University of Traditional Chinese Medicine(Y2019063)。
文摘The human UDP-glucuronosyltransferase 1A1(UGT1A1),one of the most essential conjugative enzymes,is responsible for the metabolism and detoxification of bilirubin and other endogenous substances,as well as many different xenobiotic compounds.Deciphering UGT1A1 relevance to human diseases and characterizing the effects of small molecules on the activities of UGT1A1 requires reliable tools for probing the function of this key enzyme in complex biological matrices.Herein,an easy-to-use assay for highly-selective and sensitive monitoring of UGT1A1 activities in various biological matrices,using liquid chromatography with fluorescence detection(LC-FD),has been developed and validated.The newly developed LC-FD based assay has been confirmed in terms of sensitivity,specificity,precision,quantitative linear range and stability.One of its main advantages is lowering the limits of detection and quantification by about 100-fold in comparison to the previous assay that used the same probe substrate,enabling reliable quantification of lower amounts of active enzyme than any other method.The precision test demonstrated that both intra-and inter-day variations for this assay were less than 5.5%.Furthermore,the newly developed assay has also been successfully used to screen and characterize the regulatory effects of small molecules on the expression level of UGT1A1 in living cells.Ove rall,an easy-to-use LC-FD based assay has been developed for ultra-sensitive UGT1A1 activities measurements in various biological systems,providing an inexpensive and practical approach for exploring the role of UGT1A1 in human diseases,interactions with xenobiotics,and characterization modulatory effects of small molecules on this conjugative enzyme.
基金Project supported by the IC Special Foundation of Shanghai Municipal Commission of Science and Technology (Grant No.09706201300)the Shanghai Municipal Commission of Economic and Information (Grant No.090344)the Shanghai High-Tech Industrialization of New Energy Vehicles (Grant No.09625029),and the Graduate Innovation Foundation of Shanghai University
文摘In this paper, the design and verification process of an automobile-engine-fan control system on chip （SoC） are introduced. The SoC system, SHU-MV08, reuses four new intellectual property （IP） cores and the design flow is accomplished with 0.35 btm chartered CMOS technology. Some special functions of IP cores, the detailed integration scheme of four IP cores, and the verification method of the entire SoC are presented. To settle the verification problems brought by analog IP cores, NanoSim based chip-level mixed-signal verification method is introduced. The verification time is greatly reduced and the first tape-out achieves success which proves the validity of our design.
文摘We investigate the structure of rings over which every finitely generated g- supplemented module is supplemented. Some characterizations of this type of rings are given. We establishe some properties of ⊙-δ-supplemented modules. It is showed that for a ring R, finitely generated δ-supplemented R-modules are supplemented if and only if finitely generated ⊙-δ-supplemented R-modules are ⊙-supplemented.
基金The author was partially supported by the National Natural Science Foundation of China(Grant No.10001017)Scientifc Research Foundation for Returned Overseas Chinese Scholars(State Education Ministry) Nanjing University Talent Development Foundation.
文摘In this paper we introduce the notion of relative syzygy modules. We then study the extension closure of the category of modules consisting of relative syzygy modules (resp. relative к-torsionfree modules).
文摘一、2014年正式实施的2项国家标准
1.GB/T 29848-2013光伏组件封装用乙烯-醋酸乙烯酯共聚物（EVA）胶膜,2014年4月15日实施。英文名称：Ethylene-vinyl acetate copolymer（EVA）film for encapsulant solar module。
基金Acknowledgements This work was supported partially by the National Natural Science Foundation of China （Grant Nos. 61422510, 11374263 and 61431166001 ）, the Doctoral Fund of Ministry of Education of China （No. 20120101110094）, the Fundamental Research Funds for the Central Universities,
文摘Silicon photonics has become very popular because of their compatibility with mature CMOS technologies. However, pure silicon is still very difficult to be utilized to obtain various photonic functional devices for large-scale photonic integration due to intrinsic properties. Silicon-plus photonics, which pluses other materials to break the limitation of silicon, is playing a very important role currently and in the future. In this paper, we give a review and discussion on the progresses of siliconplus photonics, including the structures, devices and applications.
文摘This paper describes a low-power low-cost 24-bit ∑-△ digital-to-analog converter （DAC） for portable digital-audio applications. The interpolation filter uses a no-multiplier scheme to implement the arithmetic units and reading-writing common storage scheme for the delay-line to significantly reduce the die area. A 15-level quantizer, third-order, single-stage ∑-△ modulator is employed to reduce the passband quantization noise, relax the out-of-band filtering requirements, and enhance immunity to clock jitter. A data weighted averaging algorithm is used to mitigate the nonlinearity caused by capacitor mismatch. A direct charge transfer switched-capacitor low-pass filter （DCT-SC LPF） is used to reconstruct the analog signal to reduce the kTIC noise and capacitor mismatch effect with a small increase of the power dissipation. The chip was fabricated in the SMIC 0.13 μm 1P5M CMOS process. The cell area of the digital part is 0.056 mm^2 and the total area of the analog part is 0.34 mm^2. The supply voltage is 1.2 V for the digital circuit and 3.3 V for the analog circuit. The power consumption of the analog part is 3.5 mW. The audio DAC achieves a 100 dB dynamic range and an 84 dB peak signal-to-noise-plus-distortion ratio over a 20 kHz passband. The results show that these performances are good enough for high quality portable audio applications.
基金supported by the National High Technology Research and Development Program of China(No.2007AA01Z2b2).
文摘This paper describes a 4 GHz fractional-N frequency synthesizer for a 3.1 to 5 GHz IR-UWB transceiver. Designed in a 0.18μm mixed-signal ＆ RF 1P6M CMOS process, the operating range of the synthesizer is 3.74 to 4.44 GHz. By using an 18-bit third-order ∑-△ modulator, the synthesizer achieves a frequency resolution of 15 Hz when the reference frequency is 20 MHz. The measured amplitude mismatch and phase error between I and Q signals are less than 0.1 dB and 0.8° respectively. The measured phase noise is -116 dBc/Hz at 3 MHz offset for a 4 GHz output. Measured spurious tones are lower than -60 dBc. The settling time is within 80°s. The core circuit conupSigmaes only 38.2 mW from a 1.8 V power supply.
文摘A multi-bit quantized high performance sigma-delta（Σ-Δ） audio DAC is presented.Compared to its singlebit counterpart,the multi-bit quantization offers many advantages,such as simplerΣ-Δmodulator circuit,lower clock frequency and smaller spurious tones.With the data weighted average（DWA） mismatch shaping algorithm,element mismatch errors induced by multi-bit quantization can be pushed out of the signal band,hence the noise floor inside the signal band is greatly lowered.To cope with the crosstalk between digital and analog circuits,every analog component is surrounded by a guard ring,which is an innovative attempt.The 18-bit DAC with the above techniques,which is implemented in a 0.18μm mixed-signal CMOS process,occupies a core area of 1.86 mm^2.The measured dynamic range（DR） and peak SNDR are 96 dB and 88 dB,respectively.
