目的探讨冠心病(coronary heart disease,CHD)患者血清转化生长因子-β_(1)(transforming growth factor-β_(1),TGF-β_(1))、氨基末端B型脑钠肽前体(nitrogen terminal B type natriuretic peptide precursor,NT-proBNP)水平对冠状动...目的探讨冠心病(coronary heart disease,CHD)患者血清转化生长因子-β_(1)(transforming growth factor-β_(1),TGF-β_(1))、氨基末端B型脑钠肽前体(nitrogen terminal B type natriuretic peptide precursor,NT-proBNP)水平对冠状动脉病变严重程度的影响。方法选取2019年7月—2022年6月在山东省潍坊市第二人民医院心内科诊治的85例CHD患者作为观察组,同期健康体检者39名作为对照组。均采用双抗体夹心酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)法检测TGF-β_(1);采用电化学发光法检测NT-proBNP。比较2组患者生化指标、血清TGF-β_(1)、NTproBNP水平,以及观察组冠状动脉病变不同程度时血清TGF-β_(1)、NT-proBNP水平,分析评估血清TGF-β_(1)、NTproBNP诊断CHD的价值。结果2组三酰甘油(triacylglycerol,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)比较,差异无统计学意义(P>0.05)。观察组TGF-β_(1)为(326.04±181.75)ng/L,低于对照组的(926.42±156.47)ng/L,观察组血清NT-proBNP为(134.94±22.16)pg/mL,高于对照组的(65.25±3.35)pg/mL,差异有统计学意义(P<0.01)。单支血管病变血清TGF-β_(1)高于两支血管病变、多支血管病变,差异有统计学意义(P<0.01);单支血管病变NTproBNP低于两支血管病变、多支血管病变,差异有统计学意义(P<0.01)。结论观察组血清TGF-β_(1)水平降低,NTproBN水平升高,与冠状动脉病变严重程度密切相关,两者联合检测可作为CHD早期诊断、病情评估的检测指标。展开更多
The environmentally friendly Cu_(2)ZnSn(S,Se)_(4)(CZTSSe) compounds are promising direct bandgap materials for application in thin film solar cells, but the spontaneous surface defects disordering would lead to large ...The environmentally friendly Cu_(2)ZnSn(S,Se)_(4)(CZTSSe) compounds are promising direct bandgap materials for application in thin film solar cells, but the spontaneous surface defects disordering would lead to large open-circuit voltage deficit(V_(oc,deficit)) and significantly limit kesterite photovoltaics performance,primarily arising from the generated more recombination centers and insufficient p to n conversion at p-n junction. Herein, we establish a surface defects ordering structure in CZTSSe system via local substitution of Cu by Ag to suppress disordered Cu_(Zn) defects and generate benign n-type Zn_(Ag) donors. Taking advantage of the decreased annealing temperature of Ag F post deposition treatment(PDT), the high concentration of Ag incorporated into surface absorber facilitates the formation of surface ordered defect environment similar to that of efficient CIGS PV. The manipulation of highly doped surface structure could effectively reduce recombination centers, increase depletion region width and enlarge the band bending near p-n junction. As a result, the Ag F-PDT device finally achieves maximum efficiency of 12.34% with enhanced V_(oc) of 0.496 V. These results offer a new solution route in surface defects and energy-level engineering, and open the way to build up high quality p-n junction for future development of kesterite technology.展开更多
Photo-generated carrier recombination loss at the CZTSSe/Cd S front interface is a key issue to the opencircuit voltage(V_(OC)) deficit of Cu_(2)ZnSnS_(x)Se_(4-x)(CZTSSe) solar cells. Here, by the aid of an easy-handl...Photo-generated carrier recombination loss at the CZTSSe/Cd S front interface is a key issue to the opencircuit voltage(V_(OC)) deficit of Cu_(2)ZnSnS_(x)Se_(4-x)(CZTSSe) solar cells. Here, by the aid of an easy-handling spin-coating method, a thin PCBM([6,6]-phenyl-C61-butyric acid methyl ester) layer as an electron extraction layer has been introduced on the top of CdS buffer layer to modify CZTSSe/CdS/ZnO-ITO(In_(2)O_(3):Sn) interfacial properties. Based on Sn^(4+)/DMSO(dimethyl sulfoxide) solution system, a totalarea efficiency of 12.87% with a VOC of 529 m V has been achieved. A comprehensive investigation on the influence of PCBM layer on carrier extraction, transportation and recombination processes has been carried out. It is found that the PCBM layer can smooth over the Cd S film roughness, thus beneficial for a dense and flat window layer. Furthermore, this CZTSSe/Cd S/PCBM heterostructure can accelerate carrier separation and extraction and block holes from the front interface as well, which is mainly ascribed to the downward band bending of the absorber and a widened space charge region. Our work provides a feasible way to improve the front interfacial property and the cell performance of CZTSSe solar cells by the aid of organic interfacial materials.展开更多
文摘目的探讨冠心病(coronary heart disease,CHD)患者血清转化生长因子-β_(1)(transforming growth factor-β_(1),TGF-β_(1))、氨基末端B型脑钠肽前体(nitrogen terminal B type natriuretic peptide precursor,NT-proBNP)水平对冠状动脉病变严重程度的影响。方法选取2019年7月—2022年6月在山东省潍坊市第二人民医院心内科诊治的85例CHD患者作为观察组,同期健康体检者39名作为对照组。均采用双抗体夹心酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)法检测TGF-β_(1);采用电化学发光法检测NT-proBNP。比较2组患者生化指标、血清TGF-β_(1)、NTproBNP水平,以及观察组冠状动脉病变不同程度时血清TGF-β_(1)、NT-proBNP水平,分析评估血清TGF-β_(1)、NTproBNP诊断CHD的价值。结果2组三酰甘油(triacylglycerol,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)比较,差异无统计学意义(P>0.05)。观察组TGF-β_(1)为(326.04±181.75)ng/L,低于对照组的(926.42±156.47)ng/L,观察组血清NT-proBNP为(134.94±22.16)pg/mL,高于对照组的(65.25±3.35)pg/mL,差异有统计学意义(P<0.01)。单支血管病变血清TGF-β_(1)高于两支血管病变、多支血管病变,差异有统计学意义(P<0.01);单支血管病变NTproBNP低于两支血管病变、多支血管病变,差异有统计学意义(P<0.01)。结论观察组血清TGF-β_(1)水平降低,NTproBN水平升高,与冠状动脉病变严重程度密切相关,两者联合检测可作为CHD早期诊断、病情评估的检测指标。
基金supported by the National Natural Science Foundation of China(61874159,62074052,61974173,52072327,51702085 and 51802081)the Joint Talent Cultivation Funds of NSFC-HN(U1704151 and U1904192)+1 种基金the Zhongyuan Thousand Talents(Zhongyuan Scholars)Program of Henan Province(202101510004)the Science and Technology Innovation Talents in Universities of Henan Province(21HASTIT023)。
文摘The environmentally friendly Cu_(2)ZnSn(S,Se)_(4)(CZTSSe) compounds are promising direct bandgap materials for application in thin film solar cells, but the spontaneous surface defects disordering would lead to large open-circuit voltage deficit(V_(oc,deficit)) and significantly limit kesterite photovoltaics performance,primarily arising from the generated more recombination centers and insufficient p to n conversion at p-n junction. Herein, we establish a surface defects ordering structure in CZTSSe system via local substitution of Cu by Ag to suppress disordered Cu_(Zn) defects and generate benign n-type Zn_(Ag) donors. Taking advantage of the decreased annealing temperature of Ag F post deposition treatment(PDT), the high concentration of Ag incorporated into surface absorber facilitates the formation of surface ordered defect environment similar to that of efficient CIGS PV. The manipulation of highly doped surface structure could effectively reduce recombination centers, increase depletion region width and enlarge the band bending near p-n junction. As a result, the Ag F-PDT device finally achieves maximum efficiency of 12.34% with enhanced V_(oc) of 0.496 V. These results offer a new solution route in surface defects and energy-level engineering, and open the way to build up high quality p-n junction for future development of kesterite technology.
基金supported by the National Natural Science Foundation of China(U2002216,52172261,51627803,51972332,22075150,and U1902218)the National Key Research and Development Program of China(2019YFE0118100)。
文摘Photo-generated carrier recombination loss at the CZTSSe/Cd S front interface is a key issue to the opencircuit voltage(V_(OC)) deficit of Cu_(2)ZnSnS_(x)Se_(4-x)(CZTSSe) solar cells. Here, by the aid of an easy-handling spin-coating method, a thin PCBM([6,6]-phenyl-C61-butyric acid methyl ester) layer as an electron extraction layer has been introduced on the top of CdS buffer layer to modify CZTSSe/CdS/ZnO-ITO(In_(2)O_(3):Sn) interfacial properties. Based on Sn^(4+)/DMSO(dimethyl sulfoxide) solution system, a totalarea efficiency of 12.87% with a VOC of 529 m V has been achieved. A comprehensive investigation on the influence of PCBM layer on carrier extraction, transportation and recombination processes has been carried out. It is found that the PCBM layer can smooth over the Cd S film roughness, thus beneficial for a dense and flat window layer. Furthermore, this CZTSSe/Cd S/PCBM heterostructure can accelerate carrier separation and extraction and block holes from the front interface as well, which is mainly ascribed to the downward band bending of the absorber and a widened space charge region. Our work provides a feasible way to improve the front interfacial property and the cell performance of CZTSSe solar cells by the aid of organic interfacial materials.
