To study the antifungal effect of chalcone derivatives. Methods Sixteenchalcone derivatives were synthesized and confirmed by ~1H NMR and IR spectra, and tested forantifungal activity against four common pathogenic fu...To study the antifungal effect of chalcone derivatives. Methods Sixteenchalcone derivatives were synthesized and confirmed by ~1H NMR and IR spectra, and tested forantifungal activity against four common pathogenic fungi. Their structure-activity relationship isdiscussed. Results Among 16 title compounds, there were 5 new compounds, which have not beenreported before. The preliminary antifungal test showed that all title compounds exhibitedantifungal activities to a certain extent. The activity of compound 8 against Trichophyton rubrumhad a potency equal to that of fluconazole, with a MIC of 4 μg·mL^(-1) . Conclusion Sixteenchalcones were prepared and their antifungal activities against four common pathogenic fungi invitro were examined. Some of them exhibited antifungal activities to a certain extent.展开更多
Objective： To systematically evaluate the effectiveness of Kangfuxin Fluid （KFX） in Ulcerative Colitis （UC） with retention enema. Methods： We searched The Cochanrane Library, Pubmed, EMbase, VIP, CNKI, ...Objective： To systematically evaluate the effectiveness of Kangfuxin Fluid （KFX） in Ulcerative Colitis （UC） with retention enema. Methods： We searched The Cochanrane Library, Pubmed, EMbase, VIP, CNKI, CBM and WanFang Data from inception to December.2017, and retrospectively incorporated into the literature reference. And a systematic review of randomized controlled trials was performed. Meta-analysis was performed with RevMan5.3 software. Results： A total of 18 randomized controlled trials and 1417 patients were enrolled, among which 731 cases were in experimental group and 686 cases were in control group. The meta-analysis results revealed that the effectiveness of KFX on UC with retention enema was significantly superior to the controlled treatment （RR=1.22 95%CI： [1.16,1.27], Z=8.14, p〈0.00001）. And, the score of quality of life was significantly increased after KFX treatment （MD=11.12, 95% CI [7.00, 15.23], Z=5.30, p〈0.00001）. Conclusion： KFX on the treatment of UC with retention enema is potentially effective to improve patient＇s quality of life, and it is worth being popularized clinically. Depth researches and high quality randomized controlled trials on the efficacy of UC are necessary.展开更多
After announcing the goal of building a moderately prosperous society in all respects by 2020, the Chinese leadership also called for a new path of industrialization, putting a premium on quality and new development c...After announcing the goal of building a moderately prosperous society in all respects by 2020, the Chinese leadership also called for a new path of industrialization, putting a premium on quality and new development concepts. Unlike traditional industrialization in the broad or narrow sense, new-type industrialization features synergy between primary, secondary, and tertiary industries, integration between traditional economy and the new economy, environmental protection, technology progress, and innovation. It represents an inclusive approach to industrial development. At the fundamental level, the success of China’s new-type industrialization can be attributed to China’s inclusive learning and innovations.展开更多
32 cases of the third lumbar transverse process syndrome were treated mainly byelectroacupuncture at Huatuojiaji points of the first and second lumbar vertebrae, andanother 30 cases of the syndrome by conventional acu...32 cases of the third lumbar transverse process syndrome were treated mainly byelectroacupuncture at Huatuojiaji points of the first and second lumbar vertebrae, andanother 30 cases of the syndrome by conventional acupuncture as the controls. The resultsshowed that treatment by electroacupuncture at Huatuojiaji points was superior inanalgesic effect and clinical total effective rate to that by conventional acupuncture. It isconsidered that the mechanism of treatment by electroacupuncture at Huatuojiaji pointsis related to the trunk of posterior ramus of the spinal nerve where the points are located.展开更多
Focusing on the reform initiatives of Chinese Academy of Medical Sciences(CAMS) & Peking Union Medical College(PUMC) in medical scientific and technological innovation from perspectives of deepening the reform and...Focusing on the reform initiatives of Chinese Academy of Medical Sciences(CAMS) & Peking Union Medical College(PUMC) in medical scientific and technological innovation from perspectives of deepening the reform and optimizing the ecosystem of science and technology innovation,this article summarizes the highlights of CAMS & PUMC’s efforts in safeguarding people’ s health and promoting the Healthy China 2030 strategy through scientific and technological innovation in the fields including basic research,disease prevention and treatment,and medical technology in the past ten years.These achievements embody the endeavors and responsibility of CAMS& PUMC in realizing self-reliance and self-improvement of Chinese medical science and technology and highlight its contributions to the development of medical science and technology of China.展开更多
AIM： To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indi- ces, and non-alcoholic fatty liver disease severity we...AIM： To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indi- ces, and non-alcoholic fatty liver disease severity were investigated in 43 young individuals with fatty liver （FL） and 41 with nonalcoholic steatohepatitis （NASH）. METHODS： Circulating levels of Bcl-2 were detected in 84 patients with ultrasonographic findings of ＂bright liver＂ and/or hyper-transaminasemia of unknown origin and/or increase in T-glutamyl-transpeptidase （T-GT） strictly in the absence of other acute or chronic liver disease, whose age was not advanced, who gave consent to liver biopsy and were then divided on the basis of the histological results into two groups （43 with FL and 41 with NASH）. Twenty lean subjects, apparently healthy and young, were chosen as controls.RESULTS： Serum Bcl-2 concentrations were significantly higher in the FL group than in the NASH group. Insulin resistance and γ-GT activity were significantly higher in NASH subjects. Apoptotic hepatocytes were significantly more numerous in NASH patients. NASH patients presented with larger spleens and augmented C-reactive protein （CRP） concentrations than healthy subjects. Steatosis grade at histology was similar in both NASH and FL populations. The number of apoptotic cells was significantly related to anti-apoptotic Bcl-2 protein values in FL patients. Bcl-2 serum levels positively correlated to body mass index （BMI） values （P ~ 0.0001） but not to age of the population. Triglycerides/HDL ratio correlated well to waist circumference in males （P = 0.0008）. γ-GT activity was associated with homeostatic metabolic assessment （HOMA） （P = 0.0003） and with serum ferritin （P = 0.02）. Bcl-2 concentrations were not related to either spleen size or CRP values. NASH patients pre- sented a weak negative correlation between Iobular inflammation and Bcl-2 levels. A prediction by low values of serum Bcl-2 towards a greater presence of metabolically unhealthy overweight/obese patients （MUOs） was evidenced. HOMA, BMI and uric acid, in that sequence, best predicted serum Bcl-2 concentrations. CONCLUSION： IvlUOs could be detected by Bcl-2 levels. By favoring the life span of hepatocytes, and enhancing triglyceride formation, the anti-apoptotic process inhibits free fatty acids toxicity in FL.展开更多
On January 12,2015,the top ten news about health and family planning in 2014were announced at the regular press briefi ng of National Health and Family Planning Commission(NHFPC).They are as follows.
No matter where he is and what he does,Dr. Shen always considers himself as a devoted researcher,and holds tough mind that he will go further along the medicine innovation, heading for the health and happiness of huma...No matter where he is and what he does,Dr. Shen always considers himself as a devoted researcher,and holds tough mind that he will go further along the medicine innovation, heading for the health and happiness of human being.展开更多
A newly designed vacuum Compton gamma-ray detector with Ta-Al clad-metal electron converter plate is described. The detecting efficiency for 1.25 MeV gamma-ray is 7.85×10-3 electron/γ,which is 2.5 times higher t...A newly designed vacuum Compton gamma-ray detector with Ta-Al clad-metal electron converter plate is described. The detecting efficiency for 1.25 MeV gamma-ray is 7.85×10-3 electron/γ,which is 2.5 times higher than that with Fe converter plate. The designed detector has the merits of well processed and static vacuum keeping and can be used for intense pulsed gamma ray detecting.展开更多
Radio and television outfits constitute a subset of the mass media belonging specifically to the broadcast system, and vitally provide information useful for development （among others） to its adherents, consumers, a...Radio and television outfits constitute a subset of the mass media belonging specifically to the broadcast system, and vitally provide information useful for development （among others） to its adherents, consumers, and audiences. Health reporting or health news is an aspect of health communication through which the audiences are informed of all matters relating to their total well-being. In this paper, the authors investigated news reporting among broadcast outfits in Lagos-Nigeria as a measure to monitor or watchdog and report the reporter to his clients. The investigation was in two parts： One looked at his strategies in covering and reporting health in the environment; while the other examined news bulletins to subject its health news to a content analysis. The study revealed that health is a neglected concern in broadcast reporting with trigger or vulture approach/practice among broadcast outfits.展开更多
Mining safety and health improvements over the past decades are remarkable by many metrics, and yet the expectation of society, and the goal of the mining industry, is zero harm. If we examine the underlying enablers ...Mining safety and health improvements over the past decades are remarkable by many metrics, and yet the expectation of society, and the goal of the mining industry, is zero harm. If we examine the underlying enablers for the significant gains that have been achieved, the key role that research to help understand the causes of problems and to develop lasting solutions is clear. Many of the remaining challenges have been resistant to solutions by various approaches. Some, such as fatalities and injuries from ground control or powered haulage are prominent year after year. Different approaches are indicated and new solutions will be required if we are to achieve a goal of zero harm. These will originate with research, but into which topics, and what are some of these different approaches? This paper examines the current state of mine safety in the United States and highlights areas of significant opportunity for research that will lead to solutions. The likely direction of research that will enable realization of the ‘‘zero harm'' goal is described in terms of evolutionary and revolutionary approaches. Both are important, but the author's view is that some of the largest gains will be made with trans-disciplinary approaches that break from the past. Topical areas of research are suggested and several research questions are given to illustrate the direction of future research in mining safety and health.展开更多
文摘To study the antifungal effect of chalcone derivatives. Methods Sixteenchalcone derivatives were synthesized and confirmed by ~1H NMR and IR spectra, and tested forantifungal activity against four common pathogenic fungi. Their structure-activity relationship isdiscussed. Results Among 16 title compounds, there were 5 new compounds, which have not beenreported before. The preliminary antifungal test showed that all title compounds exhibitedantifungal activities to a certain extent. The activity of compound 8 against Trichophyton rubrumhad a potency equal to that of fluconazole, with a MIC of 4 μg·mL^(-1) . Conclusion Sixteenchalcones were prepared and their antifungal activities against four common pathogenic fungi invitro were examined. Some of them exhibited antifungal activities to a certain extent.
文摘Objective： To systematically evaluate the effectiveness of Kangfuxin Fluid （KFX） in Ulcerative Colitis （UC） with retention enema. Methods： We searched The Cochanrane Library, Pubmed, EMbase, VIP, CNKI, CBM and WanFang Data from inception to December.2017, and retrospectively incorporated into the literature reference. And a systematic review of randomized controlled trials was performed. Meta-analysis was performed with RevMan5.3 software. Results： A total of 18 randomized controlled trials and 1417 patients were enrolled, among which 731 cases were in experimental group and 686 cases were in control group. The meta-analysis results revealed that the effectiveness of KFX on UC with retention enema was significantly superior to the controlled treatment （RR=1.22 95%CI： [1.16,1.27], Z=8.14, p〈0.00001）. And, the score of quality of life was significantly increased after KFX treatment （MD=11.12, 95% CI [7.00, 15.23], Z=5.30, p〈0.00001）. Conclusion： KFX on the treatment of UC with retention enema is potentially effective to improve patient＇s quality of life, and it is worth being popularized clinically. Depth researches and high quality randomized controlled trials on the efficacy of UC are necessary.
文摘After announcing the goal of building a moderately prosperous society in all respects by 2020, the Chinese leadership also called for a new path of industrialization, putting a premium on quality and new development concepts. Unlike traditional industrialization in the broad or narrow sense, new-type industrialization features synergy between primary, secondary, and tertiary industries, integration between traditional economy and the new economy, environmental protection, technology progress, and innovation. It represents an inclusive approach to industrial development. At the fundamental level, the success of China’s new-type industrialization can be attributed to China’s inclusive learning and innovations.
文摘32 cases of the third lumbar transverse process syndrome were treated mainly byelectroacupuncture at Huatuojiaji points of the first and second lumbar vertebrae, andanother 30 cases of the syndrome by conventional acupuncture as the controls. The resultsshowed that treatment by electroacupuncture at Huatuojiaji points was superior inanalgesic effect and clinical total effective rate to that by conventional acupuncture. It isconsidered that the mechanism of treatment by electroacupuncture at Huatuojiaji pointsis related to the trunk of posterior ramus of the spinal nerve where the points are located.
文摘Focusing on the reform initiatives of Chinese Academy of Medical Sciences(CAMS) & Peking Union Medical College(PUMC) in medical scientific and technological innovation from perspectives of deepening the reform and optimizing the ecosystem of science and technology innovation,this article summarizes the highlights of CAMS & PUMC’s efforts in safeguarding people’ s health and promoting the Healthy China 2030 strategy through scientific and technological innovation in the fields including basic research,disease prevention and treatment,and medical technology in the past ten years.These achievements embody the endeavors and responsibility of CAMS& PUMC in realizing self-reliance and self-improvement of Chinese medical science and technology and highlight its contributions to the development of medical science and technology of China.
文摘AIM： To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indi- ces, and non-alcoholic fatty liver disease severity were investigated in 43 young individuals with fatty liver （FL） and 41 with nonalcoholic steatohepatitis （NASH）. METHODS： Circulating levels of Bcl-2 were detected in 84 patients with ultrasonographic findings of ＂bright liver＂ and/or hyper-transaminasemia of unknown origin and/or increase in T-glutamyl-transpeptidase （T-GT） strictly in the absence of other acute or chronic liver disease, whose age was not advanced, who gave consent to liver biopsy and were then divided on the basis of the histological results into two groups （43 with FL and 41 with NASH）. Twenty lean subjects, apparently healthy and young, were chosen as controls.RESULTS： Serum Bcl-2 concentrations were significantly higher in the FL group than in the NASH group. Insulin resistance and γ-GT activity were significantly higher in NASH subjects. Apoptotic hepatocytes were significantly more numerous in NASH patients. NASH patients presented with larger spleens and augmented C-reactive protein （CRP） concentrations than healthy subjects. Steatosis grade at histology was similar in both NASH and FL populations. The number of apoptotic cells was significantly related to anti-apoptotic Bcl-2 protein values in FL patients. Bcl-2 serum levels positively correlated to body mass index （BMI） values （P ~ 0.0001） but not to age of the population. Triglycerides/HDL ratio correlated well to waist circumference in males （P = 0.0008）. γ-GT activity was associated with homeostatic metabolic assessment （HOMA） （P = 0.0003） and with serum ferritin （P = 0.02）. Bcl-2 concentrations were not related to either spleen size or CRP values. NASH patients pre- sented a weak negative correlation between Iobular inflammation and Bcl-2 levels. A prediction by low values of serum Bcl-2 towards a greater presence of metabolically unhealthy overweight/obese patients （MUOs） was evidenced. HOMA, BMI and uric acid, in that sequence, best predicted serum Bcl-2 concentrations. CONCLUSION： IvlUOs could be detected by Bcl-2 levels. By favoring the life span of hepatocytes, and enhancing triglyceride formation, the anti-apoptotic process inhibits free fatty acids toxicity in FL.
文摘On January 12,2015,the top ten news about health and family planning in 2014were announced at the regular press briefi ng of National Health and Family Planning Commission(NHFPC).They are as follows.
文摘No matter where he is and what he does,Dr. Shen always considers himself as a devoted researcher,and holds tough mind that he will go further along the medicine innovation, heading for the health and happiness of human being.
文摘A newly designed vacuum Compton gamma-ray detector with Ta-Al clad-metal electron converter plate is described. The detecting efficiency for 1.25 MeV gamma-ray is 7.85×10-3 electron/γ,which is 2.5 times higher than that with Fe converter plate. The designed detector has the merits of well processed and static vacuum keeping and can be used for intense pulsed gamma ray detecting.
文摘Radio and television outfits constitute a subset of the mass media belonging specifically to the broadcast system, and vitally provide information useful for development （among others） to its adherents, consumers, and audiences. Health reporting or health news is an aspect of health communication through which the audiences are informed of all matters relating to their total well-being. In this paper, the authors investigated news reporting among broadcast outfits in Lagos-Nigeria as a measure to monitor or watchdog and report the reporter to his clients. The investigation was in two parts： One looked at his strategies in covering and reporting health in the environment; while the other examined news bulletins to subject its health news to a content analysis. The study revealed that health is a neglected concern in broadcast reporting with trigger or vulture approach/practice among broadcast outfits.
文摘Mining safety and health improvements over the past decades are remarkable by many metrics, and yet the expectation of society, and the goal of the mining industry, is zero harm. If we examine the underlying enablers for the significant gains that have been achieved, the key role that research to help understand the causes of problems and to develop lasting solutions is clear. Many of the remaining challenges have been resistant to solutions by various approaches. Some, such as fatalities and injuries from ground control or powered haulage are prominent year after year. Different approaches are indicated and new solutions will be required if we are to achieve a goal of zero harm. These will originate with research, but into which topics, and what are some of these different approaches? This paper examines the current state of mine safety in the United States and highlights areas of significant opportunity for research that will lead to solutions. The likely direction of research that will enable realization of the ‘‘zero harm'' goal is described in terms of evolutionary and revolutionary approaches. Both are important, but the author's view is that some of the largest gains will be made with trans-disciplinary approaches that break from the past. Topical areas of research are suggested and several research questions are given to illustrate the direction of future research in mining safety and health.
