Aluminum is the primary structural material in nuclear engineering,and its cross section induced by 14-MeV neutrons is of great significance.To address the issue of insufficient accuracy for the^(27)Al(n,2n)^(26)Al re...Aluminum is the primary structural material in nuclear engineering,and its cross section induced by 14-MeV neutrons is of great significance.To address the issue of insufficient accuracy for the^(27)Al(n,2n)^(26)Al reaction cross section,the activation method and accelerator mass spectrometry(AMS)technique were used to determine the^(27)Al(n,2n)^(26)Al cross section,which could be used as a D-T plasma ion temperature monitor in fusion reactors.At the China Academy of Engineering Physics,neutron activation was performed using a K-400 neutron generator produced by the T(d,n)4He reaction.The^(26)Al∕^(27)Al isotope ratios were measured using the newly installed GYIG 1 MV AMS at the Institute of Geochemistry,Chinese Academy of Sciences.The neutron flux was monitored by measuring the activity of 92mNb produced by the 93Nb(n,2n)92mNb reaction.The measured results were compared with available data in the experimental nuclear reaction database,and the measured values showed a reasonable degree of consistency with partially available literature data.The newly acquired cross-sectional data at 12 neutron energy points through systematic measurements clarified the divergence,which has two different growth trends from the existing experimental values.The obtained results are also compared with the corresponding evaluated database,and the newly calculated excitation functions with TALYS−1.95 and EMPIRE−3.2 codes,the agreement with CENDL−3.2,TENDL-2021 and EMPIRE−3.2 results are generally acceptable.A substantial improvement in the knowledge of the^(27)Al(n,2n)^(26)Al reaction excitation function was obtained in the present work,which will lay the foundation for the diagnosis of the fusion ion temperature,testing of the nuclear physics model,evaluation of nuclear data,etc.展开更多
The development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo implantation is a complex dynamic process in which the morphology and physiological states of the endometrial epith...The development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo implantation is a complex dynamic process in which the morphology and physiological states of the endometrial epithelium undergo a series of significant changes, including cell proliferation and apoptosis. However, the molecular mechanisms are not yet fully understood. In this study, a higher circRNA3669 level was observed in PE than in RE of goats. Functional assays revealed that this overexpression promoted the proliferation of goat endometrial epithelial cells(GEECs) by activating the expression of genes related to the PI3K/AKT-mTOR and MAPK pathways,thereby inhibiting apoptosis in vitro. Furthermore, circRNA3669 functioned as a competing endogenous RNA(ceRNA) to upregulate Reticulocalbin-2(RCN2) expression at the post-transcriptional level by interacting with and downregulating miR-26a in GEECs. In addition, RCN2, which is highly expressed in the PE of goats, was found to be regulated by β-estradiol(E2) and progesterone(P4). Our results demonstrated that RCN2 also affected the key proteins PI3K, AKT, mTOR, JNK, and P38 in the PI3K/AKT-mTOR and MAPK pathways, thereby facilitating GEECs proliferation and suppressing their apoptosis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which further provides strong evidence that circRNA could potentially play a crucial regulatory role in the development of RE in goats.展开更多
BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untran...BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ANKRD26.However,the positive regulators of ANKRD26 are still unknown.AIM To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 transcription.METHODS Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family POTE.According to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activity of the mitogen activated protein kinase and extracellular signal regulated kinase 1/2 signaling pathways,which are potentially involved in the regulation of thrombopoietin-dependent signaling and further impair proplatelet formation by megakaryocytes(MKs)[11].However,the positive regulators of ANKRD26,which might be associated with THC2 pathology,are still unknown.展开更多
This paper investigates the marginal abatement cost （MAC） of CO： emissions across 104 Chinese cities between 2001 and 2008. Based on parametric directional distance function, this paper discovers that the mean marg...This paper investigates the marginal abatement cost （MAC） of CO： emissions across 104 Chinese cities between 2001 and 2008. Based on parametric directional distance function, this paper discovers that the mean marginal abatement cost of CO2 emissions for sample cities was 967 yuan/ton. In terms of region, CO： marginal abatement cost is significantly higher in China＇s eastern region than in central and western regions; in terms of provincial-level region, it is the highest in Shanghai and the lowest in Shaanxi in terms of city, it is the highest in Shanghai and the lowest in Zhangjiajie with the ratio between their medians being at 48：1; in terms of time, marginal abatement cost has been always on the rise with significant intercity disparities. There is a U-shaped curve relationship between marginal abatement cost of cities and CO2 emissions per unit of GDP, which is negatively correlated with the share of secondary industry and positively correlated with the level of urbanization.展开更多
目的调查分析平凉市2型糖尿病患者用药情况,以期提高临床用药安全性与有效性。方法选取2023年1—12月在平凉市2家三级综合医院就诊及在1家基层社区卫生服务中心、1家乡镇医院建立健康档案的2型糖尿病患者956例,调查其人口基线学资料、...目的调查分析平凉市2型糖尿病患者用药情况,以期提高临床用药安全性与有效性。方法选取2023年1—12月在平凉市2家三级综合医院就诊及在1家基层社区卫生服务中心、1家乡镇医院建立健康档案的2型糖尿病患者956例,调查其人口基线学资料、临床检查指标、实验室检测指标、用药方式、用药类型、治疗方案、血糖控制效果,分析不同治疗方案达标率和用药前后空腹血糖(FBG)、餐后2 h血糖(2 hPBG)。结果956例2型糖尿病患者主要用药方式为口服降糖药物(67.99%),其次为口服降糖药物+胰岛素注射(22.28%),第3位为胰岛素注射(9.73%);使用双胍类药物最多,之后依次为α糖苷酶抑制剂、磺脲类、胰岛素、复合制剂、钠-葡萄糖协同转运蛋白2抑制剂、苯甲酸衍生物;单联用药和三联及以上用药方案的FBG达标率高于二联用药,单联用药的糖化血红蛋白(HbA1c)达标率高于二联用药和三联及以上用药,二联用药的HbA1c达标率高于三联及以上用药,差异有统计学意义(P<0.05);用药后FBG、2 h PBG水平均低于用药前,差异有统计学意义(P<0.05)。结论平凉市2型糖尿病患者多采用口服降糖药物治疗,使用双胍类药物最多,单联用药可提高HbA1C达标率,临床医师需针对2型糖尿病患者用药方式等自身特点选择敏感降糖药物治疗。展开更多
基金the Open Project of Guangxi Key Laboratory of Nuclear Physics and Nuclear Technology(NLK 2022-04)the Central Government Guidance Funds for Local Scientific and Technological Development,China(No.Guike,ZY22096024)+1 种基金the National Natural Science Foundation of China(12065003)Guangxi Key R&D Project(2023AB07029).
文摘Aluminum is the primary structural material in nuclear engineering,and its cross section induced by 14-MeV neutrons is of great significance.To address the issue of insufficient accuracy for the^(27)Al(n,2n)^(26)Al reaction cross section,the activation method and accelerator mass spectrometry(AMS)technique were used to determine the^(27)Al(n,2n)^(26)Al cross section,which could be used as a D-T plasma ion temperature monitor in fusion reactors.At the China Academy of Engineering Physics,neutron activation was performed using a K-400 neutron generator produced by the T(d,n)4He reaction.The^(26)Al∕^(27)Al isotope ratios were measured using the newly installed GYIG 1 MV AMS at the Institute of Geochemistry,Chinese Academy of Sciences.The neutron flux was monitored by measuring the activity of 92mNb produced by the 93Nb(n,2n)92mNb reaction.The measured results were compared with available data in the experimental nuclear reaction database,and the measured values showed a reasonable degree of consistency with partially available literature data.The newly acquired cross-sectional data at 12 neutron energy points through systematic measurements clarified the divergence,which has two different growth trends from the existing experimental values.The obtained results are also compared with the corresponding evaluated database,and the newly calculated excitation functions with TALYS−1.95 and EMPIRE−3.2 codes,the agreement with CENDL−3.2,TENDL-2021 and EMPIRE−3.2 results are generally acceptable.A substantial improvement in the knowledge of the^(27)Al(n,2n)^(26)Al reaction excitation function was obtained in the present work,which will lay the foundation for the diagnosis of the fusion ion temperature,testing of the nuclear physics model,evaluation of nuclear data,etc.
基金supported by the China Postdoctoral Science Foundation(2019M653776 and 2020M673516)the Natural Science Basis Research Plan in Shaanxi Province of China(2023-JC-QN-0181)+1 种基金the Shaanxi Livestock and Poultry Breeding Double-chain Fusion Key Project,China(2022GD-TSLD-46-0202)the Natural Science Fundation of Tibet Autonomous Region,China(XZ202101ZR0063G)。
文摘The development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo implantation is a complex dynamic process in which the morphology and physiological states of the endometrial epithelium undergo a series of significant changes, including cell proliferation and apoptosis. However, the molecular mechanisms are not yet fully understood. In this study, a higher circRNA3669 level was observed in PE than in RE of goats. Functional assays revealed that this overexpression promoted the proliferation of goat endometrial epithelial cells(GEECs) by activating the expression of genes related to the PI3K/AKT-mTOR and MAPK pathways,thereby inhibiting apoptosis in vitro. Furthermore, circRNA3669 functioned as a competing endogenous RNA(ceRNA) to upregulate Reticulocalbin-2(RCN2) expression at the post-transcriptional level by interacting with and downregulating miR-26a in GEECs. In addition, RCN2, which is highly expressed in the PE of goats, was found to be regulated by β-estradiol(E2) and progesterone(P4). Our results demonstrated that RCN2 also affected the key proteins PI3K, AKT, mTOR, JNK, and P38 in the PI3K/AKT-mTOR and MAPK pathways, thereby facilitating GEECs proliferation and suppressing their apoptosis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which further provides strong evidence that circRNA could potentially play a crucial regulatory role in the development of RE in goats.
基金Supported by General Program of National Natural Science Foundation of China,No.81770197Scientific and Technological Research Major Program of Chongqing Municipal Education Commission,No.KJZD-M202312802+1 种基金Chongqing Natural Science Foundation of China,No.CSTB2022NSCQ-MSX0190,No.CSTB2022NSCQ-MSX0176,and No.cstc2020jcyj-msxmX0051Xinqiao Young Postdoc Talent Incubation Program,No.2022YQB098.
文摘BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ANKRD26.However,the positive regulators of ANKRD26 are still unknown.AIM To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 transcription.METHODS Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family POTE.According to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activity of the mitogen activated protein kinase and extracellular signal regulated kinase 1/2 signaling pathways,which are potentially involved in the regulation of thrombopoietin-dependent signaling and further impair proplatelet formation by megakaryocytes(MKs)[11].However,the positive regulators of ANKRD26,which might be associated with THC2 pathology,are still unknown.
基金supported by the National Natural Sciences Foundation(Approval No.41201582)Beijing Natural Sciences Foundation(9152011)+1 种基金Mingde Scholars Program of Renmin University of China(Approval No.13XNJ016)Peking University-Lincoln Institute Center for Urban Development and Land Policy
文摘This paper investigates the marginal abatement cost （MAC） of CO： emissions across 104 Chinese cities between 2001 and 2008. Based on parametric directional distance function, this paper discovers that the mean marginal abatement cost of CO2 emissions for sample cities was 967 yuan/ton. In terms of region, CO： marginal abatement cost is significantly higher in China＇s eastern region than in central and western regions; in terms of provincial-level region, it is the highest in Shanghai and the lowest in Shaanxi in terms of city, it is the highest in Shanghai and the lowest in Zhangjiajie with the ratio between their medians being at 48：1; in terms of time, marginal abatement cost has been always on the rise with significant intercity disparities. There is a U-shaped curve relationship between marginal abatement cost of cities and CO2 emissions per unit of GDP, which is negatively correlated with the share of secondary industry and positively correlated with the level of urbanization.
文摘目的调查分析平凉市2型糖尿病患者用药情况,以期提高临床用药安全性与有效性。方法选取2023年1—12月在平凉市2家三级综合医院就诊及在1家基层社区卫生服务中心、1家乡镇医院建立健康档案的2型糖尿病患者956例,调查其人口基线学资料、临床检查指标、实验室检测指标、用药方式、用药类型、治疗方案、血糖控制效果,分析不同治疗方案达标率和用药前后空腹血糖(FBG)、餐后2 h血糖(2 hPBG)。结果956例2型糖尿病患者主要用药方式为口服降糖药物(67.99%),其次为口服降糖药物+胰岛素注射(22.28%),第3位为胰岛素注射(9.73%);使用双胍类药物最多,之后依次为α糖苷酶抑制剂、磺脲类、胰岛素、复合制剂、钠-葡萄糖协同转运蛋白2抑制剂、苯甲酸衍生物;单联用药和三联及以上用药方案的FBG达标率高于二联用药,单联用药的糖化血红蛋白(HbA1c)达标率高于二联用药和三联及以上用药,二联用药的HbA1c达标率高于三联及以上用药,差异有统计学意义(P<0.05);用药后FBG、2 h PBG水平均低于用药前,差异有统计学意义(P<0.05)。结论平凉市2型糖尿病患者多采用口服降糖药物治疗,使用双胍类药物最多,单联用药可提高HbA1C达标率,临床医师需针对2型糖尿病患者用药方式等自身特点选择敏感降糖药物治疗。
