The Corona Virus Disease 2019(COVID-19) pandemic has taught us many valuable lessons regarding the importance of our physical and mental health. Even with so many technological advancements, we still lag in developing...The Corona Virus Disease 2019(COVID-19) pandemic has taught us many valuable lessons regarding the importance of our physical and mental health. Even with so many technological advancements, we still lag in developing a system that can fully digitalize the medical data of each individual and make it readily accessible for both the patient and health worker at any point in time. Moreover, there are also no ways for the government to identify the legitimacy of a particular clinic. This study merges modern technology with traditional approaches,thereby highlighting a scenario where artificial intelligence(AI) merges with traditional Chinese medicine(TCM), proposing a way to advance the conventional approaches. The main objective of our research is to provide a one-stop platform for the government, doctors,nurses, and patients to access their data effortlessly. The proposed portal will also check the doctors’ authenticity. Data is one of the most critical assets of an organization, so a breach of data can risk users’ lives. Data security is of primary importance and must be prioritized. The proposed methodology is based on cloud computing technology which assures the security of the data and avoids any kind of breach. The study also accounts for the difficulties encountered in creating such an infrastructure in the cloud and overcomes the hurdles faced during the project, keeping enough room for possible future innovations. To summarize, this study focuses on the digitalization of medical data and suggests some possible ways to achieve it. Moreover, it also focuses on some related aspects like security and potential digitalization difficulties.展开更多
The present study is part of the Executive Scientific Project 2 in the ItalMed Project which aims to elaborate a feasibility study for new transport connections between Italy and Algeria. The main objectives of the st...The present study is part of the Executive Scientific Project 2 in the ItalMed Project which aims to elaborate a feasibility study for new transport connections between Italy and Algeria. The main objectives of the study are to increase the degree of economic integration between the two countries and improve commercial exchanges and direct investments in Algeria by Italian private companies. Moreover, the study tries to promote Italy＇s role as logistic platform for Mediterranean Countries along the east-west and north-south corridors and to improve the capacity of Italian regions to manage international cooperation programs on transport and logistics, finally, to support regional entrepreneurship in the foreign services sector.展开更多
A simple one step solvothermal strategy using non-toxic and cost-effective precursors has been developed to prepare magnetite/reduced graphene oxide （MRGO） nanocomposites for removal of dye pollutants. Taking advant...A simple one step solvothermal strategy using non-toxic and cost-effective precursors has been developed to prepare magnetite/reduced graphene oxide （MRGO） nanocomposites for removal of dye pollutants. Taking advantage of the combined benefits of graphene and magnetic nanoparticles, these MRGO nanocomposites exhibit excellent removal efficiency （over 91% for rhodamine B and over 94% for malachite green） and rapid separation from aqueous solution by an external magnetic field. Interestingly, the performance of the MRGO composites is strongly dependent on both the loading of Fe304 and the pH value. In addition, the adsorption behavior of this new adsorbent fits well with the Freundlich isotherm and the pseudo-second-order kinetic model. In further applications, real samples--including industrial waste water and lake water--have been treated using the MRGO composites. All the results demonstrate that the MRGO composites are effective adsorbents for removal of dye pollutants and thus could provide a new platform for dye decontamination.展开更多
Smoothly attaching the stretchable epidermal electronic devices(EEDs) onto the skin surface is highly desired to improve the measurement accuracy of electrophysiological signal.The paper presents an analytical approac...Smoothly attaching the stretchable epidermal electronic devices(EEDs) onto the skin surface is highly desired to improve the measurement accuracy of electrophysiological signal.The paper presents an analytical approach to study interfacial mechanics of the 2D planar EEDs on the checkerboard buckling patterns of human skin.Energy variation method is proposed to determine a criterion whether EEDs laminate conformally onto the skin surface under undeformed and stretched cases.EEDs with low bending stiffness(thin,soft devices/backing layer),smooth and soft skin,and strong adhesion promote conformal contact.Furthermore,the adhesion energy at the EED/skin interface is measured by the homemade peeling experiment platform with different substrate thicknesses and areal coverages.The upper limit of the areal coverage for EED conformal contact with the skin is proposed with given EED/skin properties.Conformability of EEDs are validated by experiments with different substrate thickness,areal coverage and external loadings.It provides a design guideline for EED to conformally contact with the skin surface for more accurate biological signal monitoring.展开更多
At the intersection between treatment and diagnosis, nanoparticles technologies are strongly impacting the development of both therapeutic and diagnostic agents.Consequently, the development of novel modalities for co...At the intersection between treatment and diagnosis, nanoparticles technologies are strongly impacting the development of both therapeutic and diagnostic agents.Consequently, the development of novel modalities for concomitant noninvasive therapy and diagnostics known as theranostics as a single platform has gained significant interests. These multifunctional theranostic platforms include carbon-based nanomaterials（e.g., carbon nanotubes）, drug conjugates, aliphatic polymers, micelles, vesicles, core-shell nanoparticles, microbubbles and dendrimers bearing different contrast agents and drugs, such as cytotoxic compounds in the oncology domain. Dendrimers emerged as a new class of highly tunable hyperbranched polymers, and have been developed as useful theranostic platforms. Magnetic resonance imaging, gamma scintigraphy, computed tomography and optical imaging are the main techniques developed with dendrimers in the theranostic domain in oncology. Different imaging agents have been used such as Gd（Ⅲ）,19F, Fe2O3（MRI）,76Br（PET）,111In,88Y,153Gd,188Re,131I（SPECT）,177Lu,gold（CT） and boronated groups, siliconnaphthalocyanines,dialkylcarbocyanines and QDs（optical imaging dyes）.展开更多
A simple approach has been developed to functionalize various substrates, such as gold and polyvinylchloride, with dopamine methacrylamide—a molecule with adhesive properties that mimic those of mussels—to produce a...A simple approach has been developed to functionalize various substrates, such as gold and polyvinylchloride, with dopamine methacrylamide—a molecule with adhesive properties that mimic those of mussels—to produce a versatile and general platform for subsequent surface modification. With active double bonds on the surface, various polymers, such as poly([2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide(PMEDSAH) and poly(N-vinylpyrrolidone)(PVP), can be grafted by conventional radical polymerization. Double bond surface functionalization and subsequent polymer grafting have been verified by static water contact angle, Fourier transform infrared–attenuated total reflectance(FTIR-ATR) spectroscopy and X-ray photoelectron spectroscopy(XPS) measurements. Protein adsorption assays showed that the polymermodified substrates have good protein-resistant properties. Considering the advantages of facility, versatility and substrate- independence, this method should be useful in designing functional interfaces for bioengineering applications.展开更多
Electronic structures in two kinds of boron structures are investigated by the first-principle density func- tional theory （DFT） calculations. One structure is from theoretical prediction, and the other is from expe...Electronic structures in two kinds of boron structures are investigated by the first-principle density func- tional theory （DFT） calculations. One structure is from theoretical prediction, and the other is from experimental in- vestigation. Binding energy calculations suggest that the boron structure designed from theory is more stable than that made by experiment. Elastic constants calculations show that both structures are mechanically stable. The electronic structure results show that the theoretical designed structure exhibits semi-metal behavior, while the other structure exhibits metMlic character. No magnetic phenomenal is discovered from them. All the calculations are carried out by the first principles calculation through the MatC1oud platform, which is developed by our research group.展开更多
文摘The Corona Virus Disease 2019(COVID-19) pandemic has taught us many valuable lessons regarding the importance of our physical and mental health. Even with so many technological advancements, we still lag in developing a system that can fully digitalize the medical data of each individual and make it readily accessible for both the patient and health worker at any point in time. Moreover, there are also no ways for the government to identify the legitimacy of a particular clinic. This study merges modern technology with traditional approaches,thereby highlighting a scenario where artificial intelligence(AI) merges with traditional Chinese medicine(TCM), proposing a way to advance the conventional approaches. The main objective of our research is to provide a one-stop platform for the government, doctors,nurses, and patients to access their data effortlessly. The proposed portal will also check the doctors’ authenticity. Data is one of the most critical assets of an organization, so a breach of data can risk users’ lives. Data security is of primary importance and must be prioritized. The proposed methodology is based on cloud computing technology which assures the security of the data and avoids any kind of breach. The study also accounts for the difficulties encountered in creating such an infrastructure in the cloud and overcomes the hurdles faced during the project, keeping enough room for possible future innovations. To summarize, this study focuses on the digitalization of medical data and suggests some possible ways to achieve it. Moreover, it also focuses on some related aspects like security and potential digitalization difficulties.
文摘The present study is part of the Executive Scientific Project 2 in the ItalMed Project which aims to elaborate a feasibility study for new transport connections between Italy and Algeria. The main objectives of the study are to increase the degree of economic integration between the two countries and improve commercial exchanges and direct investments in Algeria by Italian private companies. Moreover, the study tries to promote Italy＇s role as logistic platform for Mediterranean Countries along the east-west and north-south corridors and to improve the capacity of Italian regions to manage international cooperation programs on transport and logistics, finally, to support regional entrepreneurship in the foreign services sector.
文摘A simple one step solvothermal strategy using non-toxic and cost-effective precursors has been developed to prepare magnetite/reduced graphene oxide （MRGO） nanocomposites for removal of dye pollutants. Taking advantage of the combined benefits of graphene and magnetic nanoparticles, these MRGO nanocomposites exhibit excellent removal efficiency （over 91% for rhodamine B and over 94% for malachite green） and rapid separation from aqueous solution by an external magnetic field. Interestingly, the performance of the MRGO composites is strongly dependent on both the loading of Fe304 and the pH value. In addition, the adsorption behavior of this new adsorbent fits well with the Freundlich isotherm and the pseudo-second-order kinetic model. In further applications, real samples--including industrial waste water and lake water--have been treated using the MRGO composites. All the results demonstrate that the MRGO composites are effective adsorbents for removal of dye pollutants and thus could provide a new platform for dye decontamination.
文摘Smoothly attaching the stretchable epidermal electronic devices(EEDs) onto the skin surface is highly desired to improve the measurement accuracy of electrophysiological signal.The paper presents an analytical approach to study interfacial mechanics of the 2D planar EEDs on the checkerboard buckling patterns of human skin.Energy variation method is proposed to determine a criterion whether EEDs laminate conformally onto the skin surface under undeformed and stretched cases.EEDs with low bending stiffness(thin,soft devices/backing layer),smooth and soft skin,and strong adhesion promote conformal contact.Furthermore,the adhesion energy at the EED/skin interface is measured by the homemade peeling experiment platform with different substrate thicknesses and areal coverages.The upper limit of the areal coverage for EED conformal contact with the skin is proposed with given EED/skin properties.Conformability of EEDs are validated by experiments with different substrate thickness,areal coverage and external loadings.It provides a design guideline for EED to conformally contact with the skin surface for more accurate biological signal monitoring.
基金support of FCT-Fundacao para a Ciência e a Tecnologia(project PEst-OE/QUI/UI0674/2013,CQM,Portuguese Government funds)ARDITI through the project M1420-01-0145-FEDER-000005-Centro de Química da Madeira-CQM+(Madeira 14-20)+2 种基金the funds from Centre National de la Recherche Scientifique(CNRS,France)the support by the National Natural Science Foundation of China(21773026 and 81761148028)the Sino-French Caiyuanpei Programme
文摘At the intersection between treatment and diagnosis, nanoparticles technologies are strongly impacting the development of both therapeutic and diagnostic agents.Consequently, the development of novel modalities for concomitant noninvasive therapy and diagnostics known as theranostics as a single platform has gained significant interests. These multifunctional theranostic platforms include carbon-based nanomaterials（e.g., carbon nanotubes）, drug conjugates, aliphatic polymers, micelles, vesicles, core-shell nanoparticles, microbubbles and dendrimers bearing different contrast agents and drugs, such as cytotoxic compounds in the oncology domain. Dendrimers emerged as a new class of highly tunable hyperbranched polymers, and have been developed as useful theranostic platforms. Magnetic resonance imaging, gamma scintigraphy, computed tomography and optical imaging are the main techniques developed with dendrimers in the theranostic domain in oncology. Different imaging agents have been used such as Gd（Ⅲ）,19F, Fe2O3（MRI）,76Br（PET）,111In,88Y,153Gd,188Re,131I（SPECT）,177Lu,gold（CT） and boronated groups, siliconnaphthalocyanines,dialkylcarbocyanines and QDs（optical imaging dyes）.
基金supported by the National Science Fund for Distinguished Young Scholars(21125418)the National Natural Science Foundation of China(21174098,21304062 and 21334004)+1 种基金the Natural Science Foundation of Jiangsu Higher Education Institutions of China(13KJB430020)the China Postdoctoral Science Foundation(2013M541714)
文摘A simple approach has been developed to functionalize various substrates, such as gold and polyvinylchloride, with dopamine methacrylamide—a molecule with adhesive properties that mimic those of mussels—to produce a versatile and general platform for subsequent surface modification. With active double bonds on the surface, various polymers, such as poly([2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide(PMEDSAH) and poly(N-vinylpyrrolidone)(PVP), can be grafted by conventional radical polymerization. Double bond surface functionalization and subsequent polymer grafting have been verified by static water contact angle, Fourier transform infrared–attenuated total reflectance(FTIR-ATR) spectroscopy and X-ray photoelectron spectroscopy(XPS) measurements. Protein adsorption assays showed that the polymermodified substrates have good protein-resistant properties. Considering the advantages of facility, versatility and substrate- independence, this method should be useful in designing functional interfaces for bioengineering applications.
基金Supported by National Natural Science Foundation of China under Grant No.11547177
文摘Electronic structures in two kinds of boron structures are investigated by the first-principle density func- tional theory （DFT） calculations. One structure is from theoretical prediction, and the other is from experimental in- vestigation. Binding energy calculations suggest that the boron structure designed from theory is more stable than that made by experiment. Elastic constants calculations show that both structures are mechanically stable. The electronic structure results show that the theoretical designed structure exhibits semi-metal behavior, while the other structure exhibits metMlic character. No magnetic phenomenal is discovered from them. All the calculations are carried out by the first principles calculation through the MatC1oud platform, which is developed by our research group.
