Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulatio...Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulation techniques offer accurate manipulation of targeted areas,even selectively modulating specific neurons,in the brain.This makes it possible to investigate the cause-and-effect connections between neural activity and behavior,allowing for a better comprehension of the intricate brain dynamics towards complex environments.Non-human primates serve as an essential animal model for investigating these complex functions in brain research,bridging the gap between the basic research and clinical applications.One of the earliest optical studies utilizing optogenetic neuromodulation in monkeys was conducted in 2009.Since then,the optical-neural stimulations have been effectively applied in non-human primates.This review summarises recent research that employed optogenetics or infrared neurostimulation techniques to regulate brain function and behavior in non-human primates.The current state of optical-neural stimulations discussed here demonstrates their efficacy in advancing the understanding of brain systems.Nevertheless,there are still challenges that need to be addressed before they can fully achieve their potential.展开更多
Eye diagnosis is a method for inspecting systemic diseases and syndromes by observing the eyes.With the development of intelligent diagnosis in traditional Chinese medicine(TCM);artificial intelligence(AI)can improve ...Eye diagnosis is a method for inspecting systemic diseases and syndromes by observing the eyes.With the development of intelligent diagnosis in traditional Chinese medicine(TCM);artificial intelligence(AI)can improve the accuracy and efficiency of eye diagnosis.However;the research on intelligent eye diagnosis still faces many challenges;including the lack of standardized and precisely labeled data;multi-modal information analysis;and artificial in-telligence models for syndrome differentiation.The widespread application of AI models in medicine provides new insights and opportunities for the research of eye diagnosis intelli-gence.This study elaborates on the three key technologies of AI models in the intelligent ap-plication of TCM eye diagnosis;and explores the implications for the research of eye diagno-sis intelligence.First;a database concerning eye diagnosis was established based on self-su-pervised learning so as to solve the issues related to the lack of standardized and precisely la-beled data.Next;the cross-modal understanding and generation of deep neural network models to address the problem of lacking multi-modal information analysis.Last;the build-ing of data-driven models for eye diagnosis to tackle the issue of the absence of syndrome dif-ferentiation models.In summary;research on intelligent eye diagnosis has great potential to be applied the surge of AI model applications.展开更多
To realize automatic modeling and dynamic simulation of the educational assembling-type robot with open structure, a general dynamic model for the educational assembling-type robot and a fast simulation algorithm are ...To realize automatic modeling and dynamic simulation of the educational assembling-type robot with open structure, a general dynamic model for the educational assembling-type robot and a fast simulation algorithm are put forward. First, the educational robot system is abstracted to a multibody system and a general dynamic model of the educational robot is constructed by the Newton-Euler method. Then the dynamic model is simplified by a combination of components with fixed connections according to the structural characteristics of the educational robot. Secondly, in order to obtain a high efficiency simulation algorithm, based on the sparse matrix technique, the augmentation algorithm and the direct projective constraint stabilization algorithm are improved. Finally, a numerical example is given. The results show that the model and the fast algorithm are valid and effective. This study lays a dynamic foundation for realizing the simulation platform of the educational robot.展开更多
The workpieces of A357 alloy were routinely heat treated to the T6 state in order to gain an adequate mechanical property.The mechanical properties of these workpieces depend mainly on solid-solution temperature,solid...The workpieces of A357 alloy were routinely heat treated to the T6 state in order to gain an adequate mechanical property.The mechanical properties of these workpieces depend mainly on solid-solution temperature,solid-solution time,artificial aging temperature and artificial aging time.An artificial neural network（ANN） model with a back-propagation（BP） algorithm was used to predict mechanical properties of A357 alloy,and the effects of heat treatment processes on mechanical behavior of this alloy were studied.The results show that this BP model is able to predict the mechanical properties with a high accuracy.This model was used to reflect the influence of heat treatments on the mechanical properties of A357 alloy.Isograms of ultimate tensile strength and elongation were drawn in the same picture,which are very helpful to understand the relationship among aging parameters,ultimate tensile strength and elongation.展开更多
Aim To study the pharmacokinetics of oxiracetam after single and multipleintravenous administrations in healthy volunteers. Method A HPLC method was used to determine theserum concentration of oxiracetam after intrave...Aim To study the pharmacokinetics of oxiracetam after single and multipleintravenous administrations in healthy volunteers. Method A HPLC method was used to determine theserum concentration of oxiracetam after intravenous single dose and daily dose of 2 000 mg for 7 din ten Chinese healthy volunteers. Pharmacokinetic analysis was carried out using Drug And Statisticsoftware. Results The AUC_(0-12), AUC_(0-∞), K_e, t_(1/2), MRT after a single dose of 2 000 mgoxiracetam were 256.26 ± 16.84 μg·mL^(-1)·h, 276.74 ±18.11 μg·mL^(-1)·h, 0.18 ±0.03 h^(-1),3.84±0.64 h, and 4.39 10.39 h, and after multiple doses of oxiracetam were 259.36 ±25.43μg·mL^(-1)·h, 285.59 ±27.38 μg·mL^(-1)·h, 0.17 ±0.04 h^(-1), 4.14 ± 0.82 h, and 4.87 ±0.69 h, respectively. Conclusion The pharmacokinetic parameters of oxiracetam do not differremarkably after single and multiple intravenous administration and there is accumulation in serumafter 2 000 mg multiple intravenous administration once a day fof 7 d.展开更多
The present paper reviews the theoretical framework and analytic methods of Critical Discourse Analysis （CDA） and then introduces the latest development of CDA from the perspectives of linguistic anthropology, cogni...The present paper reviews the theoretical framework and analytic methods of Critical Discourse Analysis （CDA） and then introduces the latest development of CDA from the perspectives of linguistic anthropology, cognitive linguistics and corpus linguistics. The prospect of CDA is accordingly advanced.展开更多
The computational fluid dynamics （CFD） method is used to investigate the aerodynamic characteristics of the seat/occupant with windblast protection devices. The upwind Osher scheme is used for the spatial discretisa...The computational fluid dynamics （CFD） method is used to investigate the aerodynamic characteristics of the seat/occupant with windblast protection devices. The upwind Osher scheme is used for the spatial discretisation. The detached-eddy simulation （DES） based on the Spalart-Allmaras one-equation turbulence model is ap- plied to the detached viscous flow simulation behind the seat/occupant, with Mach numbers 0.6 and 1.2 at attack angles between --10 and 30°, and at two sideslip angles of 0 and 15°, respectively. The aerodynamic characteristics of seat/occupants with and without windblast protection devices are calculated in cases of the freestream Mach numbers 0. 8 and 1.6, attack angles from 5 to 30°, and three sideslip angles of 0, --20 and --50°, respectively. Results show that simulation results agree well with experimental data. And the occupant is efficiently protected by windblast protection devices.展开更多
Two minor saponins were isolated from the leaves of P. ginseng and their struc-tures were elucidated as 3β,12β, 20(S)-trihydroxyl-dammar-24(25)-ene-(20-O-α-L-arabinofurano-syl(1→6)-β-D-glucopyranosyl)-3-O-β-D-gl...Two minor saponins were isolated from the leaves of P. ginseng and their struc-tures were elucidated as 3β,12β, 20(S)-trihydroxyl-dammar-24(25)-ene-(20-O-α-L-arabinofurano-syl(1→6)-β-D-glucopyranosyl)-3-O-β-D-glucopyranoside (1),and 3β,12β, 20(S)-trihydroxyl-dam-mar-24(25)-ene-(20-O-α-L-arabinopyranosyl(1→6)-β-D-glucopyranosyl)-3-O-β-glucopyranoside(2),respectively The fonner corresponds to notoginsenoside-Fe which is isolated for the first time from the title plant The latter is a new natural product and named as ginsenoside-Rd2.展开更多
This paper deals with the stabilization of dynamic systems for two omni directional mobile robots by using the inner product of two vectors, one is from a robot's position to another's, the other is from a ro...This paper deals with the stabilization of dynamic systems for two omni directional mobile robots by using the inner product of two vectors, one is from a robot's position to another's, the other is from a robot's target point to another's. The multi step control laws given can exponentially stabilize the dynamic system and make the distance between two robots be greater than or equal to the collision free safe distance. The application of it to two omni directional mobile robots is described. Simulation result shows that the proposed controller is effective.展开更多
[Objective] The aim was to analyze the phenomenon of employment diffi- culty and labor shortage, and to reveal the influencing factors of employment difli- culty and labor shortage. [Method] On the basis of the econom...[Objective] The aim was to analyze the phenomenon of employment diffi- culty and labor shortage, and to reveal the influencing factors of employment difli- culty and labor shortage. [Method] On the basis of the economic principle of popu- lation dividend, the use of human resources and natural resource constraints The IS-LM model describes these two states. [Results] The resource constraints have a ＂squeeze＂ effect on the demographic dividend, and employment pressure is shown in terms of the population opportunity window; the labor market segmentation, the ir- rational industrial structure, the backward curriculum and employment concept are the main factors affecting employment and labor shortage. [Conclusion] The way to solve this dilemma must be removed from the division of labor market, the adjust- ment of industrial structure, the setting of university specialty, the change of em- ployment concept of university graduates as well as the improvement of the quality of labor.展开更多
Neural network models of mechanical properties prediction for wrought magnesium alloys were improved by using more reasonable parameters, and were used to develop new types of magnesium alloys. The parameters were con...Neural network models of mechanical properties prediction for wrought magnesium alloys were improved by using more reasonable parameters, and were used to develop new types of magnesium alloys. The parameters were confirmed by comparing prediction errors and correlation coefficients of models, which have been built with all the parameters used commonly with training of all permutations and combinations. The application was focused on Mg-Zn-Mn and Mg-Zn-Y-Zr alloys. The prediction of mechanical properties of Mg-Zn-Mn alloys and the effects of mole ratios of Y to Zn on the strengths in Mg-Zn-Y-Zr alloys were investigated by using the improved models. The predicted results are good agreement with the experimental values. A high strength extruded Mg-Zn-Zr-Y alloy was also developed by the models. The applications of the models indicate that the improved models can be used to develop new types of wrought magnesium alloys.展开更多
To develop a HPIX-UV-MS method for identifying the constituents in theChinese drug Notoginseng (the root of Panax notoginseng). Methods A Phenomenex Luna C_(18) column(250 mm x 4.6 mm ID, 5 μm) was utilized. Water co...To develop a HPIX-UV-MS method for identifying the constituents in theChinese drug Notoginseng (the root of Panax notoginseng). Methods A Phenomenex Luna C_(18) column(250 mm x 4.6 mm ID, 5 μm) was utilized. Water containing 0.005% formic acid (A) and acetonitrilecontaining 0.005% formic acid (B) were used as gradient eluents. UV spectra were recorded in range195 - 400 nm. Both positive and negative ion ESI modes were used. Results The constituents inNotoginseng were well separated and detected. Fourteen compounds were identified by comparing theirretention time and ESI-MS data with those obtained from the reference compounds. Forty-one compoundswere deduced by data analysis of MS and literature; among them, yesanchinosides-H and -E,chikusetsusaponin-L_5, malonyl-ginsenoside-R_(g_1), the isomers of notoginsenosides-J, -A, -R_1, -G,-R_2, and ginsenoside-Rh_3 were discovered in Notoginseng for the first time. Conclusion Thismethod gives high sensitivity and good separation, and is suitable for identifying the constituentsin Notoginseng. This result is helpful for further phytochemical research on Notoginseng. Based onthis result, further quality control can be studied.展开更多
The history and current status of Pharmacy Administration discipline atpharmacy schools in China are illustrated. Several current issues are explored including: (1)insufficient teaching organizations and curriculum, (...The history and current status of Pharmacy Administration discipline atpharmacy schools in China are illustrated. Several current issues are explored including: (1)insufficient teaching organizations and curriculum, (2) faculty deficiency both in quantity andquality, and (3) much improvement needed in the scope, methodology, and sophistication of research.Several development strategies are formulated such as (1) integrating native education resources inorder to better foster quality professionals, (2) accelerating inter-university cooperation both inteaching and research, and (3) studying the regularites of discipline development and enhancinginternational exchange.展开更多
AIMS To investigate the alterations of RBC immunoadherence function in patients with various hepatitis B. METHODS RBCC3bRR,RBCICRR and serum CIC levels were measured in 42 patients with acute and chronic hepatitis B a...AIMS To investigate the alterations of RBC immunoadherence function in patients with various hepatitis B. METHODS RBCC3bRR,RBCICRR and serum CIC levels were measured in 42 patients with acute and chronic hepatitis B at ac- tive and convalescence stages. RESULTS RBCC3bRRs at the active/acute stage of various hepatitis were decreased.They were 13,54%±5,23% in AH, 7.61%±4.12% in AFH,and 16.18%±6.10% in CH, respectively,all of which were lower than those in normal persons (18.12%±3.91% ).At the quiescent/recovery stage of various hepatitis,the RBCC3bRRs were increased significantly.The changes of RBCICRR and serum CIC level were contrary to those of RBCC3bRR. CONCLUSIONS RBC immunoadherence function is decreased in acute and chronic hepatitis.The decrease is in direct proportion to the severity of the diseases.展开更多
文摘Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulation techniques offer accurate manipulation of targeted areas,even selectively modulating specific neurons,in the brain.This makes it possible to investigate the cause-and-effect connections between neural activity and behavior,allowing for a better comprehension of the intricate brain dynamics towards complex environments.Non-human primates serve as an essential animal model for investigating these complex functions in brain research,bridging the gap between the basic research and clinical applications.One of the earliest optical studies utilizing optogenetic neuromodulation in monkeys was conducted in 2009.Since then,the optical-neural stimulations have been effectively applied in non-human primates.This review summarises recent research that employed optogenetics or infrared neurostimulation techniques to regulate brain function and behavior in non-human primates.The current state of optical-neural stimulations discussed here demonstrates their efficacy in advancing the understanding of brain systems.Nevertheless,there are still challenges that need to be addressed before they can fully achieve their potential.
基金National Natural Science Foundation of China(82274265 and 82274588)Hunan University of Traditional Chinese Medicine Research Unveiled Marshal Programs(2022XJJB003).
文摘Eye diagnosis is a method for inspecting systemic diseases and syndromes by observing the eyes.With the development of intelligent diagnosis in traditional Chinese medicine(TCM);artificial intelligence(AI)can improve the accuracy and efficiency of eye diagnosis.However;the research on intelligent eye diagnosis still faces many challenges;including the lack of standardized and precisely labeled data;multi-modal information analysis;and artificial in-telligence models for syndrome differentiation.The widespread application of AI models in medicine provides new insights and opportunities for the research of eye diagnosis intelli-gence.This study elaborates on the three key technologies of AI models in the intelligent ap-plication of TCM eye diagnosis;and explores the implications for the research of eye diagno-sis intelligence.First;a database concerning eye diagnosis was established based on self-su-pervised learning so as to solve the issues related to the lack of standardized and precisely la-beled data.Next;the cross-modal understanding and generation of deep neural network models to address the problem of lacking multi-modal information analysis.Last;the build-ing of data-driven models for eye diagnosis to tackle the issue of the absence of syndrome dif-ferentiation models.In summary;research on intelligent eye diagnosis has great potential to be applied the surge of AI model applications.
基金Hexa-Type Elites Peak Program of Jiangsu Province(No.2008144)Qing Lan Project of Jiangsu ProvinceFund for Excellent Young Teachers of Southeast University
文摘To realize automatic modeling and dynamic simulation of the educational assembling-type robot with open structure, a general dynamic model for the educational assembling-type robot and a fast simulation algorithm are put forward. First, the educational robot system is abstracted to a multibody system and a general dynamic model of the educational robot is constructed by the Newton-Euler method. Then the dynamic model is simplified by a combination of components with fixed connections according to the structural characteristics of the educational robot. Secondly, in order to obtain a high efficiency simulation algorithm, based on the sparse matrix technique, the augmentation algorithm and the direct projective constraint stabilization algorithm are improved. Finally, a numerical example is given. The results show that the model and the fast algorithm are valid and effective. This study lays a dynamic foundation for realizing the simulation platform of the educational robot.
文摘The workpieces of A357 alloy were routinely heat treated to the T6 state in order to gain an adequate mechanical property.The mechanical properties of these workpieces depend mainly on solid-solution temperature,solid-solution time,artificial aging temperature and artificial aging time.An artificial neural network（ANN） model with a back-propagation（BP） algorithm was used to predict mechanical properties of A357 alloy,and the effects of heat treatment processes on mechanical behavior of this alloy were studied.The results show that this BP model is able to predict the mechanical properties with a high accuracy.This model was used to reflect the influence of heat treatments on the mechanical properties of A357 alloy.Isograms of ultimate tensile strength and elongation were drawn in the same picture,which are very helpful to understand the relationship among aging parameters,ultimate tensile strength and elongation.
文摘Aim To study the pharmacokinetics of oxiracetam after single and multipleintravenous administrations in healthy volunteers. Method A HPLC method was used to determine theserum concentration of oxiracetam after intravenous single dose and daily dose of 2 000 mg for 7 din ten Chinese healthy volunteers. Pharmacokinetic analysis was carried out using Drug And Statisticsoftware. Results The AUC_(0-12), AUC_(0-∞), K_e, t_(1/2), MRT after a single dose of 2 000 mgoxiracetam were 256.26 ± 16.84 μg·mL^(-1)·h, 276.74 ±18.11 μg·mL^(-1)·h, 0.18 ±0.03 h^(-1),3.84±0.64 h, and 4.39 10.39 h, and after multiple doses of oxiracetam were 259.36 ±25.43μg·mL^(-1)·h, 285.59 ±27.38 μg·mL^(-1)·h, 0.17 ±0.04 h^(-1), 4.14 ± 0.82 h, and 4.87 ±0.69 h, respectively. Conclusion The pharmacokinetic parameters of oxiracetam do not differremarkably after single and multiple intravenous administration and there is accumulation in serumafter 2 000 mg multiple intravenous administration once a day fof 7 d.
文摘The present paper reviews the theoretical framework and analytic methods of Critical Discourse Analysis （CDA） and then introduces the latest development of CDA from the perspectives of linguistic anthropology, cognitive linguistics and corpus linguistics. The prospect of CDA is accordingly advanced.
基金Supported by the Aeronautical Science Foundation of China(2008ZC52039)~~
文摘The computational fluid dynamics （CFD） method is used to investigate the aerodynamic characteristics of the seat/occupant with windblast protection devices. The upwind Osher scheme is used for the spatial discretisation. The detached-eddy simulation （DES） based on the Spalart-Allmaras one-equation turbulence model is ap- plied to the detached viscous flow simulation behind the seat/occupant, with Mach numbers 0.6 and 1.2 at attack angles between --10 and 30°, and at two sideslip angles of 0 and 15°, respectively. The aerodynamic characteristics of seat/occupants with and without windblast protection devices are calculated in cases of the freestream Mach numbers 0. 8 and 1.6, attack angles from 5 to 30°, and three sideslip angles of 0, --20 and --50°, respectively. Results show that simulation results agree well with experimental data. And the occupant is efficiently protected by windblast protection devices.
文摘Two minor saponins were isolated from the leaves of P. ginseng and their struc-tures were elucidated as 3β,12β, 20(S)-trihydroxyl-dammar-24(25)-ene-(20-O-α-L-arabinofurano-syl(1→6)-β-D-glucopyranosyl)-3-O-β-D-glucopyranoside (1),and 3β,12β, 20(S)-trihydroxyl-dam-mar-24(25)-ene-(20-O-α-L-arabinopyranosyl(1→6)-β-D-glucopyranosyl)-3-O-β-glucopyranoside(2),respectively The fonner corresponds to notoginsenoside-Fe which is isolated for the first time from the title plant The latter is a new natural product and named as ginsenoside-Rd2.
文摘This paper deals with the stabilization of dynamic systems for two omni directional mobile robots by using the inner product of two vectors, one is from a robot's position to another's, the other is from a robot's target point to another's. The multi step control laws given can exponentially stabilize the dynamic system and make the distance between two robots be greater than or equal to the collision free safe distance. The application of it to two omni directional mobile robots is described. Simulation result shows that the proposed controller is effective.
基金Supported by the National Social Science Fund of China(13XSH017)~~
文摘[Objective] The aim was to analyze the phenomenon of employment diffi- culty and labor shortage, and to reveal the influencing factors of employment difli- culty and labor shortage. [Method] On the basis of the economic principle of popu- lation dividend, the use of human resources and natural resource constraints The IS-LM model describes these two states. [Results] The resource constraints have a ＂squeeze＂ effect on the demographic dividend, and employment pressure is shown in terms of the population opportunity window; the labor market segmentation, the ir- rational industrial structure, the backward curriculum and employment concept are the main factors affecting employment and labor shortage. [Conclusion] The way to solve this dilemma must be removed from the division of labor market, the adjust- ment of industrial structure, the setting of university specialty, the change of em- ployment concept of university graduates as well as the improvement of the quality of labor.
基金Project(50725413)supported by the National Natural Science Foundation of ChinaProject(2007CB613704)supported by the National Basic Research Program of ChinaProject(2010CSTC-BJLKR)supported by Chongqing Science and Technology Commission,China
文摘Neural network models of mechanical properties prediction for wrought magnesium alloys were improved by using more reasonable parameters, and were used to develop new types of magnesium alloys. The parameters were confirmed by comparing prediction errors and correlation coefficients of models, which have been built with all the parameters used commonly with training of all permutations and combinations. The application was focused on Mg-Zn-Mn and Mg-Zn-Y-Zr alloys. The prediction of mechanical properties of Mg-Zn-Mn alloys and the effects of mole ratios of Y to Zn on the strengths in Mg-Zn-Y-Zr alloys were investigated by using the improved models. The predicted results are good agreement with the experimental values. A high strength extruded Mg-Zn-Zr-Y alloy was also developed by the models. The applications of the models indicate that the improved models can be used to develop new types of wrought magnesium alloys.
基金NationalBasicResearchProgramofChina (No .G19990 5 44 0 6)NationalNaturalScienceFoundationofChina(No .3 9970 898)
文摘To develop a HPIX-UV-MS method for identifying the constituents in theChinese drug Notoginseng (the root of Panax notoginseng). Methods A Phenomenex Luna C_(18) column(250 mm x 4.6 mm ID, 5 μm) was utilized. Water containing 0.005% formic acid (A) and acetonitrilecontaining 0.005% formic acid (B) were used as gradient eluents. UV spectra were recorded in range195 - 400 nm. Both positive and negative ion ESI modes were used. Results The constituents inNotoginseng were well separated and detected. Fourteen compounds were identified by comparing theirretention time and ESI-MS data with those obtained from the reference compounds. Forty-one compoundswere deduced by data analysis of MS and literature; among them, yesanchinosides-H and -E,chikusetsusaponin-L_5, malonyl-ginsenoside-R_(g_1), the isomers of notoginsenosides-J, -A, -R_1, -G,-R_2, and ginsenoside-Rh_3 were discovered in Notoginseng for the first time. Conclusion Thismethod gives high sensitivity and good separation, and is suitable for identifying the constituentsin Notoginseng. This result is helpful for further phytochemical research on Notoginseng. Based onthis result, further quality control can be studied.
文摘The history and current status of Pharmacy Administration discipline atpharmacy schools in China are illustrated. Several current issues are explored including: (1)insufficient teaching organizations and curriculum, (2) faculty deficiency both in quantity andquality, and (3) much improvement needed in the scope, methodology, and sophistication of research.Several development strategies are formulated such as (1) integrating native education resources inorder to better foster quality professionals, (2) accelerating inter-university cooperation both inteaching and research, and (3) studying the regularites of discipline development and enhancinginternational exchange.
文摘AIMS To investigate the alterations of RBC immunoadherence function in patients with various hepatitis B. METHODS RBCC3bRR,RBCICRR and serum CIC levels were measured in 42 patients with acute and chronic hepatitis B at ac- tive and convalescence stages. RESULTS RBCC3bRRs at the active/acute stage of various hepatitis were decreased.They were 13,54%±5,23% in AH, 7.61%±4.12% in AFH,and 16.18%±6.10% in CH, respectively,all of which were lower than those in normal persons (18.12%±3.91% ).At the quiescent/recovery stage of various hepatitis,the RBCC3bRRs were increased significantly.The changes of RBCICRR and serum CIC level were contrary to those of RBCC3bRR. CONCLUSIONS RBC immunoadherence function is decreased in acute and chronic hepatitis.The decrease is in direct proportion to the severity of the diseases.
