Objective: To provide a kinetic model(s) and reveal the mechanism of thymoquinone and Poloxin blocking an emerging anti-cancer target, human Polo-like kinase 1 (hPlkl) Polo-box domain (PBD). Methods: The bindi...Objective: To provide a kinetic model(s) and reveal the mechanism of thymoquinone and Poloxin blocking an emerging anti-cancer target, human Polo-like kinase 1 (hPlkl) Polo-box domain (PBD). Methods: The binding kinetics was determined by using a fluorescence polarization based assay. The putative mechanism was examined with a competition test. Results: Thymoquinone follows a one-step binding with an association rate constant (k1) of 6.635× 10^3 L.mol^-1 min^-1.Poloxin fit a two-step binding with a dissociation constant (Ki) of 118 μmol/L for the intermediate complex and its isomerization rate (k4) of 0.131 5 minJ to form an irreversible adduct. No significant dissociation was observed for either ligand up to 13 h. The inhibitors responded insignificantly to the presence of Michael donors as hPIkl-PBD competitors. Conclusion: Thymoquinone and Poloxin are slow-tight ligands to the hPlkl-PBD with kinetic models distinct from each other. Michael addition as the mechanism is excluded.展开更多
More and more foreigners come to China on business or for a tour, which makes the translation of public signs important and necessary. Focused on the public sign in scenic resorts, this article briefly gives a short p...More and more foreigners come to China on business or for a tour, which makes the translation of public signs important and necessary. Focused on the public sign in scenic resorts, this article briefly gives a short presentation for the present study status; and the errors in the translation of signs are set forth from the viewpoint of three rules of Skopostheorie. Some suggestions are proposed to make a further study of public signs with a wide scope of examples.展开更多
Due to the compromise of the security of the underlying system or machine stonng the key, exposure of the private key can be a devastating attack on a cryptosystem. Key insulation is an important technique to protect ...Due to the compromise of the security of the underlying system or machine stonng the key, exposure of the private key can be a devastating attack on a cryptosystem. Key insulation is an important technique to protect private keys. To deal with the private (signing) key exposure problem in identity-based signature systems, we propose an identity-based threshold key-insulated signature (IBTKIS) scheme. It strengthens the security and flexibility of existing identity-based key-insulated signature schemes. Our scheme' s security is proven in the random oracle model and rests on the hardness of the computational Diffie-Helhnan problem in groups equipped with a pairing. To the best of our knowledge, it is the first IBTKIS scheme up to now.展开更多
Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of World Journal of Gastroenterology. The editors and authors of the articles submitted to the journ...Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of World Journal of Gastroenterology. The editors and authors of the articles submitted to the journal are grateful to the following reviewers for evaluating the articles (including those were published and those were rejected in this issue) during the last editing period of time.展开更多
Wolfgang Amadeus Mozart, one of the greatest musicians in the world, enchants people across eras with his fabulous music. Peter Shaffer, in Amadeus (2001), depicts the mysterious life and death of this musician in a...Wolfgang Amadeus Mozart, one of the greatest musicians in the world, enchants people across eras with his fabulous music. Peter Shaffer, in Amadeus (2001), depicts the mysterious life and death of this musician in a very different way. Instead of presenting an intelligent and refined artist, Shaffer, from the perspective of his rival, Antonio Salieri, gives us a "foul-mouthed, immature jackanapes" that shocks his audiences in the theatre. Lady Thatcher's displeased response after seeing the play tells the gap between Shaffer's Mozart and the Mozart image in most public's mind. However, the image of the vulgar Mozart, though a contrast to his music, lights up the uniqueness of his music at the age of Enlightenment. The paper, aims to analyze the difference in Mozart's music and the different Mozart character Shaffer presents in his play by drawing on Ren6 Girard's notion of collective violence and scapegoat mechanism. Also, the author intends to examine the playwright's intention and exegesis as he composes this mysterious musician in such a different way展开更多
When considering indigenous people in Brazil, both in academic and non-academic settings, the individuals' names are almost always ignored for the sake of representing their collectivity as communities, as Peoples. D...When considering indigenous people in Brazil, both in academic and non-academic settings, the individuals' names are almost always ignored for the sake of representing their collectivity as communities, as Peoples. Discussing autobiographies or indigenous biographies is still an uncommon endeavor, even in our field of Letters/Liberal Arts or in Indigenous Ethnology. However, since the beginning of the process of reclaiming the lands that once belonged to them, the indigenous Peoples have been producing autobiographical narratives, demonstrating how this genre of text production--traditionally linked to the development of the Western individual---can constitute and be appropriated in different Amerindian translations. It is fi'om this perspective that I intend to present a discussion about those text productions, analyzing what their collective signatures express, and how their proper names are constructed and signified on behalf of the group.展开更多
A face-to-face qualitative interview study was conducted to examine the perceived gender roles and gender identities among 10 to 12 years old girls in Hong Kong. Sixteen girls aged 10 to 12 were asked to take pictures...A face-to-face qualitative interview study was conducted to examine the perceived gender roles and gender identities among 10 to 12 years old girls in Hong Kong. Sixteen girls aged 10 to 12 were asked to take pictures from the media they consumed that illustrated "What girls or women should or should not be; and what girls or women should or should not do". Analysis of interviews and images captured found that celebrities and characters in popular media play a significant role in socializing preadolescent girls on gender roles and gender identity formation. Celebrities and media characters that caught the interviewees' attention were mainly female adult entertainers and media characters. Girls showed admiration of specific talents and personalities of the celebrities and media characters. They paid much attention to the private lives of the celebrities. They learned from celebrities and media characters that certain behaviors were not acceptable in the social arena.展开更多
Personification is widely acknowledged for its central role in the understanding of a nation.However,empirical evidence of its pervasiveness in authentic language data is lacking.In a selfbuilt corpus of news report,t...Personification is widely acknowledged for its central role in the understanding of a nation.However,empirical evidence of its pervasiveness in authentic language data is lacking.In a selfbuilt corpus of news report,this study coded,categorized,and analyzed the metaphoric and metonymic use of two country names:China and Australia.The distribution of the use of country names shows a continuum ranging from the literal,through metonymy,to metaphor.A clear majority of the figurative use of national names in the corpus lies in the category of metonymy,and the fuzzy area between metonymy and metaphor.In contrast,metaphors only take up a minor proportion,and most of them are based on metonymic link.By examining the mundane and seemingly literate use of country names,this study exemplifies that consistent patterns of conventional metonymy and metaphor are able to incur significant cognitive impact.Thus,this study calls for more attention on metonymy and metonymy-metaphor interaction in empirical studies on metaphor.展开更多
Objective Category-specific recognition and naming deficits have been observed in a variety of patient populations. However, the category-specific cortices for naming famous faces, animals and man-made objects remain ...Objective Category-specific recognition and naming deficits have been observed in a variety of patient populations. However, the category-specific cortices for naming famous faces, animals and man-made objects remain controversial. The present study aimed to study the specific areas involved in naming pictures of these 3 categories using functional magnetic resonance imaging. Methods Functional images were analyzed using statistical parametric mapping and the 3 different contrasts were evaluated using t statistics by comparing the naming tasks to their baselines.The contrast images were entered into a random-effects group level analysis.The results were reported in Montreal Neurological Institute co-ordinates,and anatomical regions were identified using an automated anatomical labeling method with XJview 8.Results Naming famous faces caused more activation in the bilateral head of the hippocampus and amygdala with significant left dominance. Bilateral activation of pars triangularis and pars opercularis in the naming of famous faces was also revealed. Naming animals evoked greater responses in the left supplementary motor area, while naming man-made objects evoked more in the left premotor area,left pars orbitalis and right supplementary motor area. The extent of bilateral fusiform gyri activation by naming man-made objects was much larger than that by naming of famous faces or animals.Even in the overlapping sites of activation,some differences among the categories were found for activation in the fusiform gyri.Conclusion The cortices involved in the naming process vary with the naming of famous faces,animals and man-made objects.This finding suggests that different categories of pictures should be used during intra-operative language mapping to generate a broader map of language function, in order to minimize the incidence of false-negative stimulation and permanent post-operative deficits.展开更多
Recently,some blind quantum signature(BQS) protocols have been proposed.But the previous schemes have security and efficiency problems.Based on the entangled Greenberger-Horne-Zeilinger(GHZ) states,a new weak BQS prot...Recently,some blind quantum signature(BQS) protocols have been proposed.But the previous schemes have security and efficiency problems.Based on the entangled Greenberger-Horne-Zeilinger(GHZ) states,a new weak BQS protocol is proposed.Compared with some existing schemes,our protocol has 100% efficiency.Besides,the protocol is simple and easy to implement.The security of the protocol is guaranteed by the correlation of the GHZ particles held by each participant.In our protocol,the signatory is kept blind from the content of the message.According to the security analysis,the signatory cannot disavowal his/her signature while the signature cannot be forged by others.展开更多
Zhao Yingcheng (1619-1657), known as "The Great Advisor", is the only Kaifeng Jew who is mentioned both in the synagogal stele of 1663 and in Chinese gazetteers during his lifetime. Zhao, given the Hebrew name of ...Zhao Yingcheng (1619-1657), known as "The Great Advisor", is the only Kaifeng Jew who is mentioned both in the synagogal stele of 1663 and in Chinese gazetteers during his lifetime. Zhao, given the Hebrew name of Moshe ben Avram, was fluent in Hebrew but also achieved success as a Confucian scholar familiar with the Chinese classics. He would have witnessed the destruction of his hometown by a catastrophic flood during the 1642 Siege of Kaifeng. In 1645, at the age of 26, he attained the jinshi rank in the Imperial Exams, in which only one in 10,000 can- didates was successful. A year later, he was appointed Minister of Justice for the newly installed Qing Dynasty and supervised the controversial decree forcing the Manchu tonsure onto the Han population as a mark of submission. In 1647, he was sent as an envoy to quell the unrest in Fujian province. After defeating bands of violent warlords funded by the notorious pirate Koxinga, Zhao set up a system of public schools to provide greater economic opportunity for the poor. After the death of his father, Zhao returned to Kaifeng for the three-year mourning period; during that time, he funded the restoration of the synagogue, which had been destroyed in the deluge, and the rectification of the Torah scrolls damaged in that catastrophe. Though the biographical facts are sparse, when these are juxtaposed with the dra- matic events that unfolded during his short lifetime, the potential for a fascinating historical fictionalization emerges. Moreover, many of those historical events in seventeenth-century China--climate change, elite corruption, populist revolt, xenophobia, terrorism, law and order, etc.--resonate with contemporary tropes. The story of "The Great Advisor" shows how a Jew in seventeenth-century China rose to national prominence at a time when Jews in Europe faced severe discrimination and persecution.展开更多
基金a co-sponsored graduate research project by China Pharmaceutical University and Shanghai Medicilon Inc
文摘Objective: To provide a kinetic model(s) and reveal the mechanism of thymoquinone and Poloxin blocking an emerging anti-cancer target, human Polo-like kinase 1 (hPlkl) Polo-box domain (PBD). Methods: The binding kinetics was determined by using a fluorescence polarization based assay. The putative mechanism was examined with a competition test. Results: Thymoquinone follows a one-step binding with an association rate constant (k1) of 6.635× 10^3 L.mol^-1 min^-1.Poloxin fit a two-step binding with a dissociation constant (Ki) of 118 μmol/L for the intermediate complex and its isomerization rate (k4) of 0.131 5 minJ to form an irreversible adduct. No significant dissociation was observed for either ligand up to 13 h. The inhibitors responded insignificantly to the presence of Michael donors as hPIkl-PBD competitors. Conclusion: Thymoquinone and Poloxin are slow-tight ligands to the hPlkl-PBD with kinetic models distinct from each other. Michael addition as the mechanism is excluded.
文摘More and more foreigners come to China on business or for a tour, which makes the translation of public signs important and necessary. Focused on the public sign in scenic resorts, this article briefly gives a short presentation for the present study status; and the errors in the translation of signs are set forth from the viewpoint of three rules of Skopostheorie. Some suggestions are proposed to make a further study of public signs with a wide scope of examples.
基金Supported by the National Natural Science Foundation of China (No. 60970111, 61133014, 60903189, 60903020).
文摘Due to the compromise of the security of the underlying system or machine stonng the key, exposure of the private key can be a devastating attack on a cryptosystem. Key insulation is an important technique to protect private keys. To deal with the private (signing) key exposure problem in identity-based signature systems, we propose an identity-based threshold key-insulated signature (IBTKIS) scheme. It strengthens the security and flexibility of existing identity-based key-insulated signature schemes. Our scheme' s security is proven in the random oracle model and rests on the hardness of the computational Diffie-Helhnan problem in groups equipped with a pairing. To the best of our knowledge, it is the first IBTKIS scheme up to now.
文摘Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of World Journal of Gastroenterology. The editors and authors of the articles submitted to the journal are grateful to the following reviewers for evaluating the articles (including those were published and those were rejected in this issue) during the last editing period of time.
文摘Wolfgang Amadeus Mozart, one of the greatest musicians in the world, enchants people across eras with his fabulous music. Peter Shaffer, in Amadeus (2001), depicts the mysterious life and death of this musician in a very different way. Instead of presenting an intelligent and refined artist, Shaffer, from the perspective of his rival, Antonio Salieri, gives us a "foul-mouthed, immature jackanapes" that shocks his audiences in the theatre. Lady Thatcher's displeased response after seeing the play tells the gap between Shaffer's Mozart and the Mozart image in most public's mind. However, the image of the vulgar Mozart, though a contrast to his music, lights up the uniqueness of his music at the age of Enlightenment. The paper, aims to analyze the difference in Mozart's music and the different Mozart character Shaffer presents in his play by drawing on Ren6 Girard's notion of collective violence and scapegoat mechanism. Also, the author intends to examine the playwright's intention and exegesis as he composes this mysterious musician in such a different way
文摘When considering indigenous people in Brazil, both in academic and non-academic settings, the individuals' names are almost always ignored for the sake of representing their collectivity as communities, as Peoples. Discussing autobiographies or indigenous biographies is still an uncommon endeavor, even in our field of Letters/Liberal Arts or in Indigenous Ethnology. However, since the beginning of the process of reclaiming the lands that once belonged to them, the indigenous Peoples have been producing autobiographical narratives, demonstrating how this genre of text production--traditionally linked to the development of the Western individual---can constitute and be appropriated in different Amerindian translations. It is fi'om this perspective that I intend to present a discussion about those text productions, analyzing what their collective signatures express, and how their proper names are constructed and signified on behalf of the group.
文摘A face-to-face qualitative interview study was conducted to examine the perceived gender roles and gender identities among 10 to 12 years old girls in Hong Kong. Sixteen girls aged 10 to 12 were asked to take pictures from the media they consumed that illustrated "What girls or women should or should not be; and what girls or women should or should not do". Analysis of interviews and images captured found that celebrities and characters in popular media play a significant role in socializing preadolescent girls on gender roles and gender identity formation. Celebrities and media characters that caught the interviewees' attention were mainly female adult entertainers and media characters. Girls showed admiration of specific talents and personalities of the celebrities and media characters. They paid much attention to the private lives of the celebrities. They learned from celebrities and media characters that certain behaviors were not acceptable in the social arena.
基金The present study is part of the Chinese MOE Key Research Project of Humanities and Social Science(Project No.16JJD740006)conducted by the Centre for Linguistics and Applied Linguistics,Guangdong University of Foreign Studies.
文摘Personification is widely acknowledged for its central role in the understanding of a nation.However,empirical evidence of its pervasiveness in authentic language data is lacking.In a selfbuilt corpus of news report,this study coded,categorized,and analyzed the metaphoric and metonymic use of two country names:China and Australia.The distribution of the use of country names shows a continuum ranging from the literal,through metonymy,to metaphor.A clear majority of the figurative use of national names in the corpus lies in the category of metonymy,and the fuzzy area between metonymy and metaphor.In contrast,metaphors only take up a minor proportion,and most of them are based on metonymic link.By examining the mundane and seemingly literate use of country names,this study exemplifies that consistent patterns of conventional metonymy and metaphor are able to incur significant cognitive impact.Thus,this study calls for more attention on metonymy and metonymy-metaphor interaction in empirical studies on metaphor.
基金supported bythe Foundation of Science and Technology Program of Guangdong Province,China(No.2008A030201021)the Natural Science Foundation of Guangdong Province,China(No.10151001002000010)
文摘Objective Category-specific recognition and naming deficits have been observed in a variety of patient populations. However, the category-specific cortices for naming famous faces, animals and man-made objects remain controversial. The present study aimed to study the specific areas involved in naming pictures of these 3 categories using functional magnetic resonance imaging. Methods Functional images were analyzed using statistical parametric mapping and the 3 different contrasts were evaluated using t statistics by comparing the naming tasks to their baselines.The contrast images were entered into a random-effects group level analysis.The results were reported in Montreal Neurological Institute co-ordinates,and anatomical regions were identified using an automated anatomical labeling method with XJview 8.Results Naming famous faces caused more activation in the bilateral head of the hippocampus and amygdala with significant left dominance. Bilateral activation of pars triangularis and pars opercularis in the naming of famous faces was also revealed. Naming animals evoked greater responses in the left supplementary motor area, while naming man-made objects evoked more in the left premotor area,left pars orbitalis and right supplementary motor area. The extent of bilateral fusiform gyri activation by naming man-made objects was much larger than that by naming of famous faces or animals.Even in the overlapping sites of activation,some differences among the categories were found for activation in the fusiform gyri.Conclusion The cortices involved in the naming process vary with the naming of famous faces,animals and man-made objects.This finding suggests that different categories of pictures should be used during intra-operative language mapping to generate a broader map of language function, in order to minimize the incidence of false-negative stimulation and permanent post-operative deficits.
基金supported by the National Natural Science Foundation of China (Grant Nos.61003287,61170272,61121061 and 61272514)the Specialized Research Fund for the Doctoral Program of Higher Education (Grant No.20100005120002)+2 种基金the Fok Ying Tong Education Foundation (Grant No.131067)the Asia Foresight Program under NSFC (Grant No.61161140320)the Fundamental Research Funds for the Central Universities (Grant No.BUPT2012RC0221)
文摘Recently,some blind quantum signature(BQS) protocols have been proposed.But the previous schemes have security and efficiency problems.Based on the entangled Greenberger-Horne-Zeilinger(GHZ) states,a new weak BQS protocol is proposed.Compared with some existing schemes,our protocol has 100% efficiency.Besides,the protocol is simple and easy to implement.The security of the protocol is guaranteed by the correlation of the GHZ particles held by each participant.In our protocol,the signatory is kept blind from the content of the message.According to the security analysis,the signatory cannot disavowal his/her signature while the signature cannot be forged by others.
文摘Zhao Yingcheng (1619-1657), known as "The Great Advisor", is the only Kaifeng Jew who is mentioned both in the synagogal stele of 1663 and in Chinese gazetteers during his lifetime. Zhao, given the Hebrew name of Moshe ben Avram, was fluent in Hebrew but also achieved success as a Confucian scholar familiar with the Chinese classics. He would have witnessed the destruction of his hometown by a catastrophic flood during the 1642 Siege of Kaifeng. In 1645, at the age of 26, he attained the jinshi rank in the Imperial Exams, in which only one in 10,000 can- didates was successful. A year later, he was appointed Minister of Justice for the newly installed Qing Dynasty and supervised the controversial decree forcing the Manchu tonsure onto the Han population as a mark of submission. In 1647, he was sent as an envoy to quell the unrest in Fujian province. After defeating bands of violent warlords funded by the notorious pirate Koxinga, Zhao set up a system of public schools to provide greater economic opportunity for the poor. After the death of his father, Zhao returned to Kaifeng for the three-year mourning period; during that time, he funded the restoration of the synagogue, which had been destroyed in the deluge, and the rectification of the Torah scrolls damaged in that catastrophe. Though the biographical facts are sparse, when these are juxtaposed with the dra- matic events that unfolded during his short lifetime, the potential for a fascinating historical fictionalization emerges. Moreover, many of those historical events in seventeenth-century China--climate change, elite corruption, populist revolt, xenophobia, terrorism, law and order, etc.--resonate with contemporary tropes. The story of "The Great Advisor" shows how a Jew in seventeenth-century China rose to national prominence at a time when Jews in Europe faced severe discrimination and persecution.