We studied the effect of two independent variables, the pectin/calcium chloride weight ratio and the overall matrix weight in HPMC/pectin/calcium matrix tablet, on the release of indomethacin. A two-factor 5-level cen...We studied the effect of two independent variables, the pectin/calcium chloride weight ratio and the overall matrix weight in HPMC/pectin/calcium matrix tablet, on the release of indomethacin. A two-factor 5-level central composite experimental design was employed. Responses of the Peppas correlation parameters n and K and the 10% release time （T0.1） were optimized by response surface methodology. Significant effect of the independent variables on the biphasic release parameters, n and K, was observed. N, K and T0.1 were well fitted with the second-order quadratic equations rather than linear equations. Moreover, the mathematic fitting and the response surfaces showed significant cross-interaction between the pectin/calcium chloride ratio and the overall matrix weight. The optimal formulation with larger n, longer T0.1 and smaller K consisted of medium pectin/calcium chloride ratio around 1.0 and medium matrix weight around 200 mg. Validation studies on the optimal formulations showed good predictability of the n, K and T0.1 values with biases within the range of-7.33% and 6.26%. Our results support that central composite design can be used to optimize drug release from HPMC/pectin/calcium matrix tablet with high predictability.展开更多
Construction of beautiful villages is an integral part of No.1 file issued by the central government and rural landscape planning plays an important role. The research reviewed the status quo of beautiful village cons...Construction of beautiful villages is an integral part of No.1 file issued by the central government and rural landscape planning plays an important role. The research reviewed the status quo of beautiful village construction, analyzed rural landscape planning and the optimized way for rural landscape planning, providing theoretical references for construction of beautiful village construction.展开更多
In recent years, sinmlated annealing algo-rithms have been extensively developed and uti-lized to solve nmlti-objective optimization problems. In order to obtain better optimization perfonmnce, this paper proposes a N...In recent years, sinmlated annealing algo-rithms have been extensively developed and uti-lized to solve nmlti-objective optimization problems. In order to obtain better optimization perfonmnce, this paper proposes a Novel Adaptive Simulated Annealing （NASA） algorithm for constrained multi-objective optimization based on Archived Multi-objective Simulated Annealing （AMOSA）. For han-dling multi-objective, NASA makes improverrents in three aspects： sub-iteration search, sub-archive and adaptive search, which effectively strengthen the stability and efficiency of the algorithnm For handling constraints, NASA introduces corresponding solution acceptance criterion. Furtherrrore, NASA has also been applied to optimize TD-LTE network perform-ance by adjusting antenna paranleters; it can achieve better extension and convergence than AMOSA, NS-GAII and MOPSO. Analytical studies and simulations indicate that the proposed NASA algorithm can play an important role in improving multi-objective optimi-zation performance.展开更多
In order to validate the control effects of integrated technology of medicine and fertilizer on tobacco bacterial wilt,field experiments were conducted by using youmeili and tetracycline as the test agents.The results...In order to validate the control effects of integrated technology of medicine and fertilizer on tobacco bacterial wilt,field experiments were conducted by using youmeili and tetracycline as the test agents.The results obtained were listed as follows:(1)The incidence rate of bacterial wilt ascended more quickly after July 10 th,the incidence of CK reached 78.30%on July 25 th.(2)The control effect of“youmeili 3 g+tetramycin 200 times liquid”reached 69.47%,significantly higher than other treatments.(3)The output value of“Youmeil 3 g+tetramycin 200 times liquid”served as 1635.66 yuan/667m^2,with the highest economic character in all treatments.In a word,integrated technology of medicine and fertilizer was a feasible approach to control tobacco bacterial wilt.展开更多
The word “chudu” comes from Qu Yuan’s Li Sao “huang lan kui yu chu du xi, zhao ci yu yi jia ming”. The original meaning was the day of birth. After the Song Dynasty, the literati began to use it to refer to birth...The word “chudu” comes from Qu Yuan’s Li Sao “huang lan kui yu chu du xi, zhao ci yu yi jia ming”. The original meaning was the day of birth. After the Song Dynasty, the literati began to use it to refer to birthdays. By the end of the Ming Dynasty, they had been calling their birthdays “chudu” once they celebrated it and they were so keen on birthday celebrations. Gu Yanwu pointed out that the word “chudu” only fits “the old ministers （or the exiled ministers） who lamented the crash of the Yingcapital of the country of “Chu” such as Qu Yuan. At the same time, its use in Huang Zongxi’s and Wang Fuzhi’s birthday poems is also consistent with this context. The unique situation and mood of the adherents led them to be close to Qu Yuan and Wen Tianxiang, which bestowed “chudu” the special meaning. It is very suitable for the ministers who suffered the crash of their Dynasties or those who were exiled distantly to express their feelings about the old dynasties and old friends. After these people, Chen Yinke consciously acknowledged this layer of interpreting “chudu” and used it, which has not only enriched the connotation of “chudu”, but also extended its cultural life. From Qu Yuan to Wen Tianxiang, until Gu Yanwu, Huang Zongxi, Wang Fuzhi, and then to Chen Yinke, we can take a glimpse of the spiritual world of the Chinese adherents of Dynasties.展开更多
This article is about the problem of optimizing of the capital structure of the concrete firm and about the possibility to use the passive way of optimizing of this capital structure on the basis of the so-called Bran...This article is about the problem of optimizing of the capital structure of the concrete firm and about the possibility to use the passive way of optimizing of this capital structure on the basis of the so-called Branch standards. Branch standards are defined as some average indebtedness that the firms are trying to follow. There are a lot of theories available, but the final process of optimizing of the capital structure of the concrete firm is very complicated and it is necessary to cope with a lot of application problems. Besides Traditional theory, none of the further theories offer some concrete recommended optimal indebtedness. For that reason, the possibility to optimize the capital structure based on the passive way is represented besides other things by the so-called Branch standards. The aim of this article is to judge if it is possible to identify this average indebtedness in different branches and in different countries. The hypothesis was stated that it is possible only in selected branches in selected countries. The research is realized in the six selected branches： Railroads, Beverages, Steel, Paper Production, Tobacco, and Electrical Equipment in the Czech Republic and in USA. Data for the years 2008-2016 were obtained from the system Albertina Data at the University of Economics in Prague and from the web pages of Prof. Aswath Damodaran in USA. There were identified so-called Branch standards in the Czech Republic for the branches Railroads 45%, Beverages 50%, Tobacco 50%, and Electrical Equipment 40%. There are also identified so-called Branch standards in USA for the branches Railroads 40% and Paper Production 40%-50%. For the branch Paper Production in the Czech Republic and for the branch Beverages in USA were identified ranges of 40%-45% and 40%-50% respectively. The so-called Branch standards were not stated for the branch Steel in both countries and for the branches Tobacco and Electrical Equipment in USA. The values were verified by the data for the year 2016 and the so-called Branch standards were confirmed excluding the branch Steel in both countries and the branches Tobacco and Electrical Equipment in the US.展开更多
The paper presents results of palynological studies of the coal-bearing Carboniferous in Central Kazakhstan. A quantitative dynamics of major genera of miospores reflects an overall succession of the Carboniferous mio...The paper presents results of palynological studies of the coal-bearing Carboniferous in Central Kazakhstan. A quantitative dynamics of major genera of miospores reflects an overall succession of the Carboniferous miospore assemblages. Visean Serpukhovian assemblages are dominanted by Lophozonotriletes fuscatus, Acanthozonotriletes cristifer, A. inclusus, Punctatisporites glabratus, Crassispora ignorata, C. scrupea, Cyclobaculisporites trichacanthus, Lycospora breviapiculata, L. echinata and Vallatisporites decrescens. Rare Punctatisporites bertschoguriensis , Stenozonotriletes marginellus , Vallatisporites appilicatus , Verrucosisporites serobiculatus , Retieulatisporites caneellatus, Granulatisporites areuatus are recorded, which are not found in assemblages from overlying sediments. Bashkirian-Moseovian assemblages are dominated by Lyeospora subtriquetra, L. pusilla, Vallatisporites ciliaris, Apiculatisporis mollis, Cyelogranisporites testieulatus, Calamospora mierorugosa, Sehopfipollenites principalis, Psilohyrnena psiloptera, Florinites grandis and Granulatisporites piroformis miospores. Cristatisporites latispinus, Angulisporites didymus, Thymospora obseura and Torispora securis are also present, as well as single Apieulatisporis eurvispinus, Raistriekia inordinata, Marsupipollenites retroflexus, Entylissa eaperata, Potonieisporites grandis and Cordaitina sp. A similar succession of miospore assemblages is recorded in the Carboniferous deposits of Europe and North America, which allows carrying out correlations, despite an endemic characters of many species of Paleozoic miospores from the coal-bearing Carboniferous of the Kazakhstan Province in the Euramerian Paleofloristic Region.展开更多
Within previous EU projects, possible modifications to the engine components have been investigated, that would allow for an optimised aerodynamic or acoustic design of the EGV （exit guide vanes） of the TEC （turbin...Within previous EU projects, possible modifications to the engine components have been investigated, that would allow for an optimised aerodynamic or acoustic design of the EGV （exit guide vanes） of the TEC （turbine exit casing）. However, the engine weight should not be increased and the aerodynamic performance must be at least the same. This paper compares the sound power level of a state-of-the-art TEC （reference TEC） with typical EGVs with an aerodynamically optimised TEC configuration for the engine operating point approach. It is shown that a significant weight reduction （only bladings considered） and reduction in engine length can be achieved but the sound power level for the fundamental tone （lst blade passing frequency） for this acoustically important operating point is increased. It is also shown that the losses of the aerodynamical optimised EGVs are higher for this off design point but significantly lower at the aero design point. Measurements were conducted in the STTF （subsonic test turbine facility） at the Institute for Thermal Turbo machinery and Machine Dynamics, Graz University of Technology. The inlet guide vanes, the LPT （low pressure turbine） stage, and the EGVs have been designed by MTU Aero Engines.展开更多
The Belt and Road Initiative has brought economic development and prosperity to the countries along its route. Latin America is an important area of economic investment for China, with special focus on oil and gas,How...The Belt and Road Initiative has brought economic development and prosperity to the countries along its route. Latin America is an important area of economic investment for China, with special focus on oil and gas,However, investment is bound to be accompanied by opportunities and risks. Before investing in oil and gas in the corresponding countries, it is necessary to analyze the risk factors from a risk management perspective so as to establish a risk identification system and early warning mechanism. In this way, enterprises can gain competitive advantages and develop in a sustainable way.展开更多
基金Shanghai Municipal Committee of Sciencc and Tcchnology (Grant No.024319114).
文摘We studied the effect of two independent variables, the pectin/calcium chloride weight ratio and the overall matrix weight in HPMC/pectin/calcium matrix tablet, on the release of indomethacin. A two-factor 5-level central composite experimental design was employed. Responses of the Peppas correlation parameters n and K and the 10% release time （T0.1） were optimized by response surface methodology. Significant effect of the independent variables on the biphasic release parameters, n and K, was observed. N, K and T0.1 were well fitted with the second-order quadratic equations rather than linear equations. Moreover, the mathematic fitting and the response surfaces showed significant cross-interaction between the pectin/calcium chloride ratio and the overall matrix weight. The optimal formulation with larger n, longer T0.1 and smaller K consisted of medium pectin/calcium chloride ratio around 1.0 and medium matrix weight around 200 mg. Validation studies on the optimal formulations showed good predictability of the n, K and T0.1 values with biases within the range of-7.33% and 6.26%. Our results support that central composite design can be used to optimize drug release from HPMC/pectin/calcium matrix tablet with high predictability.
基金Supported by Postgraduate Innovation Fund Project by Jiangxi Normal University in 2016(YJS2016061)Art Design and Practice Teaching Reform Driven by Universityindustry Base(JXJG-15-2-29)~~
文摘Construction of beautiful villages is an integral part of No.1 file issued by the central government and rural landscape planning plays an important role. The research reviewed the status quo of beautiful village construction, analyzed rural landscape planning and the optimized way for rural landscape planning, providing theoretical references for construction of beautiful village construction.
基金supported by the Major National Science & Technology Specific Project of China under Grants No.2010ZX03002-007-02,No.2009ZX03002-002,No.2010ZX03002-002-03
文摘In recent years, sinmlated annealing algo-rithms have been extensively developed and uti-lized to solve nmlti-objective optimization problems. In order to obtain better optimization perfonmnce, this paper proposes a Novel Adaptive Simulated Annealing （NASA） algorithm for constrained multi-objective optimization based on Archived Multi-objective Simulated Annealing （AMOSA）. For han-dling multi-objective, NASA makes improverrents in three aspects： sub-iteration search, sub-archive and adaptive search, which effectively strengthen the stability and efficiency of the algorithnm For handling constraints, NASA introduces corresponding solution acceptance criterion. Furtherrrore, NASA has also been applied to optimize TD-LTE network perform-ance by adjusting antenna paranleters; it can achieve better extension and convergence than AMOSA, NS-GAII and MOPSO. Analytical studies and simulations indicate that the proposed NASA algorithm can play an important role in improving multi-objective optimi-zation performance.
基金Supported by Science and Technology Project of Yunnan Tobacco Company(2015YN07,2017YN26)~~
文摘In order to validate the control effects of integrated technology of medicine and fertilizer on tobacco bacterial wilt,field experiments were conducted by using youmeili and tetracycline as the test agents.The results obtained were listed as follows:(1)The incidence rate of bacterial wilt ascended more quickly after July 10 th,the incidence of CK reached 78.30%on July 25 th.(2)The control effect of“youmeili 3 g+tetramycin 200 times liquid”reached 69.47%,significantly higher than other treatments.(3)The output value of“Youmeil 3 g+tetramycin 200 times liquid”served as 1635.66 yuan/667m^2,with the highest economic character in all treatments.In a word,integrated technology of medicine and fertilizer was a feasible approach to control tobacco bacterial wilt.
文摘The word “chudu” comes from Qu Yuan’s Li Sao “huang lan kui yu chu du xi, zhao ci yu yi jia ming”. The original meaning was the day of birth. After the Song Dynasty, the literati began to use it to refer to birthdays. By the end of the Ming Dynasty, they had been calling their birthdays “chudu” once they celebrated it and they were so keen on birthday celebrations. Gu Yanwu pointed out that the word “chudu” only fits “the old ministers （or the exiled ministers） who lamented the crash of the Yingcapital of the country of “Chu” such as Qu Yuan. At the same time, its use in Huang Zongxi’s and Wang Fuzhi’s birthday poems is also consistent with this context. The unique situation and mood of the adherents led them to be close to Qu Yuan and Wen Tianxiang, which bestowed “chudu” the special meaning. It is very suitable for the ministers who suffered the crash of their Dynasties or those who were exiled distantly to express their feelings about the old dynasties and old friends. After these people, Chen Yinke consciously acknowledged this layer of interpreting “chudu” and used it, which has not only enriched the connotation of “chudu”, but also extended its cultural life. From Qu Yuan to Wen Tianxiang, until Gu Yanwu, Huang Zongxi, Wang Fuzhi, and then to Chen Yinke, we can take a glimpse of the spiritual world of the Chinese adherents of Dynasties.
文摘This article is about the problem of optimizing of the capital structure of the concrete firm and about the possibility to use the passive way of optimizing of this capital structure on the basis of the so-called Branch standards. Branch standards are defined as some average indebtedness that the firms are trying to follow. There are a lot of theories available, but the final process of optimizing of the capital structure of the concrete firm is very complicated and it is necessary to cope with a lot of application problems. Besides Traditional theory, none of the further theories offer some concrete recommended optimal indebtedness. For that reason, the possibility to optimize the capital structure based on the passive way is represented besides other things by the so-called Branch standards. The aim of this article is to judge if it is possible to identify this average indebtedness in different branches and in different countries. The hypothesis was stated that it is possible only in selected branches in selected countries. The research is realized in the six selected branches： Railroads, Beverages, Steel, Paper Production, Tobacco, and Electrical Equipment in the Czech Republic and in USA. Data for the years 2008-2016 were obtained from the system Albertina Data at the University of Economics in Prague and from the web pages of Prof. Aswath Damodaran in USA. There were identified so-called Branch standards in the Czech Republic for the branches Railroads 45%, Beverages 50%, Tobacco 50%, and Electrical Equipment 40%. There are also identified so-called Branch standards in USA for the branches Railroads 40% and Paper Production 40%-50%. For the branch Paper Production in the Czech Republic and for the branch Beverages in USA were identified ranges of 40%-45% and 40%-50% respectively. The so-called Branch standards were not stated for the branch Steel in both countries and for the branches Tobacco and Electrical Equipment in USA. The values were verified by the data for the year 2016 and the so-called Branch standards were confirmed excluding the branch Steel in both countries and the branches Tobacco and Electrical Equipment in the US.
文摘The paper presents results of palynological studies of the coal-bearing Carboniferous in Central Kazakhstan. A quantitative dynamics of major genera of miospores reflects an overall succession of the Carboniferous miospore assemblages. Visean Serpukhovian assemblages are dominanted by Lophozonotriletes fuscatus, Acanthozonotriletes cristifer, A. inclusus, Punctatisporites glabratus, Crassispora ignorata, C. scrupea, Cyclobaculisporites trichacanthus, Lycospora breviapiculata, L. echinata and Vallatisporites decrescens. Rare Punctatisporites bertschoguriensis , Stenozonotriletes marginellus , Vallatisporites appilicatus , Verrucosisporites serobiculatus , Retieulatisporites caneellatus, Granulatisporites areuatus are recorded, which are not found in assemblages from overlying sediments. Bashkirian-Moseovian assemblages are dominated by Lyeospora subtriquetra, L. pusilla, Vallatisporites ciliaris, Apiculatisporis mollis, Cyelogranisporites testieulatus, Calamospora mierorugosa, Sehopfipollenites principalis, Psilohyrnena psiloptera, Florinites grandis and Granulatisporites piroformis miospores. Cristatisporites latispinus, Angulisporites didymus, Thymospora obseura and Torispora securis are also present, as well as single Apieulatisporis eurvispinus, Raistriekia inordinata, Marsupipollenites retroflexus, Entylissa eaperata, Potonieisporites grandis and Cordaitina sp. A similar succession of miospore assemblages is recorded in the Carboniferous deposits of Europe and North America, which allows carrying out correlations, despite an endemic characters of many species of Paleozoic miospores from the coal-bearing Carboniferous of the Kazakhstan Province in the Euramerian Paleofloristic Region.
文摘Within previous EU projects, possible modifications to the engine components have been investigated, that would allow for an optimised aerodynamic or acoustic design of the EGV （exit guide vanes） of the TEC （turbine exit casing）. However, the engine weight should not be increased and the aerodynamic performance must be at least the same. This paper compares the sound power level of a state-of-the-art TEC （reference TEC） with typical EGVs with an aerodynamically optimised TEC configuration for the engine operating point approach. It is shown that a significant weight reduction （only bladings considered） and reduction in engine length can be achieved but the sound power level for the fundamental tone （lst blade passing frequency） for this acoustically important operating point is increased. It is also shown that the losses of the aerodynamical optimised EGVs are higher for this off design point but significantly lower at the aero design point. Measurements were conducted in the STTF （subsonic test turbine facility） at the Institute for Thermal Turbo machinery and Machine Dynamics, Graz University of Technology. The inlet guide vanes, the LPT （low pressure turbine） stage, and the EGVs have been designed by MTU Aero Engines.
文摘The Belt and Road Initiative has brought economic development and prosperity to the countries along its route. Latin America is an important area of economic investment for China, with special focus on oil and gas,However, investment is bound to be accompanied by opportunities and risks. Before investing in oil and gas in the corresponding countries, it is necessary to analyze the risk factors from a risk management perspective so as to establish a risk identification system and early warning mechanism. In this way, enterprises can gain competitive advantages and develop in a sustainable way.
