AIM： To investigate genetic differences between Crohn＇s disease （CD） patients with a sustained remission vs relapsers after discontinuing infliximab while in cortico- steroid-free remission. METHODS： Forty-eight ...AIM： To investigate genetic differences between Crohn＇s disease （CD） patients with a sustained remission vs relapsers after discontinuing infliximab while in cortico- steroid-free remission. METHODS： Forty-eight CD patients received infliximab and were in full corticosteroid-free clinical remission but then discontinued infliximab for reasons other than a loss of response, were identified by review of an electronic database and charts. Infliximab-associated remis- sion was defined as corticosteroid-free plus normaliza- tion of clinical disease activity [CD activity index （CDAI） 〈 150] during follow-up visits based on physician global assessments. A CD relapse （loss of infliximab-induced remission） was clinically defined as a physician visit for symptoms of disease activity （CDAI 〉 220） and a thera- peutic intervention with CD medication（s）, or a hospital- ization with complications related to active CD. Genetic analyses were performed on samples from 14 patients （n = 6 who had a sustained long term remission after stopping infliximab, n -- 8 who rapidly relapsed after stopping infliximab）. Nucleotide-binding oligomerization domain 2 （NOD2）/caspase activation recruitment do- main 15 （CARD15） polymorphisms （R702W, G908R and L1007fs） and the inflammatory bowel disease 5 （IBDS） polymorphisms （IGR2060a1 and IGR3081a1） were ana- lyzed in each group. RESULTS： Five single nucleotide polymorphisms of IBD5 and NOD2/CARD15 genes were successfully analyzed for all 14 subjects. There was no signifcant increase in frequency of the NOD2/CARD15 polymor- phisms （R702W, G908R and L1007fs） and the IBD5 polymorphisms （IGR2060al and IGR3081a1） in either group of patients; those whose disease relapsed rap- idly or those who remained in sustained long term remission following the discontinuation of infliximab. Nearly a third of patients in full clinical remission who stopped infliximab for reasons other than loss of re- sponse remained in sustained clinical remission, while two-thirds relapsed rapidly. There was a marked dif- ference in the duration of clinical remission following discontinuance of infliximab between the two groups. The patients who lost remission did so after 1.0 years 4- 0.6 years, while those still in remission were at the time of this study, 8.1 years 4- 2.6 years post-discon- tinuation of infliximab, P 〈 0.001. The 8 patients who had lost remission after discontinuing infiiximab had a mean number of 5 infusions （range 3-7）, with a mean treatment time of 7.2 mo （range 1.5 mo-15 mo）. The mean duration of time from the last infusion of inflix- imab to the time of loss of remission was 382 d （range 20 d-701 d）. The 6 patients who remained in remission after discontinuing infliximab had a mean number of 6 infusions （range 3-12）, with a mean treatment dura- tion of 12 mo （range 3.6 mo-32 too） （P = 0.45 relative to those who lost remission）. CONCLUSION： There are no IBD5 or NOD2/CARD15 mutations that predict which patients might have sus- tained remission and which will relapse rapidly after stopping infliximab.展开更多
In this paper, we conduct research on the new mode of computer education based on project driving methodology and teaching practice. Computer education is an important part in college education, application of compute...In this paper, we conduct research on the new mode of computer education based on project driving methodology and teaching practice. Computer education is an important part in college education, application of computer technology can effectively cultivate students＇ ability and quality of information. Collaborative project teaching method of the implementation of the method can make students accept knowledge by only listen into doing which will not only enhance the students＇ ability but help teachers obtain better feedback as well which is meaningful and necessary. The proposed methodology and education pattern is proven to be effective and feasible.展开更多
This study discusses the application of the regulatory focus of the individual motivation systems to green public service advertisements advocating environmental protection. First, it aims to determine whether the pre...This study discusses the application of the regulatory focus of the individual motivation systems to green public service advertisements advocating environmental protection. First, it aims to determine whether the previously proposed regulatory fit theory can be applied to public service advertisements with characteristics different from those of commercial advertisements. Second, it aims to understand how to design messages to achieve the best effect on audiences with different foci. This study takes the regulatory focus theory as the basis and green public service advertisements as the films. After adopting 2 ~ 2 ~ 2 three-factor design to test the interaction relations among the individual regulatory focus, message regulatory focus, and message framing. The results from the 217 college respondents indicate that the audience is influenced by regulatory focus when receiving messages from public service advertisements, which is similar to the influence of commercial advertisements. That is, when audience with a promotion focus, films with promotion focus and positive framing have a best advertisement effect. On the other hand, the audience with a prevention focus, films with prevention focus and negative framing also has a better advertisement effect.展开更多
Science and technology proceed by leaps and bounds; our network is growing at an alarming rate which is reflected in the rapid development and popularization. Facing highly developed information technology, and the ra...Science and technology proceed by leaps and bounds; our network is growing at an alarming rate which is reflected in the rapid development and popularization. Facing highly developed information technology, and the rapid development of the network, strengthen ideological and political education is very important, the network has put impressive and comprehensive impact on the university teachers and students＇ lives, learning, work, moral, ideological and political attitudes, moral outlook, political literacy, life values, and ideological and political education in universities is facing a new challenge ; Meanwhile, the network also provides many new challenges and opportunities, expanding the channel and space of ideological and political education, it also can improve the quality of the main ideological and political education of high demand. Therefore, the educators of ideological and political education in colleges should keep up the pace of the rapid development of large- era, became not only who has a good ideological and political quality and comprehensive cultural knowledge quality, but also has very high literal ability and a solid information of network technology skills, so they could give full play to the advantages of information networks, do research and create a new situation in a large network of ideological and political education, then make the traditional ideological and political education produce a qualitative leap.展开更多
Computer technology is one of the main technologies of the information society, the development of computer education satisfies for requirements to science, the world and the future, and it is an important part of stu...Computer technology is one of the main technologies of the information society, the development of computer education satisfies for requirements to science, the world and the future, and it is an important part of students＇ quality education, it is of great significance to improve the scientific and cultural level of the students, to promote the teaching content modernization of education and teaching reform, to improve the quality of education and the level of management.展开更多
Based on the fuzzy characters of eco-environmental quality conception and classification standards, the incompatibility of evaluation indexes, the statistical fluctuation of index values, an information entropy fuzzy ...Based on the fuzzy characters of eco-environmental quality conception and classification standards, the incompatibility of evaluation indexes, the statistical fluctuation of index values, an information entropy fuzzy matter-element model for evaluating regional eco-environmental quality is proposed by way of comprehensively utilizing such theories as information theory, fuzzy sets and matter-element theory, etc. As a case, the model established here is used to evaluate the eco-environmental quality of Lake Chaohu basin. In the case, the eco-environmental quality standards and the evaluated schemes are indicated as matter-elements, together. Through constructing compound fuzzy matter-element, probability compound fuzzy matter-element and self-information compound fuzzy matter- element, the information entropy of each matter-element （including evaluated schemes and classification standards） is calculated in the end. According to these obtained information entropy values, the evaluated schemes can be not only arranged in quality state order but also classified by classification standards .Study result shows that information entropy fuzzy matter-element model is suitable for regional eco-environmental quality assessment.展开更多
基金Supported by Center of Excellence for Gastrointestinal,Inflammation and Immunity Research at the University of Alberta
文摘AIM： To investigate genetic differences between Crohn＇s disease （CD） patients with a sustained remission vs relapsers after discontinuing infliximab while in cortico- steroid-free remission. METHODS： Forty-eight CD patients received infliximab and were in full corticosteroid-free clinical remission but then discontinued infliximab for reasons other than a loss of response, were identified by review of an electronic database and charts. Infliximab-associated remis- sion was defined as corticosteroid-free plus normaliza- tion of clinical disease activity [CD activity index （CDAI） 〈 150] during follow-up visits based on physician global assessments. A CD relapse （loss of infliximab-induced remission） was clinically defined as a physician visit for symptoms of disease activity （CDAI 〉 220） and a thera- peutic intervention with CD medication（s）, or a hospital- ization with complications related to active CD. Genetic analyses were performed on samples from 14 patients （n = 6 who had a sustained long term remission after stopping infliximab, n -- 8 who rapidly relapsed after stopping infliximab）. Nucleotide-binding oligomerization domain 2 （NOD2）/caspase activation recruitment do- main 15 （CARD15） polymorphisms （R702W, G908R and L1007fs） and the inflammatory bowel disease 5 （IBDS） polymorphisms （IGR2060a1 and IGR3081a1） were ana- lyzed in each group. RESULTS： Five single nucleotide polymorphisms of IBD5 and NOD2/CARD15 genes were successfully analyzed for all 14 subjects. There was no signifcant increase in frequency of the NOD2/CARD15 polymor- phisms （R702W, G908R and L1007fs） and the IBD5 polymorphisms （IGR2060al and IGR3081a1） in either group of patients; those whose disease relapsed rap- idly or those who remained in sustained long term remission following the discontinuation of infliximab. Nearly a third of patients in full clinical remission who stopped infliximab for reasons other than loss of re- sponse remained in sustained clinical remission, while two-thirds relapsed rapidly. There was a marked dif- ference in the duration of clinical remission following discontinuance of infliximab between the two groups. The patients who lost remission did so after 1.0 years 4- 0.6 years, while those still in remission were at the time of this study, 8.1 years 4- 2.6 years post-discon- tinuation of infliximab, P 〈 0.001. The 8 patients who had lost remission after discontinuing infiiximab had a mean number of 5 infusions （range 3-7）, with a mean treatment time of 7.2 mo （range 1.5 mo-15 mo）. The mean duration of time from the last infusion of inflix- imab to the time of loss of remission was 382 d （range 20 d-701 d）. The 6 patients who remained in remission after discontinuing infliximab had a mean number of 6 infusions （range 3-12）, with a mean treatment dura- tion of 12 mo （range 3.6 mo-32 too） （P = 0.45 relative to those who lost remission）. CONCLUSION： There are no IBD5 or NOD2/CARD15 mutations that predict which patients might have sus- tained remission and which will relapse rapidly after stopping infliximab.
文摘In this paper, we conduct research on the new mode of computer education based on project driving methodology and teaching practice. Computer education is an important part in college education, application of computer technology can effectively cultivate students＇ ability and quality of information. Collaborative project teaching method of the implementation of the method can make students accept knowledge by only listen into doing which will not only enhance the students＇ ability but help teachers obtain better feedback as well which is meaningful and necessary. The proposed methodology and education pattern is proven to be effective and feasible.
文摘This study discusses the application of the regulatory focus of the individual motivation systems to green public service advertisements advocating environmental protection. First, it aims to determine whether the previously proposed regulatory fit theory can be applied to public service advertisements with characteristics different from those of commercial advertisements. Second, it aims to understand how to design messages to achieve the best effect on audiences with different foci. This study takes the regulatory focus theory as the basis and green public service advertisements as the films. After adopting 2 ~ 2 ~ 2 three-factor design to test the interaction relations among the individual regulatory focus, message regulatory focus, and message framing. The results from the 217 college respondents indicate that the audience is influenced by regulatory focus when receiving messages from public service advertisements, which is similar to the influence of commercial advertisements. That is, when audience with a promotion focus, films with promotion focus and positive framing have a best advertisement effect. On the other hand, the audience with a prevention focus, films with prevention focus and negative framing also has a better advertisement effect.
文摘Science and technology proceed by leaps and bounds; our network is growing at an alarming rate which is reflected in the rapid development and popularization. Facing highly developed information technology, and the rapid development of the network, strengthen ideological and political education is very important, the network has put impressive and comprehensive impact on the university teachers and students＇ lives, learning, work, moral, ideological and political attitudes, moral outlook, political literacy, life values, and ideological and political education in universities is facing a new challenge ; Meanwhile, the network also provides many new challenges and opportunities, expanding the channel and space of ideological and political education, it also can improve the quality of the main ideological and political education of high demand. Therefore, the educators of ideological and political education in colleges should keep up the pace of the rapid development of large- era, became not only who has a good ideological and political quality and comprehensive cultural knowledge quality, but also has very high literal ability and a solid information of network technology skills, so they could give full play to the advantages of information networks, do research and create a new situation in a large network of ideological and political education, then make the traditional ideological and political education produce a qualitative leap.
文摘Computer technology is one of the main technologies of the information society, the development of computer education satisfies for requirements to science, the world and the future, and it is an important part of students＇ quality education, it is of great significance to improve the scientific and cultural level of the students, to promote the teaching content modernization of education and teaching reform, to improve the quality of education and the level of management.
文摘Based on the fuzzy characters of eco-environmental quality conception and classification standards, the incompatibility of evaluation indexes, the statistical fluctuation of index values, an information entropy fuzzy matter-element model for evaluating regional eco-environmental quality is proposed by way of comprehensively utilizing such theories as information theory, fuzzy sets and matter-element theory, etc. As a case, the model established here is used to evaluate the eco-environmental quality of Lake Chaohu basin. In the case, the eco-environmental quality standards and the evaluated schemes are indicated as matter-elements, together. Through constructing compound fuzzy matter-element, probability compound fuzzy matter-element and self-information compound fuzzy matter- element, the information entropy of each matter-element （including evaluated schemes and classification standards） is calculated in the end. According to these obtained information entropy values, the evaluated schemes can be not only arranged in quality state order but also classified by classification standards .Study result shows that information entropy fuzzy matter-element model is suitable for regional eco-environmental quality assessment.
