“健脾”中药对急性运动大鼠线粒体呼吸链复合体的影响

目的:探讨补充"健脾"中药对急性运动大鼠肌肉、肝脏线粒体呼吸链复合体活性的影响。方法:27只SD大鼠,随机分成正常对照组(9只)、急性运动组(9只)、中药补剂组(9只)。采用双抗体两步夹心酶联免疫吸附法(ELISA)测定大鼠肌肉、肝脏线粒体呼吸链复合体活性浓度。结果:急性运动组大鼠肌肉、肝脏线粒体呼吸链复合体活性浓度略高于正常对照组,但无显著差异;而中药补剂组大鼠肌肉组织的呼吸链复合体Ⅰ、Ⅲ及肝脏组织的呼吸链复合体Ⅱ、Ⅲ活性明显高于正常对照组(P<0.05)。结论:"健脾"中药可提高大鼠肌肉、肝脏线粒体呼吸链酶复合体活性,维持线粒体正常功能,改善急性运动过程中的能量代谢。

Clinical efficacy and safety of TCM prescriptions combined with nucleoside(acid)analogues in treating chronic hepatitis B:a meta-analysis

Objective There are many clinical reports on traditional Chinese medicine(TCM)combined with nucleoside(acid)analogues(NAs)for the treatment of chronic hepatitis B(CHB),but its efficacy and safety are not completely clear.This meta-analysis aims to evaluate the clinical efficacy and safety thus providing evidence for clinical applications.Methods We searched Chinese databases the China National Knowledge Infrastructure(CNKI),Wanfang Data,and China Science and Technology Journal Database(VIP),as well as English databases Pub Med and Cochrane Library,from time of establishment to April 14,2021.Literature quality was evaluated according to the bias risk assessment criteria of Cochrane Collaboration network.Rev Man 5.3 and Stata 12.0 software were used to perform this research.Results A total of 23 articles,3282 patients,and 25 TCM prescriptions were included in this study.NAs plus TCM remarkably improved the clinical total effective rate[Odds ratio(OR)=3.92,P<0.00001],TCM syndrome score(Mean difference=-3.73,P<0.00001),hepatitis B virus(HBV)DNA negative conversion rate(OR=1.49,P=0.0001),hepatitis Be antigen(HBe Ag)negative conversion rate(OR=2.03,P<0.00001),alanine aminotransferase levels[Std mean difference(SMD)=-0.95,P<0.00001],and aspartate aminotransferase levels(SMD=-0.70,P=0.0004).Adverse reaction rates did not increase in the combined treatment group(OR=0.97,P=0.84).A comprehensive analysis of the 25 TCM prescriptions suggested that the combination of spleen-strengthening prescriptions with NAs showed better effects than other prescriptions.Conclusion TCM in combination with NAs,demonstrated better clinical efficacy against CHB than NAs alone.In addition,the combination of spleen-strengthening prescriptions and NAs was identified as the best therapeutic strategy.However,more randomized controlled trials of high quality are needed to provide more reliable clinical basis for the application of TCM.

Effects of Jianpi herbal suppository on hemorheology and CD62p in patients with ulcerative colitis

OBJECTIVE: To compare the effects of a Chinese herbal suppository(Jianpi suppository) and Western Medicine(mesalazine) on hemorheology and CD62p in patients with ulcerative colitis(UC).METHODS: In a randomized trial, 120 mild to moderate UC patients were randomly divided into two equal groups. The Jianpi suppository group used Chinese herbal suppository rectally, while the mesalazine group was treated with mesalazine tablets orally. Two 15-day courses of treatment were carried out in both groups. Changes in the hemorheology and CD62p indices in patients were observed.RESULTS: The hemorheology and CD62p indices in the Jianpi suppository group decreased significantly more than those of the mesalazine group.CONCLUSION: Jianpi suppository is effective in improving the hypercoagulability of UC patients, and therefore may be worth using in clinical practice.

Clinical observation of pediatric Tuina plus oral Chinese medication for pediatric anorexia due to spleen failing in transportation

Objective To observe the clinical efficacy of pediatric Tuina(Chinese therapeutic massage)plus oral administration of Chinese medication for pediatric anorexia due to spleen failing in transportation.Methods A total of 94 children with anorexia due to spleen failing in transportation were randomized into an observation group and a control group by the random number table method at a ratio of 1:1,with 47 cases in each group.The control group was treated with modified Bu Huan Jin Zheng Qi San,and the observation group was treated with additional Tuina manipulation of Yun Shui Ru Tu based on the treatment in the control group.After 4 weeks of treatment,the clinical efficacy of the two groups was observed,and the traditional Chinese medicine(TCM)symptom score,serum leptin,neuropeptide Y,and serum zinc and calcium levels were compared.Results After 4 weeks of treatment,the total effective rate of the observation group was 87.2%,and that of the control group was 74.5%.The difference between the two groups was statistically significant( P<0.05).After treatment,the TCM symptom scores in both groups decreased significantly(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).After treatment,the serum leptin level in both groups decreased,and the level in the observation group was lower than that in the control group(P<0.05).The serum neuropeptide Y,zinc,and calcium levels in both groups increased after treatment,and the levels in the observation group were higher than those in the control group(P<0.05).Conclusion Tuina manipulation of Yun Shui Ru Tu plus oral administration of Chinese medication is significantly effective in treating pediatric anorexia due to spleen failing in transportation,which can improve the appetite of children and improve the symptoms of anorexia,and the curative effect is better than that of oral administration of Chinese medication alone.