期刊文献+
共找到108篇文章
< 1 2 6 >
每页显示 20 50 100
浅析数码相机的“像素”
1
作者 张桂兰 《数码印刷》 2003年第12期62-64,共3页
随着数码相机技术的不断成熟和产品价格的持续下降,数码相机市场正在高速增长,它的发展速度和人们的热衷程度已赶上或超过了扫描仪、刻录机等计算机外设。2003年是数码相机精彩缤纷的一年,不仅其成像质量有了大幅度提高,而且随着价格的... 随着数码相机技术的不断成熟和产品价格的持续下降,数码相机市场正在高速增长,它的发展速度和人们的热衷程度已赶上或超过了扫描仪、刻录机等计算机外设。2003年是数码相机精彩缤纷的一年,不仅其成像质量有了大幅度提高,而且随着价格的下降,数码相机已越来越多地进入普通百姓的工作与生活娱乐中,为人们留下了精彩, 展开更多
关键词 数码相机 选购 “像素” 成像质量 分辨率
下载PDF
A New AC Driving Method for a Current-Programmed AM-OLED Pixel Circuit 被引量:2
2
作者 司玉娟 徐艳蕾 +2 位作者 郎六琪 陈新发 刘式墉 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2006年第9期1562-1565,共4页
A new,improved pixel-driving circuit is presented based on a current-programmed pixel circuit in order to achieve an AC-driving mode. This driving method realizes an AC-driving mode,removes the threshold voltage varia... A new,improved pixel-driving circuit is presented based on a current-programmed pixel circuit in order to achieve an AC-driving mode. This driving method realizes an AC-driving mode,removes the threshold voltage variation of the driving TFT due to the process variation or long-term operation,which can bring about brightness non-uniformity, and eliminates high peak pulse currents at the beginning and end of recovery time. Simulation is done with AIM-SPICE,and simulation results demonstrate that the OLED is in the reverse-biased state during recovery time. 展开更多
关键词 active matrix OLED AC pixel-driving circuit TFT AIM-SPICE simulation current-programmed pixel-driving circuit
下载PDF
Design,Analysis,and Optimization of a CMOS Active Pixel Sensor 被引量:2
3
作者 徐江涛 姚素英 +2 位作者 李斌桥 史再峰 高静 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2006年第9期1548-1551,共4页
A three-transistor active pixel sensor and its double sampling readout circuit implemented by a switch capacitor amplifier are designed. The circuit is embedded in a 64 × 64 pixel array CMOS image sensor and succ... A three-transistor active pixel sensor and its double sampling readout circuit implemented by a switch capacitor amplifier are designed. The circuit is embedded in a 64 × 64 pixel array CMOS image sensor and success-fully taped out with a Chartered 0.35μm process. The pixel pitch is 8μm × 8μm with a fill factor of 57%, the photo-sensitivity is 0.8V/(lux · s) ,and the dynamic range is 50dB. Theoretical analysis and test results indicate that as the process is scaled down, a smaller pixel pitch reduces the sensitivity. A deep junction n-well/p-substrate photodiode with a reasonable fill factor and high sensitivity are more appropriate for submicron processes. 展开更多
关键词 CMOS image sensor active pixel sensor fill factor photo-response sensitivity
下载PDF
Sub-pixel extraction of laser stripeand itsapplication in laser plane calibration 被引量:2
4
作者 陈平 张志胜 +1 位作者 戴敏 陈恺 《Journal of Southeast University(English Edition)》 EI CAS 2015年第1期107-112,共6页
For calibrating the laser plane to implement 3D shape measurement, an algorithm for extracting the laser stripe with sub-pixel accuracy is proposed. The proposed algorithm mainly consists of two stages: two-side edge... For calibrating the laser plane to implement 3D shape measurement, an algorithm for extracting the laser stripe with sub-pixel accuracy is proposed. The proposed algorithm mainly consists of two stages: two-side edge detection and center line extraction. First, the two-side edge of laser stripe is detected using the principal component angle-based progressive probabilistic Hough transform and its width is calculated through the distance between these two edges. Secondly, the center line of laser strip is extracted with 2D Taylor expansion at a sub-pixel level and the laser plane is calibrated with the 3D reconstructed coordinates from the extracted 2D sub-pixel ones. Experimental results demonstrate that the proposed method can not only extract the laser stripe at a high speed, nearly average 78 ms/frame, but also calibrate the coplanar laser stripes at a low error, limited to 0.3 mm. The proposed algorithm can satisfy the system requirement of two-side edge detection and center line extraction, and rapid speed, high precision, as well as strong anti-jamming. 展开更多
关键词 sub-pixel extraction center line extraction laser plane calibration progressive probabilistic Hough transform (PPHT) principal component (PC) angle 2D Taylor expan- sion
下载PDF
Non-iterative image feature matching algorithm based on reference point correspondences 被引量:1
5
作者 张维中 张丽艳 +2 位作者 王小平 丁志安 周玲 《Journal of Southeast University(English Edition)》 EI CAS 2007年第2期190-195,共6页
Based on the coded and non-coded targets, the targets are extracted from the images according to their size, shape and intensity etc., and thus an improved method to identify the unique identity(D) of every coded ta... Based on the coded and non-coded targets, the targets are extracted from the images according to their size, shape and intensity etc., and thus an improved method to identify the unique identity(D) of every coded target is put forward and the non-coded and coded targets are classified. Moreover, the gray scale centroid algorithm is applied to obtain the subpixel location of both uncoded and coded targets. The initial matching of the uncoded target correspondences between an image pair is established according to similarity and compatibility, which are based on the ID correspondences of the coded targets. The outliers in the initial matching of the uncoded target are eliminated according to three rules to finally obtain the uncoded target correspondences. Practical examples show that the algorithm is rapid, robust and is of high precision and matching ratio. 展开更多
关键词 reference points detection coded and non-coded target SUBPIXEL gray scale centroid point correspondence
下载PDF
Image quality assessment based on perceptual grouping
6
作者 王同罕 张璐 +3 位作者 贾惠珍 孔佑勇 李宝生 舒华忠 《Journal of Southeast University(English Edition)》 EI CAS 2016年第1期29-34,共6页
To further explore the human visual system( HVS),the perceptual grouping( PG), which has been proven to play an important role in the HVS, is adopted to design an effective image quality assessment( IQA) model. ... To further explore the human visual system( HVS),the perceptual grouping( PG), which has been proven to play an important role in the HVS, is adopted to design an effective image quality assessment( IQA) model. Compared with the existing fixed-window-based models, the proposed one is an adaptive window-like model that introduces the perceptual grouping strategy into the IQA model. It works as follows: first,it preprocesses the images by clustering similar pixels into a group to the greatest extent; then the structural similarity is used to compute the similarity of the superpixels between reference and distorted images; finally, it integrates all the similarity of superpixels of an image to yield a quality score. Experimental results on three databases( LIVE, IVC and MICT) showthat the proposed method yields good performance in terms of correlation with human judgments of visual quality. 展开更多
关键词 perceptual grouping perceptual image quality assessment superpixels full reference
下载PDF
Principle and Analysis of Novel Gate-Induced Noise in Pixel MOSFET of CMOS Imagers
7
作者 金湘亮 陈杰 仇玉林 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2003年第9期921-926,共6页
A detailed principle and a rigorous analysis of a new noise,the gate-induced noise,in pixel MOSFET of CMOS imagers are provided.The gate-induced noise of the MOSFET is more notable in the strong reversion region than... A detailed principle and a rigorous analysis of a new noise,the gate-induced noise,in pixel MOSFET of CMOS imagers are provided.The gate-induced noise of the MOSFET is more notable in the strong reversion region than that in the subthreshold region when the applied gate voltage is low.However,the applied gate voltage being up to 3V,the gate-induced noise is more notable with the ω/ω T increasing when the MOSFET operates in the subthreshold region than that in the strong reversion region.Between the photocurrent I D and the root mean square value of the gated-induced noise,current i 2 d presents the relation of i 2 d∝I D in the saturation region of the strong reversion and approximately i 2 d∝I D in the subthreshold region.A deta iled and rigorous study of the gate-induced noise in the reset MOSFET for the p hotodiode APS and improved photodiode APS are provided.The improvement of logari thmic response APS is analyzed and the simulation results show that the gate-in duced noise can be reduced. 展开更多
关键词 gate-induced noise pixel MOSFET improved photodiode APS CMOS imagers
下载PDF
A New CMOS Image Sensor with a High Fill Factor and the Dynamic Digital Double Sampling Technique
8
作者 刘宇 王国裕 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2006年第2期313-317,共5页
A single CMOS image sensor based on a 0.35μm process along with its design and implementation is introduced. The architecture of an active pixel sensor is used in the chip. The fill factor of a pixel cell can reach 4... A single CMOS image sensor based on a 0.35μm process along with its design and implementation is introduced. The architecture of an active pixel sensor is used in the chip. The fill factor of a pixel cell can reach 43%,higher than the traditional factor of 30%. Moreover, compared with the conventional method whose fixed pattern noise (FPN) is around 0.5%, a dynamic digital double sampling technique is developed, which possesses simpler circuit architecture and a better FPN suppression outcome. The CMOS image sensor chip is implemented in the 0.35μm mixed signal process of a Chartered by MPW. The experimental results show that the chip operates welt,with an FPN of about 0.17%. 展开更多
关键词 active pixel CMOS image sensor fill factor dynamic digital double sampling fixed pattern noise
下载PDF
Responses of some landscape trees to the drought and high temperature events during 2006 and 2007 in Yamaguchi,Japan
9
作者 王斐 山本晴彦 《Journal of Forestry Research》 SCIE CAS CSCD 2009年第A3期254-260,287,共8页
Extreme weather events were analyzed based on the meteorological data from the year of 1967 to 2007 for Yamaguchi, Japan. The responses from landscape trees were also investigated mainly by the analysis of image pixel... Extreme weather events were analyzed based on the meteorological data from the year of 1967 to 2007 for Yamaguchi, Japan. The responses from landscape trees were also investigated mainly by the analysis of image pixel and spectral reflectance. Results show that after the dry, hot and windy summer in 2007, many landscape trees in Yamaguchi City tended to respond the extreme weather events by reducing their leaf surface area and receiving less radiation energy. Premature leaf discoloration or defoliation appeared on some landscape tree species and leaf necrosis occurred on tip and margin of many Kousa dogwood (Cornus kousa) trees at unfavorable sites. Described by image pixel analysis method, the leaf necrotic area percentage (LNAP) of sampled dogwood trees averaged 41.6% and the sampled Sasanqua camellia (Camelia sasanqua) tree also showed fewer flowers in flower season of 2007 than that in 2006. By differential analysis of partial discolored crown, it presented a logistic differential equation of crown color for sweet gum (Liquidambar styraciflua) trees. It suggested that the persistent higher temperature and lower precipitation could be injurious to the sensitive landscape trees at poor sites, even in relative humid area like Yamaguchi. 展开更多
关键词 extreme meteorological event drought and high temperature landscape tree image pixel analysis response
下载PDF
RESEARCH OF VOXELIZATION PROCESS IN SWEPT-VOLUME TECHNIQUE 被引量:2
10
作者 姜太平 沈春林 +1 位作者 何亦征 王金岩 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2004年第1期24-30,共7页
Now the image display techniques have made great progress. The planar display and a fully new true 3-D volumetric display technique are rapidly researched and come into the application. A method based on the voxel mak... Now the image display techniques have made great progress. The planar display and a fully new true 3-D volumetric display technique are rapidly researched and come into the application. A method based on the voxel makes the observer able to get a true 3-D effect freely without any additional facilities. This paper introduces the basic form of the swept-volume display technique and discusses its voxelization process. By the translational motion prototype, this paper emphasizes how to get the voxel mapping matrix. The translated image data are the data of the beam source deflections. Finally the voxel ordering and the optimizing are also discussed. 展开更多
关键词 voxelization process swept-volume voxel ordering
下载PDF
Response of Ficus microcarpa L.Foliage to Water Stress Determined by Chlorophyll Fluorescence Imaging Technique
11
作者 林淑玲 陈华 +3 位作者 董蕾 曹洪麟 陈贻竹 顾群 《Agricultural Science & Technology》 CAS 2012年第4期739-745,共7页
[Objective] This study was to determine the response of Ficus microcarpa L. foliage to polyethylene glycol (PEG) simulated water stress using chlorophyll fluo- rescence imaging technique. [Method] The responses of d... [Objective] This study was to determine the response of Ficus microcarpa L. foliage to polyethylene glycol (PEG) simulated water stress using chlorophyll fluo- rescence imaging technique. [Method] The responses of detached leaves from Ficus microcarpa, Ficus benjamina and Nerium oleander to PEG-6000 simulated water stress were detected, and the chlorophyll fluorescence imaging technique was used to detect and analyze the stress at different spots of a single leaf simultaneously. [Result] The responses of Ficus microcarpa, Ficus benjamina and Nerium oleander to dehydration showed that: ~1~) the maximal photochemical efficiency (Fv/Fm) and non- photo-chemical quenching (NPQ) values were small in the reaction center among different detected spots of leaves, and there were great differences between relative electron transport rate (ETR), photochemical quenching (qP) and quantum efficiency of PSII photochemistry ((φPSII); (2) the differences of these parameters were more ob- vious among different spots of water-stressed leaves; (3) the discrete degrees of the species with strong resitances decreased significantly. [Conclusion] This study lays the foundation for the further research on the response of plants to drought stress using chlorophyll fluorescence imaging technique. 展开更多
关键词 Ficus microcarpa Water stress Chlorophyll a fluorescence imaging
下载PDF
Multivariate Analysis of Recurrence in Meningioma
12
作者 吴涛 吴志敏 +1 位作者 袁先厚 陈卫国 《The Chinese-German Journal of Clinical Oncology》 CAS 2005年第1期26-29,66,共5页
Objective: To evaluate the clinical and radiological factors that affect therecurrence of the meningioma patient so as to effectively prevent and cure recurrence of meningiomapatients more earlier. Methods: The clinic... Objective: To evaluate the clinical and radiological factors that affect therecurrence of the meningioma patient so as to effectively prevent and cure recurrence of meningiomapatients more earlier. Methods: The clinical features and radiological aspects in 145 cases ofmeningiomas undergoing operation during 1993-1997 were retrospectively studied. The data of only 83cases of all 145 cases were available. The factors were evaluated with univariate and multivariateanalysis. Results: With univariate analysis, 7 factors showed highly significance to recurrence ofmeningiomas: tumor size, tumor location, tumor shape, edema, extent of resection, pathologicalgrade, CT enhancement. With multivariate analysis, 4 factors showed significant danger to recurrenceof meningiomas: pathological grade, extent of resection, tumor shape and CT enhancement.Conclusion: The main factors that affect the recurrence of meningioma patients are pathologicalgrade, extent of resection, tumor shape and CT enhancement. 展开更多
关键词 MENINGIOMA clinical factors radiological features RECURRENCE
下载PDF
A New Software for GIS Image Pixel Topographic Fac-tors in Remote Sensing Monitoring of Soil Losses 被引量:4
13
作者 TANGWAN-LONG BUZHAO-HONG 《Pedosphere》 SCIE CAS CSCD 1995年第1期67-74,共8页
Based on the new algorithm for GIS image pixel topographic factors in remote sensing monitoring ofsoil losses, a software was developed for microcomputer to carry out computation at a medium river basin(county). This ... Based on the new algorithm for GIS image pixel topographic factors in remote sensing monitoring ofsoil losses, a software was developed for microcomputer to carry out computation at a medium river basin(county). This paper lays its emphasis on algorithmic skills and programming techniques as well as applicationof the software. 展开更多
关键词 algorithmic skills programming techniques remote sensing monitoring SOFTWARE soil losses
下载PDF
Pixel and Column Fixed Pattern Noise Suppression Mechanism in CMOS Image Sensor 被引量:5
14
作者 徐江涛 姚素英 李斌桥 《Transactions of Tianjin University》 EI CAS 2006年第6期442-445,共4页
A double sampling circuit to eliminating fixed pattern noise(FPN) in CMOS image sensor (CIS) is presented. Double sampling is implemented by column switch capacitor amplifier directly, and offset compensation is added... A double sampling circuit to eliminating fixed pattern noise(FPN) in CMOS image sensor (CIS) is presented. Double sampling is implemented by column switch capacitor amplifier directly, and offset compensation is added to the amplifier to suppress column FPN. The amplifier is embedded in a 64×64 CIS and successfully fabricated with chartered 0.35 μm process. Theory analysis and circuit simulation indicate that FPN can be suppressed from millivolt to microvolt. Test results show that FPN is smaller than one least-significant bit of 8 bit ADC. FPN is reduced to an acceptable level with double sampling technique implemented with switch capacitor amplifier. 展开更多
关键词 CMOS image sensor active pixel fixed pattern noise double sampling offset compensation
下载PDF
Individualized Pixel Synthesis and Characterization of Combinatorial Materials Chips 被引量:7
15
作者 Xiao-Dong Xiang Gang Wang +2 位作者 Xiaokun Zhang Yong Xiang Hong Wang 《Engineering》 SCIE EI 2015年第2期225-233,共9页
Conventionally, an experimentally determined phase diagram requires studies of phase formation at a range of temperatures for each composition, which takes years of effort from multiple research groups. Combinatorial ... Conventionally, an experimentally determined phase diagram requires studies of phase formation at a range of temperatures for each composition, which takes years of effort from multiple research groups. Combinatorial materials chip technology, featuring high-throughput synthesis and characterization, is able to determine the phase diagram of an entire composition spread of a binary or ternary system at a single temperature on one materials library, which, though significantly increasing efficiency, still requires many libraries processed at a series of temperatures in order to complete a phase diagram. In this paper, we propose a "one-chip method" to construct a complete phase diagram by individually synthesizing each pixel step by step with a progressive pulse of energy to heat at different temperatures while monitoring the phase evolution on the pixel in situ in real time. Repeating this process pixel by pixel throughout the whole chip allows the entire binary or ternary phase diagram to be mapped on one chip in a single experiment. The feasibility of this methodology is demonstrated in a study of a Ge-Sb-Te ternary alloy system, on which the amorphouscrystalline phase boundary is determined. 展开更多
关键词 combinatorial materials chip phase diagram pixel synthesis in-situ characterization phase-boundary determination
下载PDF
Sparse representation-based color visualization method for hyperspectral imaging
16
作者 王立国 刘丹凤 赵亮 《Applied Geophysics》 SCIE CSCD 2013年第2期210-221,237,共13页
In this paper, we designed a color visualization model for sparse representation of the whole hyperspectral image, in which, not only the spectral information in the sparse representation but also the spatial informat... In this paper, we designed a color visualization model for sparse representation of the whole hyperspectral image, in which, not only the spectral information in the sparse representation but also the spatial information of the whole image is retained. After the sparse representation, the color labels of the effective elements of the sparse coding dictionary are selected according to the sparse coefficient and then the mixed images are displayed. The generated images maintain spectral distance preservation and have good separability. For local ground objects, the proposed single-pixel mixed array and improved oriented sliver textures methods are integrated to display the specific composition of each pixel. This avoids the confusion of the color presentation in the mixed-pixel color display and can also be used to reconstruct the original hyperspectral data. Finally, the model effectiveness was proved using real data. This method is promising and can find use in many fields, such as energy exploration, environmental monitoring, disaster warning, and so on. 展开更多
关键词 HYPERSPECTRAL color visualization sparse representation multilayer visualization
下载PDF
Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study 被引量:6
17
作者 Yasushi Adachi Masanori Nojima +7 位作者 Mitsuru Mori Kentaro Yamashita Hiro-o Yamano Hiroshi Nakase Takao Endo Kenji Wakai Kiyomi Sakata Akiko Tamakoshi 《World Journal of Gastroenterology》 SCIE CAS 2017年第19期3488-3495,共8页
To assess the relationship between serum levels of insulin-like growth factor-1 (IGF1)/IGF-binding protein-3 (IGFBP3) and the risk of esophageal carcinoma.METHODSWe assessed the relationship between the serum levels o... To assess the relationship between serum levels of insulin-like growth factor-1 (IGF1)/IGF-binding protein-3 (IGFBP3) and the risk of esophageal carcinoma.METHODSWe assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective, nested case-control study of participants from the Japan Collaborative Cohort Study. A baseline survey was conducted from 1988 to 1990. Of the 110585 enrolled participants, 35% donated blood samples. Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies. A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 levels.RESULTSThirty-one cases and 86 controls were eligible for the present assessment. The molar ratio of IGF1/IGFBP3, which represents the free and active form of IGF1, was not correlated with the risk of esophageal carcinoma. A higher molar difference between IGFBP3 and IGF1, which estimates the free form of IGFBP3, was associated with a decreased risk of esophageal carcinoma (P = 0.0146), and people in the highest tertile had the lowest risk (OR = 0.107, 95%CI: 0.017-0.669). After adjustment for body mass index, tobacco use, and alcohol intake, the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma (P = 0.0150).CONCLUSIONThe free form of IGFBP3, which is estimated by this molar difference, may be inversely associated with esophageal cancer incidence. 展开更多
关键词 Esophageal cancer Insulin-like growth factor Insulin-like growth factor binding protein Nested case-control study Odds ratio
下载PDF
POLYNOMIAL MODEL BASED FAST FRACTIONAL PIXEL SEARCH ALGORITHM FOR H.264/AVC 被引量:3
18
作者 Xi Yinglai Hao Chongyang Lai Changcai 《Journal of Electronics(China)》 2006年第6期873-876,共4页
This paper proposed a novel fast fractional pixel search algorithm based on polynomial model. With the analysis of distribution characteristics of motion compensation error surface inside tractional pixel searching wi... This paper proposed a novel fast fractional pixel search algorithm based on polynomial model. With the analysis of distribution characteristics of motion compensation error surface inside tractional pixel searching window, the matching error is fitted with parabola along horizontal and vertical direction respectively. The proposcd searching strategy needs to check only 6 points rather than 16 or 24 points, which are used in the l lierarchical Fractional Pel Search algorithm (HFPS) for 1/4-pel and 1/8-pel Motion Estimation (ME). The experimental results show that the proposed algorithm shows very good capability in keeping the rate distortion performance while reduces computation load to a large extent compared with HFPS algorithm. 展开更多
关键词 Motion Estimation (ME) Fractional pixel Polynomial model
下载PDF
Color image segmentation using mean shift and improved ant clustering 被引量:3
19
作者 刘玲星 谭冠政 M.Sami Soliman 《Journal of Central South University》 SCIE EI CAS 2012年第4期1040-1048,共9页
To improve the segmentation quality and efficiency of color image,a novel approach which combines the advantages of the mean shift(MS) segmentation and improved ant clustering method is proposed.The regions which can ... To improve the segmentation quality and efficiency of color image,a novel approach which combines the advantages of the mean shift(MS) segmentation and improved ant clustering method is proposed.The regions which can preserve the discontinuity characteristics of an image are segmented by MS algorithm,and then they are represented by a graph in which every region is represented by a node.In order to solve the graph partition problem,an improved ant clustering algorithm,called similarity carrying ant model(SCAM-ant),is proposed,in which a new similarity calculation method is given.Using SCAM-ant,the maximum number of items that each ant can carry will increase,the clustering time will be effectively reduced,and globally optimized clustering can also be realized.Because the graph is not based on the pixels of original image but on the segmentation result of MS algorithm,the computational complexity is greatly reduced.Experiments show that the proposed method can realize color image segmentation efficiently,and compared with the conventional methods based on the image pixels,it improves the image segmentation quality and the anti-interference ability. 展开更多
关键词 color image segmentation improved ant clustering graph partition mean shift
下载PDF
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice 被引量:3
20
作者 shan zhuang yong-mei jian yong-ning sun 《World Journal of Gastroenterology》 SCIE CAS 2017年第23期4233-4242,共10页
AIM To investigate the inhibitory effect of Liuwei Dihuang Pill(LDP) on gastric tumorigenesis induced by N-methyl-N-nitrosourea(MNU) in diabetic mice.METHODS Four-week-old mice were divided into four groups: A, 12 db/... AIM To investigate the inhibitory effect of Liuwei Dihuang Pill(LDP) on gastric tumorigenesis induced by N-methyl-N-nitrosourea(MNU) in diabetic mice.METHODS Four-week-old mice were divided into four groups: A, 12 db/m mice treated with MNU and saline, as the non-diabetic control; B, 12 db/db mice treated with MNU and saline, as the diabetic control; C, 12 db/db mice treated with MNU and metformin, as the positive control; and D, 12 db/db mice treated with MNU and LDP. MNU was administrated for 20 wk to induce gastric carcinogenesis. LDP was administrated for 10 wk for improvement of insulin resistance. Body weight and food intake were measured every week. Blood samples were collected for assays of fasting blood glucose, insulin, insulin-like growth factor(IGF)-1, adiponectin and leptin. Stomach tissues were collected for histopathological analysis, immunohistochemical staining of Ki67, quantitative reverse transcriptionpolymerase chain reaction and western blotting. RESULTS The incidence of MNU-induced gastric dysplasia was significantly elevated in diabetic(db/db) mice relative to the control(db/m) mice. The incidence of gastricdysplasia was significantly reduced by LDP with suppression of cell proliferation, as demonstrated by a decrease in Ki67 staining. Hyperglycemia, hyperinsulinemia and serum IGF-1 were inhibited by LDP. Expression of IGF-1 and insulin receptor m RNAs was decreased, phosphorylation of IGF-1 receptor and AKT protein was reduced in the stomach tissues by LDP. In addition, adiponectin was increased and leptin was decreased in the serum by LDP. CONCLUSION LDP decreased risk of gastric dysplasia in type 2 diabetic mice by down-regulation of IGF and insulin activity and correction of adipokines disorders. 展开更多
关键词 DIABETES Gastric cancer Liuwei Dihuang Pill INSULIN Insulin-like growth factor
下载PDF
上一页 1 2 6 下一页 到第
使用帮助 返回顶部