AIM To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH). METHODS In this retrospective study, 36 patients (19 treated and 17 untreated) w...AIM To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH). METHODS In this retrospective study, 36 patients (19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness (LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologists evaluated morphological features of cirrhosis on conventional magnetic resonance imaging (MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis. RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease (r = 0.88 vs -0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed (3.7 kPa vs 3.84 kPa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis (0.97 vs 0.53-0.80, p < 0.01), and cirrhosis (0.98 vs 0.58-0.80, p < 0.01) and better than conventional MRI for diagnosis of cirrhosis (0.98 vs 0.78, p = 0.002). CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI.展开更多
Ethics and morality are old and constantly updated topic. In the modern science and technology rapid development situation, study of ethics of science and technology is relatively backward. The times call for advanced...Ethics and morality are old and constantly updated topic. In the modern science and technology rapid development situation, study of ethics of science and technology is relatively backward. The times call for advanced and reasonable ethics of science-technology. Basic concepts and characteristics of ethics and morals are distinguished and defined in this paper. Three ethic essences of science-technology are abstracted from scientific-technological generation, application, and development. The three-dimension system of basic principles for scientific-technologic ethics is created, as illustrated by the portions given in this paper. The evolution formula of value system is derived, and used for appraising whether the science-technology activity is in all reason. Furthermore, it provides the theory base for quantified management. Finally, it is pointed out that morality and law should be supplemented each other in the science-technology management.展开更多
Welding is a vital component of several industries such as automotive,aerospace,robotics,and construction.Without welding,these industries utilize aluminum alloys for the manufacturing of many components or systems.Ho...Welding is a vital component of several industries such as automotive,aerospace,robotics,and construction.Without welding,these industries utilize aluminum alloys for the manufacturing of many components or systems.However,fusion welding of aluminum alloys is challenging due to several factors,including the presence of non-heat-treatable alloys,porosity,solidification,and liquation of cracks.Many manufacturers adopt conventional in-air friction stir welding(FSW)to weld metallic alloys and dissimilar materials.Many researchers reported the drawbacks of this traditional in-air FSW technique in welding metallic and polymeric materials in general and aluminum alloys and aluminum matrix composites in specific.A number of FSW techniques were developed recently,such as underwater friction stir welding(UFSW),vibrational friction-stir welding(VFSW),and others,for welding of aluminum alloy joints to overcome the issues of welding using conventional FSW.Therefore,the main objective of this review is to summarize the recent trends in FSW process of aluminum alloys and aluminum metal matrix composites(Al MMCs).Also,it discusses the effect of welding parameters of the traditional and state-of-the-art developed FSW techniques on the welding quality and strength of aluminum alloys and Al MMCs.Comparison among the techniques and advantages and limitations of each are considered.The review suggests that VFSW is a viable option for welding aluminum joints due to its energy efficiency,economic cost,and versatile modifications that can be employed based on the application.This review also illustrated that significantly less attention has been paid to FSW of Al-MMCs and considerable attention is demanded to produce qualified joint.展开更多
A total of 1,101 heads were used to improve the selection of superior cows in Gangwon regional Hanwoo. Characteristics of each cow were analyzed using ultrasound evaluation and trace of reproductive potential. A compa...A total of 1,101 heads were used to improve the selection of superior cows in Gangwon regional Hanwoo. Characteristics of each cow were analyzed using ultrasound evaluation and trace of reproductive potential. A comparison of live carcass traits classified by parity was analyzed in all characteristics. The results of the comparison showed all characteristic increased rapidly after the 2nd parity, and decreased after the 4th parity (P 〈 0.01). The result of comparison classified by the group showed a tendency, whereas Back Fat Thickness Ultrasound (BFTU) and P8 Fat Thickness Ultrasound (P8-FTU) were significant (P 〈 0.01) thinnest in Pedigree group and using a lot of reproduction in advanced group. Also, we made comparisons of the cow's calves on the carcass traits among the group. High quality calves of the pedigree group showed 30.77%. These are the highest carcass traits in meat quality grade above 1+ and yield grade above A. Frequency of fertilization failure per rump fat thickness showed a significantly (P 〈 0.0|) higher difference. The average frequency of fertilization failure demonstrated 1.11 times of experimental Hanwoo cows. In the analysis, frequency of fertilization failure appeared 0.9 times at rump fat thickness below 5 mm. However, it is higher than average above 5 mm. The result of the study will be used to improve cows, select optimum semen, as well as contribute to the improvement of farms income.展开更多
SMART (system-integrated modular advanced reactor) is a small-sized advanced integral reactor with a rated thermal power of 330 MW. It can produce 100 MW of electricity, or 90 MW of electricity and 40,000 t of desal...SMART (system-integrated modular advanced reactor) is a small-sized advanced integral reactor with a rated thermal power of 330 MW. It can produce 100 MW of electricity, or 90 MW of electricity and 40,000 t of desalinated water concurrently, which is sufficient for 100,000 residents. SMART technology is a sensible mixture of new innovative design features and proven technologies through a PWR. The enhancement of safety and reliability is realized by incorporating inherent safety features and reliable passive safety systems. The improvement in the economics is achieved through system simplification, component modularization, construction time reduction, and increased plant availability. All technologies and design features implemented into SMART have been proven in industries and/or qualified through the SMART design verification program including comprehensive test and experiments. The full scope of the safety analyses carried out to confirm that the inherent safety-improvement design characteristics and safety systems of SMART ensure reactor safety. After a thorough licensing review, SDA (standard design approval) for SMART was granted on July 4th, 2012 by the Korea NSSC (Nuclear Safety and Security Commission). This marks the first license for an integral-type reactor in the world. This paper presents the SMART characteristics, safety features and technology validation. The licensing process of SMART is also described.展开更多
In the last few years, interest in burnup calculations using Monte Carlo methods has increased. Previous burnup codes have used diffusion theory for the neutronic portion of the codes. Diffusion theory works well for ...In the last few years, interest in burnup calculations using Monte Carlo methods has increased. Previous burnup codes have used diffusion theory for the neutronic portion of the codes. Diffusion theory works well for most reactors. However, diffusion theory does not produce accurate results in burnup problems that include strong absorbers or large voids. MCNPX code based on Mont Carlo Method, is used to design a three dimensional model for a BWR fuel assembly in a typical operating temperature and pressure conditions. A test case was compared with a benchmark problem and good agreement was found. The model is used to calculate the distribution of pin by pin power and flux inside the assembly. The effect of axial variation of water (coolant) density, and of control rods motion on the neutron flux and power distribution is analyzed. The effect of addition of Gd2O3 to natural uranium (0.711%) on both the thermal neutron flux and normalized power are analyzed. The concentration of U^235, U^238, Pu^239, and its isotopes is also calculated at burn-up 50 GWD/T.展开更多
Within the OECD/NEA Benchmarking of Thermal-Hydraulic Loop Models for Lead-Alloy Cooled Advanced Nuclear Energy Systems (LACANES), the Institute for Neutron Physics and Reactor Technology takes part in the validatio...Within the OECD/NEA Benchmarking of Thermal-Hydraulic Loop Models for Lead-Alloy Cooled Advanced Nuclear Energy Systems (LACANES), the Institute for Neutron Physics and Reactor Technology takes part in the validation process of system codes and the characterization of the thermal-hydraulic behavior of an experimental loop operated with liquid lead-bismuth-eutectics. To confirm the calculations, the results were compared to experimental data obtained from the HELIOS facility at the Seoul National University and to the results of other benchmark participants. The comparison showed that the calculations are within measurement tolerance but nevertheless discrepancies among the participants exist. The pressure drop estimation is determined by a variety of empirical correlations for the friction and the form loss coefficients. Hence, uncertainty and sensitivity measures were applied to find out which parameter is more relevant for the overall pressure drop. In the frame of this investigation, the system code TRACE and the software system for uncertainty and sensitivity, SUSA, were used. The results show that the total pressure drop varies between -30 and +15% related to the reference case.展开更多
Advanced Chinese culture today has three interconnected requirements: a) it is an organic component of today's advanced world culture; b) it critically absorbs all the best elements of foreign cultures in an organ...Advanced Chinese culture today has three interconnected requirements: a) it is an organic component of today's advanced world culture; b) it critically absorbs all the best elements of foreign cultures in an organic combination with the best elements of traditional Chinese culture; and c) it transcends the argument over "modernism" and "post-modernism." From a world- historical perspective, all other necessary features of advanced culture in contemporary China represent the logical unfolding of these three requirements. A full and correct grasp of the three elements constituting the world-historicality of this advanced culture is of important methodological significance in clarifying the world-historical mode of the construction of contemporary Chinese culture and the path to cultural innovation.展开更多
Electronic skins and flexible pressure sensors are important devices for advanced healthcare and intelligent robotics.Sensitivity is a key parameter of flexible pressure sensors.Whereas introducing surface microstruct...Electronic skins and flexible pressure sensors are important devices for advanced healthcare and intelligent robotics.Sensitivity is a key parameter of flexible pressure sensors.Whereas introducing surface microstructures in a capacitive-type sensor can significantly improve its sensitivity,the signal becomes nonlinear and the pressure response range gets much narrower,significantly limiting the applications of flexible pressure sensors.Here,we designed a pressure sensor that utilizes a nanoscale iontronic interface of an ionic gel layer and a micropillared electrode,for highly linear capacitance-to-pressure response and high sensitivity over a wide pressure range.The micropillars undergo three stages of deformation upon loading:initial contact(0-6 k Pa)and structure buckling(6-12 k Pa)that exhibit a low and nonlinear response,as well as a post-buckling stage that has a high signal linearity with high sensitivity(33.16 k Pa-1)over a broad pressure range of 12-176 k Pa.The high linearity lies in the subtle balance between the structure compression and mechanical matching of the two materials at the gel-electrode interface.Our sensor has been applied in pulse detection,plantar pressure mapping,and grasp task of an artificial limb.This work provides a physical insight in achieving linear response through the design of appropriate microstructures and selection of materials with suitable modulus in flexible pressure sensors,which are potentially useful in intelligent robots and health monitoring.展开更多
The progress in the science of energy utilizations will act crucial effect on the developments of energy science and technology, which will then promote social and economical developments and fulfill requirements for ...The progress in the science of energy utilizations will act crucial effect on the developments of energy science and technology, which will then promote social and economical developments and fulfill requirements for the national strategic objectives. For the sake of sustainable development, a harmonious blend of energy utilizations and environment considerations will become one of the vital topics in the future research area of energy science. It is suggested that clean and high-efficiency utilization of traditional or fossil energy resources, fundamental investigations on the energy and environment theory, renewable energy utilizations, and the development of nuclear energy are selected as priority research areas during the period of the Tenth Five-year Plan of China, according to the development trend of the world energy science and the research background of Chinese energy science, It is expected to promote the interdisciplinary investigations in the science of energy utilizations and provide scientific and technological supports for the development of related advanced high technologies,展开更多
基金Supported by National Institutes of Health,No.EB001981 to Ehman RL and No.EB017197 to Yin Mthe National Natural Science Foundation of China,No.81271562 to Wang J
文摘AIM To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH). METHODS In this retrospective study, 36 patients (19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness (LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologists evaluated morphological features of cirrhosis on conventional magnetic resonance imaging (MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis. RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease (r = 0.88 vs -0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed (3.7 kPa vs 3.84 kPa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis (0.97 vs 0.53-0.80, p < 0.01), and cirrhosis (0.98 vs 0.58-0.80, p < 0.01) and better than conventional MRI for diagnosis of cirrhosis (0.98 vs 0.78, p = 0.002). CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI.
文摘Ethics and morality are old and constantly updated topic. In the modern science and technology rapid development situation, study of ethics of science and technology is relatively backward. The times call for advanced and reasonable ethics of science-technology. Basic concepts and characteristics of ethics and morals are distinguished and defined in this paper. Three ethic essences of science-technology are abstracted from scientific-technological generation, application, and development. The three-dimension system of basic principles for scientific-technologic ethics is created, as illustrated by the portions given in this paper. The evolution formula of value system is derived, and used for appraising whether the science-technology activity is in all reason. Furthermore, it provides the theory base for quantified management. Finally, it is pointed out that morality and law should be supplemented each other in the science-technology management.
基金United Arab Emirates University (UAEU), Al-Ain, UAE, and Sultan Qaboos University (SQU), Muscat, Sultanate of Oman, for providing research support through a collaborative research project (UAEU: 31N270)。
文摘Welding is a vital component of several industries such as automotive,aerospace,robotics,and construction.Without welding,these industries utilize aluminum alloys for the manufacturing of many components or systems.However,fusion welding of aluminum alloys is challenging due to several factors,including the presence of non-heat-treatable alloys,porosity,solidification,and liquation of cracks.Many manufacturers adopt conventional in-air friction stir welding(FSW)to weld metallic alloys and dissimilar materials.Many researchers reported the drawbacks of this traditional in-air FSW technique in welding metallic and polymeric materials in general and aluminum alloys and aluminum matrix composites in specific.A number of FSW techniques were developed recently,such as underwater friction stir welding(UFSW),vibrational friction-stir welding(VFSW),and others,for welding of aluminum alloy joints to overcome the issues of welding using conventional FSW.Therefore,the main objective of this review is to summarize the recent trends in FSW process of aluminum alloys and aluminum metal matrix composites(Al MMCs).Also,it discusses the effect of welding parameters of the traditional and state-of-the-art developed FSW techniques on the welding quality and strength of aluminum alloys and Al MMCs.Comparison among the techniques and advantages and limitations of each are considered.The review suggests that VFSW is a viable option for welding aluminum joints due to its energy efficiency,economic cost,and versatile modifications that can be employed based on the application.This review also illustrated that significantly less attention has been paid to FSW of Al-MMCs and considerable attention is demanded to produce qualified joint.
文摘A total of 1,101 heads were used to improve the selection of superior cows in Gangwon regional Hanwoo. Characteristics of each cow were analyzed using ultrasound evaluation and trace of reproductive potential. A comparison of live carcass traits classified by parity was analyzed in all characteristics. The results of the comparison showed all characteristic increased rapidly after the 2nd parity, and decreased after the 4th parity (P 〈 0.01). The result of comparison classified by the group showed a tendency, whereas Back Fat Thickness Ultrasound (BFTU) and P8 Fat Thickness Ultrasound (P8-FTU) were significant (P 〈 0.01) thinnest in Pedigree group and using a lot of reproduction in advanced group. Also, we made comparisons of the cow's calves on the carcass traits among the group. High quality calves of the pedigree group showed 30.77%. These are the highest carcass traits in meat quality grade above 1+ and yield grade above A. Frequency of fertilization failure per rump fat thickness showed a significantly (P 〈 0.0|) higher difference. The average frequency of fertilization failure demonstrated 1.11 times of experimental Hanwoo cows. In the analysis, frequency of fertilization failure appeared 0.9 times at rump fat thickness below 5 mm. However, it is higher than average above 5 mm. The result of the study will be used to improve cows, select optimum semen, as well as contribute to the improvement of farms income.
文摘SMART (system-integrated modular advanced reactor) is a small-sized advanced integral reactor with a rated thermal power of 330 MW. It can produce 100 MW of electricity, or 90 MW of electricity and 40,000 t of desalinated water concurrently, which is sufficient for 100,000 residents. SMART technology is a sensible mixture of new innovative design features and proven technologies through a PWR. The enhancement of safety and reliability is realized by incorporating inherent safety features and reliable passive safety systems. The improvement in the economics is achieved through system simplification, component modularization, construction time reduction, and increased plant availability. All technologies and design features implemented into SMART have been proven in industries and/or qualified through the SMART design verification program including comprehensive test and experiments. The full scope of the safety analyses carried out to confirm that the inherent safety-improvement design characteristics and safety systems of SMART ensure reactor safety. After a thorough licensing review, SDA (standard design approval) for SMART was granted on July 4th, 2012 by the Korea NSSC (Nuclear Safety and Security Commission). This marks the first license for an integral-type reactor in the world. This paper presents the SMART characteristics, safety features and technology validation. The licensing process of SMART is also described.
文摘In the last few years, interest in burnup calculations using Monte Carlo methods has increased. Previous burnup codes have used diffusion theory for the neutronic portion of the codes. Diffusion theory works well for most reactors. However, diffusion theory does not produce accurate results in burnup problems that include strong absorbers or large voids. MCNPX code based on Mont Carlo Method, is used to design a three dimensional model for a BWR fuel assembly in a typical operating temperature and pressure conditions. A test case was compared with a benchmark problem and good agreement was found. The model is used to calculate the distribution of pin by pin power and flux inside the assembly. The effect of axial variation of water (coolant) density, and of control rods motion on the neutron flux and power distribution is analyzed. The effect of addition of Gd2O3 to natural uranium (0.711%) on both the thermal neutron flux and normalized power are analyzed. The concentration of U^235, U^238, Pu^239, and its isotopes is also calculated at burn-up 50 GWD/T.
文摘Within the OECD/NEA Benchmarking of Thermal-Hydraulic Loop Models for Lead-Alloy Cooled Advanced Nuclear Energy Systems (LACANES), the Institute for Neutron Physics and Reactor Technology takes part in the validation process of system codes and the characterization of the thermal-hydraulic behavior of an experimental loop operated with liquid lead-bismuth-eutectics. To confirm the calculations, the results were compared to experimental data obtained from the HELIOS facility at the Seoul National University and to the results of other benchmark participants. The comparison showed that the calculations are within measurement tolerance but nevertheless discrepancies among the participants exist. The pressure drop estimation is determined by a variety of empirical correlations for the friction and the form loss coefficients. Hence, uncertainty and sensitivity measures were applied to find out which parameter is more relevant for the overall pressure drop. In the frame of this investigation, the system code TRACE and the software system for uncertainty and sensitivity, SUSA, were used. The results show that the total pressure drop varies between -30 and +15% related to the reference case.
文摘Advanced Chinese culture today has three interconnected requirements: a) it is an organic component of today's advanced world culture; b) it critically absorbs all the best elements of foreign cultures in an organic combination with the best elements of traditional Chinese culture; and c) it transcends the argument over "modernism" and "post-modernism." From a world- historical perspective, all other necessary features of advanced culture in contemporary China represent the logical unfolding of these three requirements. A full and correct grasp of the three elements constituting the world-historicality of this advanced culture is of important methodological significance in clarifying the world-historical mode of the construction of contemporary Chinese culture and the path to cultural innovation.
基金supported by the Science Technology and Innovation Committee of Shenzhen Municipality(JCYJ20170817111714314)the National Natural Science Foundation of China(52073138 and 51771089)+2 种基金the Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06G587)the Shenzhen Sci-Tech Fund(KYTDPT20181011104007)the Tencent Robotics X Lab Rhino-Bird Focused Research Program(JR201984)。
文摘Electronic skins and flexible pressure sensors are important devices for advanced healthcare and intelligent robotics.Sensitivity is a key parameter of flexible pressure sensors.Whereas introducing surface microstructures in a capacitive-type sensor can significantly improve its sensitivity,the signal becomes nonlinear and the pressure response range gets much narrower,significantly limiting the applications of flexible pressure sensors.Here,we designed a pressure sensor that utilizes a nanoscale iontronic interface of an ionic gel layer and a micropillared electrode,for highly linear capacitance-to-pressure response and high sensitivity over a wide pressure range.The micropillars undergo three stages of deformation upon loading:initial contact(0-6 k Pa)and structure buckling(6-12 k Pa)that exhibit a low and nonlinear response,as well as a post-buckling stage that has a high signal linearity with high sensitivity(33.16 k Pa-1)over a broad pressure range of 12-176 k Pa.The high linearity lies in the subtle balance between the structure compression and mechanical matching of the two materials at the gel-electrode interface.Our sensor has been applied in pulse detection,plantar pressure mapping,and grasp task of an artificial limb.This work provides a physical insight in achieving linear response through the design of appropriate microstructures and selection of materials with suitable modulus in flexible pressure sensors,which are potentially useful in intelligent robots and health monitoring.
文摘The progress in the science of energy utilizations will act crucial effect on the developments of energy science and technology, which will then promote social and economical developments and fulfill requirements for the national strategic objectives. For the sake of sustainable development, a harmonious blend of energy utilizations and environment considerations will become one of the vital topics in the future research area of energy science. It is suggested that clean and high-efficiency utilization of traditional or fossil energy resources, fundamental investigations on the energy and environment theory, renewable energy utilizations, and the development of nuclear energy are selected as priority research areas during the period of the Tenth Five-year Plan of China, according to the development trend of the world energy science and the research background of Chinese energy science, It is expected to promote the interdisciplinary investigations in the science of energy utilizations and provide scientific and technological supports for the development of related advanced high technologies,