[Objective] A study on the classification of 24 species of Calyptratae entering Ningbo port using DNA barcoding technique was carried out.[Method] The CO I genes of the 24 species of Calyptratae were first sequenced.B...[Objective] A study on the classification of 24 species of Calyptratae entering Ningbo port using DNA barcoding technique was carried out.[Method] The CO I genes of the 24 species of Calyptratae were first sequenced.Based on the comparison and analysis of the obtained sequences,the phylogenetic tree was constructed using MEGA6.0.[Result] The cluster analysis showed the classification of the 24 species of Calyptratae was consistent with the morphological classification at the family and genus levels.However,the cluster analysis could not fully distinguish the closely-related species.[Discussion] The DNA barcoding technique cannot be singly used for classifying and identifying Calyptratae.It should be combined with morphological classification methods,and can be treated as a beneficial supplement for morphological classification methods.展开更多
[Objective] The study aimed to solve the problem of morphological identi- fication difficulties and propose solutions for the identification of foreign mosquitoes that are difficult to identify. [Method] Based on the ...[Objective] The study aimed to solve the problem of morphological identi- fication difficulties and propose solutions for the identification of foreign mosquitoes that are difficult to identify. [Method] Based on the sequencing, alignment and anal- ysis of COl gene fragment, DNA barcode technology was used to identify 7 exotic mosquitoes, and the phylogenetic analysis was performed using MEGA6.0 and DNASTAR software. Then the morphological characteristics of the mosquitoes were reviewed. [Result[ These mosquitoes were Armigeres subalbatus, Culex gefidus, Anopheles gambiae, and Culiseta incidens. [Conclusion] DNA barcode technology is a useful supplement to the morphological classification method of mosquitoes.展开更多
Comprehending regional characteristics and influencing factors of China's inbound tourism economy is im- portant to make effective policies that will help inbound tourism develop harmoniously and shrink regional disp...Comprehending regional characteristics and influencing factors of China's inbound tourism economy is im- portant to make effective policies that will help inbound tourism develop harmoniously and shrink regional disparity. This paper studied the regional disparity and convergence of China's inbound tourism economy during 1996-2008 with the methods of a-convergence, club convergence and r-convergence. The results indicate that 1) inbound tourism receipts per capita (ITRPC) of the whole country, the eastern, central and western regions presented the rapid increasing trend; 2) ITRPC of the whole country was characterized by convergence; 3) the eastern region presented club con- vergence, but the central and western regions did not show this trend; 4) the star-hotel levels and investment in fixed assets for the tourism industry per capita had a same trend to growth rates of ITRPC, promoting inbound tourism de- velopment, and there was no difference among the 31 provinces (municipalities) in the mainland of China; 5) but the proportion of employed persons in the tourism industry accounting for total population and the proportion of the terti- ary industry accounting for GDP had a reversal trend to growth rates of ITRPC, shrinking the provincial disparity in inbound tourism economy, and there were differences between the developed provinces and the developing provinces. Based on these analyses, we put forward some suggestions for the developing provinces to speed up inbound tourism economy.展开更多
Based on the engineering background of gob-side entry retaining in fully-mechanized longwall with top coal caving(GER-FLTC) on N2105 working face of Yuwu coal mine, by adopting the methods of theoretical analysis and ...Based on the engineering background of gob-side entry retaining in fully-mechanized longwall with top coal caving(GER-FLTC) on N2105 working face of Yuwu coal mine, by adopting the methods of theoretical analysis and numerical calculation, the control techniques of surrounding rocks in GER-FLTC working face are studied in this paper. The two main difficulties of stability of surrounding rocks at gob-side retained entry in fully-mechanized longwall working face are the stability control of top coal and control of large deformation of GER-FLTC working face. Interaction mechanical model between roofing and roadside backfilling in GER-FLTC is established and the equations for the calculation of roof-cutting resistance of roadside backfilling are derived. Results of numerical calculation show that the damage zones of top coal can be categorized into the delaminating zone of top coal above the backfilling, tensile damage zone of top coal above the retained roadway and shear damage zone of the upper rib of the solid coal. Stability control of top coal is the critical part to success of GER-FLTC. With consideration of large deformation of surrounding rocks of gob-side retained entry in fully-mechanized longwall, the support technique of‘‘roofing control and wall strengthening'' is proposed where high strength and highly prestressed anchor rods and diagonal tensile anchor cables support are used for top coal, high strength and highly prestressed yielding anchor rod support is used for solid coal and roadside prestressed load-carrying backfilling is constructed by high-water material, in order to maintain the integrity of the top coal, transfer load, high resistance yielding load-carrying of solid coal, roof-cutting of roadside backfilling and support,and to achieve GER-FLTC. Results from this study are successfully applied in engineering practice.展开更多
The glycoprotein (GP) of Ebola is the sole structural protein that forms the spikes on the viral envelope. The GP contains two subunits, GPI and GP2, linked by a disulfide bond, which are responsible for receptor bi...The glycoprotein (GP) of Ebola is the sole structural protein that forms the spikes on the viral envelope. The GP contains two subunits, GPI and GP2, linked by a disulfide bond, which are responsible for receptor binding and membrane fusion, respectively. In this study, the full length of GP gene of Ebola Zaire species, 2028 base pairs in length, was synthesized using 38 overlapping oligonucleotides by multiple rounds of polymerase chain reaction (PCR). The synthesized GP gene was shown to be efficiently expressed in mammalian cells. Furthermore, an efficient HIV-based pseudotyping system was developed using the synthetic GP gene, providing a safe approach to dissecting the entry mechanism of Ebola viruses. Using this pseudotyping system and mutational analysis, the role of the charged residues in the GP2 helical regions was examined. It was found that substitutions of the most charged residues in the regions did not adversely affect GP expression, processing, or viral incorporation, however, most of the mutations greatly impaired the ability of GP to mediate efficient viral infection. These results demonstrate that these charged residues of GP2 play an important role in GP-mediated Ebola entry into its host cells. We propose that these charged residues are involved in forming the intermediate conformation(s) of GP in membrane fusion and Ebola entry.展开更多
Based on the survey data for 2120 inbound and domestic tourists at the Shanghai World Expo,a structural equation model was constructed for the relationship among tourists' perceived value dimensions,behavioral int...Based on the survey data for 2120 inbound and domestic tourists at the Shanghai World Expo,a structural equation model was constructed for the relationship among tourists' perceived value dimensions,behavioral intention and revisit intention.Additionally,the influence of tourists' perceived value dimensions on the behavioral intention and revisit intention was explored.The results show that the utilitarian value and enjoyment value significantly affect the inbound and domestic tourists' behavioral intention,while the convenience value and aesthetic value have no significant influence.The service value only significantly affects the domestic tourists' behavioral intention,and the aesthetic value only significantly affects the inbound tourists' behavioral intention.The utilitarian value,service value and enjoyment value significantly affect the inbound and domestic tourists' revisit intention,while the convenience value only significantly affects the domestic tourists' revisit intention.The utilitarian value is the primary factor affecting the inbound tourists' behavioral intention and revisit intention,and the perceived price has no significant effect on either inbound or domestic tourists' behavioral intention or revisit intention.The study explores the relationships between tourists' perceived value,behavioral intention and revisit intention,analyzes the divergence and causation,theoretically enriches the research field of tourism geography and behavioral geography,and has great practical significance to the sustainable development of mega events in China,including the further development of the Shanghai World Expo.展开更多
Map data display is the basic information representation mode under embedded real-time navigation. After a navigation display data set (NDIS_SET) with several dimensions and corresponding mathematical description fo...Map data display is the basic information representation mode under embedded real-time navigation. After a navigation display data set (NDIS_SET) with several dimensions and corresponding mathematical description formula are designed, a series of rules and algorithms are advanced to optimize embedded navigation data and promote data index and input efficiency. A new parallel display algorithm with navigation data named N PDIS is then presented to adapt to limited embedded resources of computation and memory after a normal navigation data display algorithm named NDIS and related problems are analyzed, N_PDIS can synchronously create two preparative bitmapa by two parallel threads and switch one of them to screen automatically. Compared with NDIS, the results show that N_PDIS is more effective in improving display efficiency.展开更多
A theoretical relationship between the wavelet transform and the fast fourier transformation(FFT) methods in broadband wireless signal is proposed for solving the direction of arrivals(DOAs) estimation problem. This l...A theoretical relationship between the wavelet transform and the fast fourier transformation(FFT) methods in broadband wireless signal is proposed for solving the direction of arrivals(DOAs) estimation problem. This leads naturally to the derivation of minimum variance distortionless response(MVDR) algorithm, which combines the benefits of subspace methods with those of wavelet, and spatially smoothed versions are utilized which exhibits good performance against correlated signals. We test the method's performance by simulating and comparing the performance of proposed algorithm, FFT MVDR and MVDR with correlated signals, and an improved performance is obtained.展开更多
Invasion and metastasis are the deadly face of malignant tumors. Considering the high rate of incidence and mortality of colorectal cancer, it is critical to determine the mechanisms of its dissemination. In the paral...Invasion and metastasis are the deadly face of malignant tumors. Considering the high rate of incidence and mortality of colorectal cancer, it is critical to determine the mechanisms of its dissemination. In the parallel investigation of the invasive front and tumor center area of colorectal cancer (CRC), observation of heterogeneous β-catenin distribution and epithelial-mesenchymal transition (EMT) at the invasive front suggested that there might be a crosstalk between tumor cells and the tumor microenvironment. Wnt signaling pathway is also involved in the cancer progression due to its key role in CRC tumorigenesis. Moreover, in recent years, there is increasing evidence that the regulators of microenvironment, including extracellular matrix, growth factors and inflammatory factors, are associated with the activation of Wnt pathway and the mobility of tumor cells. In this review, we will try to explain how these molecules trigger metastasis via the Wnt pathway.展开更多
Large quantities of ballast water discharge from ocean going ships in sea ports of China is one of the important factorswhich cause the spread of aquatic nonindigenous harmful species isolated geographically by waters...Large quantities of ballast water discharge from ocean going ships in sea ports of China is one of the important factorswhich cause the spread of aquatic nonindigenous harmful species isolated geographically by waters,the deteriorating environment of the near-shore water area and the frequent outbreaks of red tides.In this paper,the total amount of the ballast water input estimation model for entry ships in Chinese ports was established.The information of foreign trade shipping and the import and export goods released publicly by the State Department of Transportation and the State General Administration of Customs were investigated.And then,the input features and its ecological environment risk of ballast water in China's offshore entry ships from2007to2012were analyzed based on the established total input amounts of ballast water from entry ships to Chinese sea ports together with the ballast water input ratio of the five major port-groups in China.The results show that:the total ballast water input amounts from entry ships of the five major port-groups in China are extremely imbalanced.The most developed Yangtze River Delta in economy has the biggest total ballast water input amounts,103.61million tons in2012.The second is the Circum-Bohai Sea Region(73.66million tons)and the third is the Pearl River Delta(67.24million tons).The total ballast water input amounts of the northwest and the southwest coastal areas are less,only16.57and5.71million tons respectively.The large quantity of entry ships’ballast water discharge has been an enormous threat to ecological environment of our country's sea areas,especially to economically developed regions.展开更多
Hepatitis C virus (HCV) infects more than three million new individuals worldwide each year. In a high percent age of patients, acute infections become chronic, eventually progressing to fibrosis, cirrhosis, and hepat...Hepatitis C virus (HCV) infects more than three million new individuals worldwide each year. In a high percent age of patients, acute infections become chronic, eventually progressing to fibrosis, cirrhosis, and hepatocellular carcinoma. Given the lack of effective prophylactic or therapeutic vaccines, and the limited sustained virological response rates to current therapies, new approaches are needed to prevent, control, and clear HCV infection.Entry into the host cell, being the first step of the viral cycle, is a potential target for the design of new antiviral compounds. Despite the recent discovery of the tight junction-associated proteins claudin-1 and occludin as HCV co-receptors, which is an important step towards the understanding of HCV entry, the precise mechanisms are still largely unknown. In addition, increasing evidence indicates that tools that are broadly employed to study HCV infection do not accurately reflect the real process in terms of viral particle composition and host cell phenotype. Thus, systems that more closely mimic natural infection are urgently required to elucidate the mechanisms of HCV entry, which will in turn help to design antiviral strategies against this part of the infection process.展开更多
Considering that traditional research and development (R&D) models cannot keep up with the disruptive advances, the incumbent firms should consider external sources for obtaining and commercializing digital innovat...Considering that traditional research and development (R&D) models cannot keep up with the disruptive advances, the incumbent firms should consider external sources for obtaining and commercializing digital innovations. By contrast, entrepreneurial ventures have the necessary tech development skills and agility to create digital innovations. There has never been a better time for incumbent firms and entrepreneurial ventures to collaborate One paradigm that establishes such mutual beneficial partnership is called "inbound open innovation". Based on a multiple-cases design, this research provides evidence of the benefits, the degree of co-creation required, and the various collaboration schemes that emerge through an open innovation initiative展开更多
In a commercialized and fragment media market where crisis and humanitarian interventions are big news that sells, how do politicians and the public respond to them? Bearing in mind that immigration is a phenomenon w...In a commercialized and fragment media market where crisis and humanitarian interventions are big news that sells, how do politicians and the public respond to them? Bearing in mind that immigration is a phenomenon with a growing presence in society and increasingly politicized, this paper explores an important and persistent question regarding the role of news media in affecting policy decisions, particularly during times of crisis (Paletz, 1998), transference of the issue and the media frames occurs. Having taken into account the agenda building paradigm and the concept of flame (Entman, 1993; Snow & Benford, 1988), the topic of immigration is analyzed in the Spanish main newspapers (El Pais & El Mundo) and in the political interventions (Parliamentary Debates). In order to implement this extraction and framing analysis, the associative method is adopted. The assaults of Ceuta and Melilla (2005) and the Canarias crisis (2006) are taken as the cases of study. The findings of this research highlight that moments of humanitarian crisis and key newsworthy events related to African immigrants increase the media's power to introduce the issue of immigration and to have influence on the frames used in the political and public agenda.展开更多
Based on the data related to the inbound tourism in Mongolia from 2007 to 2017, the structure of inbound tourist market is anatomized. As the result indicates, the inbound tourism market of Mongolia has increased year...Based on the data related to the inbound tourism in Mongolia from 2007 to 2017, the structure of inbound tourist market is anatomized. As the result indicates, the inbound tourism market of Mongolia has increased yearly in concentration index. Yourism has become an important sector that has an impact on development of Mongolia's economy. Foreigners take up the major place in the inbound tourism market of Mongolia, and tourists from China, Russia, South Korea, Japan and USA take up the most important place in the inbound tourism market in Mongolia.展开更多
Objectives:This study aims to investigate the environmental and individual factors contributing to male nurses'psychological well-being and to explore the psychological mechanisms that may explain the links betwee...Objectives:This study aims to investigate the environmental and individual factors contributing to male nurses'psychological well-being and to explore the psychological mechanisms that may explain the links between nurses'practice environment and work engagement,thereby presenting the implications for nurse managers.Methods:A total of 161 male nurses from three tertiary first-class hospitals in Changsha City in China participated in the study.We collected the data using the Practice Environment Scale of the Nursing Work Index,the Psychological Capital Questionnaire,and the Utrecht Work Engagement Scale.Results:Scores of male nurses'practice environment(2.88±0.31),psychological capital(4.42±0.62),and work engagement(3.17±1.39)were all above the midpoint;however,the subscales"the nursing staffing and resources adequacy"(2.72±0.48),"hope"(4.33±0.72),and"dedication"(2.96±1.61)scored lowest.Nurses'practice environment and psychological capital positively predicted nurses'work engagement;psychological capital fully mediated the influence of nurses'practice environment on work engagement.Conclusions:Creating a supportive nursing practice environment can increase male nurses'work engagement by developing their psychological capital.Nurse managers can then provide reasonable workload and pathways for male nurses to achieve goals,thereby fostering their hope.展开更多
文摘[Objective] A study on the classification of 24 species of Calyptratae entering Ningbo port using DNA barcoding technique was carried out.[Method] The CO I genes of the 24 species of Calyptratae were first sequenced.Based on the comparison and analysis of the obtained sequences,the phylogenetic tree was constructed using MEGA6.0.[Result] The cluster analysis showed the classification of the 24 species of Calyptratae was consistent with the morphological classification at the family and genus levels.However,the cluster analysis could not fully distinguish the closely-related species.[Discussion] The DNA barcoding technique cannot be singly used for classifying and identifying Calyptratae.It should be combined with morphological classification methods,and can be treated as a beneficial supplement for morphological classification methods.
文摘[Objective] The study aimed to solve the problem of morphological identi- fication difficulties and propose solutions for the identification of foreign mosquitoes that are difficult to identify. [Method] Based on the sequencing, alignment and anal- ysis of COl gene fragment, DNA barcode technology was used to identify 7 exotic mosquitoes, and the phylogenetic analysis was performed using MEGA6.0 and DNASTAR software. Then the morphological characteristics of the mosquitoes were reviewed. [Result[ These mosquitoes were Armigeres subalbatus, Culex gefidus, Anopheles gambiae, and Culiseta incidens. [Conclusion] DNA barcode technology is a useful supplement to the morphological classification method of mosquitoes.
基金Under the auspices of National Natural Science Foundation of China (No. 40971019)National Basic Research Program of China (No. 2007CB411501)
文摘Comprehending regional characteristics and influencing factors of China's inbound tourism economy is im- portant to make effective policies that will help inbound tourism develop harmoniously and shrink regional disparity. This paper studied the regional disparity and convergence of China's inbound tourism economy during 1996-2008 with the methods of a-convergence, club convergence and r-convergence. The results indicate that 1) inbound tourism receipts per capita (ITRPC) of the whole country, the eastern, central and western regions presented the rapid increasing trend; 2) ITRPC of the whole country was characterized by convergence; 3) the eastern region presented club con- vergence, but the central and western regions did not show this trend; 4) the star-hotel levels and investment in fixed assets for the tourism industry per capita had a same trend to growth rates of ITRPC, promoting inbound tourism de- velopment, and there was no difference among the 31 provinces (municipalities) in the mainland of China; 5) but the proportion of employed persons in the tourism industry accounting for total population and the proportion of the terti- ary industry accounting for GDP had a reversal trend to growth rates of ITRPC, shrinking the provincial disparity in inbound tourism economy, and there were differences between the developed provinces and the developing provinces. Based on these analyses, we put forward some suggestions for the developing provinces to speed up inbound tourism economy.
基金supported by Chinese National Programs for Fundamental Research and Development(973 Program)(2013CB227905)Natural Science Foundation of Jiangsu Province of China(BK20140210)
文摘Based on the engineering background of gob-side entry retaining in fully-mechanized longwall with top coal caving(GER-FLTC) on N2105 working face of Yuwu coal mine, by adopting the methods of theoretical analysis and numerical calculation, the control techniques of surrounding rocks in GER-FLTC working face are studied in this paper. The two main difficulties of stability of surrounding rocks at gob-side retained entry in fully-mechanized longwall working face are the stability control of top coal and control of large deformation of GER-FLTC working face. Interaction mechanical model between roofing and roadside backfilling in GER-FLTC is established and the equations for the calculation of roof-cutting resistance of roadside backfilling are derived. Results of numerical calculation show that the damage zones of top coal can be categorized into the delaminating zone of top coal above the backfilling, tensile damage zone of top coal above the retained roadway and shear damage zone of the upper rib of the solid coal. Stability control of top coal is the critical part to success of GER-FLTC. With consideration of large deformation of surrounding rocks of gob-side retained entry in fully-mechanized longwall, the support technique of‘‘roofing control and wall strengthening'' is proposed where high strength and highly prestressed anchor rods and diagonal tensile anchor cables support are used for top coal, high strength and highly prestressed yielding anchor rod support is used for solid coal and roadside prestressed load-carrying backfilling is constructed by high-water material, in order to maintain the integrity of the top coal, transfer load, high resistance yielding load-carrying of solid coal, roof-cutting of roadside backfilling and support,and to achieve GER-FLTC. Results from this study are successfully applied in engineering practice.
基金supported by National Institutes of Health grants CA 092459 and AI48056. L. R. was a recipient of the Schweppe Foundation Career Development Award.
文摘The glycoprotein (GP) of Ebola is the sole structural protein that forms the spikes on the viral envelope. The GP contains two subunits, GPI and GP2, linked by a disulfide bond, which are responsible for receptor binding and membrane fusion, respectively. In this study, the full length of GP gene of Ebola Zaire species, 2028 base pairs in length, was synthesized using 38 overlapping oligonucleotides by multiple rounds of polymerase chain reaction (PCR). The synthesized GP gene was shown to be efficiently expressed in mammalian cells. Furthermore, an efficient HIV-based pseudotyping system was developed using the synthetic GP gene, providing a safe approach to dissecting the entry mechanism of Ebola viruses. Using this pseudotyping system and mutational analysis, the role of the charged residues in the GP2 helical regions was examined. It was found that substitutions of the most charged residues in the regions did not adversely affect GP expression, processing, or viral incorporation, however, most of the mutations greatly impaired the ability of GP to mediate efficient viral infection. These results demonstrate that these charged residues of GP2 play an important role in GP-mediated Ebola entry into its host cells. We propose that these charged residues are involved in forming the intermediate conformation(s) of GP in membrane fusion and Ebola entry.
基金Under the auspices of National Natural Science Foundation of China(No.41271171,41230631)
文摘Based on the survey data for 2120 inbound and domestic tourists at the Shanghai World Expo,a structural equation model was constructed for the relationship among tourists' perceived value dimensions,behavioral intention and revisit intention.Additionally,the influence of tourists' perceived value dimensions on the behavioral intention and revisit intention was explored.The results show that the utilitarian value and enjoyment value significantly affect the inbound and domestic tourists' behavioral intention,while the convenience value and aesthetic value have no significant influence.The service value only significantly affects the domestic tourists' behavioral intention,and the aesthetic value only significantly affects the inbound tourists' behavioral intention.The utilitarian value,service value and enjoyment value significantly affect the inbound and domestic tourists' revisit intention,while the convenience value only significantly affects the domestic tourists' revisit intention.The utilitarian value is the primary factor affecting the inbound tourists' behavioral intention and revisit intention,and the perceived price has no significant effect on either inbound or domestic tourists' behavioral intention or revisit intention.The study explores the relationships between tourists' perceived value,behavioral intention and revisit intention,analyzes the divergence and causation,theoretically enriches the research field of tourism geography and behavioral geography,and has great practical significance to the sustainable development of mega events in China,including the further development of the Shanghai World Expo.
文摘Map data display is the basic information representation mode under embedded real-time navigation. After a navigation display data set (NDIS_SET) with several dimensions and corresponding mathematical description formula are designed, a series of rules and algorithms are advanced to optimize embedded navigation data and promote data index and input efficiency. A new parallel display algorithm with navigation data named N PDIS is then presented to adapt to limited embedded resources of computation and memory after a normal navigation data display algorithm named NDIS and related problems are analyzed, N_PDIS can synchronously create two preparative bitmapa by two parallel threads and switch one of them to screen automatically. Compared with NDIS, the results show that N_PDIS is more effective in improving display efficiency.
基金supported by the Chinese Natural Science Foundation 61401075Central University Business Fee ZYGX2015J106
文摘A theoretical relationship between the wavelet transform and the fast fourier transformation(FFT) methods in broadband wireless signal is proposed for solving the direction of arrivals(DOAs) estimation problem. This leads naturally to the derivation of minimum variance distortionless response(MVDR) algorithm, which combines the benefits of subspace methods with those of wavelet, and spatially smoothed versions are utilized which exhibits good performance against correlated signals. We test the method's performance by simulating and comparing the performance of proposed algorithm, FFT MVDR and MVDR with correlated signals, and an improved performance is obtained.
基金Supported by The Science and Technology Development Foundation of Shanghai, No. 064119512
文摘Invasion and metastasis are the deadly face of malignant tumors. Considering the high rate of incidence and mortality of colorectal cancer, it is critical to determine the mechanisms of its dissemination. In the parallel investigation of the invasive front and tumor center area of colorectal cancer (CRC), observation of heterogeneous β-catenin distribution and epithelial-mesenchymal transition (EMT) at the invasive front suggested that there might be a crosstalk between tumor cells and the tumor microenvironment. Wnt signaling pathway is also involved in the cancer progression due to its key role in CRC tumorigenesis. Moreover, in recent years, there is increasing evidence that the regulators of microenvironment, including extracellular matrix, growth factors and inflammatory factors, are associated with the activation of Wnt pathway and the mobility of tumor cells. In this review, we will try to explain how these molecules trigger metastasis via the Wnt pathway.
文摘Large quantities of ballast water discharge from ocean going ships in sea ports of China is one of the important factorswhich cause the spread of aquatic nonindigenous harmful species isolated geographically by waters,the deteriorating environment of the near-shore water area and the frequent outbreaks of red tides.In this paper,the total amount of the ballast water input estimation model for entry ships in Chinese ports was established.The information of foreign trade shipping and the import and export goods released publicly by the State Department of Transportation and the State General Administration of Customs were investigated.And then,the input features and its ecological environment risk of ballast water in China's offshore entry ships from2007to2012were analyzed based on the established total input amounts of ballast water from entry ships to Chinese sea ports together with the ballast water input ratio of the five major port-groups in China.The results show that:the total ballast water input amounts from entry ships of the five major port-groups in China are extremely imbalanced.The most developed Yangtze River Delta in economy has the biggest total ballast water input amounts,103.61million tons in2012.The second is the Circum-Bohai Sea Region(73.66million tons)and the third is the Pearl River Delta(67.24million tons).The total ballast water input amounts of the northwest and the southwest coastal areas are less,only16.57and5.71million tons respectively.The large quantity of entry ships’ballast water discharge has been an enormous threat to ecological environment of our country's sea areas,especially to economically developed regions.
基金Supported by CIBERehd to Moreno-Otero R, López-Cabrera M and Majano PLSAF2007-61201 (Ministerio de Educación y Ciencia) to López-Cabrera M+3 种基金CP03/0020 (Instituto de Salud Carlos Ⅲ)SAF2007-60677 (Ministerio de Educación y Ciencia)PI10/00101 (Ministerio de Ciencia e Innovación, Instituto de Salud Carlos Ⅲ, FEDER) to Majano PL. Benedictosupported by CIBERehd and Molina-Jiménez F by Instituto de Salud Carlos Ⅲ and FIB Hospital de la Princesa
文摘Hepatitis C virus (HCV) infects more than three million new individuals worldwide each year. In a high percent age of patients, acute infections become chronic, eventually progressing to fibrosis, cirrhosis, and hepatocellular carcinoma. Given the lack of effective prophylactic or therapeutic vaccines, and the limited sustained virological response rates to current therapies, new approaches are needed to prevent, control, and clear HCV infection.Entry into the host cell, being the first step of the viral cycle, is a potential target for the design of new antiviral compounds. Despite the recent discovery of the tight junction-associated proteins claudin-1 and occludin as HCV co-receptors, which is an important step towards the understanding of HCV entry, the precise mechanisms are still largely unknown. In addition, increasing evidence indicates that tools that are broadly employed to study HCV infection do not accurately reflect the real process in terms of viral particle composition and host cell phenotype. Thus, systems that more closely mimic natural infection are urgently required to elucidate the mechanisms of HCV entry, which will in turn help to design antiviral strategies against this part of the infection process.
文摘Considering that traditional research and development (R&D) models cannot keep up with the disruptive advances, the incumbent firms should consider external sources for obtaining and commercializing digital innovations. By contrast, entrepreneurial ventures have the necessary tech development skills and agility to create digital innovations. There has never been a better time for incumbent firms and entrepreneurial ventures to collaborate One paradigm that establishes such mutual beneficial partnership is called "inbound open innovation". Based on a multiple-cases design, this research provides evidence of the benefits, the degree of co-creation required, and the various collaboration schemes that emerge through an open innovation initiative
文摘In a commercialized and fragment media market where crisis and humanitarian interventions are big news that sells, how do politicians and the public respond to them? Bearing in mind that immigration is a phenomenon with a growing presence in society and increasingly politicized, this paper explores an important and persistent question regarding the role of news media in affecting policy decisions, particularly during times of crisis (Paletz, 1998), transference of the issue and the media frames occurs. Having taken into account the agenda building paradigm and the concept of flame (Entman, 1993; Snow & Benford, 1988), the topic of immigration is analyzed in the Spanish main newspapers (El Pais & El Mundo) and in the political interventions (Parliamentary Debates). In order to implement this extraction and framing analysis, the associative method is adopted. The assaults of Ceuta and Melilla (2005) and the Canarias crisis (2006) are taken as the cases of study. The findings of this research highlight that moments of humanitarian crisis and key newsworthy events related to African immigrants increase the media's power to introduce the issue of immigration and to have influence on the frames used in the political and public agenda.
文摘Based on the data related to the inbound tourism in Mongolia from 2007 to 2017, the structure of inbound tourist market is anatomized. As the result indicates, the inbound tourism market of Mongolia has increased yearly in concentration index. Yourism has become an important sector that has an impact on development of Mongolia's economy. Foreigners take up the major place in the inbound tourism market of Mongolia, and tourists from China, Russia, South Korea, Japan and USA take up the most important place in the inbound tourism market in Mongolia.
文摘Objectives:This study aims to investigate the environmental and individual factors contributing to male nurses'psychological well-being and to explore the psychological mechanisms that may explain the links between nurses'practice environment and work engagement,thereby presenting the implications for nurse managers.Methods:A total of 161 male nurses from three tertiary first-class hospitals in Changsha City in China participated in the study.We collected the data using the Practice Environment Scale of the Nursing Work Index,the Psychological Capital Questionnaire,and the Utrecht Work Engagement Scale.Results:Scores of male nurses'practice environment(2.88±0.31),psychological capital(4.42±0.62),and work engagement(3.17±1.39)were all above the midpoint;however,the subscales"the nursing staffing and resources adequacy"(2.72±0.48),"hope"(4.33±0.72),and"dedication"(2.96±1.61)scored lowest.Nurses'practice environment and psychological capital positively predicted nurses'work engagement;psychological capital fully mediated the influence of nurses'practice environment on work engagement.Conclusions:Creating a supportive nursing practice environment can increase male nurses'work engagement by developing their psychological capital.Nurse managers can then provide reasonable workload and pathways for male nurses to achieve goals,thereby fostering their hope.