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“关系理性”的哲学指涉——基于马克思自由人联合体思想的嵌入
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作者 杨柳 《南方论刊》 2023年第10期6-9,共4页
“关系理性”是现代性背景下重新界定个体与共同体关系的可行性路径,它与马克思自由人联合体思想具有高度契合性。以马克思自由人联合体思想对“关系理性”进行解析和建构,使其秉持关注现实的个人、价值维度、真实的“共同体”的原则,... “关系理性”是现代性背景下重新界定个体与共同体关系的可行性路径,它与马克思自由人联合体思想具有高度契合性。以马克思自由人联合体思想对“关系理性”进行解析和建构,使其秉持关注现实的个人、价值维度、真实的“共同体”的原则,加之以科学性及浓厚的人文关怀,从而避免陷入抽象性、工具性、空想性误区。“关系理性”是以个体独立为基础的价值自觉、与他人“共存互依”为前提的实践自觉,二者相互交织,共同构成“关系理性”的核心指涉,推动实现个体自觉与共同体生活自觉,助推真实与真正的“共同体”构建。 展开更多
关键词 “关系理性” 自由人联合体 个性独立 “共同感” 共同体
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试论中国人的“关系理性” 被引量:11
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作者 李芊蕾 秦琴 《中共浙江省委党校学报》 CSSCI 2008年第3期40-45,共6页
中国是一个"伦理本位"、"关系本位"的社会,这是儒家经典积淀的结果。本文将这种"关系取向"定位为"关系理性",并在韦伯的理性框架内,将"关系理性"理想类型地划分为价值型"关系理... 中国是一个"伦理本位"、"关系本位"的社会,这是儒家经典积淀的结果。本文将这种"关系取向"定位为"关系理性",并在韦伯的理性框架内,将"关系理性"理想类型地划分为价值型"关系理性"和工具型"关系理性"。进而认为,中国传统社会中行动者的行动遵循价值型"关系理性"的原则,但是,随着社会的发展和变迁,这种价值型"关系理性"在市场导向的社会转型中,逐渐迂回地成长为了一种工具型"关系理性"。 展开更多
关键词 关系 理性 价值型“关系理性” 工具型“关系理性”
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以“关系理性”回应自然——当代生态文明建设前提性反思 被引量:5
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作者 贺来 冯珊 《理论探讨》 CSSCI 北大核心 2018年第2期66-72,共7页
现代社会的环境问题和生态危机日渐成为威胁人类生存的主要问题,传统社会和现代社会中人与自然的关系,经历了以自然为尊到以人为主宰的演变,导致这种转变的根本原因是人类理性形态的转换和变革,即由"客观理性"转变为"主... 现代社会的环境问题和生态危机日渐成为威胁人类生存的主要问题,传统社会和现代社会中人与自然的关系,经历了以自然为尊到以人为主宰的演变,导致这种转变的根本原因是人类理性形态的转换和变革,即由"客观理性"转变为"主观理性",这既是个人解放的重大成果,也隐藏着巨大的生态危机。二者的逻辑共性和弊端即是"实体思维"。解决危机的根本方法是转换视角,冲破"实体思维"的"总体性"和"同一性"规制,基于"关系理性"的视域,形成彼此尊重、相互承认、互为目的的新型生态关系,使人与自然呈现其自身的合理性,展现其应然状态下的本真面貌,敞开其面向未来发展的可能性,为当代生态文明建设提供前提性的反思。 展开更多
关键词 人化自然 主观理性 客观理性 实体思维 “关系理性”
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Application of PCA and HCA to the Structure-Activity Relationship Study of Fluoroquinolones 被引量:2
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作者 李小红 张现周 +2 位作者 程新路 杨向东 朱遵略 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 北大核心 2006年第2期143-148,共6页
Density functional theory (DFT) was used to calculate molecular descriptors (properties) for 12 fluoro-quinolone with anti-S.pneumoniae activity. Principal component analysis (PCA) and hierarchical cluster analy... Density functional theory (DFT) was used to calculate molecular descriptors (properties) for 12 fluoro-quinolone with anti-S.pneumoniae activity. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were employed to reduce dimensionality and investigate in which variables should be more effective for classifying fluoroquinolones according to their degree of an-S.pneumoniae activity. The PCA results showed that the variables ELUMO, Q3, Q5, QA, logP, MR, VOL and △EHL of these compounds were responsible for the anti-S.pneumoniae activity. The HCA results were similar to those obtained with PCA.The methodologies of PCA and HCA provide a reliable rule for classifying new fluoroquinolones with antiS.pneumoniae activity. By using the chemometric results, 6 synthetic compounds were analyzed through the PCA and HCA and two of them are proposed as active molecules with anti-S.pneumoniae, which is consistent with the results of clinic experiments. 展开更多
关键词 Structure-activity relationship Density functional theory Principal component analysis Hierarchical cluster analysis
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Polymerization Mechanism of α-Linear Olefin 被引量:3
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作者 邢文国 张长桥 +2 位作者 于萍 刘成卜 魏云鹤 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2010年第1期39-44,I0001,共7页
The density functional theory on the level of B3LYP/6-31G was empolyed to study the chain growth mechanism in polymerization process of α-linear olefin in TiCl3/AlEt2Cl catalytic system to synthesize drag reduction a... The density functional theory on the level of B3LYP/6-31G was empolyed to study the chain growth mechanism in polymerization process of α-linear olefin in TiCl3/AlEt2Cl catalytic system to synthesize drag reduction agent. Full parameter optimization without symmetry restrictions for reactants, products, the possible transition states, and intermediates was calculated. Vibration frequency was analyzed for all of stagnation points on the potential energy surface at the same theoretical level. The internal reaction coordinate was calculated from the transition states to reactants and products respectively. The results showed as flloes: (i) Coordination compounds were formed on the optimum configuration of TiCl3/AlEt2Cl.(ii) The transition states were formed. The energy di?erence between transition states and the coordination compounds was 40.687 kJ/mol. (iii) Double bond opened and Ti-C(4) bond fractured, and the polymerization was completed. The calculation results also showed that the chain growth mechanism did not essentially change with the increase of carbon atom number of α-linear olefin. From the relationship between polymerization activation energy and carbon atom number of the α-linear olefin, it can be seen that the α-linear olefin monomers with 6-10 carbon atoms had low activation energy and wide range. It was optimum to synthesize drag reduction agent by polymerization. 展开更多
关键词 Density functional theory Polymerization mechanism α-Linear olefin Drag reduction agent Ziegler-Natta catalyst
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On the pragmatic functions of non-restrictive relational clauses in English news report discourse
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作者 胡江 《Sino-US English Teaching》 2009年第12期33-37,共5页
Traditional syntactic or semantic theories failed to provide a satistactory explanation for the unique features of non-restrictive relational clauses in people's daily use of English language. This paper would adopt ... Traditional syntactic or semantic theories failed to provide a satistactory explanation for the unique features of non-restrictive relational clauses in people's daily use of English language. This paper would adopt the theoretical framework of pragmatics and use relevance theory as well as face theory to discuss the unique pragmatic functions of non-restrictive relational clauses in English news report discourse. The three major pragmatic functions are: (1) optimizing the relevance of information; (2) seeking for the consistence with readers; and (3) avoiding imposing the author's opinion on readers. 展开更多
关键词 non-restrictive relational clauses relevance theory face theory pragmatic functions
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Hybrid enzyme catalysts synthesized by a de novo approach for expanding biocatalysis 被引量:3
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作者 Yufei Cao Jun Ge 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2021年第10期1625-1633,共9页
The two major challenges in industrial enzymatic catalysis are the limited number of chemical reaction types that are catalyzed by enzymes and the instability of enzymes under harsh conditions in industrial catalysis.... The two major challenges in industrial enzymatic catalysis are the limited number of chemical reaction types that are catalyzed by enzymes and the instability of enzymes under harsh conditions in industrial catalysis.Expanding enzyme catalysis to a larger substrate scope and greater variety of chemical reactions and tuning the microenvironment surrounding enzyme molecules to achieve high enzyme performance are urgently needed.In this account,we focus on our efforts using the de novo approach to synthesis hybrid enzyme catalysts that can address these two challenges and the structure-function relationship is discussed to reveal the principles of designing hybrid enzyme catalysts.We hope that this account will promote further efforts toward fundamental research and wide applications of designed enzyme hybrid catalysts for expanding biocatalysis. 展开更多
关键词 Expanding biocatalysis In situ synthesis Hybrid enzyme catalysts Structure-function relationship Rational design
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Theory-guided electrocatalyst engineering:From mechanism analysis to structural design 被引量:3
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作者 Mingcheng Zhang Kexin Zhang +4 位作者 Xuan Ai Xiao Liang Qi Zhang Hui Chen Xiaoxin Zou 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2022年第12期2987-3018,共32页
The exploitation of competent electrocatalysts is a key issue of the broad application of many promising electrochemical processes,including the hydrogen evolution reaction(HER),the oxygen evolution reaction(OER),the ... The exploitation of competent electrocatalysts is a key issue of the broad application of many promising electrochemical processes,including the hydrogen evolution reaction(HER),the oxygen evolution reaction(OER),the oxygen reduction reaction(ORR),the CO_(2) reduction reaction(CO_(2)RR)and the nitrogen reduction reaction(NRR).The traditional searches for good electrocatalysts rely on the trial-and-error approaches,which are typically tedious and inefficient.In the past decades,some fundamental principles,activity descriptors and catalytic mechanisms have been established to accelerate the discovery of advanced electrocatalysts.Hence,it is time to summarize these theory-related research advances that unravel the structure-performance relationships and enables predictive ability in electrocatalysis studies.In this review,we summarize some basic aspects of catalytic theories that are commonly used in the design of electrocatalysts(e.g.,Sabatier principle,d-band theory,adsorption-energy scaling relation,activity descriptors)and their relevance.Then,we briefly introduced the fundamental mechanisms and central challenges of HER,OER,ORR,CO_(2)RR and NRR electrocatalysts,and highlight the theory-based efforts used to address the challenges facing these electrocatalysis processes.Finally,we propose the key challenges and opportunities of theory-driven electrocatalysis on their future. 展开更多
关键词 ELECTROCATALYSIS d-band theory Scaling relation Sabatier principle DESCRIPTOR
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A simulation of diesel hydrotreating process with real component method 被引量:1
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作者 Zengzhi Du Chunxi Li +1 位作者 Wei Sun Jianhong Wang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2015年第5期780-788,共9页
Computer simulation is a good guide and reference for development and research on petroleum refining processes. Traditionally, pseudo-components are used in the simulation, in which their physical properties are estim... Computer simulation is a good guide and reference for development and research on petroleum refining processes. Traditionally, pseudo-components are used in the simulation, in which their physical properties are estimated by empirical relations and cannot be associated with actual chemical reactions, as no molecular structure is available for pseudo-components. This limitation can be overcome if real components are used. In this paper, a real component based method is proposed for the simulation of a diesel hydrotreating process by using the software of Unisim Design. This process includes reaction units and distillation units. The chemical reaction network is established by analyzing the feedstock. The feedstock is characterized by real components, which are obtained based on true boiling point curve. Simulation results are consistent with actual data. 展开更多
关键词 Simulation Real components Diesel hydrotreating True boiling point
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Generalization Rough Set Theory 被引量:2
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作者 肖迪 张军峰 胡寿松 《Journal of Donghua University(English Edition)》 EI CAS 2008年第6期654-658,共5页
In order to avoid the discretization in the classical rough set theory, a generlization rough set theory is proposed. At first, the degree of general importance of an attribute and attribute subsets are presented. The... In order to avoid the discretization in the classical rough set theory, a generlization rough set theory is proposed. At first, the degree of general importance of an attribute and attribute subsets are presented. Then, depending on the degree of general importance of attribute, the space distance can be measured with weighted method. At last, a generalization rough set theory based on the general near neighborhood relation is proposed. The proposed theory partitions the universe into the tolerant modules, and forms lower approximation and upper approximation of the set under general near neighborhood relationship, which avoids the discretization in Pawlak's rough set theory. 展开更多
关键词 generalization rough set theory the degree of general importance general near neighborhood relation
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IMPROVED ACCURACY AND ROUGHNESS MEASURES FOR ROUGH SETS 被引量:2
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作者 ZhouYuming XuBaowen 《Journal of Electronics(China)》 2002年第3期320-323,共4页
Accuracy and roughness, proposed by Pawlak(1982), might draw a conclusion inconsistent with our intuition in some cases. This letter analyzes the limitations in these measures and proposes improved accuracy and roughn... Accuracy and roughness, proposed by Pawlak(1982), might draw a conclusion inconsistent with our intuition in some cases. This letter analyzes the limitations in these measures and proposes improved accuracy and roughness measures based on information theory. 展开更多
关键词 Rough sets Equivalence relations UNCERTAINTY Information theory Excess entropy
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On Maintenance of Inter-connectivity Among Multi-representations 被引量:1
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作者 WANG Yan-hui MENG Hao LIU Xiao-meng 《Journal of China University of Mining and Technology》 EI 2006年第4期494-499,共6页
As the problems of conceptual and representational differences will arise among multi-representations, in- ter-connectivity maintenance among multi-representations exists as a foundational task in building multi-scale... As the problems of conceptual and representational differences will arise among multi-representations, in- ter-connectivity maintenance among multi-representations exists as a foundational task in building multi-scale data model. Since the existing methods are still not satisfactory in practice, the inter-connectivity among multiple representa- tions can be only achieved if the multi-scale model is capable of explicitly inter-relating them and dealing with their differences. So, this paper firstly explores the relation among multiple representations from the same entity, such as multi-semantic, multi-geometry, multi-attributes, hierarchical semantic relations and so on. Based on these, this paper proposes aggregation-based semantic hierarchical matching rules (ASHMR) as the basis of tackling inter-connectivity among multi-representations, and defines the available hierarchical semantic knowledge, namely semantically equal, semantically related and semantically irrelevant. According to different change among multi-representations from dif- ferent types of objects, the applications and techniques of the corresponding hierarchy inter-connectivity matching crite- rion are explored. And taken the road intersections as examples, a case in point is given in details for describing the strategies of inter-connectivity maintenance, showing that this method is feasible to deal with inter-connectivity. 展开更多
关键词 inter-connectivity multi-representation ASHMR hierarchical semantic relations data matching
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The Characteristic Relationship Between Oil Uptake and Moisture Content during the High Temperature Immersion Frying of Thin Potato Crisps 被引量:4
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作者 Christopher R.Southern 陈晓东 Mohammed M.Farid 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2004年第6期818-821,共4页
Thin potato crisps (2mm) were fried at 170℃, 180℃ and 190℃ for varioustimes from 10s to 180s inclusive. It was found that definite oil uptake, moisture loss trends existduring the frying process. No significant dif... Thin potato crisps (2mm) were fried at 170℃, 180℃ and 190℃ for varioustimes from 10s to 180s inclusive. It was found that definite oil uptake, moisture loss trends existduring the frying process. No significant difference in the oil uptake or moisture loss ratesbetween flat-cut and ridge-cut crisps exists. Also found in this study was that an increased oiltemperature promoted higher moisture loss rates. In turn, the higher moisture loss rates contributedto a higher oil uptake rate. It was found, based on the volumetric plots of oil content υs. watercontent, that the oil uptake rate was proportional to the moisture loss rate. As a result, it hasbeen shown that there is a possibility of having a characteristic curve of oil uptake againstmoisture content. 展开更多
关键词 oil uptake moisture content frying process thin potato crisps
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Gas reservoir identification by seismic AVO attributes on fluid substitution 被引量:1
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作者 李景叶 《Applied Geophysics》 SCIE CSCD 2012年第2期139-148,233,234,共12页
Traditionally, fluid substitutions are often conducted on log data for calculating reservoir elastic properties with different pore fluids. Their corresponding seismic responses are computed by seismic forward modelin... Traditionally, fluid substitutions are often conducted on log data for calculating reservoir elastic properties with different pore fluids. Their corresponding seismic responses are computed by seismic forward modeling for direct gas reservoir identification. The workflow provides us with the information about reservoir and seismic but just at the well. For real reservoirs, the reservoir parameters such as porosity, clay content, and thickness vary with location. So the information from traditional fluid substitution just at the well is limited. By assuming a rock physics model linking the elastic properties to porosity and mineralogy, we conducted seismic forward modeling and AVO attributes computation on a three-layer earth model with varying porosity, clay content, and formation thickness. Then we analyzed the relations between AVO attributes at wet reservoirs and those at the same but gas reservoirs. We arrived at their linear relations within the assumption framework used in the forward modeling. Their linear relations make it possible to directly conduct fluid substitution on seismic AVO attributes. Finally, we applied these linear relations for fluid substitution on seismic data and identified gas reservoirs by the cross-plot between the AVO attributes from seismic data and those from seismic data after direct fluid substitution. 展开更多
关键词 fluid substitution AVO gas reservoir Gassmann's equation rock physics
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Debye Entropic Force and Modified Newtonian Dynamics 被引量:1
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作者 李昕 常哲 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第4期733-736,共4页
Verlinde has suggested that the gravity has an entropic origin, and a gravitational system could be regarded as a thermodynarnical system. It is well-known that the equipartition law of energy is invalid at very low t... Verlinde has suggested that the gravity has an entropic origin, and a gravitational system could be regarded as a thermodynarnical system. It is well-known that the equipartition law of energy is invalid at very low temperature. Therefore, entropic force should be modified while the temperature of the holographic screen is very low. It is shown that the modified entropic force is proportional to the square of the acceleration, while the temperature of the holographic screen is much lower than the Debye temperature TD. The modified entropic force returns to the Newton's law of gravitation while the temperature of the holographic screen is much higher than the Debye temperature. The modified entropic force is connected with modified Newtonian dynamics (MOND). The constant ao involved in MOND is linear in the Debye frequency WD, which can be regarded as the largest frequency of the bits in screen. We find that there do have a strong connection between MOND and cosmology in the framework of Verlinde's entropic force, if the holographic screen is taken to be bound of the Universe. The Debye frequency is linear in the Hubble constant Ho. 展开更多
关键词 entropic force modified Newtonian dynamics
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Relatedness of Helicobacter pylori populations to gastric carcinogenesis 被引量:4
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作者 Quan-Jiang Dong Shu-Hui Zhan +3 位作者 Li-Li Wang Yong-Ning Xin Man Jiang Shi-Ying Xuan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第45期6571-6576,共6页
Helicobacter pylori (H. pylorl) is a Gram-negative bac- terium that infects half of the human population. The infection is associated with chronic inflammation of the gastric mucosa and peptic ulcers. It is also a m... Helicobacter pylori (H. pylorl) is a Gram-negative bac- terium that infects half of the human population. The infection is associated with chronic inflammation of the gastric mucosa and peptic ulcers. It is also a major risk factor for gastric cancer. Phylogenetic analysis of global strains reveals there are seven populations of H. pylori, including hpAfrical, hpAfrica2, hpEastAsia, hpEurope, hpNEAfrica, hpAsia2 and hpSahul. These populations are consistent with their geographical origins, and pos- sibly result from geographical separation of the bac- terium leading to reduced bacterial recombination in some populations. For each population, H. pylori has evolved to possess genomic contents distinguishable from others. The hpEurope population is distinct in that it has the largest genome of 1.65 mbp on average, and the highest number of coding sequences. This confers its competitive advantage over other populations but at the cost of a lower infection rate. The large genomic size could be a cause of the frequent occurrence of the deletion of the cag pathogenicity island in H. pylori strains from hpEurope. The incidence of gastric cancer varies among different geographical regions. This can be attributed in part to different rates of infection of H. pylori. Recent studies found that different popula- tions of H, pylori vary in their carcinogenic potential and contribute to the variation in incidence of gastric cancer among geographical regions. This could be related to the ancestral origin of H, pylori. Further studies are indi- cated to investigate the bacterial factors contributing to differential virulence and their influence on the clinical features in infected individuals. 展开更多
关键词 Helicobacter pylori Population genetics Gastric cancer VIRULENCE GENOME
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Modelling of Eruptive Fire Occurrence and Behaviour 被引量:1
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作者 Jacques-Henri Balbi Frangois Joseph Chatelon +3 位作者 Jean Louis Rossi Albert Simeoni Domingos Xavier Viegas Carlos Rossa 《Journal of Environmental Science and Engineering(B)》 2014年第3期115-132,共18页
Eruptive fires are one of the main causes of human losses in forest fire fighting. The sudden change in fire behaviour due to a fire eruption is extremely dangerous for fire-fighters because it is unpredictable. Very ... Eruptive fires are one of the main causes of human losses in forest fire fighting. The sudden change in fire behaviour due to a fire eruption is extremely dangerous for fire-fighters because it is unpredictable. Very little literature is available to support either modelling or occurrence prediction for this phenomenon. In this study, an unsteady physical model of fire spread is detailed, which describes the initiation and development of eruptive fires with an induced wind sub-model. The latter phenomenon is proposed as the mainspring of fire eruptions. Induced wind is proportional to the rate of spread and the rate of spread is in a non-linear relationship with induced wind. This feedback can converge or diverge depending on the conditions. The model allows both explaining why an eruption can occur and predicting explicitly its occurrence according to meteorological conditions, topographic parameters, fuel bed properties and fire front width. The model is tested by comparing its results to a set of experiments carried out at laboratory scale and during an outdoor wildfire, the Kornati accident. 展开更多
关键词 Eruptive fire unsteady solutions fire spread physical model.
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Research on the Management Mechanism of Teachers in Public Security Colleges and Universities Based on Psychological Contract
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作者 SONG Liqu 《International English Education Research》 2017年第4期24-25,共2页
In today's management of the teaching staff of public security colleges and universities, the research on the Psychological Contract problem is not only beneficial to the management and estimation of the teachers, bu... In today's management of the teaching staff of public security colleges and universities, the research on the Psychological Contract problem is not only beneficial to the management and estimation of the teachers, but also has an important role in the coordination and stability of the whole system of public security colleges and universities. Based on the theory of Psychological Contract, this paper expounds the basic understanding and research value of Psychological Contract, and puts forward the measures to cultivate teachers' good character and understanding, and as well as coordinate teachers' needs, effectively change teachers' attitude and actively promote the establishment of good interpersonal relationship to explain the research on the Management Mechanism of Teachers in Public Security Colleges and Universities from the Perspective of Psychological Contract. 展开更多
关键词 Psychological Contract public security colleges and universities teacher management mechanism
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An Improved Direction Relation Detection Model for Spatial Objects
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作者 FENGYucai YIBaolin 《Geo-Spatial Information Science》 2004年第4期297-302,共6页
Direction is a common spatial concept that is used in our daily life. It is frequently used as a selection condition in spatial queries. As a result, it is important for spatial databases to provide a mechanism for mo... Direction is a common spatial concept that is used in our daily life. It is frequently used as a selection condition in spatial queries. As a result, it is important for spatial databases to provide a mechanism for modeling and processing direction queries and reasoning. Depending on the direction relation matrix, an inverted direction relation matrix and the concept of direction pre- dominance are proposed to improve the detection of direction relation between objects. Direction predicates of spatial systems are also extended. These techniques can improve the veracity of direction queries and reasoning. Experiments show excellent efficiency and performance in view of direction queries. 展开更多
关键词 spatial databases geographic information systemst direction relations direction relation matrix
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Chronic Toxicity of a Novel Recombinant Human Granulocyte Colony-stimulating Factor in Rats 被引量:6
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作者 Fei Xia Qing-yu Zhang Yong-ping Jiang 《Chinese Medical Sciences Journal》 CAS CSCD 2011年第1期20-27,共8页
Objective To assess the severity and reversibility of the chronic toxicity of a novel recombinant human granulocyte colony-stimulating factor (rhG-CSFa) in rats and the dose-effect relationship.Methods A total of 100 ... Objective To assess the severity and reversibility of the chronic toxicity of a novel recombinant human granulocyte colony-stimulating factor (rhG-CSFa) in rats and the dose-effect relationship.Methods A total of 100 Sprague-Dawley rats (equal numbers of male and female) were randomly divided into five groups (20 rats in each group):four groups were treated with rhG-CSFa at 500,100,10,1 μg/kg,respectively,and one group was treated with vehicle only to serve as the control.The rats were received subcutaneous injections of rhG-CSFa or vehicle daily for 13 weeks.During the course of the chronic toxicity study,the physical status,body weight,and food consumption were monitored.Half of the rats in each group (n=10) were sacrificed after the last rhG-CSFa administration,and the other half were sacrificed at five weeks after the last rhG-CSFa administration.Urinalyses,blood biochemistry,hematological analysis,histopathological examination,and immunological tests were performed for each of the rats.Results The hematological analyses revealed that the mean white blood cells count,neutrophils count,and neutrophils percentage were increased in male rats at the dose of 10 μg/kg or higher,and these were related with the biological activity of rhG-CSFa.Some small abnormalities were observed in the spleen of a few rats when used highest dose (500 μg/kg,a dosage of 200 folds higher than the normal clinical dosage),but these abnormalities were recovered within 5-week recovery period.No other rhG-CSFa-related abnormalities were observed in this chronic toxicity study.Conclusion No significant toxicity and immunogenicity are observed with rhG-CSFa administration to rats in the chronic toxicity studies. 展开更多
关键词 chronic toxicity Sprague-Dawley rat novel recombinant human granulocytecolony-stimulating factor
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