Gastric cancer and cancer of the gastro-oesophageal junction(GOJ) are the 4th most common cancer diagnoses worldwide with regional differences in incidence rates.The treatment of gastric and GOJ cancers is complex and...Gastric cancer and cancer of the gastro-oesophageal junction(GOJ) are the 4th most common cancer diagnoses worldwide with regional differences in incidence rates.The treatment of gastric and GOJ cancers is complex and requires multimodality treatment including chemotherapy treatment,surgery,and radiotherapy.During the past decade considerable improvements were achieved by advanced surgical techniques,tailored chemotherapies/radiotherapy and technical innovations in clinical diagnostics.In patients with advanced or metastatic gastric/GOJ cancer systemic chemotherapy with fluoropyrimidine/platinum-based regimens(+/-human epidermal growth factor receptor-2 antibody) is the mainstay of treatment.Despite these improvements,the clinical outcome for patients with advanced or metastatic disease is generally poor with 5-year survival rates ranging between 5%-15%.These poor survival rates may to some extent be related that standard therapies beyond first-line therapies have never been defined.Considering that this patient population is often not fit enough to receive further treatments there is an increasing body of evidence from phase-2 studies that in fact second-line therapies may have a positive impact in terms of overall survival.Moreover two recently published phase-3 studies support the use of second-line chemotherapy.A South Korean study compared either,irinotecan or docetaxel with best supportive care and a German study compared irinotecan with best supportive care-both studies met their primary endpoint overall survival.In this "Field of Vision" article,we review these recently published phase-3 studies and put them into the context of clinical prognostic factors helping to guide treatment decisions in patients who most likely benefit.展开更多
This paper presents the method for the performance calibration of AACMM （articulated arm coordinate measuring machines） according to ASME B89.4.22 Standard. The growing use of this class of measurement equipment has...This paper presents the method for the performance calibration of AACMM （articulated arm coordinate measuring machines） according to ASME B89.4.22 Standard. The growing use of this class of measurement equipment has been accompanied by an absence of authorized laboratories to provide calibration certificates for its performance. Due to ASME B89.4.22 and VD12617-9 are nowadays the unique standards in the field of AACMM verification, IK4 Tekniker has compared both of them in order to develop internal test procedures to yield reliable performance calibration results. As a result, IK4 Tekniker has been recognized by the Spanish Accreditation Body （ENAC） in the field of AACMM calibration. Internal test procedures and uncertainty evaluation analysis have been developed as well as ENAC certificated reference test equipments have been acquired to ensure a suitable AACMM calibration process.展开更多
Calcium sulfoaluminate,3CaO·3Al2O3·CaSO4,has been widely recognized in the realms of high-temperature combustion and cement chemistry.However,the lack of relevant thermodynamic data limits the progress of it...Calcium sulfoaluminate,3CaO·3Al2O3·CaSO4,has been widely recognized in the realms of high-temperature combustion and cement chemistry.However,the lack of relevant thermodynamic data limits the progress of its research and development.Through comparative calculations using several different approaches,we obtain the thermochemical properties of 3CaO·3Al2O3·CaSO4 in this work,such as its standard formation enthalpy,Gibbs free en- ergy of formation,entropy,and molar heat capacity.With these fundamental data,thermodynamic calculations become possible for reactions involving this mineral.It is found that some reactions proposed in literature to generate this mineral may not proceed thermodynamically.展开更多
Here reproduction and death toxicity data were selected for 4-nonylphenol based on endocrine disrupting properties of the re- productive system. Assessment factor （AF） and species sensitivity distribution （SSD） cu...Here reproduction and death toxicity data were selected for 4-nonylphenol based on endocrine disrupting properties of the re- productive system. Assessment factor （AF） and species sensitivity distribution （SSD） curve were employed to derive criteria maximum concentration （CMC） and criteria continuous concentration （CCC） of three different 4-nonylphenols for protection of aquatic life. The results showed that the CMC and CCC based on SSD method and death toxicity data for three different 4-nonylphenols （CAS No： 104405, 25154523, 84852163） were 26.7, 13.6, 3.84μg L-1 and 8.86, 2.21, 0.97 μg L-1, respectively. Based on SSD and reproductive toxicity data, the CCC values of different 4-nonylphenols （CAS No： 104405, 25154523） were 1.59 and 1.34μg L-l, respectively. The CCC values obtained by the AF for three different 4-nonylphenol （CAS No： 104405, 25154523, 84852163） were 0.165, 1.03, 0.74 μg L -1 and 0.5, 0.5, 0.1μg L-1, respectively, based on death toxicity data and re- productive toxicity data. The CCC values obtained by AF were all lower than the corresponding criteria values obtained by SSD, and the CCC values based on reproductive toxicity data were less than those based on the death toxicity data. This study provides a useful method for deriving water quality criteria for endocrine disruptors.展开更多
文摘Gastric cancer and cancer of the gastro-oesophageal junction(GOJ) are the 4th most common cancer diagnoses worldwide with regional differences in incidence rates.The treatment of gastric and GOJ cancers is complex and requires multimodality treatment including chemotherapy treatment,surgery,and radiotherapy.During the past decade considerable improvements were achieved by advanced surgical techniques,tailored chemotherapies/radiotherapy and technical innovations in clinical diagnostics.In patients with advanced or metastatic gastric/GOJ cancer systemic chemotherapy with fluoropyrimidine/platinum-based regimens(+/-human epidermal growth factor receptor-2 antibody) is the mainstay of treatment.Despite these improvements,the clinical outcome for patients with advanced or metastatic disease is generally poor with 5-year survival rates ranging between 5%-15%.These poor survival rates may to some extent be related that standard therapies beyond first-line therapies have never been defined.Considering that this patient population is often not fit enough to receive further treatments there is an increasing body of evidence from phase-2 studies that in fact second-line therapies may have a positive impact in terms of overall survival.Moreover two recently published phase-3 studies support the use of second-line chemotherapy.A South Korean study compared either,irinotecan or docetaxel with best supportive care and a German study compared irinotecan with best supportive care-both studies met their primary endpoint overall survival.In this "Field of Vision" article,we review these recently published phase-3 studies and put them into the context of clinical prognostic factors helping to guide treatment decisions in patients who most likely benefit.
文摘This paper presents the method for the performance calibration of AACMM （articulated arm coordinate measuring machines） according to ASME B89.4.22 Standard. The growing use of this class of measurement equipment has been accompanied by an absence of authorized laboratories to provide calibration certificates for its performance. Due to ASME B89.4.22 and VD12617-9 are nowadays the unique standards in the field of AACMM verification, IK4 Tekniker has compared both of them in order to develop internal test procedures to yield reliable performance calibration results. As a result, IK4 Tekniker has been recognized by the Spanish Accreditation Body （ENAC） in the field of AACMM calibration. Internal test procedures and uncertainty evaluation analysis have been developed as well as ENAC certificated reference test equipments have been acquired to ensure a suitable AACMM calibration process.
基金Supported by the National Natural Science Foundation of China(50906046)the National High-Tech Research and Development Program of China(2009AA05Z303)the Program for New Century Excellent Talents in University(NCET-10-0529)
文摘Calcium sulfoaluminate,3CaO·3Al2O3·CaSO4,has been widely recognized in the realms of high-temperature combustion and cement chemistry.However,the lack of relevant thermodynamic data limits the progress of its research and development.Through comparative calculations using several different approaches,we obtain the thermochemical properties of 3CaO·3Al2O3·CaSO4 in this work,such as its standard formation enthalpy,Gibbs free en- ergy of formation,entropy,and molar heat capacity.With these fundamental data,thermodynamic calculations become possible for reactions involving this mineral.It is found that some reactions proposed in literature to generate this mineral may not proceed thermodynamically.
基金supported by National Key Basic Research Development Program (Grant No. 2008CB418205)Major Project of Water Pollution Control and Management (Grant No. 2009ZX07528-002-04)+1 种基金Outstanding Young Teacher Research and Special Projects (Grant No. Shu10040)Shanghai Leading Academic Discipline (Grant No. S30109)
文摘Here reproduction and death toxicity data were selected for 4-nonylphenol based on endocrine disrupting properties of the re- productive system. Assessment factor （AF） and species sensitivity distribution （SSD） curve were employed to derive criteria maximum concentration （CMC） and criteria continuous concentration （CCC） of three different 4-nonylphenols for protection of aquatic life. The results showed that the CMC and CCC based on SSD method and death toxicity data for three different 4-nonylphenols （CAS No： 104405, 25154523, 84852163） were 26.7, 13.6, 3.84μg L-1 and 8.86, 2.21, 0.97 μg L-1, respectively. Based on SSD and reproductive toxicity data, the CCC values of different 4-nonylphenols （CAS No： 104405, 25154523） were 1.59 and 1.34μg L-l, respectively. The CCC values obtained by the AF for three different 4-nonylphenol （CAS No： 104405, 25154523, 84852163） were 0.165, 1.03, 0.74 μg L -1 and 0.5, 0.5, 0.1μg L-1, respectively, based on death toxicity data and re- productive toxicity data. The CCC values obtained by AF were all lower than the corresponding criteria values obtained by SSD, and the CCC values based on reproductive toxicity data were less than those based on the death toxicity data. This study provides a useful method for deriving water quality criteria for endocrine disruptors.
