Molecular dynamics simulation has emerged as a powerful computational tool for studying biomolecules as it can provide atomic insights into the conformational transitions involved in biological functions.However,when ...Molecular dynamics simulation has emerged as a powerful computational tool for studying biomolecules as it can provide atomic insights into the conformational transitions involved in biological functions.However,when applied to complex biological macromolecules,the conformational sampling ability of conventional molecular dynamics is limited by the rugged free energy landscapes,leading to inherent timescale gaps between molecular dynamics simulations and real biological processes.To address this issue,several advanced enhanced sampling methods have been proposed to improve the sampling efficiency in molecular dynamics.In this review,the theoretical basis,practical applications,and recent improvements of both constraint and unconstrained enhanced sampling methods are summarized.Furthermore,the combined utilizations of different enhanced sampling methods that take advantage of both approaches are also briefly discussed.展开更多
In this paper, the problems of redundant traffic and redundant replicas tor efficient object replication in P2P overlay are studies. Firstly, a hierarchical and topology-aware P2P overlay is developed with κ-Medoids ...In this paper, the problems of redundant traffic and redundant replicas tor efficient object replication in P2P overlay are studies. Firstly, a hierarchical and topology-aware P2P overlay is developed with κ-Medoids partition algorithm to achieve the minimal physical distance of all super peer pairs. Secondly, a new idea of placing at most one replica in a cluster of physically adjacent nodes is introduced to achieve scattered distribution of replicas. Lastly, an efficient replicas-query algorithm based on multiple hash functions is proposed. Theoretical analysis and simulation experiment on several performance metrics are given, and it is verified that the method in this paper can efficiently disseminate replicas across the network, increase query-hit ratio, and decrease redundant messages and storage spaces required.展开更多
Replication is an approach often used to speed up the execution of queries submitted to a large dataset.A compile-time/run-time approach is presented for minimizing the response time of 2-dimensional range when a dist...Replication is an approach often used to speed up the execution of queries submitted to a large dataset.A compile-time/run-time approach is presented for minimizing the response time of 2-dimensional range when a distributed replica of a dataset exists.The aim is to partition the query payload(and its range) into subsets and distribute those to the replica nodes in a way that minimizes a client's response time.However,since query size and distribution characteristics of data(data dense/sparse regions) in varying ranges are not known a priori,performing efficient load balancing and parallel processing over the unpredictable workload is difficult.A technique based on the creation and manipulation of dynamic spatial indexes for query payload estimation in distributed queries was proposed.The effectiveness of this technique was demonstrated on queries for analysis of archived earthquake-generated seismic data records.展开更多
In cloud computing,the number of replicas and deployment strategy have extensive impacts on user's requirement and storage efficiency.Therefore,in this paper,a new definition of file access popularity according to...In cloud computing,the number of replicas and deployment strategy have extensive impacts on user's requirement and storage efficiency.Therefore,in this paper,a new definition of file access popularity according to users' preferences,and its prediction algorithm are provided to predict file access trend with historical data.Files are sorted by priority depending on their popularity.A mathematical model between file access popularity and the number of replicas is built so that the reliability is increased efficiently.Most importantly,we present an optimal strategy of dynamic replicas deployment based on the file access popularity strategy with the overall concern of nodes' performance and load condition.By this strategy,files with high priority will be deployed on nodes with better performance therefore higher quality of service is guaranteed.The strategy is realized in the Hadoop platform.Performance is compared with that of default strategy in Hadoop and CDRM strategy.The result shows that the proposed strategy can not only maintain the system load balance,but also supply better service performance,which is consistent with the theoretical analysis.展开更多
The paper examines the assignment of the visual experience in the context of interrelation between civilization and art. Civilization is defined as "the survival of the weak". It is stressed that this definition can...The paper examines the assignment of the visual experience in the context of interrelation between civilization and art. Civilization is defined as "the survival of the weak". It is stressed that this definition can be applied to man, animal and every living being. Lie as "someone else's truth" and art as "the process of the creation of 'copies of the copies of nature'" are considered to be the weak man's tools for survival. The author argues that purpose of erotic scenes and scenes of hunting (death and violence) both in the past and in the present is the excitation at the woman of desire to reproduction.展开更多
The aim of this paper is firstly to determine if the Korean television drama Winter Sonata and its spinoffs are contributing to contemporary cross-cultural diffusion in Japan. Secondly, if cross-cultural diffusion is ...The aim of this paper is firstly to determine if the Korean television drama Winter Sonata and its spinoffs are contributing to contemporary cross-cultural diffusion in Japan. Secondly, if cross-cultural diffusion is occurring, is it contributing to a loss of local identity? Winter Sonata is a small but significant part of the Korean Wave and in the vanguard of Korean television drama content viewed in Japan. There have been macro political changes in East Asia, largely driven by Korea, resulting in an easing of restrictions on cross-border media trade. These in turn have progressively created a new dynamic in content and volume. The methodology used for the study is triangulation including document analysis, audience analysis, and commercial outcomes. The convergent validation derived from the three parameters advances the proposition that Winter Sonata has contributed to cultural diffusion from a Japanese perspective but not to a loss of local identity. Arguably, the process is an enriching one in East Asia reinforced by multi-lateral media trade.展开更多
Distributed key value storage systems are among the most important types of distributed storage systems currently deployed in data centers. Nowadays, enterprise data centers are facing growing pressure in reducing the...Distributed key value storage systems are among the most important types of distributed storage systems currently deployed in data centers. Nowadays, enterprise data centers are facing growing pressure in reducing their power consumption. In this paper, we propose GreenCHT, a reliable power management scheme for consistent hashing based distributed key value storage systems. It consists of a multi-tier replication scheme, a reliable distributed log store, and a predictive power mode scheduler (PMS). Instead of randomly placing replicas of each object on a number of nodes in the consistent hash ring, we arrange the replicas of objects on nonoverlapping tiers of nodes in the ring. This allows the system to fall in various power modes by powering down subsets of servers while not violating data availability. The predictive PMS predicts workloads and adapts to load fluctuation. It cooperates with the multi-tier replication strategy to provide power proportionality for the system. To ensure that the reliability of the system is maintained when replicas are powered down, we distribute the writes to standby replicas to active servers, which ensures failure tolerance of the system. GreenCHT is implemented based on Sheepdog, a distributed key value storage system that uses consistent hashing as an underlying distributed hash table. By replaying 12 typical real workload traces collected from Microsoft, the evaluation results show that GreenCHT can provide significant power savings while maintaining a desired performance. We observe that GreenCHT can reduce power consumption by up to 35%-61%.展开更多
SiO2 and ZnO inverse structure replicas have been synthesized using butterfly wings as templates. The laser diffraction performance of the SiO2 inverse structure replica was investigated and it was found that the zero...SiO2 and ZnO inverse structure replicas have been synthesized using butterfly wings as templates. The laser diffraction performance of the SiO2 inverse structure replica was investigated and it was found that the zero-order light spot split into a matrix pattern when the distance between the screen and the sample was increased. This unique diffraction phenomenon is closely related to the structure of the SiO2 inverse structure replica. On the other hand, by analyzing the photoluminescence spectrum of the ZnO replica, optical anisotropy in the ultraviolet band was demonstrated for this material.展开更多
A multi-stage dual replica bit-line delay (MDRBD) technique is proposed for reducing access time by suppressing the sense-amplifier enable (SAE) timing variation of low voltage static randomaccess memory (SRAM) ...A multi-stage dual replica bit-line delay (MDRBD) technique is proposed for reducing access time by suppressing the sense-amplifier enable (SAE) timing variation of low voltage static randomaccess memory (SRAM) applications. Compared with the traditional technique, this strategy, using statistical theory, reduces the timing variation by using multi-stage ideas, meanwhile doubling the replica bit-fine (RBL) capacitance and discharge path simultaneously in each stage. At a supply voltage of 0.6 V, the simulation results show that the standard deviations of the SAE timing and cycle time with the proposed technique are 69.2% and 47.2%, respectively, smaller than that with a conventional RBL delay technique in TSMC 65 nm CMOS technology (Taiwan Semiconductor Manufacturing Company, Taiwan).展开更多
基金supported by the National Natural Science Foundation of China(No.31700647,No.21625302,and No.21573217)
文摘Molecular dynamics simulation has emerged as a powerful computational tool for studying biomolecules as it can provide atomic insights into the conformational transitions involved in biological functions.However,when applied to complex biological macromolecules,the conformational sampling ability of conventional molecular dynamics is limited by the rugged free energy landscapes,leading to inherent timescale gaps between molecular dynamics simulations and real biological processes.To address this issue,several advanced enhanced sampling methods have been proposed to improve the sampling efficiency in molecular dynamics.In this review,the theoretical basis,practical applications,and recent improvements of both constraint and unconstrained enhanced sampling methods are summarized.Furthermore,the combined utilizations of different enhanced sampling methods that take advantage of both approaches are also briefly discussed.
基金Supported by the National Natural Science Foundation of China ( No. 60903195 ) and the Key Technological Problems Tackling Project of Wuhan ( No. 200750499172).
文摘In this paper, the problems of redundant traffic and redundant replicas tor efficient object replication in P2P overlay are studies. Firstly, a hierarchical and topology-aware P2P overlay is developed with κ-Medoids partition algorithm to achieve the minimal physical distance of all super peer pairs. Secondly, a new idea of placing at most one replica in a cluster of physically adjacent nodes is introduced to achieve scattered distribution of replicas. Lastly, an efficient replicas-query algorithm based on multiple hash functions is proposed. Theoretical analysis and simulation experiment on several performance metrics are given, and it is verified that the method in this paper can efficiently disseminate replicas across the network, increase query-hit ratio, and decrease redundant messages and storage spaces required.
文摘Replication is an approach often used to speed up the execution of queries submitted to a large dataset.A compile-time/run-time approach is presented for minimizing the response time of 2-dimensional range when a distributed replica of a dataset exists.The aim is to partition the query payload(and its range) into subsets and distribute those to the replica nodes in a way that minimizes a client's response time.However,since query size and distribution characteristics of data(data dense/sparse regions) in varying ranges are not known a priori,performing efficient load balancing and parallel processing over the unpredictable workload is difficult.A technique based on the creation and manipulation of dynamic spatial indexes for query payload estimation in distributed queries was proposed.The effectiveness of this technique was demonstrated on queries for analysis of archived earthquake-generated seismic data records.
基金Supported by the National Natural Science Foundation of China(No.61170209,61272508,61202432,61370132,61370092)
文摘In cloud computing,the number of replicas and deployment strategy have extensive impacts on user's requirement and storage efficiency.Therefore,in this paper,a new definition of file access popularity according to users' preferences,and its prediction algorithm are provided to predict file access trend with historical data.Files are sorted by priority depending on their popularity.A mathematical model between file access popularity and the number of replicas is built so that the reliability is increased efficiently.Most importantly,we present an optimal strategy of dynamic replicas deployment based on the file access popularity strategy with the overall concern of nodes' performance and load condition.By this strategy,files with high priority will be deployed on nodes with better performance therefore higher quality of service is guaranteed.The strategy is realized in the Hadoop platform.Performance is compared with that of default strategy in Hadoop and CDRM strategy.The result shows that the proposed strategy can not only maintain the system load balance,but also supply better service performance,which is consistent with the theoretical analysis.
文摘The paper examines the assignment of the visual experience in the context of interrelation between civilization and art. Civilization is defined as "the survival of the weak". It is stressed that this definition can be applied to man, animal and every living being. Lie as "someone else's truth" and art as "the process of the creation of 'copies of the copies of nature'" are considered to be the weak man's tools for survival. The author argues that purpose of erotic scenes and scenes of hunting (death and violence) both in the past and in the present is the excitation at the woman of desire to reproduction.
文摘The aim of this paper is firstly to determine if the Korean television drama Winter Sonata and its spinoffs are contributing to contemporary cross-cultural diffusion in Japan. Secondly, if cross-cultural diffusion is occurring, is it contributing to a loss of local identity? Winter Sonata is a small but significant part of the Korean Wave and in the vanguard of Korean television drama content viewed in Japan. There have been macro political changes in East Asia, largely driven by Korea, resulting in an easing of restrictions on cross-border media trade. These in turn have progressively created a new dynamic in content and volume. The methodology used for the study is triangulation including document analysis, audience analysis, and commercial outcomes. The convergent validation derived from the three parameters advances the proposition that Winter Sonata has contributed to cultural diffusion from a Japanese perspective but not to a loss of local identity. Arguably, the process is an enriching one in East Asia reinforced by multi-lateral media trade.
文摘Distributed key value storage systems are among the most important types of distributed storage systems currently deployed in data centers. Nowadays, enterprise data centers are facing growing pressure in reducing their power consumption. In this paper, we propose GreenCHT, a reliable power management scheme for consistent hashing based distributed key value storage systems. It consists of a multi-tier replication scheme, a reliable distributed log store, and a predictive power mode scheduler (PMS). Instead of randomly placing replicas of each object on a number of nodes in the consistent hash ring, we arrange the replicas of objects on nonoverlapping tiers of nodes in the ring. This allows the system to fall in various power modes by powering down subsets of servers while not violating data availability. The predictive PMS predicts workloads and adapts to load fluctuation. It cooperates with the multi-tier replication strategy to provide power proportionality for the system. To ensure that the reliability of the system is maintained when replicas are powered down, we distribute the writes to standby replicas to active servers, which ensures failure tolerance of the system. GreenCHT is implemented based on Sheepdog, a distributed key value storage system that uses consistent hashing as an underlying distributed hash table. By replaying 12 typical real workload traces collected from Microsoft, the evaluation results show that GreenCHT can provide significant power savings while maintaining a desired performance. We observe that GreenCHT can reduce power consumption by up to 35%-61%.
基金Acknowledgements The authors acknowledge the financial support from the National Natural Science Foundation (NSF) of China (Grant Nos. 60976014, 60976004, and 11074075), and the Key Basic Research Project of the Scientific and Technology Committee of Shanghai (Grant No. 09DJ1400200).
文摘SiO2 and ZnO inverse structure replicas have been synthesized using butterfly wings as templates. The laser diffraction performance of the SiO2 inverse structure replica was investigated and it was found that the zero-order light spot split into a matrix pattern when the distance between the screen and the sample was increased. This unique diffraction phenomenon is closely related to the structure of the SiO2 inverse structure replica. On the other hand, by analyzing the photoluminescence spectrum of the ZnO replica, optical anisotropy in the ultraviolet band was demonstrated for this material.
基金Project supported by the National Natural Science Foundation of China (No. 61474001)
文摘A multi-stage dual replica bit-line delay (MDRBD) technique is proposed for reducing access time by suppressing the sense-amplifier enable (SAE) timing variation of low voltage static randomaccess memory (SRAM) applications. Compared with the traditional technique, this strategy, using statistical theory, reduces the timing variation by using multi-stage ideas, meanwhile doubling the replica bit-fine (RBL) capacitance and discharge path simultaneously in each stage. At a supply voltage of 0.6 V, the simulation results show that the standard deviations of the SAE timing and cycle time with the proposed technique are 69.2% and 47.2%, respectively, smaller than that with a conventional RBL delay technique in TSMC 65 nm CMOS technology (Taiwan Semiconductor Manufacturing Company, Taiwan).