乡村振兴背景下千阳刺绣布艺的“发陈”实践

千阳刺绣作为陕西非物质文化遗产的典型代表,造型及色彩大胆夸张,蕴涵了原始的生命意识,体现了民间文化的精神理想。从非遗文化资源创新设计转化的角度提出了“发陈”的概念,分别从千阳刺绣的现代价值、设计实践等方面进行了探讨,重点论述了立足于传统形式进行“发陈”的设计教育课程实践,指出“发陈”就是传承文化与现代创新设计的融合过程。千阳刺绣布艺为现代视觉设计提供了丰富的营养,民艺的“发陈”是体现民族文化自信的重要途径。

Gastric xanthelasma and metabolic disorders: A large retrospective study among Chinese population

AIM To gain knowledge of xanthelasma,a large populationbased study was conducted. METHODS Patients who underwent upper gastrointestinal endoscopy at the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China during Jan 2009 to Nov 2016 were included. General characteristics as well as clinical data were collected,including blood routine,serum biochemical analysis,endoscopic findinds,histological evaluation and comorbiditie. Statistical analyses was performed using SPSS 20.0 software for Windows(IBM Inc.,Chicago,IL,United States) using Student's t-test,Mann-Whitney U test,χ2 test,univariable and multivariable logistic analysis. 2-tailed P value less than 0.05 was considered to be statistically significant. RESULTS A total of 176006 endoscopies were retrieved and we included 1370 xanthelasma participants(703 men,667 women) in this study. Prevalence of xanthelasma was 0.78% with average age of 56.6 ± 11.2 years. Chief complaint of xanthelasma consisted abdominal pain (24.2%),up-abdominal discomfort(14.1%),abdominal distention(10.1%),dyspepsia(9.1%),et al. Most xanthelasma occurred as single lesion in gastric antrum. Xanthelasma patients witnessed higher Helicobacter pylori(H. pylori) infection rate,more of other gastric lesions including atrophy,intestinal metaplasia and dysplasia(P < 0.01). In xanthelasma patients,serum carcinoembryonic antigen,triglyceride,fasting glucose,neutrophil,neutrophil-to-lymphocyte ratio were significantly higher,and high density lipoprotein-cholesterol,lymphocyte was lower(P < 0.05). Xanthelasma accompanied with more fatty liver disease and hepatic cyst,but fewer gallbladder polyp(P < 0.05). In logistic regression,it revealed that fasting plasma glucose(OR = 3.347,1.170-9.575,P < 0.05),neutrophil(OR = 1.617,1.003-2.605,P < 0.05),and carcinoembryonic antigen(OR = 2.011,1.236-3.271,P < 0.01) were all independent risk factors in xanthelasma. CONCLUSION Current study described a large xanthelasma cohort in Chinese population,revealed its relationship with H. pylori infection,carcinogenesis,metabolic dysfunction and inflammation as well.

An innovative approach for the treatment of Alzheimer's disease: the role of peroxisome proliferator-activated receptors and their ligands in development of alternative therapeutic interventions

Alzheimer＇s disease is a multifactorial pathology, for which no cure is currently available. Nowadays, researchers are moving towards a new hypothesis of the onset of the illness, linking it to a metabolic impairment, q-his innovative approach will lead to the identification of new targets for the preparation of new effective drugs. Peroxisome proliferator-activated receptors and their ligands are the ideal candidates to reach the necessary breakthrough to defeat this complicate disease.

Positional statement of companies＇ corporate governance rating reports： Evidence from Turkey

The Organisation for Economic Cooperation and Development （OECD） defines corporate governance as, ＂the way in which boards oversee the running of a company by its managers, and how board members are in turn accountable to shareholders and the company.＂ In recent years the issue of corporate governance and committees related to it and their impacts on corporate performance have continued to gain widespread prominence in the capital market economy. Corporate Governance Rating is meant to indicate the relative level to which an organisation accepts and follows the codes and guidelines of corporate governance practices. The purpose of the paper is to examine the rating reports of 27 companies which have obtained the corporate governance rating by rating agencies. The study highlights that the ＂stakeholders＂ sections of the reports are the most powerful part of the reports whereas the ＂board of directors＂ sections are the weakest. Potential areas for improvements are also identified.

Modulation of mitochondrial respiration underpins neuronal differentiation enhanced by lutein

Lutein is a dietary carotenoid of particular nutritional interest as it is preferentially taken up by neural tissues. Often linked with beneficial effects on vision, a broader role for lutein in neuronal differentiation has emerged recently, although the underlying mechanisms for these effects are not yet dear. The purpose of this study was to investigate the effect of lutein on neuronal differentiation and explore the associated underpinning mechanisms. We found that lutein treatment enhanced the differentiation of SH-SYSY cells, specifically increasing neuronal arborization and expression of the neuronal process filament protein microtubule-associated protein 2. This effect was mediated by the intracellular phosphoinositide-3-kinase （PI3K） signaling pathway. While PI3K activity is a known trigger of neuronal differentiation, more recently it has also been shown to modulate the metabolic state of cells. Our analysis of bioenergetics found that lutein treatment increased glucose consumption, rates of glycolysis and enhanced respiratory activity of mitochondrial complexes. Concomitantly, the generation of reactive oxygen species was increased （con- sistent with previous reports that reactive oxygen species promote neuronal differentiation）, as well as the production of the key metabolic intermediate acetyl-CoA, an essential determinant of epigenetic status in the cell. We suggest that lutein-stimulated neuronal differentiation is mediated by PI3K-dependent modulation of mitochondrial respiration and signaling, and that the consequential metabolic shifts initiate epigenetically dependent transcriptomic reprogramming in support of this morphogenesis. These obser- vations support the potential importance of micronutrients supplementation to neurogenesis, both during normal development and in regenerative repair.

Recognition and Measurement of Losses Caused by Systematic Risk in Damages of False Statements

Based on the single-factor market model, this paper examines the confirmation basis and measurement of the losses arising from systematic risk in the civil damages of false statements. The paper argues that the systematic risk not only affects the investment in securities during times of financial crisis, but also causes losses in daily securities trading. The paper carries out an empirical analysis on the existence of fl coefficient for China＇s listed companies within a period of one year, and examines the impact of systematic risk on the losses of investors. The civil damages of false statements should take full account of the losses arising from systematic risk. After analysis, the paper uses the correlation coefficient to represent the ratio of losses arising from systematic risk of all the transactions of a particular stock during a certain period of time, and tries to develop two methods to measure the damages after adjusting the losses caused by the systematic risk. The paper has a theoretical foundation for the estimation of losses caused by systematic risk, and matches the risks and returns. The result of the paper has provided an effective method of calculation in the determination of reasonable damages in the case of China Langfang Development Co., Ltd.

On fundamental groups of Finsler manifolds In memory of the centenary birthday of Professor S.S.Chern

In this paper,we study the growth of fundamental groups of Finsler manifolds.Some relationships between the growth of fundamental groups and the volume growth of universal covers of Finsler manifolds are found.Some estimates of entropies and the number of generators of fundamental groups of Finsler manifolds are given.Moreover,the quasi-isometry and the geometric norm in Finsler geometry are considered.