A Fe/Al clad tube was prepared by explosive welding.Then the bonding characteristic of the interface was investigated by compression,flattening and compression-shear test.The test results exhibit that the clad tubes p...A Fe/Al clad tube was prepared by explosive welding.Then the bonding characteristic of the interface was investigated by compression,flattening and compression-shear test.The test results exhibit that the clad tubes possessing good bonding interface have higher shear strength than that of pure aluminum and can bear both axial and radial deformation.The original interface between aluminum layer and ferrite layer was observed by scanning electron microscopy（SEM）.The results show that the clad tubes with good bonding properties possess the interface in wave and straight shape.The Fe/Al clad tube was used to manufacture the T-shape by hydro-bulging.It is found that the good-bonding interface of the Fe/Al clad tube plays a dominant role in the formation of the T-shape.展开更多
Structural features, aging behavior, precipitation kinetics and mechanical properties of a 6013 Al–Mg–Si aluminum alloy subjected to equal channel angular pressing （ECAP） at different temperatures were comparative...Structural features, aging behavior, precipitation kinetics and mechanical properties of a 6013 Al–Mg–Si aluminum alloy subjected to equal channel angular pressing （ECAP） at different temperatures were comparatively investigated with that in conventional static aging by quantitative X-ray diffraction （XRD） measurements, differential scanning calorimetry （DSC） and tensile tests. Average grain sizes measured by XRD are in the range of 66-112 nm while the average dislocation density is in the range of 1.20×10^14-1.70×10^14 m^-2 in the deformed alloy. The DSC analysis reveals that the precipitation kinetics in the deformed alloy is much faster as compared with the peak-aged sample due to the smaller grains and higher dislocation density developed after ECAP. Both the yield strength （YS） and ultimate tensile strength （UTS） are dramatically increased in all the ECAP samples as compared with the undeformed counterparts. The maximum strength appears in the samples ECAP treated at room temperature and the maximum YS is about 1.6 times that of the statically peak-aged sample. The very high strength in the ECAP alloy is suggested to be related to the grain size strengthening and dislocation strengthening, as well as the precipitation strengthening contributing from the dynamic precipitation during ECAP.展开更多
Some applications of crystal plasticity modeling in equal channel angular extrusion（ECAE） of face-centered cubic metals were highlighted.The results show that such simulations can elucidate the dependency of grain r...Some applications of crystal plasticity modeling in equal channel angular extrusion（ECAE） of face-centered cubic metals were highlighted.The results show that such simulations can elucidate the dependency of grain refinement efficiency on processing route and the directionality of substructure development,which cannot be explained by theories that consider only the macroscopic deformation behavior.They can also capture satisfactorily the orientation stability and texture evolution under various processing conditions.It is demonstrated that crystal plasticity models are useful tools in exploring the crystallographic nature of grain deformation and associated behavior that are overlooked or sometimes erroneously interpreted by existing phenomenological theories.展开更多
Cyclic nucleotide-gated ion channels （CNGs） are distributed most widely in the neuronal cell. Great progress has been made in molecular mechanisms of CNG channel gating in the recent years. Results of many experimen...Cyclic nucleotide-gated ion channels （CNGs） are distributed most widely in the neuronal cell. Great progress has been made in molecular mechanisms of CNG channel gating in the recent years. Results of many experiments have indicated that the stoichiometry and assembly of CNG channels affect their property and gating. Experiments of CNG mutants and analyses of cys- teine accessibilities show that cyclic nucleotide-binding domains （CNBD） bind cyclic nucleotides and subsequently conformational changes occurred followed by the concerted or cooperative conformational change of all four subunits during CNG gating. In order to provide theoretical assistances for further investigation on CNG channels, especially regarding the disease pathogenesis of ion channels, this paper reviews the latest progress on mechanisms of CNG channels, functions of subunits, processes of subunit assembly, and conformational changes of subunit regions during gating.展开更多
To meet the demands for different supply voltage levels on SOC required by digital modules like CPU core and analog modules,a novel dual-output charge pump is proposed. The charge pump can output a step-up and a step-...To meet the demands for different supply voltage levels on SOC required by digital modules like CPU core and analog modules,a novel dual-output charge pump is proposed. The charge pump can output a step-up and a step-down voltage simultaneously with a high driving capability. The multiple gain pair technique was introduced to enhance its efficiency. The proposed co-use technology for capacitors and switch arrays reduced its cost. The charge pump was designed and fabricated in a TSMC 0.35μm mixed-signal CMOS process. A group of analytical equations were derived to model its static characteristics. A state-space model was derived to describe its small-signal dynamic behavior. Analytical predictions were verified by Spectre simulation and testing. The consistency of simulated results as well as test results with analytical predictions demonstrated the high precision of the derived analytical equations and the developed models.展开更多
An innovative one-step semi-solid processing technique of A356 Al alloy,the serpentine channel pouring rheo-diecasting process （SCRC）,was explored.The mechanical properties and microstructures of the tensile samples...An innovative one-step semi-solid processing technique of A356 Al alloy,the serpentine channel pouring rheo-diecasting process （SCRC）,was explored.The mechanical properties and microstructures of the tensile samples made by the SCRC technique were tested in the as-cast and T6 heat treatment conditions.The experimental results show that the as-cast ultimate tensile strength can reach about 250MPa and the elongation is 8.6%？13.2%.The ultimate tensile strength can increase approximately 30% higher than that of the as-cast one but there is some slight sacrifice of the plasticity after T6 heat treatment.Under these experimental conditions,the semi-solid A356 Al alloy slurry with primary α1（Al） grains,which have the shape factor of 0.78？0.89 and the grain diameter of 35？45μm,can be prepared by the serpentine channel pouring process.The primary α2（Al） grains are very fine during the secondary solidification stage.Compared with the conventional HPDC process,the SCRC process can improve the microstructures and mechanical properties of the tensile test samples.The advantages of the SCRC process include easily incorporating with an existing HPDC machine,cancelling the preservation and transportation process of the semi-solid alloy slurry,and a higher cost performance.展开更多
In the clinical reports, the E1784K mutation in SCN5A is recognized as a phenotypic overlap between the long QT syndrome （LQT3） and the Brugada syndrome （BrS） in the characteristics of electrocardiograms （ECGs） ...In the clinical reports, the E1784K mutation in SCN5A is recognized as a phenotypic overlap between the long QT syndrome （LQT3） and the Brugada syndrome （BrS） in the characteristics of electrocardiograms （ECGs） since the mutation can influence sodium channel functions. However it is still unclear if the E1784K mutation-induced sodium ionic channel alterations account for the overlap at tissue level. Thsu, a detailed computational model is developed to underpin the functional impacts of the E1784K mutation on the action potential （AP）, the effective refractory period （ERP） and the abnormal ECG. Simulation results stlggest＇that the E1784K mutation-induced sodium channel alterations are insufficient to produce the phenotypic overlap between LQT3 and BrS, and the overlap may arise from the complicated effects of the E1784K mutation-induced changes in sodium channel currents with an increase of the transient outward current ITo or a decrease of the L-type calcium current ICaL .展开更多
The deformation characteristic in the forming process of aluminum alloy 7075 cross valve under multi-way loading was investigated by numerical simulation method. The results indicate that there exist 4 deformation pat...The deformation characteristic in the forming process of aluminum alloy 7075 cross valve under multi-way loading was investigated by numerical simulation method. The results indicate that there exist 4 deformation patterns in the multi-way loading forming process of cross valve, such as forward extrusion, backward extrusion, forward-lateral extrusion and backward-lateral extrusion; one or several patterns occur at different forming stages depending on loading path. In general, the main deformation pattern is forward extrusion or backward extrusion at the initial stage; the main deformation pattern is backward extrusion at the intermediate stage, and the backward extrusion and forward-lateral extrusion occur at the final stage. In order to improve the cavity fill and reduce the forming defects, the lateral extrusion deformation should be increased at the initial and intermediate stages, and the forward extrusion deformation at the final forging stage should be reduced or avoided.展开更多
As a new attempt, equal channel angular extrusion （ECAE） of nickel-titanium shape memory alloy （NiTi SMA） tube was investigated by means of process experiment, finite element method （FEM） and microscopy. NiTi SM...As a new attempt, equal channel angular extrusion （ECAE） of nickel-titanium shape memory alloy （NiTi SMA） tube was investigated by means of process experiment, finite element method （FEM） and microscopy. NiTi SMA tube with the steel core in it was inserted into the steel can during ECAE of NiTi SMA tube. Based on rigid-viscoplastic FEM, multiple coupled boundary conditions and multiple constitutive models were used for finite element simulation of ECAE of NiTi SMA tube, where the effective stress field, the effective strain field and the velocity field were obtained. Finite element simulation results are in good accordance with the experimental ones. Finite element simulation results reveal that the velocity field shows the minimum value in the corner of NiTi SMA tube, where severe shear deformation occurs. Microstructural observation results reveal that severe plastic deformation leads to a certain grain orientation as well as occurrence of substructures in the grain interior and dynamic recovery occurs during ECAE of NiTi SMA tube. ECAE of NiTi SMA tube provides a new approach to manufacturing ultrafine-grained NiTi SMA tube.展开更多
[Objective] The aim was to explore interannual changes of soil nutrients in tobacco soils in Zhaotong, in order to provide theoretical references for tobacco bal- anced fertilization in Zhaotong. [Method] The research...[Objective] The aim was to explore interannual changes of soil nutrients in tobacco soils in Zhaotong, in order to provide theoretical references for tobacco bal- anced fertilization in Zhaotong. [Method] The research analyzed nutrient changes in tobacco soils in Zhaotong during 2011-2013. [Result] In Zhaotong, pH value of to- bacco soils was increasing; the contents of organic matter and N, P and K contents were in the range suitable for tobacco growth; CI- content was growing in tobacco soils and reached the highest in 2013. [Conclusion] In general, soil nutrients show insignificant differences internannually in Zhaotong.展开更多
基金Project(BA2006067)supported by Achievement Transitional Foundation of Jiangsu Province,China
文摘A Fe/Al clad tube was prepared by explosive welding.Then the bonding characteristic of the interface was investigated by compression,flattening and compression-shear test.The test results exhibit that the clad tubes possessing good bonding interface have higher shear strength than that of pure aluminum and can bear both axial and radial deformation.The original interface between aluminum layer and ferrite layer was observed by scanning electron microscopy（SEM）.The results show that the clad tubes with good bonding properties possess the interface in wave and straight shape.The Fe/Al clad tube was used to manufacture the T-shape by hydro-bulging.It is found that the good-bonding interface of the Fe/Al clad tube plays a dominant role in the formation of the T-shape.
基金Project(BK2012715)supported by the Basic Research Program(Natural Science Foundation)of Jiangsu Province,ChinaProject(14KJA430002)supported by the Key University Science Research Project of Jiangsu Province,China+3 种基金Project(50971087)supported by the National Natural Science Foundation of ChinaProjects(11JDG070,11JDG140)supported by the Senior Talent Research Foundation of Jiangsu University,ChinaProject(hsm1301)supported by the Foundation of the Jiangsu Province Key Laboratory of High-end Structural Materials,ChinaProject(Kjsmcx2011004)supported by the Foundation of the Jiangsu Province Key Laboratory of Materials Tribology,China
文摘Structural features, aging behavior, precipitation kinetics and mechanical properties of a 6013 Al–Mg–Si aluminum alloy subjected to equal channel angular pressing （ECAP） at different temperatures were comparatively investigated with that in conventional static aging by quantitative X-ray diffraction （XRD） measurements, differential scanning calorimetry （DSC） and tensile tests. Average grain sizes measured by XRD are in the range of 66-112 nm while the average dislocation density is in the range of 1.20×10^14-1.70×10^14 m^-2 in the deformed alloy. The DSC analysis reveals that the precipitation kinetics in the deformed alloy is much faster as compared with the peak-aged sample due to the smaller grains and higher dislocation density developed after ECAP. Both the yield strength （YS） and ultimate tensile strength （UTS） are dramatically increased in all the ECAP samples as compared with the undeformed counterparts. The maximum strength appears in the samples ECAP treated at room temperature and the maximum YS is about 1.6 times that of the statically peak-aged sample. The very high strength in the ECAP alloy is suggested to be related to the grain size strengthening and dislocation strengthening, as well as the precipitation strengthening contributing from the dynamic precipitation during ECAP.
基金Projects(50871040,51271204) supported by the National Natural Science Foundation of ChinaProject(2012CB619500) supported by the National Basic Research Program of ChinaProject(NCET-06-0741) supported by the Program for New Century Excellent Talents, China
文摘Some applications of crystal plasticity modeling in equal channel angular extrusion（ECAE） of face-centered cubic metals were highlighted.The results show that such simulations can elucidate the dependency of grain refinement efficiency on processing route and the directionality of substructure development,which cannot be explained by theories that consider only the macroscopic deformation behavior.They can also capture satisfactorily the orientation stability and texture evolution under various processing conditions.It is demonstrated that crystal plasticity models are useful tools in exploring the crystallographic nature of grain deformation and associated behavior that are overlooked or sometimes erroneously interpreted by existing phenomenological theories.
基金This work was supported by the Provincial Key Projects for Scientifical and Technological Research of Zhejiang Province (No. 2006C12058)National Natural Science Foundation of China (No. 30571335) and a Grant-in-Aid for Innovative Training of Doctoral Students in JIangsu Province,China.
文摘Cyclic nucleotide-gated ion channels （CNGs） are distributed most widely in the neuronal cell. Great progress has been made in molecular mechanisms of CNG channel gating in the recent years. Results of many experiments have indicated that the stoichiometry and assembly of CNG channels affect their property and gating. Experiments of CNG mutants and analyses of cys- teine accessibilities show that cyclic nucleotide-binding domains （CNBD） bind cyclic nucleotides and subsequently conformational changes occurred followed by the concerted or cooperative conformational change of all four subunits during CNG gating. In order to provide theoretical assistances for further investigation on CNG channels, especially regarding the disease pathogenesis of ion channels, this paper reviews the latest progress on mechanisms of CNG channels, functions of subunits, processes of subunit assembly, and conformational changes of subunit regions during gating.
文摘To meet the demands for different supply voltage levels on SOC required by digital modules like CPU core and analog modules,a novel dual-output charge pump is proposed. The charge pump can output a step-up and a step-down voltage simultaneously with a high driving capability. The multiple gain pair technique was introduced to enhance its efficiency. The proposed co-use technology for capacitors and switch arrays reduced its cost. The charge pump was designed and fabricated in a TSMC 0.35μm mixed-signal CMOS process. A group of analytical equations were derived to model its static characteristics. A state-space model was derived to describe its small-signal dynamic behavior. Analytical predictions were verified by Spectre simulation and testing. The consistency of simulated results as well as test results with analytical predictions demonstrated the high precision of the derived analytical equations and the developed models.
基金Project(2006AA03Z115) supported by the National High-tech Research and Development Program of ChinaProject(2011CB606302-1) supported by the National Basic Research Program of ChinaProject(50774007) supported by the National Natural Science Foundation of China
文摘An innovative one-step semi-solid processing technique of A356 Al alloy,the serpentine channel pouring rheo-diecasting process （SCRC）,was explored.The mechanical properties and microstructures of the tensile samples made by the SCRC technique were tested in the as-cast and T6 heat treatment conditions.The experimental results show that the as-cast ultimate tensile strength can reach about 250MPa and the elongation is 8.6%？13.2%.The ultimate tensile strength can increase approximately 30% higher than that of the as-cast one but there is some slight sacrifice of the plasticity after T6 heat treatment.Under these experimental conditions,the semi-solid A356 Al alloy slurry with primary α1（Al） grains,which have the shape factor of 0.78？0.89 and the grain diameter of 35？45μm,can be prepared by the serpentine channel pouring process.The primary α2（Al） grains are very fine during the secondary solidification stage.Compared with the conventional HPDC process,the SCRC process can improve the microstructures and mechanical properties of the tensile test samples.The advantages of the SCRC process include easily incorporating with an existing HPDC machine,cancelling the preservation and transportation process of the semi-solid alloy slurry,and a higher cost performance.
基金Supported by the National Natural Science Foundation of China(61001167,61172149)~~
文摘In the clinical reports, the E1784K mutation in SCN5A is recognized as a phenotypic overlap between the long QT syndrome （LQT3） and the Brugada syndrome （BrS） in the characteristics of electrocardiograms （ECGs） since the mutation can influence sodium channel functions. However it is still unclear if the E1784K mutation-induced sodium ionic channel alterations account for the overlap at tissue level. Thsu, a detailed computational model is developed to underpin the functional impacts of the E1784K mutation on the action potential （AP）, the effective refractory period （ERP） and the abnormal ECG. Simulation results stlggest＇that the E1784K mutation-induced sodium channel alterations are insufficient to produce the phenotypic overlap between LQT3 and BrS, and the overlap may arise from the complicated effects of the E1784K mutation-induced changes in sodium channel currents with an increase of the transient outward current ITo or a decrease of the L-type calcium current ICaL .
基金Project(2011ZX04016-081)supported by the National Science and Technology Major Project of China
文摘The deformation characteristic in the forming process of aluminum alloy 7075 cross valve under multi-way loading was investigated by numerical simulation method. The results indicate that there exist 4 deformation patterns in the multi-way loading forming process of cross valve, such as forward extrusion, backward extrusion, forward-lateral extrusion and backward-lateral extrusion; one or several patterns occur at different forming stages depending on loading path. In general, the main deformation pattern is forward extrusion or backward extrusion at the initial stage; the main deformation pattern is backward extrusion at the intermediate stage, and the backward extrusion and forward-lateral extrusion occur at the final stage. In order to improve the cavity fill and reduce the forming defects, the lateral extrusion deformation should be increased at the initial and intermediate stages, and the forward extrusion deformation at the final forging stage should be reduced or avoided.
基金Project(51071056)supported by the National Natural Science Foundation of ChinaProjects(HEUCF121712,HEUCF201317002)supported by the Fundamental Research Funds for the Central Universities of China
文摘As a new attempt, equal channel angular extrusion （ECAE） of nickel-titanium shape memory alloy （NiTi SMA） tube was investigated by means of process experiment, finite element method （FEM） and microscopy. NiTi SMA tube with the steel core in it was inserted into the steel can during ECAE of NiTi SMA tube. Based on rigid-viscoplastic FEM, multiple coupled boundary conditions and multiple constitutive models were used for finite element simulation of ECAE of NiTi SMA tube, where the effective stress field, the effective strain field and the velocity field were obtained. Finite element simulation results are in good accordance with the experimental ones. Finite element simulation results reveal that the velocity field shows the minimum value in the corner of NiTi SMA tube, where severe shear deformation occurs. Microstructural observation results reveal that severe plastic deformation leads to a certain grain orientation as well as occurrence of substructures in the grain interior and dynamic recovery occurs during ECAE of NiTi SMA tube. ECAE of NiTi SMA tube provides a new approach to manufacturing ultrafine-grained NiTi SMA tube.
基金Supported by China Tobacco Yunnan Industrial.Co.,Ltd S&T Project([2013]No.494)~~
文摘[Objective] The aim was to explore interannual changes of soil nutrients in tobacco soils in Zhaotong, in order to provide theoretical references for tobacco bal- anced fertilization in Zhaotong. [Method] The research analyzed nutrient changes in tobacco soils in Zhaotong during 2011-2013. [Result] In Zhaotong, pH value of to- bacco soils was increasing; the contents of organic matter and N, P and K contents were in the range suitable for tobacco growth; CI- content was growing in tobacco soils and reached the highest in 2013. [Conclusion] In general, soil nutrients show insignificant differences internannually in Zhaotong.
