The apparatus for static and dynamic universal triaxial and torsional shear soil testing is employed to perform stress-controlled cyclic single-direction torsional shear tests and two-direction coupled shear tests und...The apparatus for static and dynamic universal triaxial and torsional shear soil testing is employed to perform stress-controlled cyclic single-direction torsional shear tests and two-direction coupled shear tests under unconsolidated-undrained conditions. Through a series of tests on saturated clay, the effects of initial shear stress and stress reversal on the clay’s strain-stress behavior are examined, and the behavior of pore water pressure is studied. The experimental results indicate that the patterns of stress-strain relations are distinctly influenced by the initial shear stress in the cyclic single-direction shear tests. When the initial shear stress is large and no stress reversal occurs, the predominant deformation behavior is characterized by an accumulative effect. When the initial shear stress is zero and symmetrical cyclic stress occurs, the predominant deformation behavior is characterized by a cyclic effect. The pore water pressure fluctuates around the confining pressure with the increase of cycle number. It seems that the fluctuating amplitude increases with the increase of the cyclic stress. But a buildup of pore water pressure does not occur. The de- formations of clay samples under the complex initial and the cyclic coupled stress conditions include the normal deviatoric deforma- tion and horizontal shear deformation, the average deformation and cyclic deformation. A general strain failure criterion taking into account these deformations is recommended and is proved more stable and suitable compared to the strain failure criteria currently used.展开更多
A non-equilibrium chromatographic rate model was employed to simulate the affinity chromatography of urokinase. The chromatography process was developed to a yield of high purity product of urokinase from crude materi...A non-equilibrium chromatographic rate model was employed to simulate the affinity chromatography of urokinase. The chromatography process was developed to a yield of high purity product of urokinase from crude materials. The affinity gel used in the process was prepared by an epichlorohydrin-activation method using epichlorohydrin activated Sepharose 4B as a matrix and p-aminobenzamidine as a ligand. The chromatographic process were numerically simulated and analyzed with the aid of VERSE-LC computer simulator. Considering the basic principles, rate model with the back mixing in column inlet was utilized in simulating and studying the effect of the column inlet pattern on other parameters. Comparison of the simulation results with the experimental data showed that the rate model can be used to describe the affinity chromatography of urokinase in a fixed bed column with satisfactory accuracy.展开更多
The last two to three decades have seen significant advances in the mechanics of unsaturated soils.It is now widely recognized that the fundamental principles in soil mechanics must cover both saturated and unsaturate...The last two to three decades have seen significant advances in the mechanics of unsaturated soils.It is now widely recognized that the fundamental principles in soil mechanics must cover both saturated and unsaturated soils.Nevertheless,there is still a great deal of uncertainties in the geotechnical community about how soil mechanics principles well-established for saturated soils can be extended to unsaturated soils.There is even wide skepticism about the necessity of such extension in engineering practice.This paper discusses some common pitfalls related to the fundamental principles that govern the volume change,shear strength and hydromechanical behaviour of unsaturated soils.It also attempts to address the issue of engineering relevance of unsaturated soil mechanics.展开更多
Experiments were carried out for a clamped rectangular aluminum plate to study the dynamic and acoustic behaviors in both pre-and post-buckling ranges under thermal loads.Plate temperature was elevated from ambient va...Experiments were carried out for a clamped rectangular aluminum plate to study the dynamic and acoustic behaviors in both pre-and post-buckling ranges under thermal loads.Plate temperature was elevated from ambient value to the level above the theoretical critical buckling temperature of the plate.In the whole test temperature range,the measured frequencies decreased to the minimum values in sequence,and then turned to increase as temperature rose.The softening effect of thermal stresses played the leading role in the decreasing stage and the stiffening effect of thermal buckling deflection became the major influence factor in the increasing stage.The later one could drive the temperature equilibrium point of the heated plate to move towards lower temperature range.All the frequencies would not drop to zero due to the inherent initial deflection which provides additional stiffness to the plate.Dynamic responses state two variation trends in different temperature ranges,shifting toward the lower frequency range and closing up in the mid-frequency range.The characters of spectrum responses changed gradually as the temperature was elevated.Numerical simulations gave predictions with same variation trend as the test results.展开更多
基金This work is supported by the National Natural Science Foundation of China (Grant Nos. 50579006, 50639010 and 50179006).
文摘The apparatus for static and dynamic universal triaxial and torsional shear soil testing is employed to perform stress-controlled cyclic single-direction torsional shear tests and two-direction coupled shear tests under unconsolidated-undrained conditions. Through a series of tests on saturated clay, the effects of initial shear stress and stress reversal on the clay’s strain-stress behavior are examined, and the behavior of pore water pressure is studied. The experimental results indicate that the patterns of stress-strain relations are distinctly influenced by the initial shear stress in the cyclic single-direction shear tests. When the initial shear stress is large and no stress reversal occurs, the predominant deformation behavior is characterized by an accumulative effect. When the initial shear stress is zero and symmetrical cyclic stress occurs, the predominant deformation behavior is characterized by a cyclic effect. The pore water pressure fluctuates around the confining pressure with the increase of cycle number. It seems that the fluctuating amplitude increases with the increase of the cyclic stress. But a buildup of pore water pressure does not occur. The de- formations of clay samples under the complex initial and the cyclic coupled stress conditions include the normal deviatoric deforma- tion and horizontal shear deformation, the average deformation and cyclic deformation. A general strain failure criterion taking into account these deformations is recommended and is proved more stable and suitable compared to the strain failure criteria currently used.
文摘A non-equilibrium chromatographic rate model was employed to simulate the affinity chromatography of urokinase. The chromatography process was developed to a yield of high purity product of urokinase from crude materials. The affinity gel used in the process was prepared by an epichlorohydrin-activation method using epichlorohydrin activated Sepharose 4B as a matrix and p-aminobenzamidine as a ligand. The chromatographic process were numerically simulated and analyzed with the aid of VERSE-LC computer simulator. Considering the basic principles, rate model with the back mixing in column inlet was utilized in simulating and studying the effect of the column inlet pattern on other parameters. Comparison of the simulation results with the experimental data showed that the rate model can be used to describe the affinity chromatography of urokinase in a fixed bed column with satisfactory accuracy.
基金supported by the National Natural Science Foundation of China(Grant No.51208519)
文摘The last two to three decades have seen significant advances in the mechanics of unsaturated soils.It is now widely recognized that the fundamental principles in soil mechanics must cover both saturated and unsaturated soils.Nevertheless,there is still a great deal of uncertainties in the geotechnical community about how soil mechanics principles well-established for saturated soils can be extended to unsaturated soils.There is even wide skepticism about the necessity of such extension in engineering practice.This paper discusses some common pitfalls related to the fundamental principles that govern the volume change,shear strength and hydromechanical behaviour of unsaturated soils.It also attempts to address the issue of engineering relevance of unsaturated soil mechanics.
基金supported by the National Natural Science Foundation of China(Grant Nos.11321062,11472206 and 91016008)
文摘Experiments were carried out for a clamped rectangular aluminum plate to study the dynamic and acoustic behaviors in both pre-and post-buckling ranges under thermal loads.Plate temperature was elevated from ambient value to the level above the theoretical critical buckling temperature of the plate.In the whole test temperature range,the measured frequencies decreased to the minimum values in sequence,and then turned to increase as temperature rose.The softening effect of thermal stresses played the leading role in the decreasing stage and the stiffening effect of thermal buckling deflection became the major influence factor in the increasing stage.The later one could drive the temperature equilibrium point of the heated plate to move towards lower temperature range.All the frequencies would not drop to zero due to the inherent initial deflection which provides additional stiffness to the plate.Dynamic responses state two variation trends in different temperature ranges,shifting toward the lower frequency range and closing up in the mid-frequency range.The characters of spectrum responses changed gradually as the temperature was elevated.Numerical simulations gave predictions with same variation trend as the test results.