传统“和治”及其在构建和谐社会中的价值

传统"和治"提出"和为贵"的治道目标、"尚中贵和"的治道方法、"仇必和而解"的治道保障,对今天如何构建社会主义和谐社会依然有重要价值。

从《医方论》看费伯雄学术思想

费伯雄强调辨证论治,反对滥用方药,无论是察脉辨证,还是立法制方,都是以醇正和缓为基础的。其学术成就同他的醇正和缓思想是紧密地联系在一起的,无论是察脉辨证,还是立法制方,都是以醇正和缓为基础的。他主张医学诊治戒偏戒杂,要"醇正""和治""缓治",以平淡之法而获奇效,不尚矜奇炫耀。

ESG趋向下的公司治理现代化

近年来,ESG理念引起国际社会的广泛关注,域外也不乏将该理念纳入公司治理的制度实践。我国公司法早已确立公司社会责任要求,最近又呈现出将公司社会责任进一步明确化、法律化的立法趋势,但其具体要求和法律效力仍不明确。这一治理要求应兼具较低限度的强制性要求和较高限度的授权性规则的结合,强制要求公司决策时考虑公司行为的负外部性,并对公司机关作出更广泛的ESG授权,允许其偏离对股东利益最大化的追求。如此,既实现这一规范的制度目的,又赋予公司在ESG趋势下的更多决策空间,实现公司治理的现代化。

FORTY-EIGHT CASES OF ACUTE GOUTY ARTHRITIS TREATED COMPREHENSIVELY WITH ELECTROACUPUNCTURE AND WARMING MOXIBUSTION

Objective To probe into the effects on acute gouty arthritis treated comprehensively with electroacupuncture (EA) and warming moxibustion. Methods 70 cases were randomized into treatment group (48 cases), in which the EA+warming moxibustion was applied; and controlled group (22 cases), in which, colchicine was prescribed for oral administration. Results The statistical outcomes after 1 course treatment in treatment group: 28 cases were cured (58.33%), 18 cases improved (37.50%) and the total effective rate was 95.83%. In controlled group: 12 cases (54.55%) were cured, 8 cases improved (36.36%) and the total effective rate was 90.91%. The therapeutic effects of two groups were basically consistent, without significant different (P>0.05). But, concerning to side effect, there was no any toxic side effects in the group treated with EA+warming moxibustion, and the occurrence rate in the group treated with colchicine was 40.91%. Conclusion Electroacupuncture+warming moxibustion achieves good therapeutic effects without any side effects.

对新形势下审美教育的重新审视

立足于现时代的新形势，在重新确定了审美教育与思想政治道德教育的关系后，我们发现加强审美教育是推进素质教育、实现人的全面发展的重要途径；是知识经济时代的直接要求；也是思想政治道德教育和精神文明建设的需要。这就要求我们转变传统的观念，通过理论教育、实践活动等途径，真正把审美教育纳入到整个教育体系中去。

ANALYSIS OF REGULATION AND HARMONIZATION IMPLIED IN A-B CLASSIC ON ACUPUNCTURE AND MOXIBUSTION

It aims to draw the conclusion that the ideas of treatment in Zhen Jiu Jia Yi Jing （《针灸甲乙经》, A-B Classic on Acupuncture and Moxibustion ） can be summarized as ＂regulation＂ and ＂harmonization＂ through the research of words in the Classic, such as ＂being normal＂, ＂regulation＂ and ＂harmonization＂. The lost of regulation of a normal person shows disharmony. Regulation can make the person-being-sick become harmony and back to ＂being normal＂. ＂Regulation＂ and ＂harmonization＂ right imply the quintessence of traditional Chinese medicine.

Stress and deformation due to embankment widening with different treatment techniques

A two-dimensional(2-D) finite element(FE) model was developed to analyze the deformation and stress of embankment on soft ground due to widening with different treatment techniques.It is found that the embankment widening induces transverse gradient change due to differential settlements and horizontal outward movements at the shoulder of the existing embankment.Embankment widening also increases the shear stress along the slope of the existing embankment,especially at the foot of slope.The failure potential due to embankment widening may increase with the increase of widening width when the widening width is smaller than 8.5 m,but may decrease with the increase of widening width as the widening width is greater than 8.5 m.The effectiveness of four ground and embankment treatment techniques,including geosynthetic reinforcement,light-weight embankment,deep mixed columns,and separating wall were compared.The results indicate that these treatments reduce the differential settlements and improve the stability.The light-weight embankment has the most effectiveness among four treatments.By using the fly-ash backfill material in widening,the transverse gradient change decreases from 0.5%-1.3% to 0.26%-0.8% and the maximum horizontal displacement decreases from 2.76 cm to 1.44 cm.

Effect of Water and Sediment Regulation on Lower Yellow River

According to the results of the water and sediment regulations of the Yellow River in year 2002—2007,the effect of erosion and deposition on the lower reaches,the amount and distribution of erosion and deposition in the river mouth area,the adjustment of river regime,the effect of river regulation projects and changes of flowing capacity of the channel are analyzed.It is revealed that the water and sediment regulation is efficient to reduce deposition and improve the flowing capacity and the conditions of sediment transport.

Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia

AIM: To investigate the efficacy and safety of n-3 polyunsaturated fatty acids (PUFA) from seal oils for patients with nonalcoholic fatty liver disease (NAFLD) associated with hyperlipidemia. METHODS: One hundred and forty-four patients with NAFLD associated with hyperlipidemia were included in the 24-wk, randomized, controlled trial. The patients were randomized into two groups. Group A (n = 72) received recommended diet and 2 g n-3 PUFA from seal oils, three times a day. Group B (n = 72) received recommended diet and 2 g placebo, three times a day. Primary endpoints were fatty liver assessed by symptom scores, liver alanine aminotransferase (ALT) and serum lipid levels after 8, 12, 16, and 24 wk. Hepatic fat inf iltration was detected by ultrasonography at weeks 12 and 24 after treatment. RESULTS: A total of 134 patients (66 in group A, 68 in group B) were included in the study except for 10 patients who were excluded from the study. After 24 wk of treatment, no change was observed in body weight, fasting blood glucose (FBG), renal function and blood cells of these patients. Total symptom scores, ALT and triglyceride (TG) levels decreased more significantly in group A than in group B (P < 0.05). As expected, there was a tendency toward improvement in aspartate aminotransferase (AST), γ-glutamyltranspeptidase (GGT), and total cholesterol (TCHO) and high- density lipoprotein (HDL) cholesterol levels (P < 0.05) after administration in the two groups. However, no significant differences were found between the two groups. The values of low-density lipoprotein (LDL) were significantly improved in group A (P < 0.05), but no significant change was found in group B at different time points and after a 24-wk treatment. After treatment, complete fatty liver regression was observed in 19.70% (13/66) of the patients, and an overall reduction was found in 53.03% (35/66) of the patients in group A. In contrast, in group B, only f ive patients (7.35%, 5/68) achieved complete fatty liver regression (P = 0.04), whereas 24 patients (35.29%, 24/68) had a certain improvement in fatty liver (P = 0.04). No serious adverse events occurred in all the patients who completed the treatment. CONCLUSION: Our results indicate that n-3 PUFA from seal oils is safe and effi cacious for patients with NAFLD associated with hyperlipidemia and can improve their total symptom scores, ALT, serum lipid levels and normalization of ultrasonographic evidence. Further study is needed to confi rm these results.

Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment

Background Available data regarding clinical profile and management of elderly patients with atrial fibrillation （AF） according to dependency, fragility and cognitive impairment are scarce. The objective of the study was to analyze the biodemographic data, clinical profile and antithrombotic treatment according to dependency, fragility and cognitive impairment in elderly AF patients. Methods Cross- sectional and multi-center study performed in consecutive AF patients ≥ 75 years treated with oral anticoagulants ≥ 3 months attended in Internal Medicine Departments in Spain. Results A total of 837 patients （83.0 ± 5.0 years; CHA2DS2-VASc： 5.0 ± 1.4; HAS-BLED： 2.1 ± 0.9） were included. 44.4% of patients had some degree of dependency, 43.3% were fragile, and 32.3% had cognitive impairment. Patients with any of these conditions were older, had a worse clinical profile, with more comorbidities and higher risks of thromboembolic and bleeding events. All these conditions were independently associated among them. Overall, 70.8% of patients were taking vitamin K antagonists, the remaining 29.2% direct oral anticoagulants and 9.7% oral antiplatelets. This distribution was independent of the presence of dependency or fragility, but there was a trend to a higher prescription of vitamin K antagonists in those patients with cognitive impairment （75.2% vs. 68.8%; P = 0.05）. Conclusions Approximately 32%-44% of elderly anticoagulated AF patients attended have some degree of dependency, fragility and/or cognitive impairment. Patients with any of these conditions are older and have a worse clinical profile. Ap？proximately 71% of patients are taking vitamin K antagonists, regardless dependency or frailty, but with a trend to higher prescription in patients with cognitive impairment.

Research progress of microRNA in prevention and treatment of osteonecrosis of the femoral head

In the 1980s,Feinbaum et al.first discovered miRNA in the development of worms and termed it as Lin-4.With the development of microbial science and continuous improvement in the gene sequencing technology,miRNA has been gradually gaining attention for intensive research in clinical medicine.Among these,one group of miRNAs has been confirmed to play fundamental roles in gene regulation in various orthopedics diseases,such as bone tumors,osteoarthritis,and rheumatoid arthritis.The study of miRNAs in the osteonecrosis of the femoral head(ONFH)can improve the understanding of the pathogenesis of the disease.ONFH is an orthopedic disease that is the primary cause of disrupted blood supply to the femoral head and the main symptoms of bone and muscle dysfunction.Recent studies showed that miRNA played a major role in the regulation of the microcirculation of ONFH,damage and repair of blood vessels,local microcirculation dysfunction caused by other diseases,and apoptosis of bone cells.In this study,recent related research results of miRNA and ONFH were analyzed and summarized,and the prospective in the prevention and treatment of the disease was also discussed.

Comparison of PPIs and H_2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia

AIM： To compare efficacy of proton pump inhibitors （PPIs） with H2-receptor antagonists （H2RA$） plus pro- kinetics （Proks） for dysmotility-like symptoms in func- tional dyspepsia （FD）. METHODS： Subjects were randomized to receive openlabel treatment with either rabeprazole 10 mg od （n = 57） or famotidine 10 mg bid plus mosapride 5 mg tid （n = 57） for 4 wk. The primary efficacy endpoint was change （%） from baseline in total dysmotility-like dyspepsia symptom score. The secondary efficacy endpoint was patient satisfaction with treatment. RESULTS： The improvement in dysmotility-like dyspep- sia symptom score on day 28 was significantly greater in the rabeprazole group （22.5% ± 29.2% of baseline） than the famotidine ＋ mosapride group （53.2%±58.6% of baseline, P 〈 0.0001）. The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori status. Significantly more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine ＋ mosapride group （87.7% vs 59.6%, P = 0.0012）. Rabeprazole therapy was the only significant predictor of treatment response （P 〈 0.0001）, defined as a total symptom score improvement ≥ 50%. CONCLUSION： PPI monotherapy improves dysmotil- ity-like symptoms significantly better than H2RAs plus Proks, and should be the treatment of first choice for Japanese FD.

Redo Coronary Artery Bypass Grafting: On-Pump and Off-Pump Coronary Artery Bypass Grafting Revascularization Techniques

Objective To analyze the short-term outcomes of redo coronary artery bypass grafting(CABG) using on-pump and off-pump CABG techniques. Methods From January 2003 to August 2013, non-randomized 80 patients were treated with redo CABG in the Department of Cardiac Surgery, Peking University Third Hospital. Among these patients, 40 underwent on-pump CABG technique(redo-ONCAB group) and 40 underwent off-pump CABG technique(redo-OPCAB group). Furthermore, transmyocardial laser revascularization was performed in high-risk patients who were not suitable to conventional grafting. Clinical data of the two groups were recorded and analyzed including operation time, coronary grafts, incomplete revascularization, postoperative ventilation, perioperative stroke, and low output syndrome, etc. Results There were no significantly differences in age, gender distribution, incidences of hypertension, stroke, and other clinical characteristics between redo-OPCAB group and redo-ONCAB group(all P>0.05), except for incidences of renal dysfunction and pulmonary disease(all P<0.05). The number of grafting vessels in the redo-ONCAB and redo-OPCAB groups was 2.1 ± 0.74 and 1.4 ±0.52 respectively. There was significant difference between the two groups(P=0.0243). Compared with the redo-ONCAB group, there was shorter operation time(P=0.0045), postoperative ventilation(P=0.0211) and intensive care unit stay(P=0.0400), as well as fewer use of platelet(P=0.0338) and blood transfusion(P=0.0034) in the redo-OPCAB group. The incidence of incomplete revascularization(P=0.0253) and the use of transmyocardial laser revascularization(P=0.0052) were higher in the redo-OPCAB group than those in the redo-ONCAB group(all P<0.05). However, no significant differences were showed for the incidence of the use of intra aortic balloon pump and continuous renal replacement therapy, perioperative stroke, low output syndrome, and in-hospital mortality between the two groups(all P>0.05). Conclusion Redo CABG is the safety and efficacy surgical procedure, and redo-OPCAB technique with better outcomes is commended especially in high-risk patients.

Dual-specificity phosphatase 6(DUSP6): a review of its molecular characteristics and clinical relevance in cancer

Mitogen-activated protein kinases(MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogenesis, which leads to development and progression of human cancer. Dual-specificity phosphatase 6(DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback regulation in the MAPK pathway of mammalian cells. This phosphatase functions in a dual manner, pro-oncogenic or tumor-suppressive, depending on the type of cancer. To date, the tumor-suppressive role of DUSP6 has been demonstrated in pancreatic cancer, non-small cell lung cancer, esophageal squamous cell and nasopharyngeal carcinoma, and ovarian cancer. Its pro-oncogenic role has been observed in human glioblastoma, thyroid carcinoma, breast cancer, and acute myeloid carcinoma. Both roles of DUSP6 have been documented in malignant melanoma depending on the histological subtype of the cancer. Loss-or gain-of-function effects of DUSP6 in these cancers highlights the significance of this phosphatase in carcinogenesis. Development of methods that use the DUSP6 gene as a therapeutic target for cancer treatment or as a prognostic factor for diagnosis and evaluation of cancer treatment outcome has great potential. This review focuses on molecular characteristics of the DUSP6 gene and its role in cancers in the purview of development, progression, and cancer treatment outcome.

Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids

We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid(ALTA) regimen. A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine. The acute liver injury was classified clinically as hepatocellular and pathologically as cholestastic. We could not classify the mechanism of injury. High eosinophil and immunoglobulin E levels characterized the injury,and a drug lymphocyte stimulation test was negative on postoperative day 25. Fluid replacement for two weeks after hospitalization improved the liver injury. ALTA therapy involves injecting chemicals into the submucosa,from the rectum to the anus,and this is the first description of a case that developed a severe liver disorder after this treatment; hence,an analysis of future cases as they accumulate is desirable.

Molecular characteristics and stages of chronic hepatitis B virus infection

Hepatitis B virus (HBV) is a common viral pathogen that causes a substantial health burden worldwide. Remarkable progress has been made in our understanding of the natural stages of chronic HBV infection. A dynamic balance between viral replication and host immune response is pivotal to the pathogenesis of liver disease. Knowledge of the HBV genome organization and replication cycle can unravel HBV genotypes and molecular variants, which contribute to the heterogeneity in outcome of chronic HBV infection. Most HBV infections are spontaneously resolved in immunocompetent adults, whereas they become chronic in most neonates and infants at a great risk of developing complications such as cirrhosis and hepatocellular carcinoma (HCC). Those with chronic HBV infection may present in one of the four phases of infection: immune tolerance, immune clearance [hepatitis B eantigen (HBeAg)-positive chronic hepatitis B (CHB)], inactive carrier state, and reactivation (HBeAg-negative CHB). Understanding the dynamic nature of chronic HBV infection is crucial in the management of HBV carriers. Long-term monitoring and optimal timing of antiviral therapy for chronic HBV infection help to prevent progression of HBV-related liver disease to its later stage, particularly in patients with higher risk markers of HCC, such as serum DNA concentration, HBeAg status, serum aminotransferase, HBV genotypes, and pre-core or core mutants.

The Impact of Outsourcing on Local Industry Upgrading: a Case of China from a Global Value Chain Perspective

This paper develops a conceptual model to assess effect of outsourcing by integrating the theories of industrial upgrading and global value chain (GVC) governance. Contrary to the widely accepted perception that outsourcing is expected to generate positive spillover in particular, the findings indicate that outsourcing has different effects in different GVC governance modes. Excess outsourcing could structurally inhibit technology and management spillovers to subcontractors within the emerging economy context. Based on a case study of the Chinese textile and apparel (T & A) industry, it is found that the Chinese T & A industry has been trapped in the captive governance relationship with foreign buyers, and at the same time is capped below the function upgrading level. Consequences of the situation and implication are then discussed.

Improvement Of Rural Social Security System and the Service Government Construction

The establishment and improvement of the social system is an important indicator of a nation political cultures and social development, and is the basic guarantee of social harmony. In recent years, our urban social security system is maturing, but rural social security system is almost a blank, affecting the economic and political development, and the progress of the farmers, and restricting the process of service government construction.Service government is a new model of government, which orients the purpose of fundamental interests for the whole people. The rural and the farmers are the focus of our country, and the improvement of rural social security system is the key point for solving the problems. Therefore, it is really important to deal with the relationship between the improvement of rural social security system and the service government construction.In my essay, based on the analysis of the theory of rural social security system and the service government, I will put forward the ideas of the improvement of rural social security system and the service government construction.

Effects of Integrated Technology of Medicine and Fertilizer on Bacterial Wilt of Tobacco

In order to validate the control effects of integrated technology of medicine and fertilizer on tobacco bacterial wilt,field experiments were conducted by using youmeili and tetracycline as the test agents.The results obtained were listed as follows:(1)The incidence rate of bacterial wilt ascended more quickly after July 10 th,the incidence of CK reached 78.30%on July 25 th.(2)The control effect of“youmeili 3 g+tetramycin 200 times liquid”reached 69.47%,significantly higher than other treatments.(3)The output value of“Youmeil 3 g+tetramycin 200 times liquid”served as 1635.66 yuan/667m^2,with the highest economic character in all treatments.In a word,integrated technology of medicine and fertilizer was a feasible approach to control tobacco bacterial wilt.

Hypotheses of ＂Harmonious Man＂： The Humanity Upgrade of Management and It＇s Sustainability Significance

Hypotheses of humanity is the logical premise and foundation of institution design and perfect. ＂Political man＂ had boosted the sprout of ancient democracy polity, ＂economic man＂ has accelerated the development of market economy in immediate and modern times, ＂free man＂ described the blueprint of future society, and ＂harmonious man＂ will promote the construction of harmonious society and the development of management to conducting oneself so as to serve others. The article explains the theory headstream, abstract ways, basic intension and sustainability effect to the hypotheses of＂harmonious man＂.